Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD + concentration

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 20957-20966

  McClure, Julie M ^a   Wierman, Margaret B ^a   Maqani, Nazif ^a   Smith, Jeffrey S ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR METABOLISM; COMBINED ACTIONS; DEACETYLASE ACTIVITY; DEACETYLATION; GENE TRANSCRIPTIONS; IN-VITRO; IN-VIVO; ISONICOTINAMIDE; LIFE SPAN; NICOTINIC ACID; SALVAGE PATHWAY; STATIONARY PHASE; YEAST CELL;

ACETYLATION; AMIDES; BIOCHEMISTRY; BIOSYNTHESIS; GENES; TRANSCRIPTION;

YEAST;

ISONICOTINAMIDE; NICOTINIC ACID; RIBOSOME DNA; SILENT INFORMATION REGULATOR PROTEIN 2;

ARTICLE; BIOSYNTHESIS; CELL GROWTH; CELL LEVEL; CELL TRANSPORT; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; FUNGAL STRAIN; GENE LOCUS; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; YEAST CELL;

DNA, FUNGAL; DNA, RIBOSOMAL; GENE SILENCING; GENETIC LOCI; NAD; NIACINAMIDE; NICOTINAMIDASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUIN 2;

EID: 84862292333     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.367524     Document Type: Article

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