SIRT6: A master epigenetic gatekeeper of glucose metabolism

Transcription

Volumn 1, Issue 1, 2010, Pages 17-21

  Zhong, Lei ^a   Mostoslavsky, Raul ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chromatin deacetylase; Epigenetic regulation metabolism; Glucose metabolism; SIRT6

Indexed keywords

6 PHOSPHOFRUCTOKINASE; GLUCOSE TRANSPORTER 1; LACTATE DEHYDROGENASE; PYRUVIC ACID; SIRTUIN 6; TRIOSEPHOSPHATE ISOMERASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL AGING; CELL SURVIVAL; CELLULAR STRESS RESPONSE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEFICIENCY; EPIGENETICS; GENE CONTROL; GENE SILENCING; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HISTONE ACETYLATION; HYPOGLYCEMIA; HYPOXIA; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION;

MAMMALIA; PYRONIA TITHONUS;

EID: 79952274786     PISSN: 21541264     EISSN: 21541272     Source Type: Journal    
DOI: 10.4161/trns.1.1.12143     Document Type: Article

References (29)

1. Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009; 460:587-91.
2. Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, et al. SIRT6 links histone H3 lysine 9 deacetylation to NFκB-dependent gene expression and organismal life span. Cell 2009; 136:62-74.
3. Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008; 452:492-6.
4. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124:315-29.
5. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140:280-93.
6. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33.
7. Kouzarides T. Chromatin modifications and their function. Cell 2007; 128:693-705.
8. Core LJ, Lis JT. Transcription regulation through promoter-proximal pausing of RNA polymerase II. Science 2008; 319:1791-2.
9. Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3:177-85.
10. Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3:187-97.
11. Aragones J, Fraisl P, Baes M, Carmeliet P. Oxygen sensors at the crossroad of metabolism. Cell Metab 2009; 9:11-22.
12. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF- 1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394:485-90.
13. Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell 2008; 32:838-48.
14. Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, et al. SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell 9:162-73.
15. Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, et al. An essential role for p300/ CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93:12969-73.
16. Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxiainducible factor-1alpha. EMBO J 1998; 17:6573-86.
17. Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, et al. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 2009; 324:1289-93.
18. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, et al. Downregulation of miR- 199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 2009; 104:879-86.
19. Warburg O. On respiratory impairment in cancer cells. Science 1956; 124:269-70.
20. Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer cell 2008; 13:472-82.
21. Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-34.
22. Ma W, Stafford LJ, Li D, Luo J, Li X, Ning G, et al. GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. J Cell Biochem 2007; 100:1376-86.
23. Yu J, Auwerx J. The role of sirtuins in the control of metabolic homeostasis. Ann NY Acad Sci 2009; 1173:10-9.
24. Canto C, Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab 2009; 20:325-31.
25. Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NFκB activity. Genes dev 2007; 21:3244-57.
26. Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell metab 2008; 7:104-12.
27. Lee SJ, Murphy CT, Kenyon C. Glucose shortens the life span of C. elegans by downregulating DAF-16/ FOXO activity and aquaporin gene expression. Cell Metab 2009; 10:379-91.
28. Chen D, Thomas EL, Kapahi P. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genetics 2009; 5:1000486.
29. Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, et al. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 2009; 324:1196-8.