메뉴 건너뛰기




Volumn 291, Issue 1, 2010, Pages 90-98

Downregulation of nuclear factor-κB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer

Author keywords

Gemcitabine; Nuclear factor B; Pancreatic cancer; Small interference RNA

Indexed keywords

CASPASE 3; CYCLIN D2; GEMCITABINE; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; VASCULOTROPIN;

EID: 77949874727     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.10.001     Document Type: Article
Times cited : (76)

References (48)
  • 1
    • 0141888993 scopus 로고    scopus 로고
    • Treatment of pancreatic cancer: challenge of the facts
    • Beger H.G., Rau B., Gansauge F., Poch B., and Link K.H. Treatment of pancreatic cancer: challenge of the facts. World J. Surg. 27 (2003) 1075-1084
    • (2003) World J. Surg. , vol.27 , pp. 1075-1084
    • Beger, H.G.1    Rau, B.2    Gansauge, F.3    Poch, B.4    Link, K.H.5
  • 4
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z., Li Y., Kong D., Banerjee S., Ahmad A., Azmi A.S., Ali S., Abbruzzese J.L., Gallick G.E., and Sarkar F.H. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res. 69 (2009) 2400-2407
    • (2009) Cancer Res. , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 5
    • 0036462584 scopus 로고    scopus 로고
    • Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine)
    • Bergman A.M., Pinedo H.M., and Peters G.J. Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine). Drug Resist. Updat. 5 (2002) 19-33
    • (2002) Drug Resist. Updat. , vol.5 , pp. 19-33
    • Bergman, A.M.1    Pinedo, H.M.2    Peters, G.J.3
  • 6
    • 34548487143 scopus 로고    scopus 로고
    • Beyond IkappaBs: alternative regulation of NF-κB activity
    • Neumann M., and Naumann M. Beyond IkappaBs: alternative regulation of NF-κB activity. FASEB J. 21 (2007) 2642-2654
    • (2007) FASEB J. , vol.21 , pp. 2642-2654
    • Neumann, M.1    Naumann, M.2
  • 9
    • 0348012946 scopus 로고    scopus 로고
    • NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells
    • Xiong H.Q., Abbruzzese J.L., Lin E., Wang L., Zheng L., and Xie K. NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int. J. Cancer 108 (2004) 181-188
    • (2004) Int. J. Cancer , vol.108 , pp. 181-188
    • Xiong, H.Q.1    Abbruzzese, J.L.2    Lin, E.3    Wang, L.4    Zheng, L.5    Xie, K.6
  • 10
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W., Abbruzzese J.L., Evans D.B., Larry L., Cleary K.R., and Chiao P.J. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer. Res. 5 (1999) 119-127
    • (1999) Clin. Cancer. Res. , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 11
    • 0037780982 scopus 로고    scopus 로고
    • Mitogenic and antiapoptotic role of constitutive NF-κB/Rel activity in pancreatic cancer
    • Liptay S., Weber C.K., Ludwig L., Wagner M., Adler G., and Schmid R.M. Mitogenic and antiapoptotic role of constitutive NF-κB/Rel activity in pancreatic cancer. Int. J. Cancer 105 (2003) 735-746
    • (2003) Int. J. Cancer , vol.105 , pp. 735-746
    • Liptay, S.1    Weber, C.K.2    Ludwig, L.3    Wagner, M.4    Adler, G.5    Schmid, R.M.6
  • 12
    • 1842850737 scopus 로고    scopus 로고
    • Increased expression of NF-κB subunits in human pancreaticcancer cells
    • Chandler N.M., Canete J.J., and Callery M.P. Increased expression of NF-κB subunits in human pancreaticcancer cells. J. Surg. Res. 118 (2004) 9-14
    • (2004) J. Surg. Res. , vol.118 , pp. 9-14
    • Chandler, N.M.1    Canete, J.J.2    Callery, M.P.3
  • 14
    • 0035139792 scopus 로고    scopus 로고
    • Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer
    • Yamamoto Y., and Gaynor R.B. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 107 (2001) 135-142
    • (2001) J. Clin. Invest. , vol.107 , pp. 135-142
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 15
    • 0029044627 scopus 로고
    • Induction of carcinoma cell migration on vitronectin by NF-kappaB-dependent gene expression
    • Yebra M., Filardo E.J., Bayna E.M., Kawahara E., Becker J.C., and Cheresh D.A. Induction of carcinoma cell migration on vitronectin by NF-kappaB-dependent gene expression. Mol. Biol. Cell 6 (1995) 841-850
    • (1995) Mol. Biol. Cell , vol.6 , pp. 841-850
    • Yebra, M.1    Filardo, E.J.2    Bayna, E.M.3    Kawahara, E.4    Becker, J.C.5    Cheresh, D.A.6
  • 16
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • Arlt A., Gehrz A., Müerköster S., Vorndamm J., Kruse M.L., Fölsch U.R., and Schäfer H. Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 22 (2003) 3243-3251
    • (2003) Oncogene , vol.22 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Müerköster, S.3    Vorndamm, J.4    Kruse, M.L.5    Fölsch, U.R.6    Schäfer, H.7
  • 17
    • 38449110353 scopus 로고    scopus 로고
    • NF-kappaB as a molecular target in the therapy of pancreatic carcinoma
    • Sebens S., Arlt A., and Schäfer H. NF-kappaB as a molecular target in the therapy of pancreatic carcinoma. Recent Results Cancer Res. 177 (2008) 151-164
    • (2008) Recent Results Cancer Res. , vol.177 , pp. 151-164
    • Sebens, S.1    Arlt, A.2    Schäfer, H.3
  • 19
    • 25444493107 scopus 로고    scopus 로고
    • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    • Banerjee S., Zhang Y., Ali S., Bhuiyan M., Wang Z., Chiao P.J., Philip P.A., Abbruzzese J., and Sarkar F.H. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res. 65 (2005) 9064-9072
    • (2005) Cancer Res. , vol.65 , pp. 9064-9072
    • Banerjee, S.1    Zhang, Y.2    Ali, S.3    Bhuiyan, M.4    Wang, Z.5    Chiao, P.J.6    Philip, P.A.7    Abbruzzese, J.8    Sarkar, F.H.9
  • 21
    • 34248573808 scopus 로고    scopus 로고
    • Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products
    • Kunnumakkara A.B., Guha S., Krishnan S., Diagaradjane P., Gelovani J., and Aggarwal B.B. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res. 67 (2007) 3853-3861
    • (2007) Cancer Res. , vol.67 , pp. 3853-3861
    • Kunnumakkara, A.B.1    Guha, S.2    Krishnan, S.3    Diagaradjane, P.4    Gelovani, J.5    Aggarwal, B.B.6
  • 22
    • 66749130761 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappa B activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy
    • Mamaghani S., Patel S., and Hedley D.W. Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappa B activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy. BMC. Cancer. 9 (2009) 132
    • (2009) BMC. Cancer. , vol.9 , pp. 132
    • Mamaghani, S.1    Patel, S.2    Hedley, D.W.3
  • 23
    • 0034724519 scopus 로고    scopus 로고
    • Double-stranded RNA as a template for gene silencing
    • Bass B.L. Double-stranded RNA as a template for gene silencing. Cell 101 (2000) 235-238
    • (2000) Cell , vol.101 , pp. 235-238
    • Bass, B.L.1
  • 24
    • 2542449068 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to irinotecan by RNA interference mediated down-regulation of the nuclear factor-κB p65 subunit
    • Guo J., Verma U.N., Gaynor R.B., Frenkel E.P., and Becerra C.R. Enhanced chemosensitivity to irinotecan by RNA interference mediated down-regulation of the nuclear factor-κB p65 subunit. Clin. Cancer Res. 10 (2004) 3333-3341
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3333-3341
    • Guo, J.1    Verma, U.N.2    Gaynor, R.B.3    Frenkel, E.P.4    Becerra, C.R.5
  • 25
    • 0025730640 scopus 로고
    • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
    • Andrews N.C., and Faller D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19 (1991) 2499
    • (1991) Nucleic Acids Res. , vol.19 , pp. 2499
    • Andrews, N.C.1    Faller, D.V.2
  • 26
    • 59449109184 scopus 로고    scopus 로고
    • Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo
    • Chen H., Sun B., Pan S., Jiang H., and Sun X. Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. Anticancer Drugs 20 (2009) 131-140
    • (2009) Anticancer Drugs , vol.20 , pp. 131-140
    • Chen, H.1    Sun, B.2    Pan, S.3    Jiang, H.4    Sun, X.5
  • 27
    • 33847288085 scopus 로고    scopus 로고
    • Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy
    • Ma L., Luo L., Qiao H., Dong X., Pan S., Jiang H., Krissansen G.W., and Sun X. Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy. J. Hepatol. 46 (2007) 98-106
    • (2007) J. Hepatol. , vol.46 , pp. 98-106
    • Ma, L.1    Luo, L.2    Qiao, H.3    Dong, X.4    Pan, S.5    Jiang, H.6    Krissansen, G.W.7    Sun, X.8
  • 28
    • 34447296461 scopus 로고    scopus 로고
    • Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice
    • Mai Z., Blackburn G.L., and Zhou J.R. Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. Carcinogenesis 28 (2007) 1217-1223
    • (2007) Carcinogenesis , vol.28 , pp. 1217-1223
    • Mai, Z.1    Blackburn, G.L.2    Zhou, J.R.3
  • 29
    • 43049101649 scopus 로고    scopus 로고
    • Two hour exposure to sodium butyrate sensitizes bladder cancer to anticancer drugs
    • Wang D., Wang Z., Tian B., Li X., Li S., and Tian Y. Two hour exposure to sodium butyrate sensitizes bladder cancer to anticancer drugs. Int. J. Urol. 15 (2008) 435-441
    • (2008) Int. J. Urol. , vol.15 , pp. 435-441
    • Wang, D.1    Wang, Z.2    Tian, B.3    Li, X.4    Li, S.5    Tian, Y.6
  • 30
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
    • Chou T.C., and Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 22 (1984) 27-55
    • (1984) Adv. Enzyme Regul. , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 31
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • Baud V., and Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug. Discov. 8 (2009) 33-40
    • (2009) Nat. Rev. Drug. Discov. , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 32
    • 2542449069 scopus 로고    scopus 로고
    • Chemoresistance: impact of nuclear factor (NF)-kappaB inhibition by small interfering RNA
    • Veiby O.P., and Read M.A. Chemoresistance: impact of nuclear factor (NF)-kappaB inhibition by small interfering RNA. Clin. Cancer Res. 10 (2004) 3262-3264
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3262-3264
    • Veiby, O.P.1    Read, M.A.2
  • 33
    • 39049107744 scopus 로고    scopus 로고
    • GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy
    • Takahashi-Yanaga F., and Sasaguri T. GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy. Cell. Signal. 20 (2008) 581-589
    • (2008) Cell. Signal. , vol.20 , pp. 581-589
    • Takahashi-Yanaga, F.1    Sasaguri, T.2
  • 34
    • 0030969478 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis
    • Gansauge S., Gansauge F., Ramadani M., Stobbe H., Rau B., Harada N., and Beger H.G. Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res. 57 (1997) 1634-1637
    • (1997) Cancer Res. , vol.57 , pp. 1634-1637
    • Gansauge, S.1    Gansauge, F.2    Ramadani, M.3    Stobbe, H.4    Rau, B.5    Harada, N.6    Beger, H.G.7
  • 35
    • 0031812131 scopus 로고    scopus 로고
    • Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival
    • Kornmann M., Ishiwata T., Itakura J., Tangvoranuntakul P., Beger H.G., and Korc M. Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. Oncology 55 (1998) 363-369
    • (1998) Oncology , vol.55 , pp. 363-369
    • Kornmann, M.1    Ishiwata, T.2    Itakura, J.3    Tangvoranuntakul, P.4    Beger, H.G.5    Korc, M.6
  • 38
    • 33745953139 scopus 로고    scopus 로고
    • BCL-2 in the crosshairs: tipping the balance of life and death
    • Walensky L.D. BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ. 13 (2006) 1339-1350
    • (2006) Cell Death Differ. , vol.13 , pp. 1339-1350
    • Walensky, L.D.1
  • 40
    • 68249152630 scopus 로고    scopus 로고
    • Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: an experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy
    • Casneuf V.F., Demetter P., Boterberg T., Delrue L., Peeters M., and Damme N.Van. Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: an experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy. Oncol. Rep. 22 (2009) 105-113
    • (2009) Oncol. Rep. , vol.22 , pp. 105-113
    • Casneuf, V.F.1    Demetter, P.2    Boterberg, T.3    Delrue, L.4    Peeters, M.5    Damme, N.Van.6
  • 41
    • 34547791887 scopus 로고    scopus 로고
    • Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice
    • Liu F., Tan G., Li J., Dong X., Krissansen G.W., and Sun X. Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice. Cancer Sci. 98 (2007) 1381-1387
    • (2007) Cancer Sci. , vol.98 , pp. 1381-1387
    • Liu, F.1    Tan, G.2    Li, J.3    Dong, X.4    Krissansen, G.W.5    Sun, X.6
  • 42
    • 54949123005 scopus 로고    scopus 로고
    • Antisense hypoxia-inducible factor 1 α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinomas
    • Liu F., Wang P., Jiang X., Tan G., Qiao H., Jiang H., Krissansen G.W., and Sun X. Antisense hypoxia-inducible factor 1 α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinomas. Cancer Sci. 99 (2008) 2055-2061
    • (2008) Cancer Sci. , vol.99 , pp. 2055-2061
    • Liu, F.1    Wang, P.2    Jiang, X.3    Tan, G.4    Qiao, H.5    Jiang, H.6    Krissansen, G.W.7    Sun, X.8
  • 43
    • 0036897097 scopus 로고    scopus 로고
    • Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs
    • Bocci G., Nicolaou K.C., and Kerbel R.S. Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res. 62 (2002) 6938-6943
    • (2002) Cancer Res. , vol.62 , pp. 6938-6943
    • Bocci, G.1    Nicolaou, K.C.2    Kerbel, R.S.3
  • 44
    • 0033621839 scopus 로고    scopus 로고
    • NF-κB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis
    • Kuhnel F., Zender L., Paul Y., Tietze M.K., Trautwein C., Manns M., and Kubicka S. NF-κB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J. Biol. Chem. 275 (2000) 6421-6427
    • (2000) J. Biol. Chem. , vol.275 , pp. 6421-6427
    • Kuhnel, F.1    Zender, L.2    Paul, Y.3    Tietze, M.K.4    Trautwein, C.5    Manns, M.6    Kubicka, S.7
  • 46
    • 33746594835 scopus 로고    scopus 로고
    • Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappa B activation
    • Ortis F., Cardozo A.K., Crispim D., Störling J., Mandrup-Poulsen T., and Eizirik D.L. Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappa B activation. Mol. Endocrinol. 20 (2006) 1867-1879
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1867-1879
    • Ortis, F.1    Cardozo, A.K.2    Crispim, D.3    Störling, J.4    Mandrup-Poulsen, T.5    Eizirik, D.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.