Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid

Journal of Biological Chemistry

Volumn 286, Issue 33, 2011, Pages 28761-28771

  Singh, Shiv K ^a   Baumgart, Sandra ^a   Singh, Garima ^a   König, Alexander O ^a   Reutlinger, Kristina ^a   Hofbauer, Lorenz C ^b   Barth, Peter ^a   Gress, Thomas M ^a   Lomberk, Gwen ^c   Urrutia, Raul ^c   Fernandez Zapico, Martin E ^c   Ellenrieder, Volker ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMORAL ACTIVITY; CANCER CELLS; GROWTH PROMOTION; GROWTH SUPPRESSIONS; IN-VITRO; LYSINE RESIDUES; MECHANISM OF ACTION; NUCLEAR ACCUMULATION; PANCREATIC CANCERS; PROTEASOMAL DEGRADATION; PROTEIN STABILITY; PROTEIN STABILIZATION; SERINE PHOSPHORYLATION; UBIQUITIN LIGASES; UBIQUITINATION; ZOLEDRONIC ACID;

AMINO ACIDS; DEGRADATION; DISEASES; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

STABILIZATION;

GLYCOGEN SYNTHASE KINASE 3BETA; LYSINE; NFATC2 PROTEIN; NUCLEAR PROTEIN; PROTEIN MDM2; SERINE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; UBIQUITINATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTINEOPLASTIC AGENTS; BONE DENSITY CONSERVATION AGENTS; BREAST NEOPLASMS; CELL NUCLEUS; DIPHOSPHONATES; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMIDAZOLES; MICE; MICE, NUDE; NEOPLASM PROTEINS; NFATC TRANSCRIPTION FACTORS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 80051694778     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.197533     Document Type: Article

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