Localization of pathology in asthma

Clinical and Experimental Allergy

Volumn 39, Issue 10, 2009, Pages 1450-1452

  James, A L ^a  

^a SIR CHARLES GAIRDNER HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; CD8 ANTIGEN; CIGARETTE SMOKE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FOOD ALLERGEN; IMMUNOGLOBULIN E; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; PADGEM PROTEIN;

ALLERGIC REACTION; ASTHMA; BRONCHOSPASM; DISEASE MARKER; EDITORIAL; ENVIRONMENTAL EXPOSURE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INFLAMMATORY CELL; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PULMONARY VASCULITIS; RISK FACTOR; SENSITIZATION;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD; ARTERITIS; ASTHMA; CHILD; CHYMASES; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTES; LUNG; MALE; MAST CELLS; MIDDLE AGED; PULMONARY ARTERY; RETROSPECTIVE STUDIES; TRYPTASES;

EID: 70349110838     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03330.x     Document Type: Editorial

References (18)

1. Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006 368 : 763 770.
2. Hogg JC, Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004 350 : 2645 2653.
3. Cosio MG, Guerassimov A. Chronic obstructive pulmonary disease. Inflammation of small airways and lung parenchyma. Am J Respir Crit Care Med 1999 160 (Part 2) : S21 5.
4. Temelkovski J, Hogan SP, Shepherd DP, Foster PS, Kumar RK. An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 1998 53 : 849 856.
5. Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000 105 (Part 1) : 193 204.
6. Siddiqui S, Sutcliffe A, Shikotra A et al. Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis. J Allergy Clin Immunol 2007 120 : 813 819.
7. Black JL, Roth M, Lee J, Carlin S, Johnson PR. Mechanisms of airway remodeling. Airway smooth muscle. Am J Respir Crit Care Med 2001 164 (Part 2) : S63 6.
8. Bai TR. Abnormalities in airway smooth muscle in fatal asthma. A comparison between trachea and bronchus. Am Rev Respir Dis 1991 143 : 441 443.
9. James AL, Bai TR, Mauad T et al. Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. Eur Respir J 2009, in press.
10. Paredi P, Barnes PJ. The airway vasculature: recent advances and clinical implications. Thorax 2009 64 : 444 450.
11. Wagner EM, Mitzner WA. Bronchial circulatory reversal of methacholine-induced airway constriction. J Appl Physiol 1990 69 : 1220 1224.
12. Shiang C, Mauad T, Senhorini A et al. Pulmonary periarterial inflammation in fatal asthma. Clin Exp Allergy 2009 39 : 1499 1507.
13. Saetta M, Di Stefano A, Rosina C, Thiene G, Fabbri LM. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991 143 : 138 143.
14. Green FH, Butt JC, James AL, Carroll NG. Abnormalities of the bronchial arteries in asthma. Chest 2006 130 : 1025 1033.
15. Tschernig T, Janardhan KS, Pabst R, Singh B. Lipopolysaccharide induced inflammation in the perivascular space in lungs. J Occup Med Toxicol 2008 3 : 17. Available at
16. Doerschuk CM. Leukocyte trafficking in alveoli and airway passages. Respir Res 2000 1 : 136 140.
17. Ainslie MP, McNulty CA, Huynh T, Symon FA, Wardlaw AJ. Characterisation of adhesion receptors mediating lymphocyte adhesion to bronchial endothelium provides evidence for a distinct lung homing pathway. Thorax 2002 57 : 1054 1059.
18. Miller LA, Hurst SD, Coffman RL et al. Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys. Clin Exp Allergy 2005 35 : 894 906.