Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes

Molecular and Cellular Biology

Volumn 23, Issue 6, 2003, Pages 2009-2016

  McCord, Ron ^a   Pierce, Michael ^a   Xie, Jianxin ^a   Wonkatal, Sandeep ^a   Mickel, Carolyn ^a   Vershon, Andrew K ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HISTONE DEACETYLASE; RFM1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN STRUCTURE; DEACETYLATION; DNA MICROARRAY; GENE REPRESSION; GENE SILENCING; IMMUNOPRECIPITATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SPOROGENESIS; TRANSCRIPTION REGULATION;

DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENE SILENCING; GENES, FUNGAL; HISTONE DEACETYLASES; MACROMOLECULAR SUBSTANCES; MODELS, GENETIC; NUCLEAR PROTEINS; OPEN READING FRAMES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; SPORES, FUNGAL;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037370393     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.6.2009-2016.2003     Document Type: Article

References (26)

1. Bernstein, B. E., J. K. Tong, and S. L. Schreiber. 2000. Genomewide studies of histone deacetylase function in yeast. Proc. Natl. Acad. Sci. USA 97:13708-13713.
2. Brachmann, C. B., J. M. Sherman, S. E. Devine, E. E. Cameron, L. Pillus, and J. D. Boeke. 1995. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9:2888-2902.
3. Bryk, M., S. D. Briggs, B. D. Strahl, M. J. Curcio, C. D. Allis, and F. Winston. 2002. Evidence that Setl, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2- independent mechanism. Curr. Biol. 12:165-170.
4. Chi, M.-H., and D. Shore. 1996 SUM1-1, a dominant suppressor of SIR mutations in Saccharomyces cerevisiae, increases transcriptional silencing at telomeres and HM mating-type loci and decreases chromosome stability. Mol. Cell. Biol. 16:4281-4294.
5. Chu, S., J. DeRisi, M. Eisen, J. Mulholland, D. Botstein, P. O. Brown, and I. Herskowitz. 1998. The transcriptional program of sporulation in budding yeast. Science 282:699-705.
6. Courey, A. J., and S. Jia. 2001. Transcriptional repression: the long and the short of it. Genes Dev. 15:2786-2796.
7. Cuperus, G., R. Shafaatian, and D. Shore. 2000. Locus specificity determinants in the multifunctional yeast silencing protein Sir2. EMBO J. 19:2641-2651.
8. Derbyshire, M. K., K. G. Weinstock, and J. N. Strathern. 1996. HST1, a new member of the SIR2 family of genes. Yeast 12:631-640.
9. Gailus-Durner, V., C. Chintamaneni, R. Wilson, S. J. Brill, and A. K. Vershon. 1997. Analysis of a meiosis-specific URS1 site: sequence requirements and involvement of replication protein A. Mol. Cell. Biol. 17:3536-3546.
10. Gasser, S. M., and M. M. Cockell. 2001. The molecular biology of the SIR proteins. Gene 279:1-16.
11. Hecht, A., T. Laroche, S. Strahl-Bolsinger, S. M. Gasser, and M. Grunstein. 1995. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80:583-592.
12. Jenuwein, T. 2001. Re-SET-ting heterochromatin by histone methyltransferases. Trends Cell Biol. 11:266-273.
13. Jenuwein, T., and C. D. Allis. 2001. Translating the histone code. Science 293:1074-1080.
14. Klar, A. J., S. N. Kakar, J. M. Ivy, J. B. Hicks, G. P. Livi, and L. M. Miglio. 1985 SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111:745-758.
15. Laurenson, P., and J. Rine. 1991. SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129:685-696.
16. Lindgren, A., D. Bungard, M. Pierce, J. Xie, A. Vershon, and E. Winter. 2000. The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J. 19:6489-6497.
17. Moazed, D. 2001. Enzymatic activities of Sir2 and chromatin silencing. Curr. Opin. Cell Biol. 13:232-238.
18. Pijnappel, W. W., D. Schaft, A. Roguev, A. Shevchenko, H. Tekotte, M. Wilm, G. Rigaut, B. Seraphin, R. Aasland, and A. F. Stewart. 2001. The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev. 15:2991-3004.
19. Rusche, L. N., and J. Rine. 2001. Conversion of a gene-specific repressor to a regional silencer. Genes Dev. 15:955-967.
20. +-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. USA 97:6658-6663.
21. Strahl-Bolsinger, S., A. Hecht, K. Luo, and M. Grunstein. 1997. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev. 11:83-93.
22. Straight, A. F., W. Shou, G. J. Dowd, C. W. Turck, R. J. Deshaies, A. D. Johnson, and D. Moazed. 1999. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97:245-256.
23. Sutton, A., R. C. Heller, J. Landry, J. S. Choy, A. Sirko, and R. Sternglanz. 2001. A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol. Cell. Biol. 21:3514-3522.
24. Wach, A. 1996. PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in S. cerevisiae. Yeast 12:259-265.
25. Wu, J., K. van Riper, N. Kacherovsky, M. Vogelauer, E. T. Young, M. Grunstein, E. Di Mauro, M. Caserta, and D. Robyr. 2002. Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. EMBO J. 21:1101-1111.
26. Xie, J., M. Pierce, V. Gailus-Durner, M. Wagner, E. Winter, and A. K. Vershon. 1999. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J. 18:6448-6454.