Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma

Respiratory Medicine

Volumn 99, Issue 2, 2005, Pages 200-207

  Nguyen, Lan Tien ^a   Lim, Sam ^a   Oates, Timothy ^a   Chung, Kian Fan ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Asthma; Corticosteroids; Eosinophil; Neutrophil

Indexed keywords

BUDESONIDE; ENZYME ANTIBODY; INTERLEUKIN 8; LEUKOCYTE ELASTASE; MAJOR BASIC PROTEIN; MYELOPEROXIDASE; PLACEBO; PREDNISOLONE; PROTEIN ANTIBODY;

ARTICLE; ASTHMA; BRONCHUS BIOPSY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; EOSINOPHIL; FIBEROPTIC BRONCHOSCOPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; LONG TERM CARE; LUNG FUNCTION TEST; NEUTROPHILIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT MUCOSA; SPUTUM ANALYSIS;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHODILATOR AGENTS; BUDESONIDE; DOUBLE-BLIND METHOD; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; MALE; NEUTROPHILS; PREDNISOLONE; SPUTUM;

EID: 12144261115     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2004.06.007     Document Type: Article

References (33)

1. J. Bousquet P. Chanez J.Y. Lacoste G. Barneon N. Ghavanian I. Enander et al. Eosinophilic inflammation in asthma New Engl J Med 323 1990 1033-1039
2. M. Romagnoli I. Vachier dlF. Tarodo H. Meziane C. Chavis J. Bousquet et al. Eosinophilic inflammation in sputum of poorly controlled asthmatics Eur Respir J 20 6 2002 1370-1377
3. R. Djukanovic J.W. Wilson K.M. Britten S.J. Wilson A.F. Walls W.R. Roche et al. The effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma Am Rev Respir Dis 145 1992 669-674
4. L.A. Laitinen A. Laitinen T. Haahtele A comparative study of the effects of an inhaled corticosteroid, budesemide, and of a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma J Allergy Clin Immunol 90 1992 32-42
5. S. Lim A. Jatakanon M. John T. Gilbey B.J. O'Connor K.F. Chung et al. Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma Am J Respir Crit Care Med 159 1 1999 22-30
6. S. Sur T.B. Crotty G.M. Kephart B.A. Hyma T.V. Colby C.E. Reed et al. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Resp Dis 148 1993 713-719
7. C. Lamblin P. Gosset I. Tillie-Leblond F. Saulnier C.H. Marquette B. Wallaert et al. Bronchial neutrophilia in patients with noninfectious status asthmaticus Am J Respir Crit Care Med 157 2 1998 394-402
8. R.J. Martin L.C. Cicutto H.R. Smith R.D. Ballard S.J. Szefler Airway inflammation in nocturnal asthma Am Rev Respir Dis 143 1991 351-357
9. J.V. Fahy K.W. Kim J. Liu H.A. Boushey Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation J Allergy Clin Immunol 95 4 1995 843-852
10. A. Jatakanon C. Uasuf W. Maziak S. Lim K.F. Chung P.J. Barnes Neutrophilic inflammation in severe persistent asthma Am J Respir Crit Care Med 160 5 Part 1 1999 1532-1539
11. S.E. Wenzel S.J. Szefler D.Y.M. Leung S.I. Sloan M.D. Rex R.J. Martin Bronchoscopic evaluation of severe asthma: Persistent inflammation associated with high dose glucocorticoids Am J Respir Crit Care Med 156 1997 737-743
12. L.C. Meagher J.M. Cousin J.R. Seckl C. Haslett Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes J Immunol 156 11 1996 4422-4428
13. A. Efthimiadis A. Spanevello Q. Hamid M.M. Kelly M. Linden R. Louis et al. Methods of sputum processing for cell counts* immunocytochemistry and in situ hybridization Eur Respir J (Suppl) 37 2002 19s-23s
14. V.M. Keatings A. Jatakanon Y.M. Worsdell P.J. Barnes Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD Am J Respir Crit Care Med 155 2 1997 542-548
15. R. Djukanovic S. Homeyard C. Gratziou J. Madden A. Walls S. Montefort et al. The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation Am J Respir Crit Care Med 155 3 1997 826-832
16. M. Hoshino Y. Nakamura Anti-inflammatory effects of inhaled beclomethasone dipropionate in nonatopic asthmatics Eur Respir J 9 4 1996 696-702
17. W. Wilmsmeyer D. Ukena T.O. Wagner G.W. Sybrecht First-time treatment with steroids in bronchial asthma: Comparison of the effects of inhaled beclomethasone and of oral prednisone on airway function, bronchial reactivity and hypothalamic-pituitary-adrenal axis Eur Respir J 3 7 1990 786-791
18. C.R. Jenkins A.J. Woolcock Effect of prednisolone and beclomethasone dipropionate on airway responsiveness in asthma: A comparative study Thorax 43 1988 378-384
19. W.W. Busse P. Chervinsky J. Condemi W.R. Lumry T.L. Petty S.I. Rennard et al. Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma J Allergy Clin Immunol 101 1998 457-463
20. G. Cox Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes J Immunol 154 9 1995 4719-4725
21. T. Nittoh H. Fujimori Y. Kozumi K. Ishihara S. Mue K. Ohuchi Effects of glucocorticoids on apoptosis of infiltrated eosinophils and neutrophils in rats Eur J Pharmacol 354 1 1998 73-81
22. W.C. Liles D.C. Dale S.J. Klebanoff Glucocorticoids inhibit apoptosis of human neutrophils Blood 86 8 1995 3181-3188
23. K.L. Woolley P.G. Gibson K. Carty A.J. Wilson S.H. Twaddell M.J. Woolley Eosinophil apoptosis and the resolution of airway inflammation in asthma Am J Respir Crit Care Med 154 1 1996 237-243
24. H.U. Simon Regulation of eosinophil and neutrophil apoptosis--similarities and differences Immunol Rev 179 2001 156-162
25. N. Carroll S. Carello C. Cooke A. James Airway structure and inflammatory cells in fatal attacks of asthma Eur Respir J 9 4 1996 709-715
26. R. Louis L.C. Lau A.O. Bron A.C. Roldaan M. Radermecker R. Djukanovic The relationship between airways inflammation and asthma severity Am J Respir Crit Care Med 161 1 2000 9-16
27. S.E. Wenzel L.B. Schwartz E.L. Langmack J.L. Halliday J.B. Trudeau R.L. Gibbs et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics Am J Respir Crit Care Med 160 3 1999 1001-1008
28. R.J. Martin L.C. Cicutto H.R. Smith R.D. Ballard S.J. Szefler Airways inflammation in nocturnal asthma Am Rev Respir Dis 143 2 1991 351-357
29. P.G. Woodruff R. Khashayar S.C. Lazarus S. Janson P. Avila H.A. Boushey et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma J Allergy Clin Immunol 108 5 2001 753-758
30. S.A. Little K.J. MacLeod G.W. Chalmers J.G. Love C. McSharry N.C. Thomson Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma Am J Med 112 6 2002 446-452
31. P.M. O'Byrne E.H. Walters B.D. Gold H.A. Aizawa L.M. Fabbri S.E. Alpert et al. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure Am Rev Respir Dis 130 1984 214-219
32. 3 -induced charge in bronchial reactivity to methacholine and airway inflammation in humans J Appl Physiol 60 1986 1321-1326
33. B. Pedersen R. Dahl R. Karlstrom C.G. Peterson P. Venge Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking Am J Respir Crit Care Med 153 5 1996 1519-1529