-
1
-
-
33645526144
-
Cancer statistics, 2006
-
Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2006. CA Cancer J Clin 56 (2006) 106-130
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 106-130
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani S.R., Petricoin E.F., Maitra A., et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4 (2003) 437-450
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
-
3
-
-
0038405066
-
Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
-
Grippo P.J., Nowlin P.S., Demeure M.J., et al. Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice. Cancer Res 63 (2003) 2016-2019
-
(2003)
Cancer Res
, vol.63
, pp. 2016-2019
-
-
Grippo, P.J.1
Nowlin, P.S.2
Demeure, M.J.3
-
4
-
-
33847419143
-
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
-
Guerra C., Schuhmacher A.J., Canamero M., et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11 (2007) 291-302
-
(2007)
Cancer Cell
, vol.11
, pp. 291-302
-
-
Guerra, C.1
Schuhmacher, A.J.2
Canamero, M.3
-
5
-
-
0035020633
-
Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
-
Hruban R.H., Adsay N.V., Bores-Saavedra J., et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 25 (2001) 579-586
-
(2001)
Am J Surg Pathol
, vol.25
, pp. 579-586
-
-
Hruban, R.H.1
Adsay, N.V.2
Bores-Saavedra, J.3
-
6
-
-
34247897276
-
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
-
Sarkisian C.J., Keister B.A., Stairs D.B., et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 9 (2007) 493-505
-
(2007)
Nat Cell Biol
, vol.9
, pp. 493-505
-
-
Sarkisian, C.J.1
Keister, B.A.2
Stairs, D.B.3
-
7
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
Aguirre A.J., Bardeesy N., Sinha M., et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17 (2003) 3112-3126
-
(2003)
Genes Dev
, vol.17
, pp. 3112-3126
-
-
Aguirre, A.J.1
Bardeesy, N.2
Sinha, M.3
-
8
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson E.L., Willis N., Mercer K., et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15 (2001) 3243-3248
-
(2001)
Genes Dev
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
-
9
-
-
0035734285
-
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
-
Jonkers J., Meuwissen R., van der Gulden H., et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 29 (2001) 418-425
-
(2001)
Nat Genet
, vol.29
, pp. 418-425
-
-
Jonkers, J.1
Meuwissen, R.2
van der Gulden, H.3
-
10
-
-
0035210964
-
Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin
-
Ji B., Bi Y., Simeone D., et al. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology 121 (2001) 1380-1390
-
(2001)
Gastroenterology
, vol.121
, pp. 1380-1390
-
-
Ji, B.1
Bi, Y.2
Simeone, D.3
-
11
-
-
52049101359
-
Robust acinar cell transgene expression of CreErT via BAC recombineering
-
Ji B., Song J., Tsou L., et al. Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis 46 (2008) 390-395
-
(2008)
Genesis
, vol.46
, pp. 390-395
-
-
Ji, B.1
Song, J.2
Tsou, L.3
-
12
-
-
0025884056
-
Efficient selection for high-expression transfectants with a novel eukaryotic vector
-
Niwa H., Yamamura K., and Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 (1991) 193-199
-
(1991)
Gene
, vol.108
, pp. 193-199
-
-
Niwa, H.1
Yamamura, K.2
Miyazaki, J.3
-
13
-
-
0031842971
-
Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture
-
Apte M.V., Haber P.S., Applegate T.L., et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43 (1998) 128-133
-
(1998)
Gut
, vol.43
, pp. 128-133
-
-
Apte, M.V.1
Haber, P.S.2
Applegate, T.L.3
-
14
-
-
41449091585
-
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
-
Qian Y., Zhang J., Yan B., et al. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 283 (2008) 2896-2905
-
(2008)
J Biol Chem
, vol.283
, pp. 2896-2905
-
-
Qian, Y.1
Zhang, J.2
Yan, B.3
-
15
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe J.P., Patil C.K., Rodier F., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6 (2008) 2853-2868
-
(2008)
PLoS Biol
, vol.6
, pp. 2853-2868
-
-
Coppe, J.P.1
Patil, C.K.2
Rodier, F.3
-
16
-
-
57749113202
-
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
-
Habbe N., Shi G., Meguid R.A., et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A 105 (2008) 18913-18918
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18913-18918
-
-
Habbe, N.1
Shi, G.2
Meguid, R.A.3
-
17
-
-
57749116315
-
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
-
De La O.J.P., Emerson L.L., Goodman J.L., et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A 105 (2008) 18907-18912
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18907-18912
-
-
De La, O.J.P.1
Emerson, L.L.2
Goodman, J.L.3
-
18
-
-
34548205213
-
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
-
Siveke J.T., Einwachter H., Sipos B., et al. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell 12 (2007) 266-279
-
(2007)
Cancer Cell
, vol.12
, pp. 266-279
-
-
Siveke, J.T.1
Einwachter, H.2
Sipos, B.3
-
19
-
-
0344736673
-
Notch signaling controls multiple steps of pancreatic differentiation
-
Murtaugh L.C., Stanger B.Z., Kwan K.M., et al. Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A 100 (2003) 14920-14925
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14920-14925
-
-
Murtaugh, L.C.1
Stanger, B.Z.2
Kwan, K.M.3
-
20
-
-
64049085356
-
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
-
Carriere C., Young A.L., Gunn J.R., et al. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem Biophys Res Commun 382 (2009) 561-565
-
(2009)
Biochem Biophys Res Commun
, vol.382
, pp. 561-565
-
-
Carriere, C.1
Young, A.L.2
Gunn, J.R.3
-
21
-
-
0028835482
-
Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini
-
Duan R.D., Zheng C.F., Guan K.L., et al. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Am J Physiol 268 (1995) G1060-G1065
-
(1995)
Am J Physiol
, vol.268
-
-
Duan, R.D.1
Zheng, C.F.2
Guan, K.L.3
-
22
-
-
34247897279
-
Barriers to Ras transformation
-
Ferbeyre G. Barriers to Ras transformation. Nat Cell Biol 9 (2007) 483-485
-
(2007)
Nat Cell Biol
, vol.9
, pp. 483-485
-
-
Ferbeyre, G.1
-
23
-
-
0035553069
-
TGF alpha transgenic mice. A model of pancreatic cancer development
-
Greten F.R., Wagner M., Weber C.K., et al. TGF alpha transgenic mice. A model of pancreatic cancer development. Pancreatology 1 (2001) 363-368
-
(2001)
Pancreatology
, vol.1
, pp. 363-368
-
-
Greten, F.R.1
Wagner, M.2
Weber, C.K.3
-
24
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani S.R., Wang L., Multani A.S., et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 (2005) 469-483
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
-
25
-
-
33645824724
-
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
Bardeesy N., Aguirre A.J., Chu G.C., et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 103 (2006) 5947-5952
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5947-5952
-
-
Bardeesy, N.1
Aguirre, A.J.2
Chu, G.C.3
-
26
-
-
34250329446
-
Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability
-
Kopnin P.B., Agapova L.S., Kopnin B.P., et al. Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. Cancer Res 67 (2007) 4671-4678
-
(2007)
Cancer Res
, vol.67
, pp. 4671-4678
-
-
Kopnin, P.B.1
Agapova, L.S.2
Kopnin, B.P.3
-
27
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c- K-ras genes
-
Almoguera C., Shibata D., Forrester K., et al. Most human carcinomas of the exocrine pancreas contain mutant c- K-ras genes. Cell 53 (1988) 549-554
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
-
28
-
-
0027733796
-
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant- enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
-
Hruban R.H., van Mansfeld A.D., Offerhaus G.J., et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant- enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 143 (1993) 545-554
-
(1993)
Am J Pathol
, vol.143
, pp. 545-554
-
-
Hruban, R.H.1
van Mansfeld, A.D.2
Offerhaus, G.J.3
-
29
-
-
0343294326
-
Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53
-
Luttges J., Diederichs A., Menke M.A., et al. Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53. Cancer 88 (2000) 2495-2504
-
(2000)
Cancer
, vol.88
, pp. 2495-2504
-
-
Luttges, J.1
Diederichs, A.2
Menke, M.A.3
-
30
-
-
13444274253
-
Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis
-
Lohr M., Kloppel G., Maisonneuve P., et al. Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis. Neoplasia 7 (2005) 17-23
-
(2005)
Neoplasia
, vol.7
, pp. 17-23
-
-
Lohr, M.1
Kloppel, G.2
Maisonneuve, P.3
-
31
-
-
0030050945
-
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
-
Tada M., Ohashi M., Shiratori Y., et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 110 (1996) 227-231
-
(1996)
Gastroenterology
, vol.110
, pp. 227-231
-
-
Tada, M.1
Ohashi, M.2
Shiratori, Y.3
-
32
-
-
33744524388
-
Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice
-
Muller-Decker K., Furstenberger G., Annan N., et al. Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. Gastroenterology 130 (2006) 2165-2178
-
(2006)
Gastroenterology
, vol.130
, pp. 2165-2178
-
-
Muller-Decker, K.1
Furstenberger, G.2
Annan, N.3
-
33
-
-
0035252589
-
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
-
Wagner M., Greten F.R., Weber C.K., et al. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev 15 (2001) 286-293
-
(2001)
Genes Dev
, vol.15
, pp. 286-293
-
-
Wagner, M.1
Greten, F.R.2
Weber, C.K.3
-
34
-
-
31544467540
-
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
-
Hruban R.H., Adsay N.V., Albores-Saavedra J., et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 66 (2006) 95-106
-
(2006)
Cancer Res
, vol.66
, pp. 95-106
-
-
Hruban, R.H.1
Adsay, N.V.2
Albores-Saavedra, J.3
|