메뉴 건너뛰기




Volumn 137, Issue 3, 2009, Pages

Ras Activity Levels Control the Development of Pancreatic Diseases

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; PROTEIN P53; RAS PROTEIN;

EID: 69249148349     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.05.052     Document Type: Article
Times cited : (165)

References (35)
  • 2
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani S.R., Petricoin E.F., Maitra A., et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4 (2003) 437-450
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 3
    • 0038405066 scopus 로고    scopus 로고
    • Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
    • Grippo P.J., Nowlin P.S., Demeure M.J., et al. Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice. Cancer Res 63 (2003) 2016-2019
    • (2003) Cancer Res , vol.63 , pp. 2016-2019
    • Grippo, P.J.1    Nowlin, P.S.2    Demeure, M.J.3
  • 4
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C., Schuhmacher A.J., Canamero M., et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11 (2007) 291-302
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3
  • 5
    • 0035020633 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
    • Hruban R.H., Adsay N.V., Bores-Saavedra J., et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 25 (2001) 579-586
    • (2001) Am J Surg Pathol , vol.25 , pp. 579-586
    • Hruban, R.H.1    Adsay, N.V.2    Bores-Saavedra, J.3
  • 6
    • 34247897276 scopus 로고    scopus 로고
    • Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
    • Sarkisian C.J., Keister B.A., Stairs D.B., et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 9 (2007) 493-505
    • (2007) Nat Cell Biol , vol.9 , pp. 493-505
    • Sarkisian, C.J.1    Keister, B.A.2    Stairs, D.B.3
  • 7
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre A.J., Bardeesy N., Sinha M., et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17 (2003) 3112-3126
    • (2003) Genes Dev , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3
  • 8
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson E.L., Willis N., Mercer K., et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15 (2001) 3243-3248
    • (2001) Genes Dev , vol.15 , pp. 3243-3248
    • Jackson, E.L.1    Willis, N.2    Mercer, K.3
  • 9
    • 0035734285 scopus 로고    scopus 로고
    • Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
    • Jonkers J., Meuwissen R., van der Gulden H., et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 29 (2001) 418-425
    • (2001) Nat Genet , vol.29 , pp. 418-425
    • Jonkers, J.1    Meuwissen, R.2    van der Gulden, H.3
  • 10
    • 0035210964 scopus 로고    scopus 로고
    • Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin
    • Ji B., Bi Y., Simeone D., et al. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology 121 (2001) 1380-1390
    • (2001) Gastroenterology , vol.121 , pp. 1380-1390
    • Ji, B.1    Bi, Y.2    Simeone, D.3
  • 11
    • 52049101359 scopus 로고    scopus 로고
    • Robust acinar cell transgene expression of CreErT via BAC recombineering
    • Ji B., Song J., Tsou L., et al. Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis 46 (2008) 390-395
    • (2008) Genesis , vol.46 , pp. 390-395
    • Ji, B.1    Song, J.2    Tsou, L.3
  • 12
    • 0025884056 scopus 로고
    • Efficient selection for high-expression transfectants with a novel eukaryotic vector
    • Niwa H., Yamamura K., and Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 (1991) 193-199
    • (1991) Gene , vol.108 , pp. 193-199
    • Niwa, H.1    Yamamura, K.2    Miyazaki, J.3
  • 13
    • 0031842971 scopus 로고    scopus 로고
    • Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture
    • Apte M.V., Haber P.S., Applegate T.L., et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43 (1998) 128-133
    • (1998) Gut , vol.43 , pp. 128-133
    • Apte, M.V.1    Haber, P.S.2    Applegate, T.L.3
  • 14
    • 41449091585 scopus 로고    scopus 로고
    • DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
    • Qian Y., Zhang J., Yan B., et al. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 283 (2008) 2896-2905
    • (2008) J Biol Chem , vol.283 , pp. 2896-2905
    • Qian, Y.1    Zhang, J.2    Yan, B.3
  • 15
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe J.P., Patil C.K., Rodier F., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6 (2008) 2853-2868
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3
  • 16
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • Habbe N., Shi G., Meguid R.A., et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A 105 (2008) 18913-18918
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18913-18918
    • Habbe, N.1    Shi, G.2    Meguid, R.A.3
  • 17
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • De La O.J.P., Emerson L.L., Goodman J.L., et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A 105 (2008) 18907-18912
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18907-18912
    • De La, O.J.P.1    Emerson, L.L.2    Goodman, J.L.3
  • 18
    • 34548205213 scopus 로고    scopus 로고
    • Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
    • Siveke J.T., Einwachter H., Sipos B., et al. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell 12 (2007) 266-279
    • (2007) Cancer Cell , vol.12 , pp. 266-279
    • Siveke, J.T.1    Einwachter, H.2    Sipos, B.3
  • 19
    • 0344736673 scopus 로고    scopus 로고
    • Notch signaling controls multiple steps of pancreatic differentiation
    • Murtaugh L.C., Stanger B.Z., Kwan K.M., et al. Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A 100 (2003) 14920-14925
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14920-14925
    • Murtaugh, L.C.1    Stanger, B.Z.2    Kwan, K.M.3
  • 20
    • 64049085356 scopus 로고    scopus 로고
    • Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
    • Carriere C., Young A.L., Gunn J.R., et al. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem Biophys Res Commun 382 (2009) 561-565
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 561-565
    • Carriere, C.1    Young, A.L.2    Gunn, J.R.3
  • 21
    • 0028835482 scopus 로고
    • Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini
    • Duan R.D., Zheng C.F., Guan K.L., et al. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Am J Physiol 268 (1995) G1060-G1065
    • (1995) Am J Physiol , vol.268
    • Duan, R.D.1    Zheng, C.F.2    Guan, K.L.3
  • 22
    • 34247897279 scopus 로고    scopus 로고
    • Barriers to Ras transformation
    • Ferbeyre G. Barriers to Ras transformation. Nat Cell Biol 9 (2007) 483-485
    • (2007) Nat Cell Biol , vol.9 , pp. 483-485
    • Ferbeyre, G.1
  • 23
    • 0035553069 scopus 로고    scopus 로고
    • TGF alpha transgenic mice. A model of pancreatic cancer development
    • Greten F.R., Wagner M., Weber C.K., et al. TGF alpha transgenic mice. A model of pancreatic cancer development. Pancreatology 1 (2001) 363-368
    • (2001) Pancreatology , vol.1 , pp. 363-368
    • Greten, F.R.1    Wagner, M.2    Weber, C.K.3
  • 24
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani S.R., Wang L., Multani A.S., et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 (2005) 469-483
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 25
    • 33645824724 scopus 로고    scopus 로고
    • Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
    • Bardeesy N., Aguirre A.J., Chu G.C., et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 103 (2006) 5947-5952
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5947-5952
    • Bardeesy, N.1    Aguirre, A.J.2    Chu, G.C.3
  • 26
    • 34250329446 scopus 로고    scopus 로고
    • Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability
    • Kopnin P.B., Agapova L.S., Kopnin B.P., et al. Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. Cancer Res 67 (2007) 4671-4678
    • (2007) Cancer Res , vol.67 , pp. 4671-4678
    • Kopnin, P.B.1    Agapova, L.S.2    Kopnin, B.P.3
  • 27
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c- K-ras genes
    • Almoguera C., Shibata D., Forrester K., et al. Most human carcinomas of the exocrine pancreas contain mutant c- K-ras genes. Cell 53 (1988) 549-554
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 28
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant- enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
    • Hruban R.H., van Mansfeld A.D., Offerhaus G.J., et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant- enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 143 (1993) 545-554
    • (1993) Am J Pathol , vol.143 , pp. 545-554
    • Hruban, R.H.1    van Mansfeld, A.D.2    Offerhaus, G.J.3
  • 29
    • 0343294326 scopus 로고    scopus 로고
    • Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53
    • Luttges J., Diederichs A., Menke M.A., et al. Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53. Cancer 88 (2000) 2495-2504
    • (2000) Cancer , vol.88 , pp. 2495-2504
    • Luttges, J.1    Diederichs, A.2    Menke, M.A.3
  • 30
    • 13444274253 scopus 로고    scopus 로고
    • Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis
    • Lohr M., Kloppel G., Maisonneuve P., et al. Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis. Neoplasia 7 (2005) 17-23
    • (2005) Neoplasia , vol.7 , pp. 17-23
    • Lohr, M.1    Kloppel, G.2    Maisonneuve, P.3
  • 31
    • 0030050945 scopus 로고    scopus 로고
    • Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
    • Tada M., Ohashi M., Shiratori Y., et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 110 (1996) 227-231
    • (1996) Gastroenterology , vol.110 , pp. 227-231
    • Tada, M.1    Ohashi, M.2    Shiratori, Y.3
  • 32
    • 33744524388 scopus 로고    scopus 로고
    • Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice
    • Muller-Decker K., Furstenberger G., Annan N., et al. Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. Gastroenterology 130 (2006) 2165-2178
    • (2006) Gastroenterology , vol.130 , pp. 2165-2178
    • Muller-Decker, K.1    Furstenberger, G.2    Annan, N.3
  • 33
    • 0035252589 scopus 로고    scopus 로고
    • A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
    • Wagner M., Greten F.R., Weber C.K., et al. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev 15 (2001) 286-293
    • (2001) Genes Dev , vol.15 , pp. 286-293
    • Wagner, M.1    Greten, F.R.2    Weber, C.K.3
  • 34
    • 31544467540 scopus 로고    scopus 로고
    • Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
    • Hruban R.H., Adsay N.V., Albores-Saavedra J., et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 66 (2006) 95-106
    • (2006) Cancer Res , vol.66 , pp. 95-106
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.