Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO

Journal of Asthma

Volumn 46, Issue 6, 2009, Pages 606-612

  Porsbjerg, Celeste ^a   Lund, Thomas Kromann ^a   Pedersen, Lars ^a   Backer, Vibeke ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Airway hyperresponsiveness; Asthma; Exhaled NO; Inflammation; Phenotype

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; MANNITOL; METHACHOLINE; NITROGEN OXIDE;

ADULT; AGED; ARTICLE; ASTHMA; ASTHMATIC STATE; ATOPY; BRONCHUS HYPERREACTIVITY; DISEASE CLASSIFICATION; DISEASE SEVERITY; EOSINOPHIL; EOSINOPHILIC ASTHMA; EXPIRED AIR; FEMALE; HUMAN; INFLAMMATION; LEUKOCYTE DIFFERENTIAL COUNT; MAJOR CLINICAL STUDY; MALE; MILD INTERMITTENT ASTHMA; MILD PERSISTENT ASTHMA; MIXED GRANULOCYTIC ASTHMA; MODERATE PERSISTENT ASTHMA; NEUTROPHIL; NEUTROPHILIC ASTHMA; PAUCIGRANULOCYTIC ASTHMA; PEAK EXPIRATORY FLOW; PRICK TEST; PROVOCATION TEST; RHINITIS; SEVERE PERSISTENT ASTHMA; SKIN TEST; SMOKING; SPIROMETRY; SPUTUM ANALYSIS;

ADOLESCENT; ADULT; ASTHMA; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; EOSINOPHILS; EXHALATION; FEMALE; HUMANS; INFLAMMATION; LUNG; MALE; MANNITOL; MIDDLE AGED; NEUTROPHILS; NITRIC OXIDE; PHENOTYPE; POWDERS; SPUTUM; YOUNG ADULT;

EID: 68849086058     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.1080/02770900903015654     Document Type: Article

References (24)

1. Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet 1999 Jun 26; 353(9171):2213-2114.
2. Haldar P, Pavord ID. Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J Allergy Clin Immunol 2007 May; 119(5):1043-1052; quiz 1053-1054.
3. Green RH, Brightling CE, Bradding P. The reclassification of asthma based on subphenotypes. Curr Opin Allergy Clin Immunol 2007 Feb; 7(1):43-50. Review.
4. Berry MA, Shaw DE, Green RH, Brightling CE, Wardlaw AJ, Pavord ID. The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy 2005 Sep; 35(9):1175-1179.
5. Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 2006 Jan; 11(1):54-61.
6. Porsbjerg C, Brannan JD, Anderson SD, Backer V. Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients. Clin Exp Allergy. 2008 Jan;38(1):43-50.
7. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008 Jan; 31(1): 143-178.
8. ATSWorkshop Proceedings. Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate: Executive Summary. Am J Respir Crit Care Med. 2006 Apr 1; 173(7):811-813.
9. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J 2005 Aug; 26(2):319-338.
10. Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, Gonda I, Walsh A, Clark AR. A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 1997 Sep; 156(3 Pt 1):758-765.
11. Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B; Aridol Study Group. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir Res 2005 Dec 9; 6:144.
12. Paggiaro PL, Chanez P, Holz O, Ind PW, Djukanovic R, Maestrelli P, Sterk PJ. Sputum induction. Eur Respir J Suppl 2002 Sep; 37:3s-8s.
13. Dreborg S. Skin tetst used in type I allergy testing (position paper). Allergy 1989; 44(suppl.10):22-30.
14. Pizzichini E, Pizzichini MM, Efthimiadis A, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluidphase measurements. Am J Respir Crit Care Med 1996; 154:308-317.
15. Spanevello A, Confalonieri M, Sulotto F, Romano F, Balzano G, Migliori GB, Bianchi A, Michetti G. Induced sputum cellularity. Reference values and distribution in normal volunteers. Am J Respir Crit Care Med 2000 Sep; 162(3 Pt 1):1172-1174.
16. Hargreave FE. Quantitative sputum cell counts as a marker of airway inflammation in clinical practice. Curr Opin Allergy Clin Immunol 2007 Feb; 7(1):102-106. Review.
17. Chaudhuri R, Livingston E, McMahon AD, Lafferty J, Fraser I, Spears M, McSharry CP, Thomson NC. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am J Respir Crit Care Med 2006 Jul 15; 174(2):127-133.
18. ten Brinke A, van Dissel JT, Sterk PJ, Zwinderman AH, Rabe KF, Bel EH. Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection. J Allergy Clin Immunol 2001 Mar; 107(3):449-454.
19. Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 2008 Jan 15; 177(2):148-155.
20. Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax. 2007 Mar; 62(3):211-218.
21. Brightling C, Berry M, Amrani Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol 2008 Jan; 121(1):5-10.
22. Peden DB, Tucker K, Murphy P, Newlin-Clapp L, Boehlecke B, Hazucha M, Bromberg P, Reed W. Eosinophil influx to the nasal airway after local, low-level LPS challenge in humans. J Allergy Clin Immunol 1999 Aug; 104(2 Pt 1):388-394.
23. Koskela HO, Hyvarinen L, Brannan JD, Chan HK, Anderson SD. Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest 2003 Oct; 124(4):1341-1349.
24. Smith AD, Cowan JO, Brassett KP, Filsell S, McLachlan C, Monti-Sheehan G, Peter Herbison G, Robin Taylor D. Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med 2005 Aug 15; 172(4):453-459.