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Volumn 1, Issue 11, 2012, Pages

The 'n-factors' in pancreatic cancer: Functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer

Author keywords

Apoptosis; Chemoresistance; Pancreatic cancer; Signal transduction; Transcription factor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NRF2;

EID: 84893155306     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2012.35     Document Type: Review
Times cited : (35)

References (146)
  • 2
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N Engl J Med 2010;362:1605-1617.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 5
    • 84858002179 scopus 로고    scopus 로고
    • Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: A comparative study in transgenic mice and human tissues
    • Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P et al. Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol 2012;226:723-734.
    • (2012) J Pathol , vol.226 , pp. 723-734
    • Aichler, M.1    Seiler, C.2    Tost, M.3    Siveke, J.4    Mazur, P.K.5    Da Silva-Buttkus, P.6
  • 6
    • 84876084668 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in pancreatic cancer
    • e-pub ahead of print 13 November 2010
    • Arlt A, Muerkoster SS, Schafer H. Targeting apoptosis pathways in pancreatic cancer. Cancer Lett (e-pub ahead of print 13 November 2010; doi:10.1016/j.canlet.2010.10.015).
    • Cancer Lett
    • Arlt, A.1    Muerkoster, S.S.2    Schafer, H.3
  • 9
    • 79961024581 scopus 로고    scopus 로고
    • Chemotherapy: Metastatic pancreatic cancer-is FOLFIRINOX the new standard?
    • Saif MW, Chabot J. Chemotherapy: metastatic pancreatic cancer-is FOLFIRINOX the new standard? Nat Rev 2011;8:452-453.
    • (2011) Nat Rev , vol.8 , pp. 452-453
    • Saif, M.W.1    Chabot, J.2
  • 10
    • 85029941530 scopus 로고    scopus 로고
    • New developments in the treatment of pancreatic cancer. Highlights from the "44th ASCO Annual Meeting". Chicago, IL, USA. May 30 - June 3, 2008
    • Saif MW. New developments in the treatment of pancreatic cancer. Highlights from the "44th ASCO Annual Meeting". Chicago, IL, USA. May 30 - June 3, 2008. JOP 2008;9:391-397.
    • (2008) JOP , vol.9 , pp. 391-397
    • Saif, M.W.1
  • 11
    • 84856596852 scopus 로고    scopus 로고
    • Combinational therapy: New hope for pancreatic cancer?
    • Shi S, Yao W, Xu J, Long J, Liu C, Yu X. Combinational therapy: new hope for pancreatic cancer? Cancer Lett 2012;317:127-135.
    • (2012) Cancer Lett , vol.317 , pp. 127-135
    • Shi, S.1    Yao, W.2    Xu, J.3    Long, J.4    Liu, C.5    Yu, X.6
  • 12
    • 69249148349 scopus 로고    scopus 로고
    • Ras activity levels control the development of pancreatic diseases
    • Ji B, Tsou L, Wang H, Gaiser S, Chang DZ, Daniluk J et al. Ras activity levels control the development of pancreatic diseases. Gastroenterology 2009;137:1072-1082.
    • (2009) Gastroenterology , vol.137 , pp. 1072-1082
    • Ji, B.1    Tsou, L.2    Wang, H.3    Gaiser, S.4    Chang, D.Z.5    Daniluk, J.6
  • 15
    • 84888201440 scopus 로고    scopus 로고
    • Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers
    • e-pub ahead of print 23 March 2012
    • Fukushige S, Horii A. Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers. Cancer Lett (e-pub ahead of print 23 March 2012; doi:10.1016/j.canlet.2012.03.022).
    • Cancer Lett
    • Fukushige, S.1    Horii, A.2
  • 17
    • 79955481608 scopus 로고    scopus 로고
    • Impact of death receptor signaling on the malignancy of pancreatic ductal adenocarcinoma
    • Roder C, Trauzold A, Kalthoff H. Impact of death receptor signaling on the malignancy of pancreatic ductal adenocarcinoma. Eur J Cell Biol 2011;90:450-455.
    • (2011) Eur J Cell Biol , vol.90 , pp. 450-455
    • Roder, C.1    Trauzold, A.2    Kalthoff, H.3
  • 18
  • 19
    • 84856213846 scopus 로고    scopus 로고
    • The diverse and complex roles of NF-kappaB subunits in cancer
    • Perkins ND. The diverse and complex roles of NF-kappaB subunits in cancer. Nat Rev Cancer 2012;12:121-132.
    • (2012) Nat Rev Cancer , vol.12 , pp. 121-132
    • Perkins, N.D.1
  • 20
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-kappaB as the matchmaker
    • Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat Immunol 2011;12:715-723.
    • (2011) Nat Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 21
    • 77952420656 scopus 로고    scopus 로고
    • Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo
    • Wang SJ, Gao Y, Chen H, Kong R, Jiang HC, Pan SH et al. Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Cancer Lett 2010;293:99-108.
    • (2010) Cancer Lett , vol.293 , pp. 99-108
    • Wang, S.J.1    Gao, Y.2    Chen, H.3    Kong, R.4    Jiang, H.C.5    Pan, S.H.6
  • 22
    • 84858337114 scopus 로고    scopus 로고
    • Identification of a novel pro-apoptotic role of NF-kappaB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
    • Jennewein C, Karl S, Baumann B, Micheau O, Debatin KM, Fulda S. Identification of a novel pro-apoptotic role of NF-kappaB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene 2011;31:1468-1474.
    • (2011) Oncogene , vol.31 , pp. 1468-1474
    • Jennewein, C.1    Karl, S.2    Baumann, B.3    Micheau, O.4    Debatin, K.M.5    Fulda, S.6
  • 23
    • 77955720243 scopus 로고    scopus 로고
    • NFkappaB anti-apoptotic or pro-apoptotic, maybe both
    • Martin AG. NFkappaB anti-apoptotic or pro-apoptotic, maybe both. Cell Cycle 2010;9:3131-3132.
    • (2010) Cell Cycle , vol.9 , pp. 3131-3132
    • Martin, A.G.1
  • 25
    • 58849100438 scopus 로고    scopus 로고
    • Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway
    • Chen PH, Yang CR. Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway. J Immunol 2008;181:8441-8449.
    • (2008) J Immunol , vol.181 , pp. 8441-8449
    • Chen, P.H.1    Yang, C.R.2
  • 26
    • 77954541163 scopus 로고    scopus 로고
    • TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5
    • Lemke J, Noack A, Adam D, Tchikov V, Bertsch U, Roder C et al. TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5. J Mol Med 2010;88:729-740.
    • (2010) J Mol Med , vol.88 , pp. 729-740
    • Lemke, J.1    Noack, A.2    Adam, D.3    Tchikov, V.4    Bertsch, U.5    Roder, C.6
  • 27
    • 17944379442 scopus 로고    scopus 로고
    • CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells
    • Trauzold A, Wermann H, Arlt A, Schutze S, Schafer H, Oestern S et al. CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells. Oncogene 2001;20:4258-4269.
    • (2001) Oncogene , vol.20 , pp. 4258-4269
    • Trauzold, A.1    Wermann, H.2    Arlt, A.3    Schutze, S.4    Schafer, H.5    Oestern, S.6
  • 28
    • 20144387486 scopus 로고    scopus 로고
    • CD95 and TRAF2 promote invasiveness of pancreatic cancer cells
    • Trauzold A, Roder C, Sipos B, Karsten K, Arlt A, Jiang P et al. CD95 and TRAF2 promote invasiveness of pancreatic cancer cells. Faseb J 2005;19:620-622.
    • (2005) Faseb J , vol.19 , pp. 620-622
    • Trauzold, A.1    Roder, C.2    Sipos, B.3    Karsten, K.4    Arlt, A.5    Jiang, P.6
  • 30
    • 33750586523 scopus 로고    scopus 로고
    • Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by upregulation of X-linked inhibitor of apoptosis protein in human cancer cells
    • Braeuer SJ, Buneker C, Mohr A, Zwacka RM. Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by upregulation of X-linked inhibitor of apoptosis protein in human cancer cells. Mol Cancer Res 2006;4:715-728.
    • (2006) Mol Cancer Res , vol.4 , pp. 715-728
    • Braeuer, S.J.1    Buneker, C.2    Mohr, A.3    Zwacka, R.M.4
  • 33
    • 0038621384 scopus 로고    scopus 로고
    • Role of NFkappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR et al. Role of NFkappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003;22:3243-3251.
    • (2003) Oncogene , vol.22 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Muerkoster, S.3    Vorndamm, J.4    Kruse, M.L.5    Folsch, U.R.6
  • 34
    • 0035864344 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin
    • Arlt A, Vorndamm J, Breitenbroich M, Folsch UR, Kalthoff H, Schmidt WE et al. Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene 2001;20:859-868.
    • (2001) Oncogene , vol.20 , pp. 859-868
    • Arlt, A.1    Vorndamm, J.2    Breitenbroich, M.3    Folsch, U.R.4    Kalthoff, H.5    Schmidt, W.E.6
  • 35
    • 77956178436 scopus 로고    scopus 로고
    • L1CAMintegrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression
    • Kiefel H, Bondong S, Erbe-Hoffmann N, Hazin J, Riedle S, Wolf J et al. L1CAMintegrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression. Oncogene 2010;29:4766-4778.
    • (2010) Oncogene , vol.29 , pp. 4766-4778
    • Kiefel, H.1    Bondong, S.2    Erbe-Hoffmann, N.3    Hazin, J.4    Riedle, S.5    Wolf, J.6
  • 36
    • 77949874727 scopus 로고    scopus 로고
    • Downregulation of nuclear factor-kappaB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer
    • Kong R, Sun B, Jiang H, Pan S, Chen H, Wang S et al. Downregulation of nuclear factor-kappaB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer. Cancer Lett 2010;291:90-98.
    • (2010) Cancer Lett , vol.291 , pp. 90-98
    • Kong, R.1    Sun, B.2    Jiang, H.3    Pan, S.4    Chen, H.5    Wang, S.6
  • 38
    • 79955465043 scopus 로고    scopus 로고
    • Mechanisms linking pathogens-associated inflammation and cancer
    • Porta C, Riboldi E, Sica A. Mechanisms linking pathogens-associated inflammation and cancer. Cancer Lett 2011;305:250-262.
    • (2011) Cancer Lett , vol.305 , pp. 250-262
    • Porta, C.1    Riboldi, E.2    Sica, A.3
  • 39
    • 77953675688 scopus 로고    scopus 로고
    • Inflammation and pancreatic ductal adenocarcinoma: A potential scenario for novel drug targets
    • Uomo I, Miraglia S, Pastorello M. Inflammation and pancreatic ductal adenocarcinoma: a potential scenario for novel drug targets. JOP 2010;11:199-202.
    • (2010) JOP , vol.11 , pp. 199-202
    • Uomo, I.1    Miraglia, S.2    Pastorello, M.3
  • 40
    • 26044444704 scopus 로고    scopus 로고
    • Role of inflammation in pancreatic carcinogenesis and the implications for future therapy
    • Garcea G, Dennison AR, Steward WP, Berry DP. Role of inflammation in pancreatic carcinogenesis and the implications for future therapy. Pancreatology 2005;5:514-529.
    • (2005) Pancreatology , vol.5 , pp. 514-529
    • Garcea, G.1    Dennison, A.R.2    Steward, W.P.3    Berry, D.P.4
  • 41
    • 0036468297 scopus 로고    scopus 로고
    • Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines
    • Arlt A, Vorndamm J, Muerkoster S, Yu H, Schmidt WE, Folsch UR et al. Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines. Cancer Res 2002;62:910-916.
    • (2002) Cancer Res , vol.62 , pp. 910-916
    • Arlt, A.1    Vorndamm, J.2    Muerkoster, S.3    Yu, H.4    Schmidt, W.E.5    Folsch, U.R.6
  • 42
    • 1942469354 scopus 로고    scopus 로고
    • Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells
    • Niu J, Li Z, Peng B, Chiao PJ. Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells. J Biol Chem 2004;279:16452-16462.
    • (2004) J Biol Chem , vol.279 , pp. 16452-16462
    • Niu, J.1    Li, Z.2    Peng, B.3    Chiao, P.J.4
  • 43
    • 42149165564 scopus 로고    scopus 로고
    • The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell
    • Zhou DH, Trauzold A, Roder C, Pan G, Zheng C, Kalthoff H. The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell. Hepatobiliary Pancreat Dis Int 2008;7:201-209.
    • (2008) Hepatobiliary Pancreat Dis Int , vol.7 , pp. 201-209
    • Zhou, D.H.1    Trauzold, A.2    Roder, C.3    Pan, G.4    Zheng, C.5    Kalthoff, H.6
  • 44
    • 79952740874 scopus 로고    scopus 로고
    • Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells
    • Kurbitz C, Heise D, Redmer T, Goumas F, Arlt A, Lemke J et al. Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. Cancer Sci 2011;102:728-734.
    • (2011) Cancer Sci , vol.102 , pp. 728-734
    • Kurbitz, C.1    Heise, D.2    Redmer, T.3    Goumas, F.4    Arlt, A.5    Lemke, J.6
  • 45
    • 80053588704 scopus 로고    scopus 로고
    • Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis
    • Treiber M, Neuhofer P, Anetsberger E, Einwachter H, Lesina M, Rickmann M et al. Myeloid, but Not Pancreatic, RelA/p65 Is Required for Fibrosis in a Mouse Model of Chronic Pancreatitis. Gastroenterology 2011;141:e1477.
    • (2011) Gastroenterology , vol.141 , pp. e1477
    • Treiber, M.1    Neuhofer, P.2    Anetsberger, E.3    Einwachter, H.4    Lesina, M.5    Rickmann, M.6
  • 46
    • 79952698464 scopus 로고    scopus 로고
    • Activated KrasG (1) (2) D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin
    • Rachagani S, Senapati S, Chakraborty S, Ponnusamy MP, Kumar S, Smith LM et al. Activated KrasG (1) (2) D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. Br J Cancer 2011;104:1038-1048.
    • (2011) Br J Cancer , vol.104 , pp. 1038-1048
    • Rachagani, S.1    Senapati, S.2    Chakraborty, S.3    Ponnusamy, M.P.4    Kumar, S.5    Smith, L.M.6
  • 47
    • 84878220272 scopus 로고    scopus 로고
    • Requirement of NEMO/IKKγ for effective expansion of KRAS-induced precancerous lesions in the pancreas
    • e-pub ahead of print 2 July 2012
    • Maier HJ, Wagner M, Schips TG, Salem HH, Baumann B, Wirth T. Requirement of NEMO/IKKγ for effective expansion of KRAS-induced precancerous lesions in the pancreas. Oncogene. (e-pub ahead of print 2 July 2012; doi:10.1038/onc.2012.272).
    • Oncogene
    • Maier, H.J.1    Wagner, M.2    Schips, T.G.3    Salem, H.H.4    Baumann, B.5    Wirth, T.6
  • 48
    • 84855946746 scopus 로고    scopus 로고
    • KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma
    • Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z et al. KrasG12D-induced IKK2/beta/NF-kappaB activation by IL-1alpha and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 2012;21:105-120.
    • (2012) Cancer Cell , vol.21 , pp. 105-120
    • Ling, J.1    Kang, Y.2    Zhao, R.3    Xia, Q.4    Lee, D.F.5    Chang, Z.6
  • 49
    • 84866619103 scopus 로고    scopus 로고
    • Kras, Pten, NF-kappaB, and inflammation: Dangerous liaisons
    • Chiao PJ, Ling J. Kras, Pten, NF-kappaB, and inflammation: dangerous liaisons. Cancer Discov 2011;1:103-105.
    • (2011) Cancer Discov , vol.1 , pp. 103-105
    • Chiao, P.J.1    Ling, J.2
  • 51
    • 0037780982 scopus 로고    scopus 로고
    • Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer
    • Liptay S, Weber CK, Ludwig L, Wagner M, Adler G, Schmid RM. Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer. Int J Cancer 2003;105:735-746.
    • (2003) Int J Cancer , vol.105 , pp. 735-746
    • Liptay, S.1    Weber, C.K.2    Ludwig, L.3    Wagner, M.4    Adler, G.5    Schmid, R.M.6
  • 52
    • 29144531155 scopus 로고    scopus 로고
    • Epidermal growth factor promotes invasiveness of pancreatic cancer cells through NF-kappaB-mediated proteinase productions
    • Zhang H, Ma G, Dong M, Zhao M, Shen X, Ma Z et al. Epidermal growth factor promotes invasiveness of pancreatic cancer cells through NF-kappaB-mediated proteinase productions. Pancreas 2006;32:101-109.
    • (2006) Pancreas , vol.32 , pp. 101-109
    • Zhang, H.1    Ma, G.2    Dong, M.3    Zhao, M.4    Shen, X.5    Ma, Z.6
  • 53
    • 67650496175 scopus 로고    scopus 로고
    • 3, 3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer
    • Banerjee S, Wang Z, Kong D, Sarkar FH. 3, 3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer. Cancer Res 2009;69:5592-5600.
    • (2009) Cancer Res , vol.69 , pp. 5592-5600
    • Banerjee, S.1    Wang, Z.2    Kong, D.3    Sarkar, F.H.4
  • 55
    • 78650697068 scopus 로고    scopus 로고
    • A phase I, dose-escalation study of pomalidomide (CC-4047) in combination with gemcitabine in metastatic pancreas cancer
    • Infante JR, Jones SF, Bendell JC, Spigel DR, Yardley DA, Weekes CD et al. A phase I, dose-escalation study of pomalidomide (CC-4047) in combination with gemcitabine in metastatic pancreas cancer. Eur J Cancer 2011;47:199-205.
    • (2011) Eur J Cancer , vol.47 , pp. 199-205
    • Infante, J.R.1    Jones, S.F.2    Bendell, J.C.3    Spigel, D.R.4    Yardley, D.A.5    Weekes, C.D.6
  • 56
    • 77956929109 scopus 로고    scopus 로고
    • Gemcitabine and lenalidomide combination in a patient with metastatic pancreatic cancer: A case study
    • Liu WM, Nizar S, Dalgleish AG. Gemcitabine and lenalidomide combination in a patient with metastatic pancreatic cancer: a case study. Med Oncol 2010;27:430-433.
    • (2010) Med Oncol , vol.27 , pp. 430-433
    • Liu, W.M.1    Nizar, S.2    Dalgleish, A.G.3
  • 57
    • 37749009156 scopus 로고    scopus 로고
    • A phase I study of combination of intravenous gemcitabine, oxaliplatin, and 5-FU with daily oral thalidomide (GOFT) in metastatic/locally advanced pancreatic carcinoma patients
    • Shan YS, Lin PW. A phase I study of combination of intravenous gemcitabine, oxaliplatin, and 5-FU with daily oral thalidomide (GOFT) in metastatic/locally advanced pancreatic carcinoma patients. Hepatogastroenterology 2007;54:2141-2145.
    • (2007) Hepatogastroenterology , vol.54 , pp. 2141-2145
    • Shan, Y.S.1    Lin, P.W.2
  • 58
    • 77953117152 scopus 로고    scopus 로고
    • Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer
    • Lo M, Ling V, Low C, Wang YZ, Gout PW. Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. Curr Oncol 2010;17:9-16.
    • (2010) Curr Oncol , vol.17 , pp. 9-16
    • Lo, M.1    Ling, V.2    Low, C.3    Wang, Y.Z.4    Gout, P.W.5
  • 59
    • 0037457422 scopus 로고    scopus 로고
    • Usage of the NFkappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer
    • Muerkoster S, Arlt A, Witt M, Gehrz A, Haye S, March C et al. Usage of the NFkappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer. Int J Cancer 2003;104:469-476.
    • (2003) Int J Cancer , vol.104 , pp. 469-476
    • Muerkoster, S.1    Arlt, A.2    Witt, M.3    Gehrz, A.4    Haye, S.5    March, C.6
  • 60
    • 53249129484 scopus 로고    scopus 로고
    • Advances in targeting IKK and IKK-related kinases for cancer therapy
    • Lee DF, Hung MC. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clin Cancer Res 2008;14:5656-5662.
    • (2008) Clin Cancer Res , vol.14 , pp. 5656-5662
    • Lee, D.F.1    Hung, M.C.2
  • 62
    • 72549111131 scopus 로고    scopus 로고
    • The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy
    • Lin Y, Bai L, Chen W, Xu S. The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets 2010;14:45-55.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 45-55
    • Lin, Y.1    Bai, L.2    Chen, W.3    Xu, S.4
  • 63
    • 77951913630 scopus 로고    scopus 로고
    • A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors
    • Ramaswamy B, Bekaii-Saab T, Schaaf LJ, Lesinski GB, Lucas DM, Young DC et al. A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 2010;66:151-158.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 151-158
    • Ramaswamy, B.1    Bekaii-Saab, T.2    Schaaf, L.J.3    Lesinski, G.B.4    Lucas, D.M.5    Young, D.C.6
  • 64
    • 70449674487 scopus 로고    scopus 로고
    • Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
    • Arlt A, Bauer I, Schafmayer C, Tepel J, Muerkoster SS, Brosch M et al. Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). Oncogene 2009;28:3983-3996.
    • (2009) Oncogene , vol.28 , pp. 3983-3996
    • Arlt, A.1    Bauer, I.2    Schafmayer, C.3    Tepel, J.4    Muerkoster, S.S.5    Brosch, M.6
  • 65
    • 0037514596 scopus 로고    scopus 로고
    • Clinical update: Proteasome inhibitors in solid tumors
    • Lenz HJ. Clinical update: proteasome inhibitors in solid tumors. Cancer Treat Rev 2003;29(Suppl 1):41-48.
    • (2003) Cancer Treat Rev , vol.29 , pp. 41-48
    • Lenz, H.J.1
  • 66
    • 63649086487 scopus 로고    scopus 로고
    • Targeting the ubiquitin system in cancer therapy
    • Hoeller D, Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009;458:438-444.
    • (2009) Nature , vol.458 , pp. 438-444
    • Hoeller, D.1    Dikic, I.2
  • 67
    • 79959612772 scopus 로고    scopus 로고
    • A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer
    • Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S et al. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol 2011;68:157-164.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 157-164
    • Kanai, M.1    Yoshimura, K.2    Asada, M.3    Imaizumi, A.4    Suzuki, C.5    Matsumoto, S.6
  • 68
    • 48549102229 scopus 로고    scopus 로고
    • Synergistic effects of multiple natural products in pancreatic cancer cells
    • Wang Z, Desmoulin S, Banerjee S, Kong D, Li Y, Deraniyagala RL et al. Synergistic effects of multiple natural products in pancreatic cancer cells. Life Sci 2008;83:293-300.
    • (2008) Life Sci , vol.83 , pp. 293-300
    • Wang, Z.1    Desmoulin, S.2    Banerjee, S.3    Kong, D.4    Li, Y.5    Deraniyagala, R.L.6
  • 69
    • 84862779635 scopus 로고    scopus 로고
    • Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
    • Shanmugam MK, Nguyen AH, Kumar AP, Tan BK, Sethi G. Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer. Cancer Lett 2012;320:158-170.
    • (2012) Cancer Lett , vol.320 , pp. 158-170
    • Shanmugam, M.K.1    Nguyen, A.H.2    Kumar, A.P.3    Tan, B.K.4    Sethi, G.5
  • 70
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, Padhye S et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res 2009;69:5575-5583.
    • (2009) Cancer Res , vol.69 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3    Kong, D.4    Mohammad, M.5    Padhye, S.6
  • 71
    • 77953798273 scopus 로고    scopus 로고
    • Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics
    • Rausch V, Liu L, Kallifatidis G, Baumann B, Mattern J, Gladkich J et al. Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. Cancer Res 2010;70:5004-5013.
    • (2010) Cancer Res , vol.70 , pp. 5004-5013
    • Rausch, V.1    Liu, L.2    Kallifatidis, G.3    Baumann, B.4    Mattern, J.5    Gladkich, J.6
  • 72
    • 67649635780 scopus 로고    scopus 로고
    • Sulforaphane: From chemoprevention to pancreatic cancer treatment?
    • Lampe JW. Sulforaphane: from chemoprevention to pancreatic cancer treatment? Gut 2009;58:900-902.
    • (2009) Gut , vol.58 , pp. 900-902
    • Lampe, J.W.1
  • 73
    • 67649637824 scopus 로고    scopus 로고
    • Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling
    • Kallifatidis G, Rausch V, Baumann B, Apel A, Beckermann BM, Groth A et al. Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. Gut 2009;58:949-963.
    • (2009) Gut , vol.58 , pp. 949-963
    • Kallifatidis, G.1    Rausch, V.2    Baumann, B.3    Apel, A.4    Beckermann, B.M.5    Groth, A.6
  • 74
    • 77955593367 scopus 로고    scopus 로고
    • Primers on molecular pathways-The NFAT transcription pathway in pancreatic cancer
    • Konig A, Fernandez-Zapico ME, Ellenrieder V. Primers on molecular pathways-the NFAT transcription pathway in pancreatic cancer. Pancreatology 2010;10:416-422.
    • (2010) Pancreatology , vol.10 , pp. 416-422
    • Konig, A.1    Fernandez-Zapico, M.E.2    Ellenrieder, V.3
  • 75
    • 84872065981 scopus 로고    scopus 로고
    • Oncogenic transcription factors: Cornerstones of inflammation-linked pancreatic carcinogenesis
    • e-pub ahead of print 13 October 2011
    • Baumgart S, Ellenrieder V, Fernandez-Zapico ME. Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesis. Gut (e-pub ahead of print 13 October 2011; doi:10.1136/gutjnl-2011-301008).
    • Gut
    • Baumgart, S.1    Ellenrieder, V.2    Fernandez-Zapico, M.E.3
  • 76
    • 70350514636 scopus 로고    scopus 로고
    • NFAT proteins: Emerging roles in cancer progression
    • Mancini M, Toker A. NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer 2009;9:810-820.
    • (2009) Nat Rev Cancer , vol.9 , pp. 810-820
    • Mancini, M.1    Toker, A.2
  • 77
    • 67449102913 scopus 로고    scopus 로고
    • Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase
    • Nayak A, Glockner-Pagel J, Vaeth M, Schumann JE, Buttmann M, Bopp T et al. Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. J Biol Chem 2009;284:10935-10946.
    • (2009) J Biol Chem , vol.284 , pp. 10935-10946
    • Nayak, A.1    Glockner-Pagel, J.2    Vaeth, M.3    Schumann, J.E.4    Buttmann, M.5    Bopp, T.6
  • 78
    • 62549124971 scopus 로고    scopus 로고
    • Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor
    • Yoeli-Lerner M, Chin YR, Hansen CK, Toker A. Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor. Mol Cancer Res 2009;7:425-432.
    • (2009) Mol Cancer Res , vol.7 , pp. 425-432
    • Yoeli-Lerner, M.1    Chin, Y.R.2    Hansen, C.K.3    Toker, A.4
  • 80
    • 84856233403 scopus 로고    scopus 로고
    • Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer
    • Baumgart S, Glesel E, Singh G, Chen NM, Reutlinger K, Zhang J et al. Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer. Gastroenterology 2012;142:e381-e387.
    • (2012) Gastroenterology , vol.142 , pp. e381-e387
    • Baumgart, S.1    Glesel, E.2    Singh, G.3    Chen, N.M.4    Reutlinger, K.5    Zhang, J.6
  • 81
    • 80051694778 scopus 로고    scopus 로고
    • Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid
    • Singh SK, Baumgart S, Singh G, Konig AO, Reutlinger K, Hofbauer LC et al. Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. J Biol Chem 2011;286:28761-28771.
    • (2011) J Biol Chem , vol.286 , pp. 28761-28771
    • Singh, S.K.1    Baumgart, S.2    Singh, G.3    Konig, A.O.4    Reutlinger, K.5    Hofbauer, L.C.6
  • 82
    • 77249176619 scopus 로고    scopus 로고
    • NFATinduced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells
    • Koenig A, Linhart T, Schlengemann K, Reutlinger K, Wegele J, Adler G et al. NFATinduced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells. Gastroenterology 2010;138:e1181-e1182.
    • (2010) Gastroenterology , vol.138 , pp. e1181-e1182
    • Koenig, A.1    Linhart, T.2    Schlengemann, K.3    Reutlinger, K.4    Wegele, J.5    Adler, G.6
  • 84
    • 40549104452 scopus 로고    scopus 로고
    • The calcineurin/NFAT signaling pathway: A novel therapeutic target in leukemia and solid tumors
    • Medyouf H, Ghysdael J. The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors. Cell Cycle 2008;7:297-303.
    • (2008) Cell Cycle , vol.7 , pp. 297-303
    • Medyouf, H.1    Ghysdael, J.2
  • 85
    • 0036171986 scopus 로고    scopus 로고
    • Calcineurin as a multifunctional regulator
    • Shibasaki F, Hallin U, Uchino H. Calcineurin as a multifunctional regulator. J Biochem 2002;131:1-15.
    • (2002) J Biochem , vol.131 , pp. 1-15
    • Shibasaki, F.1    Hallin, U.2    Uchino, H.3
  • 86
    • 70350500090 scopus 로고    scopus 로고
    • Immunosuppressive drugs in kidney transplantation: Impact on patient survival, and incidence of cardiovascular disease, malignancy and infection
    • Marcen R. Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection. Drugs 2009;69:2227-2243.
    • (2009) Drugs , vol.69 , pp. 2227-2243
    • Marcen, R.1
  • 88
    • 0037418199 scopus 로고    scopus 로고
    • Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506
    • Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M. Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. Proc Natl Acad Sci USA 2003;100:2322-2327.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2322-2327
    • Padilla, P.I.1    Chang, M.J.2    Pacheco-Rodriguez, G.3    Adamik, R.4    Moss, J.5    Vaughan, M.6
  • 89
    • 77951661580 scopus 로고    scopus 로고
    • Novel immunosuppressive agents in kidney transplantation
    • Cooper JE, Wiseman AC. Novel immunosuppressive agents in kidney transplantation. Clin Nephrol 2010;73:333-343.
    • (2010) Clin Nephrol , vol.73 , pp. 333-343
    • Cooper, J.E.1    Wiseman, A.C.2
  • 90
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009;284:13291-13295.
    • (2009) J Biol Chem , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 92
    • 84865280525 scopus 로고    scopus 로고
    • Keap1: One stone kills three birds Nrf2, IKKbeta and Bcl-2/Bcl-xL
    • Tian H, Zhang B, Di J, Jiang G, Chen F, Li H et al. Keap1: One stone kills three birds Nrf2, IKKbeta and Bcl-2/Bcl-xL. Cancer Lett 2012;325:26-34.
    • (2012) Cancer Lett , vol.325 , pp. 26-34
    • Tian, H.1    Zhang, B.2    Di, J.3    Jiang, G.4    Chen, F.5    Li, H.6
  • 93
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes JD, McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 2009;34:176-188.
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 94
    • 47849083585 scopus 로고    scopus 로고
    • Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
    • Osburn WO, Kensler TW. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res 2008;659:31-39.
    • (2008) Mutat Res , vol.659 , pp. 31-39
    • Osburn, W.O.1    Kensler, T.W.2
  • 96
    • 46949099638 scopus 로고    scopus 로고
    • Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
    • Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y et al. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008;29:1235-1243.
    • (2008) Carcinogenesis , vol.29 , pp. 1235-1243
    • Wang, X.J.1    Sun, Z.2    Villeneuve, N.F.3    Zhang, S.4    Zhao, F.5    Li, Y.6
  • 97
    • 77955488723 scopus 로고    scopus 로고
    • Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype
    • Singh A, Wu H, Zhang P, Happel C, Ma J, Biswal S. Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype. Mol Cancer Ther 2010;9:2365-2376.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2365-2376
    • Singh, A.1    Wu, H.2    Zhang, P.3    Happel, C.4    Ma, J.5    Biswal, S.6
  • 98
    • 84858972249 scopus 로고    scopus 로고
    • Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress
    • Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJ. Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress. J Biol Chem 2012;287:10021-10031.
    • (2012) J Biol Chem , vol.287 , pp. 10021-10031
    • Pickering, A.M.1    Linder, R.A.2    Zhang, H.3    Forman, H.J.4    Davies, K.J.5
  • 99
    • 81755181689 scopus 로고    scopus 로고
    • Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection
    • Sebens S, Bauer I, Geismann C, Grage-Griebenow E, Ehlers S, Kruse ML et al. Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection. J Biol Chem 2011;286:40911-40921.
    • (2011) J Biol Chem , vol.286 , pp. 40911-40921
    • Sebens, S.1    Bauer, I.2    Geismann, C.3    Grage-Griebenow, E.4    Ehlers, S.5    Kruse, M.L.6
  • 100
    • 84863091925 scopus 로고    scopus 로고
    • Mutation of the Nrf2 gene in non-small cell lung cancer
    • Hu Y, Ju Y, Lin D, Wang Z, Huang Y, Zhang S et al. Mutation of the Nrf2 gene in non-small cell lung cancer. Mol Biol Rep 2011;39:4743-4747.
    • (2011) Mol Biol Rep , vol.39 , pp. 4743-4747
    • Hu, Y.1    Ju, Y.2    Lin, D.3    Wang, Z.4    Huang, Y.5    Zhang, S.6
  • 101
    • 76749106638 scopus 로고    scopus 로고
    • Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
    • Kim YR, Oh JE, Kim MS, Kang MR, Park SW, Han JY et al. Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol 2010;220:446-451.
    • (2010) J Pathol , vol.220 , pp. 446-451
    • Kim, Y.R.1    Oh, J.E.2    Kim, M.S.3    Kang, M.R.4    Park, S.W.5    Han, J.Y.6
  • 102
    • 81755171451 scopus 로고    scopus 로고
    • MiR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
    • Eades G, Yang M, Yao Y, Zhang Y, Zhou Q. miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. J Biol Chem 2011;286:40725-40733.
    • (2011) J Biol Chem , vol.286 , pp. 40725-40733
    • Eades, G.1    Yang, M.2    Yao, Y.3    Zhang, Y.4    Zhou, Q.5
  • 103
    • 80054724249 scopus 로고    scopus 로고
    • Succination of keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2
    • Kinch L, Grishin NV, Brugarolas J. Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2. Cancer Cell 2011;20:418-420.
    • (2011) Cancer Cell , vol.20 , pp. 418-420
    • Kinch, L.1    Grishin, N.V.2    Brugarolas, J.3
  • 104
    • 34548577395 scopus 로고    scopus 로고
    • A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
    • Nioi P, Nguyen T. A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity. Biochem Biophys Res Commun 2007;362:816-821.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 816-821
    • Nioi, P.1    Nguyen, T.2
  • 105
    • 45849133744 scopus 로고    scopus 로고
    • Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
    • Wang R, An J, Ji F, Jiao H, Sun H, Zhou D. Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem Biophys Res Commun 2008;373:151-154.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 151-154
    • Wang, R.1    An, J.2    Ji, F.3    Jiao, H.4    Sun, H.5    Zhou, D.6
  • 106
    • 67650922529 scopus 로고    scopus 로고
    • Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
    • Akhdar H, Loyer P, Rauch C, Corlu A, Guillouzo A, Morel F. Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells. Eur J Cancer 2009;45:2219-2227.
    • (2009) Eur J Cancer , vol.45 , pp. 2219-2227
    • Akhdar, H.1    Loyer, P.2    Rauch, C.3    Corlu, A.4    Guillouzo, A.5    Morel, F.6
  • 107
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011;475:106-109.
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3    Gopinathan, A.4    Wei, C.5    Frese, K.6
  • 108
    • 77951710223 scopus 로고    scopus 로고
    • Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells
    • Hong YB, Kang HJ, Kwon SY, Kim HJ, Kwon KY, Cho CH et al. Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells. Pancreas 2010;39:463-472.
    • (2010) Pancreas , vol.39 , pp. 463-472
    • Hong, Y.B.1    Kang, H.J.2    Kwon, S.Y.3    Kim, H.J.4    Kwon, K.Y.5    Cho, C.H.6
  • 109
    • 77954351631 scopus 로고    scopus 로고
    • High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    • Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W et al. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res 2010;70:5486-5496.
    • (2010) Cancer Res , vol.70 , pp. 5486-5496
    • Jiang, T.1    Chen, N.2    Zhao, F.3    Wang, X.J.4    Kong, B.5    Zheng, W.6
  • 110
    • 79952749190 scopus 로고    scopus 로고
    • NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha
    • Kim TH, Hur EG, Kang SJ, Kim JA, Thapa D, Lee YM et al. NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha. Cancer Res 2011;71:2260-2275.
    • (2011) Cancer Res , vol.71 , pp. 2260-2275
    • Kim, T.H.1    Hur, E.G.2    Kang, S.J.3    Kim, J.A.4    Thapa, D.5    Lee, Y.M.6
  • 111
    • 46649112474 scopus 로고    scopus 로고
    • Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells
    • Kim SK, Yang JW, Kim MR, Roh SH, Kim HG, Lee KY et al. Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells. Free Radic Biol Med 2008;45:537-546.
    • (2008) Free Radic Biol Med , vol.45 , pp. 537-546
    • Kim, S.K.1    Yang, J.W.2    Kim, M.R.3    Roh, S.H.4    Kim, H.G.5    Lee, K.Y.6
  • 113
  • 115
    • 77954695549 scopus 로고    scopus 로고
    • Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    • Solis LM, Behrens C, Dong W, Suraokar M, Ozburn NC, Moran CA et al. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res 2010;16:3743-3753.
    • (2010) Clin Cancer Res , vol.16 , pp. 3743-3753
    • Solis, L.M.1    Behrens, C.2    Dong, W.3    Suraokar, M.4    Ozburn, N.C.5    Moran, C.A.6
  • 116
    • 77955279350 scopus 로고    scopus 로고
    • A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
    • Kim J, Cha YN, Surh YJ. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res 2010;690:12-23.
    • (2010) Mutat Res , vol.690 , pp. 12-23
    • Kim, J.1    Cha, Y.N.2    Surh, Y.J.3
  • 117
    • 81755181689 scopus 로고    scopus 로고
    • Inflammatory macrophages induce NRF2 dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection
    • Sebens S, Bauer I, Geismann C, Grage-Griebenow E, Ehlers S, Kruse ML et al. Inflammatory macrophages induce NRF2 dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection. J Biol Chem 2011;286:40911-40921.
    • (2011) J Biol Chem , vol.286 , pp. 40911-40921
    • Sebens, S.1    Bauer, I.2    Geismann, C.3    Grage-Griebenow, E.4    Ehlers, S.5    Kruse, M.L.6
  • 118
    • 77958004285 scopus 로고    scopus 로고
    • Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases
    • Singh S, Vrishni S, Singh BK, Rahman I, Kakkar P. Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radic Res 2010;44:1267-1288.
    • (2010) Free Radic Res , vol.44 , pp. 1267-1288
    • Singh, S.1    Vrishni, S.2    Singh, B.K.3    Rahman, I.4    Kakkar, P.5
  • 119
    • 79955647069 scopus 로고    scopus 로고
    • Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells
    • Du ZX, Yan Y, Zhang HY, Liu BQ, Gao YY, Niu XF et al. Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells. J Clin Endocrinol Metab 2011;96:E763-E771.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. E763-E771
    • Du, Z.X.1    Yan, Y.2    Zhang, H.Y.3    Liu, B.Q.4    Gao, Y.Y.5    Niu, X.F.6
  • 120
    • 77958129306 scopus 로고    scopus 로고
    • Gain of Nrf2 function in nonsmallcell lung cancer cells confers radioresistance
    • Singh A, Bodas M, Wakabayashi N, Bunz F, Biswal S. Gain of Nrf2 function in nonsmallcell lung cancer cells confers radioresistance. Antioxid Redox Signal 2010;13:1627-1637.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1627-1637
    • Singh, A.1    Bodas, M.2    Wakabayashi, N.3    Bunz, F.4    Biswal, S.5
  • 121
    • 79960815640 scopus 로고    scopus 로고
    • Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: Implications of posttranslational modifications
    • Keum YS. Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications. Ann NY Acad Sci 2011;1229:184-189.
    • (2011) Ann NY Acad Sci , vol.1229 , pp. 184-189
    • Keum, Y.S.1
  • 122
    • 77957240142 scopus 로고    scopus 로고
    • Nrf2-ARE signaling pathway and natural products for cancer chemoprevention
    • Zhao CR, Gao ZH, Qu XJ. Nrf2-ARE signaling pathway and natural products for cancer chemoprevention. Cancer Epidemiol 2010;34:523-533.
    • (2010) Cancer Epidemiol , vol.34 , pp. 523-533
    • Zhao, C.R.1    Gao, Z.H.2    Qu, X.J.3
  • 123
    • 19444379739 scopus 로고    scopus 로고
    • Nrf2 as a novel molecular target for chemoprevention
    • Lee JS, Surh YJ. Nrf2 as a novel molecular target for chemoprevention. Cancer Lett 2005;224:171-184.
    • (2005) Cancer Lett , vol.224 , pp. 171-184
    • Lee, J.S.1    Surh, Y.J.2
  • 124
    • 37649017714 scopus 로고    scopus 로고
    • Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
    • Wang XJ, Hayes JD, Henderson CJ, Wolf CR. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc Natl Acad Sci USA 2007;104:19589-19594.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19589-19594
    • Wang, X.J.1    Hayes, J.D.2    Henderson, C.J.3    Wolf, C.R.4
  • 126
    • 84885177241 scopus 로고    scopus 로고
    • Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
    • e-pub ahead of print 29 October 2012
    • Arlt A, Sebens S, Krebs S, Geismann C, Grossmann M, Kruse ML et al. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene. (e-pub ahead of print 29 October 2012; doi:10.1038/onc.2012.493).
    • Oncogene
    • Arlt, A.1    Sebens, S.2    Krebs, S.3    Geismann, C.4    Grossmann, M.5    Kruse, M.L.6
  • 128
    • 79955612814 scopus 로고    scopus 로고
    • Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
    • Tang X, Wang H, Fan L, Wu X, Xin A, Ren H et al. Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs. Free Radic Biol Med 2011;50:1599-1609.
    • (2011) Free Radic Biol Med , vol.50 , pp. 1599-1609
    • Tang, X.1    Wang, H.2    Fan, L.3    Wu, X.4    Xin, A.5    Ren, H.6
  • 129
    • 79954610780 scopus 로고    scopus 로고
    • Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE) - Dependent gene expression
    • Boettler U, Sommerfeld K, Volz N, Pahlke G, Teller N, Somoza V et al. Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE) - dependent gene expression. J Nutr Biochem 2011;22:426-440.
    • (2011) J Nutr Biochem , vol.22 , pp. 426-440
    • Boettler, U.1    Sommerfeld, K.2    Volz, N.3    Pahlke, G.4    Teller, N.5    Somoza, V.6
  • 130
    • 84864405467 scopus 로고    scopus 로고
    • An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses
    • Lee S, Lim MJ, Kim MH, Yu CH, Yun YS, Ahn J et al. An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses. Free Radic Biol Med 2012;53:807-816.
    • (2012) Free Radic Biol Med , vol.53 , pp. 807-816
    • Lee, S.1    Lim, M.J.2    Kim, M.H.3    Yu, C.H.4    Yun, Y.S.5    Ahn, J.6
  • 133
    • 79958083217 scopus 로고    scopus 로고
    • A cross-talk between NFAT and NFkappaB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells
    • Cai T, Li X, Ding J, Luo W, Li J, Huang C. A cross-talk between NFAT and NFkappaB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Curr Cancer Drug Targets 2011;11:548-559.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 548-559
    • Cai, T.1    Li, X.2    Ding, J.3    Luo, W.4    Li, J.5    Huang, C.6
  • 134
    • 33744486857 scopus 로고    scopus 로고
    • Constitutive NFkappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas
    • Fu L, Lin-Lee YC, Pham LV, Tamayo A, Yoshimura L, Ford RJ. Constitutive NFkappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas. Blood 2006;107:4540-4548.
    • (2006) Blood , vol.107 , pp. 4540-4548
    • Fu, L.1    Lin-Lee, Y.C.2    Pham, L.V.3    Tamayo, A.4    Yoshimura, L.5    Ford, R.J.6
  • 135
    • 33744484033 scopus 로고    scopus 로고
    • Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: Topical therapeutic strategies targeting COX-2 expression and activity
    • Telliez A, Furman C, Pommery N, Henichart JP. Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity. Anticancer Agents Med Chem 2006;6:187-208.
    • (2006) Anticancer Agents Med Chem , vol.6 , pp. 187-208
    • Telliez, A.1    Furman, C.2    Pommery, N.3    Henichart, J.P.4
  • 136
    • 84876078256 scopus 로고    scopus 로고
    • Targeting apoptosis pathways by Celecoxib in cancer
    • e-pub ahead of print 21 February 2011
    • Jendrossek V. Targeting apoptosis pathways by Celecoxib in cancer. Cancer Lett (e-pub ahead of print 21 February 2011; doi:10.1016/j.canlet.2011.01.012).
    • Cancer Lett
    • Jendrossek, V.1
  • 137
    • 77950006166 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer
    • Lipton A, Campbell-Baird C, Witters L, Harvey H, Ali S. Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer. J Clin Gastroenterol 2010;44:286-288.
    • (2010) J Clin Gastroenterol , vol.44 , pp. 286-288
    • Lipton, A.1    Campbell-Baird, C.2    Witters, L.3    Harvey, H.4    Ali, S.5
  • 138
    • 55949120110 scopus 로고    scopus 로고
    • Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis
    • Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S et al. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol 2008;76:1485-1489.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1485-1489
    • Li, W.1    Khor, T.O.2    Xu, C.3    Shen, G.4    Jeong, W.S.5    Yu, S.6
  • 139
    • 84858273322 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate prevents TNF-alpha-induced NF-kappaB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells
    • Jiang J, Mo ZC, Yin K, Zhao GJ, Lv YC, Ouyang XP et al. Epigallocatechin-3-gallate prevents TNF-alpha-induced NF-kappaB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells. Int J Mol Med 2012;29:946-956.
    • (2012) Int J Mol Med , vol.29 , pp. 946-956
    • Jiang, J.1    Mo, Z.C.2    Yin, K.3    Zhao, G.J.4    Lv, Y.C.5    Ouyang, X.P.6
  • 140
    • 84858992660 scopus 로고    scopus 로고
    • Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells
    • Yeang HX, Hamdam JM, Al-Huseini LM, Sethu S, Djouhri L, Walsh J et al. Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells. J Biol Chem 2012;287:10556-10564.
    • (2012) J Biol Chem , vol.287 , pp. 10556-10564
    • Yeang, H.X.1    Hamdam, J.M.2    Al-Huseini, L.M.3    Sethu, S.4    Djouhri, L.5    Walsh, J.6
  • 142
    • 77955653742 scopus 로고    scopus 로고
    • Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
    • Kim JE, You DJ, Lee C, Ahn C, Seong JY, Hwang JI. Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. Cell Signal 2010;22:1645-1654.
    • (2010) Cell Signal , vol.22 , pp. 1645-1654
    • Kim, J.E.1    You, D.J.2    Lee, C.3    Ahn, C.4    Seong, J.Y.5    Hwang, J.I.6
  • 143
    • 79951853800 scopus 로고    scopus 로고
    • Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
    • Yu M, Li H, Liu Q, Liu F, Tang L, Li C et al. Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal 2011;23:883-892.
    • (2011) Cell Signal , vol.23 , pp. 883-892
    • Yu, M.1    Li, H.2    Liu, Q.3    Liu, F.4    Tang, L.5    Li, C.6
  • 145
    • 77958011209 scopus 로고    scopus 로고
    • Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
    • Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer 2010;62:919-930.
    • (2010) Nutr Cancer , vol.62 , pp. 919-930
    • Goel, A.1    Aggarwal, B.B.2


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