Yeast sirtuins and the regulation of aging

FEMS Yeast Research

Volumn 14, Issue 1, 2014, Pages 73-88

  Wierman, Margaret B ^a   Smith, Jeffrey S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Caloric restriction; Lifespan; Metabolism; NAD +; Silencing; Sir2

Indexed keywords

HISTONE DEACETYLASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN;

AGING; ARTICLE; CALORIC RESTRICTION; DEACETYLATION; DOUBLE STRANDED DNA BREAK; ENVIRONMENTAL STRESS; EUKARYOTE; GENE DOSAGE; GENE MAPPING; GENE SILENCING; GENETIC TRANSCRIPTION; HETEROCHROMATIN; HOMOLOGOUS RECOMBINATION; LIFESPAN; LONGEVITY; NONHUMAN; SACCHAROMYCES CEREVISIAE; TELOMERE; YEAST; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

GENE EXPRESSION REGULATION, FUNGAL; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE; SIRTUINS;

EID: 84893760820     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/1567-1364.12115     Document Type: Article

References (143)

1. Aguilaniu H, Gustafsson L, Rigouet M & Nystrom T (2003) Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299: 1751-1753.
2. + levels. J Biol Chem 277: 18881-18890.
3. Anderson RM, Latorre-Esteves M, Rute Neves A, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H & Sinclair DA (2003a) Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 302: 2124-2126.
4. Anderson RM, Bitterman KJ, Wood JG & Sinclair DA (2003b) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185.
5. Bedalov A, Hirao M, Posakony J, Nelson M & Simon JA (2003) NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol 23: 7044-7054.
6. +. Cell 129: 473-484.
7. Belenky PA, Moga TG & Brenner C (2008) Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1. J Biol Chem 283: 8075-8079.
8. + homeostasis and allows engineering of vitamin production. PLoS One 6: e19710.
9. + in fungi and humans. Cell 117: 495-502.
10. + synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. J Biol Chem 278: 33049-33055.
11. Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M & Sinclair DA (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1. J Biol Chem 277: 45099-45107.
12. Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L & Boeke JD (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9: 2888-2902.
13. Braunstein M, Rose AB, Holmes SG, Allis CD & Broach JR (1993) Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev 7: 592-604.
14. Bryk M, Banerjee M, Murphy M, Knudsen KE, Garfinkel DJ & Curcio MJ (1997) Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes Dev 11: 255-269.
15. Buck SW, Sandmeier JJ & Smith JS (2002) RNA polymerase I propagates unidirectional spreading of rDNA silent chromatin. Cell 111: 1003-1014.
16. Burtner CR, Murakami CJ, Kennedy BK & Kaeberlein M (2009) A molecular mechanism of chronological aging in yeast. Cell Cycle 8: 1256-1270.
17. Burtner CR, Murakami CJ, Olsen B, Kennedy BK & Kaeberlein M (2011) A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle 10: 1385-1396.
18. Caballero A, Ugidos A, Liu B, Oling D, Kvint K, Hao X, Mignat C, Nachin L, Molin M & Nystrom T (2011) Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing. Mol Cell 42: 390-400.
19. Casatta N, Porro A, Orlandi I, Brambilla L & Vai M (2013) Lack of Sir2 increases acetate consumption and decreases extracellular pro-aging factors. Biochim Biophys Acta 1833: 593-601.
20. Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD & Verreault A (2006) The Sirtuins Hst3 and Hst4p preserve genome integrity by controlling histone H3 lysine 56 deacetylation. Curr Biol 16: 1280-1289.
21. Chan JN, Poon BP, Salvi J, Olsen JB, Emili A & Mekhail K (2011) Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains. Dev Cell 20: 867-879.
22. Cioci F, Vu L, Eliason K, Oakes M, Siddiqi IN & Nomura M (2003) Silencing in yeast rDNA chromatin. Mol Cell 12: 135-145.
23. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK & Berger SL (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459: 802-807.
24. Defossez PA, Prusty R, Kaeberlein M, Lin S-J, Ferrigno P, Silver PA, Keil RL & Guarente L (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3: 447-455.
25. Delaney JR, Sutphin GL, Dulken B et al. (2011) Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10: 1089-1091.
26. Derbyshire MK, Weinstock KG & Strathern JN (1996) HSTl, a new member of the SIR2 family of genes. Yeast 12: 631-640.
27. D'Mello NP & Jazwinski SM (1991) Telomere length constancy during aging of Saccharomyces cerevisiae. J Bacteriol 173: 6709-6713.
28. Donze D, Adams CR, Rine J & Kamakaka RT (1999) The boundaries of the silenced HMR domain in Saccharomyces cerevisiae. Genes Dev 13: 698-708.
29. Draskovic I & Londono-Vallejo A (2013) Telomere recombination and alternative telomere lengthening mechanisms. Front Biosci, 18: 1-20.
30. Dubarry M, Loiodice I, Chen CL, Thermes C & Taddei A (2011) Tight protein-DNA interactions favor gene silencing. Genes Dev 25: 1365-1370.
31. Easlon E, Tsang F, Dilova I, Wang C, Lu SP, Skinner C & Lin SJ (2006) The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension. J Biol Chem 282: 6161-6171.
32. Easlon E, Tsang F, Skinner C, Wang C & Lin SJ (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 22: 931-944.
33. Erjavec N & Nystrom T (2007) Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. P Natl Acad Sci USA 104: 10877-10881.
34. Essary BD & Marshall PA (2009) Assessment of FUN-1 vital dye staining: yeast with a block in the vacuolar sorting pathway have impaired ability to form CIVS when stained with FUN-1 fluorescent dye. J Microbiol Methods 78: 208-212.
35. + metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity. BMC Chem Biol 10: 2.
36. Fabrizio P, Liou L-L, Moy VN, Diaspro A, Selverstone Valentine J, Longo VD & Gralla EB (2003) SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163: 35-46.
37. Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K & Longo VD (2005) Sir2 blocks extreme life-span extension. Cell 123: 655-667.
38. Falcon AA & Aris JP (2003) Plasmid accumulation reduces life span in Saccharomyces cerevisiae. J Biol Chem 278: 41607-41617.
39. Fritze CE, Verschueren K, Strich R & Esposito RE (1997) Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J 16: 6495-6509.
40. Gallo CM, Smith DL Jr & Smith JS (2004) Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol 24: 1301-1312.
41. Ganley AR, Ide S, Saka K & Kobayashi T (2009) The effect of replication initiation on gene amplification in the rDNA and its relationship to aging. Mol Cell 35: 683-693.
42. Ghidelli S, Donze D, Dhillon N & Kamakaka RT (2001) Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities. EMBO J 20: 4522-4535.
43. Gottlieb S & Esposito RE (1989) A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56: 771-776.
44. Gray JV, Petsko GA, Johnston GC, Ringe D, Singer RA & Werner-Washburne M (2004) "Sleeping Beauty": quiescence in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 68: 187-206.
45. Ha CW & Huh WK (2011) Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae. Nucleic Acids Res 39: 1336-1350.
46. Hachinohe M, Yamane M, Akazawa D, Ohsawa K, Ohno M, Terashita Y & Masumoto H (2013) A reduction in age-enhanced gluconeogenesis extends lifespan. PLoS One 8: e54011.
47. Halme A, Bumgarner S, Styles C & Fink GR (2004) Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast. Cell 116: 405-415.
48. Hecht A, Strahl-Bolsinger S & Grunstein M (1996) Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature 385: 92-96.
49. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M & Choudhary C (2012) Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Mol Cell Proteomics 11: 1510-1522.
50. Hickman MA & Rusche LN (2007) Substitution as a mechanism for genetic robustness: the duplicated deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae. PLoS Genet 3: e126.
51. Hoppe GJ, Tanny JC, Rudner AD, Gerber SA, Danaie S, Gygi SP & Moazed D (2002) Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol 22: 4167-4180.
52. Houtkooper RH, Pirinen E & Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13: 225-238.
53. Huang J & Moazed D (2003) Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev 17: 2162-2176.
54. Huang J, Brito IL, Villen J, Gygi SP, Amon A & Moazed D (2006) Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev 20: 2887-2901.
55. Ide S, Saka K & Kobayashi T (2013) Rtt109 prevents hyper-amplification of ribosomal RNA genes through histone modificaiton in budding yeast. PLoS Genet 9: 1-14.
56. Imai S, Armstrong CM & Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800.
57. Ivy JM, Klar AJ & Hicks JB (1986) Cloning and characterization of four SIR genes of Saccharomyces cerevisiae. Mol Cell Biol 6: 688-702.
58. Jiang JC, Wawryn J, Shantha Kumara HM & Jazwinski SM (2002) Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. Exp Gerontol 37: 1023-1030.
59. Kaeberlein M, McVey M & Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580.
60. Kaeberlein M, Kirkland KT, Fields S & Kennedy BK (2004) Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2: e296.
61. Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S & Kennedy BK (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193-1196.
62. Kaeberlein M, Steffen KK, Hu D, Dang N, Kerr EO, Tsuchiya M, Fields S & Kennedy BK (2006) Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science 312: 1312.
63. Kennedy BK, Austriaco NR Jr, Zhang J & Guarente L (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80: 485-496.
64. Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM & Guarente L (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89: 381-391.
65. Kobayashi T & Ganley AR (2005) Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats. Science 309: 1581-1584.
66. Kobayashi T & Ganley AR (2013) Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging. FEMS Yeast Res, (in press).
67. Kobayashi T, Heck DJ, Nomura M & Horiuchi T (1998) Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. Genes Dev 12: 3821-3830.
68. Kucharczyk R, Zagulski M, Rytka J & Herbert CJ (1998) The yeast gene YJR025c encodes a 3-hydroxyanthranilic acid dioxygenase and is involved in nicotinic acid biosynthesis. FEBS Lett 424: 127-130.
69. Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK & Bedalov A (2013) A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet 9: e1003329.
70. Lamming DW, Lattore-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin S & Sinclair DA (2005) HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309: 1861-1864.
71. + in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun 278: 685-690.
72. Laun P, Pichova A, Madeo F, Fuchs J, Ellinger A, Kohlwein S, Dawes I, Frohlich KU & Breitenbach M (2001) Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol 39: 1166-1173.
73. +-dependent histone deacetylase Hst1. Mol Cell Biol 30: 3329-3341.
74. Li M, Valsakumar V, Poorey K, Bekiranov S & Smith JS (2013) Genome-wide analysis of functional sirtuin chromatin targets in yeast. Genome Biol 14: R48.
75. Lieb JD, Liu X, Botstein D & Brown PO (2001) Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet 28: 327-334.
76. Lin SJ, Defossez P & Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
77. Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR & Guarente L (2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344-348.
78. Lin SJ, Ford E, Haigis M, Liszt G & Guarente L (2004) Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18: 12-16.
79. Lin YY, Lu JY, Zhang J et al. (2009) Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell 136: 1073-1084.
80. Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V & Cech TR (1997) Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276: 561-567.
81. Liu B, Larsson L, Caballero A, Hao X, Öling D, Grantham J & Nyström T (2010) The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 140: 257-267.
82. Liu IC, Chiu SW, Lee HY & Leu JY (2012) The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells. Mol Biol Cell 23: 1231-1242.
83. + metabolism in Saccharomyces cerevisiae. J Biol Chem 286: 14271-14281.
84. Lu SP, Kato M & Lin SJ (2009) Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae. J Biol Chem 284: 17110-17119.
85. Lundblad V & Szostak JW (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57: 633-643.
86. Maas NL, Miller KM, DeFazio LG & Toczyski DP (2006) Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell 23: 109-119.
87. MacLean M, Harris N & Piper PW (2001) Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms. Yeast 18: 499-509.
88. Maicher A, Kastner L, Dees M & Luke B (2012) Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res 40: 6649-6659.
89. Matecic M, Smith DL, Pan X, Maqani N, Bekiranov S, Boeke JD & Smith JS (2010) A microarray-based genetic screen for yeast chronological aging factors. PLoS Genet 6: e1000921.
90. + concentration. J Biol Chem 287: 20957-20966.
91. McCord R, Pierce M, Xie J, Wonkatal S, Mickel C & Vershon AK (2003) Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes. Mol Cell Biol 23: 1-8.
92. McFaline-Figueroa JR, Vevea J, Swayne TC, Zhou C, Liu C, Leung G, Boldogh IR & Pon LA (2011) Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. Aging Cell 10: 885-895.
93. Medvedik O, Lamming DW, Kim KD & Sinclair DA (2007) MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol 5: e261.
94. Moretti P, Freeman K, Coodly L & Shore D (1994) Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev 8: 2257-2269.
95. Mortimer RK & Johnston JR (1959) Life span of individual yeast cells. Nature, 183: 1751-1752.
96. Murray AW & Szostak JW (1983) Pedigree analysis of plasmid segregation in yeast. Cell 34: 961-970.
97. Nestelbachera R, Laun P, Vondrakova D, Pichova A, Schuller C & Breitenbach M (2000) The influence of oxygen toxicity on yeast mother cell-specific aging. Exp Gerontol 35: 63-70.
98. Oppikofer M, Kueng S, Martino F, Soeroes S, Hancock SM, Chin JW, Fischle W & Gasser SM (2011) A dual role of H4K16 acetylation in the establishment of yeast silent chromatin. EMBO J 30: 2610-2621.
99. Orlandi I, Bettiga M, Alberghina L, Nyström T & Vai M (2010) Sir2-dependent asymmetric segregation of damaged proteins in ubp10 null mutants is independent of genomic silencing. Biochim Biophys Acta 1803: 630-638.
100. Orozco H, Matallana E & Aranda A (2012) Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium. Mech Ageing Dev 133: 348-358.
101. Parrella E & Longo VD (2010) Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal 10: 161-177.
102. Perrod S, Cockell MM, Laroche T, Renauld H, Ducrest A, Bonnard C & Gasser SM (2001) A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J 20: 197-209.
103. Piper PW (2006) Long-lived yeast as a model for ageing research. Yeast 23: 215-226.
104. Radman-Livaja M, Ruben G, Weiner A, Friedman N, Kamakaka R & Rando OJ (2011) Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localization. EMBO J 30: 1012-1026.
105. Rahat O, Maoz N & Cohen HY (2011) Multiple pathways regulating the calorie restriction response in yeast. J Gerontol A Biol Sci Med Sci 66: 163-169.
106. Ralser M, Michel S & Breitenbach M (2012) Sirtuins as regulators of the yeast metabolic network. Front Pharmacol 3: 32.
107. Reverter-Branchat G, Cabiscol E, Tamarit J, Sorolla MA, Angeles de la Torre M & Ros J (2007) Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1. Microbiology 153: 3667-3676.
108. Riesen ML & Morgan A (2009) Calorie restriction reduces rDNA recombination independently of rDNA silencing. Aging Cell 8: 624-632.
109. Rine J & Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116: 9-22.
110. Rusche LN, Kirchmaier AL & Rine J (2002) Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae. Mol Biol Cell 13: 2207-2222.
111. Rusche LN, Kirchmaier AL & Rine J (2003) The establishment, inheritance, and function of silencing chromatin in. Annu Rev Biochem 72: 481-516.
112. Salvi JS, Chan JN, Pettigrew C, Liu TT, Wu JD & Mekhail K (2013) Enforcement of a lifespan-sustaining distribution of Sir2 between telomeres, mating-type loci, and rDNA repeats by Rif1. Aging Cell 12: 67-75.
113. + salvage pathway. Genetics 160: 877-889.
114. Schmidt MT, Smith BC, Jackson MD & Denu JM (2004) Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation. J Biol Chem 279: 40122-40129.
115. Shcheprova Z, Baldi S, Frei SB, Gonnet G & Barral Y (2008) A mechanism for asymmetric segregation of age during yeast budding. Nature 454: 728-734.
116. Shi L, Sutter BM, Ye X & Tu BP (2010) Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth. Mol Biol Cell 21: 1982-1990.
117. Shia WJ, Osada S, Florens L, Swanson SK, Washburn MP & Workman JL (2005) Characterization of the yeast trimeric-SAS acetyltransferase complex. J Biol Chem 280: 11987-11994.
118. Shou W, Seol JH, Shevchenko A, Baskerville C, Moazed D, Chen ZW, Jang J, Shevchenko A, Charbonneau H & Deshaies RJ (1999) Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97: 233-244.
119. Sinclair DA & Guarente L (1997) Extrachromosomal rDNA circles- A cause of aging in yeast. Cell 91: 1033-1042.
120. Smeal T, Claus J, Kennedy B, Cole F & Guarente L (1996) Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84: 1-10.
121. Smith JS & Boeke JD (1997) An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev 11: 241-254.
122. Smith JS, Brachmann CB, Pillus L & Boeke JD (1998) Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics 149: 1205-1219.
123. +-dependent protein deacetylase activity in the Sir2 protein family. P Natl Acad Sci USA 97: 6658-6663.
124. Smith DL Jr, McClure JM, Matecic M & Smith JS (2007) Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 6: 649-662.
125. Smith DL Jr, Li C, Matecic M, Maqani N, Bryk M & Smith JS (2009) Calorie restriction effects on silencing and recombination at the yeast rDNA. Aging Cell 8: 633-642.
126. Steffen KK, Kennedy BK & Kaeberlein M (2009) Measuring replicative life span in the budding yeast. J Vis Exp 28: 1029.
127. Strahl-Bolsinger S, Hecht A, Luo K & Grunstein M (1997) SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev 11: 83-93.
128. Straight AF, Shou W, Dowd GJ, Turck CW, Deshaies RJ, Johnson AD & Moazed D (1999) Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97: 245-256.
129. Stumpferl SW, Brand SE, Jiang JC, Korona B, Tiwari A, Dai J, Seo JG & Jazwinski SM (2012) Natural genetic variation in yeast longevity. Genome Res 22: 1963-1973.
130. + synthestase that is functionally conserved in mammals. Yeast 20: 995-1005.
131. Suka N, Suka Y, Carmen AA, Wu J & Grunstein M (2001) Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Mol Cell 8: 473-479.
132. Suka N, Luo K & Grunstein M (2002) Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat Genet 32: 378-383.
133. Tahara EB, Cunha FM, Basso TO, Bianca Della BE, Gombert AK & Kowaltowski AJ (2013) Calorie restriction hysteretically primes aging Saccharomyces cerevisiae toward more effective oxidative metabolism. PLoS One 8: e56388.
134. Tanny JC & Moazed D (2001) Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: evidence for acetyl transfer from substrate to an NAD breakdown product. P Natl Acad Sci USA 98: 415-420.
135. Tsang CK, Li H & Zheng XS (2007) Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J 26: 1-11.
136. Tsuchiya M, Dang N, Kerr EO, Hu D, Steffen KK, Oakes JA, Kennedy BK & Kaeberlein M (2006) Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell 5: 505-514.
137. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L & Longo VD (2008) Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 4: e13.
138. Werner-Washburne M, Braun E, Johnston GC & Singer RA (1993) Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol Rev 57: 383-401.
139. Wilson JM, Le VQ, Zimmerman C, Marmorstein R & Pillus L (2006) Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep 7: 1247-1251.
140. Wu Z, Song L, Liu SQ & Huang D (2011) A high throughput screening assay for determination of chronological lifespan of yeast. Exp Gerontol 46: 915-922.
141. Xie J, Pierce M, Gailus-Durner V, Wagner M, Winter E & Vershon AK (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18: 6448-6454.
142. Zhong L & Mostoslavsky R (2010) SIRT6: a master epigenetic gatekeeper of glucose metabolism. Transcription 1: 17-21.
143. Zhu X, Liu B, Carlsten JO, Beve J, Nystrom T, Myers LC & Gustafsson CM (2011) Mediator influences telomeric silencing and cellular life span. Mol Cell Biol 31: 2413-2421.