Akt/protein kinase B and glycogen synthase kinase-3β signaling pathway regulates cell migration through the NFAT1 transcription factor

Molecular Cancer Research

Volumn 7, Issue 3, 2009, Pages 425-432

  Yoeli Lerner, Merav ^a   Chin, Y Rebecca ^a   Hansen, Christopher K ^a   Toker, Alex ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN KINASE B; PROTEIN KINASE B ALPHA; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; CELL MIGRATION; CELL MOTILITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANIMALS; BREAST NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; NFATC TRANSCRIPTION FACTORS; NIH 3T3 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 62549124971     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0342     Document Type: Article

References (38)

1. Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3- kinases as regulators of growth and metabolism.Nat Rev 2006;7:606-19.
2. Brugge J, Hung MC, Mills GB. A new mutational AKTivation in the PI3K pathway.Cancer Cell 2007;12:104-7.
3. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-74.
4. Stambolic V, Woodgett JR. Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration.T rends Cell Biol 2006;16: 461-6.
5. Y oeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.Mol Cell 2005;20:539-50.
6. Irie HY, Pearline RV, Grueneberg D, et al. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.J Cell Biol 2005; 171:1023-34.
7. 1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.Cancer Res 2003;63: 196-206.
8. Liu H, Radisky DC, Nelson CM, et al. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.Proc Natl Acad Sci U S A 2006;103:4134-9.
9. Jauliac S, Lopez-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion.Nat Cell Biol 2002;4:540-4.
10. 4promotes expression of autotaxin/ ENPP2 autocrine motility factor in breast carcinoma cells.Oncogene 2005;24: 5125-30.
11. Y iu GK, Toker A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.J Biol Chem 2006;281:12210-7.
12. Hutchi nson JN, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt-1 (PKB-α) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion.Cancer Res 2004;64:3171-8.
13. Maro ulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.Cancer Res 2007;67:167-77.
14. Crabtre e GR, Olson EN. NFAT signaling: choreographing the social lives of cells.Cell 2002;109 Suppl:S67-79.
15. 2+/calcineurin-NFAT-mediated signaling.Mol Cells 2004;18:1-9.
16. Beal s CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.Science 1997;275:1930-4.
17. W oodgett JR, Cohen P. Multisite phosphorylation of glycogen synthase. Molecular basis for the substrate specificity of glycogen synthase kinase-3 and casein kinase-II (glycogen synthase kinase-5).Biochim Biophys Acta 1984;788: 339-47.
18. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.Natur e 1995;378:785-9.
19. Stambo lic V, Woodgett JR. Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation.Bioche m J 1994;303: 701-4.
20. Hoeflic h KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3β in cell survival and NF-KB activation.Nature 2000;406:86-90.
21. Hardt SE, Sadoshima J. Glycogen synthase kinase-3β: a novel regulator of cardiac hypertrophy and development.Circ Res 2002;90:1055-63.
22. Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A. Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3β-dependent phosphorylation of β-catenin and downregulates β-catenin.J Biol Chem 2000;275:34399-406.
23. Y amamoto H, Kishida S, Kishida M, Ikeda S, Takada S, Kikuchi A. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3β regulates its stability.J Biol Chem 1999;274:10681-4.
24. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. Binding of GSK3β to the APC-B-catenin complex and regulation of complex assembly. Science 1996;272:1023-6.
25. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer.Biochim Biophys Acta 2003;1653:1-24.
26. Coghlan MP, Culbert AA, Cross DA, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.Chem Biol 2000;7:793-803.
27. Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J. Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.J Biol Chem 2006;281:36443-53.
28. 1 integrins.M ol Cell Biol 2004;24:1505-15.
29. Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition.J Cell Biol 2005;168: 29-33.
30. Kobayashi T, Hino S-i, Oue N, et al. Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.Mol Cell Biol 2006;26: 898-911.
31. Koivisto L, Alavian K, Hakkinen L, Pelech S, McCulloch CA, Larjava H. Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes.J Cell Sci 2003;116:3749-60.
32. Cai X, Li M, Vrana J, Schaller MD. Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.Mol Cell Biol 2006;26:2857-68.
33. Patra AK, Na SY, Bommhardt U. Active protein kinase B regulates TCR responsiveness by modulating cytoplasmic-nuclear localization of NFAT and NFKB proteins.J Immunol 2004;172:4812-20.
34. Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A. A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.M ol Cell Biol 2004;24:4184-95.
35. Macian F, Garcia-Rodriguez C, Rao A. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun.EMBO J 2000; 19:4783-95.
36. Northrop JP, Ho SN, Chen L, et al. NF-AT components define a family of transcription factors targeted in T-cell activation.Nature 1994; 369:497-502.
37. Ding VW, Chen RH, McCormick F. Differential regulation of glycogen synthase kinase 3β by insulin and Wnt signaling.J Biol Chem 2000;275: 32475-81.
38. Flanagan L, Van Weelden K, Ammerman C, Ethier SP, Welsh J. SUM-159PT cells: a novel estrogen independent human breast cancer model system.Breas t Cancer Res Treat 1999;58:193-204.