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Volumn 342, Issue 2, 2014, Pages 231-237

Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers

Author keywords

DNA methylation; Early detection; MiRNA; Pancreatic cancer; Satellite repeats

Indexed keywords

HISTONE H3; HISTONE H4; MICRORNA; TRANSCRIPTION FACTOR EZH2;

EID: 84888201440     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.03.022     Document Type: Review
Times cited : (35)

References (85)
  • 1
    • 34547160717 scopus 로고    scopus 로고
    • Biology and management of pancreatic cancer
    • Ghaneh P., Costello E., Neoptolemos J.P. Biology and management of pancreatic cancer. Gut 2007, 56:1134-1152.
    • (2007) Gut , vol.56 , pp. 1134-1152
    • Ghaneh, P.1    Costello, E.2    Neoptolemos, J.P.3
  • 2
    • 0038297512 scopus 로고    scopus 로고
    • Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds
    • Rulyak S.J., Lowenfels A.B., Maisonneuve P., Brentnall T.A. Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds. Gastroenterology 2003, 124:1292-1299.
    • (2003) Gastroenterology , vol.124 , pp. 1292-1299
    • Rulyak, S.J.1    Lowenfels, A.B.2    Maisonneuve, P.3    Brentnall, T.A.4
  • 9
    • 0033578479 scopus 로고    scopus 로고
    • Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer
    • Brentnall T.A., Bronner M.P., Byrd D.R., Haggitt R.C., Kimmey M.B. Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer. Ann. Intern. Med. 1999, 131:247-255.
    • (1999) Ann. Intern. Med. , vol.131 , pp. 247-255
    • Brentnall, T.A.1    Bronner, M.P.2    Byrd, D.R.3    Haggitt, R.C.4    Kimmey, M.B.5
  • 14
    • 22844448456 scopus 로고    scopus 로고
    • Molecular markers of early pancreatic cancer
    • Goggins M. Molecular markers of early pancreatic cancer. J. Clin. Oncol. 2005, 23:4524-4531.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 4524-4531
    • Goggins, M.1
  • 15
    • 0027502624 scopus 로고
    • Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation
    • Yanagisawa A., Ohtake K., Ohashi K., Hori M., Kitagawa T., Sugano H., Kato Y. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation. Cancer Res. 1993, 53:953-956.
    • (1993) Cancer Res. , vol.53 , pp. 953-956
    • Yanagisawa, A.1    Ohtake, K.2    Ohashi, K.3    Hori, M.4    Kitagawa, T.5    Sugano, H.6    Kato, Y.7
  • 16
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg A.P., Tycko B. The history of cancer epigenetics. Nat. Rev. Cancer 2004, 4:143-153.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 17
    • 0029854322 scopus 로고    scopus 로고
    • Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: identification of a 1-cM region of common allelic loss
    • Kimura M., Abe T., Sunamura M., Matsuno S., Horii A. Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: identification of a 1-cM region of common allelic loss. Genes Chromosomes Cancer 1996, 17:88-93.
    • (1996) Genes Chromosomes Cancer , vol.17 , pp. 88-93
    • Kimura, M.1    Abe, T.2    Sunamura, M.3    Matsuno, S.4    Horii, A.5
  • 24
    • 55849135224 scopus 로고    scopus 로고
    • Age-specific incidence of cancer: phases, transitions, and biological implications
    • Meza R., Jeon J., Moolgavkar S.H., Luebeck E.G. Age-specific incidence of cancer: phases, transitions, and biological implications. Proc. Natl. Acad. Sci. USA 2008, 105:16284-16289.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16284-16289
    • Meza, R.1    Jeon, J.2    Moolgavkar, S.H.3    Luebeck, E.G.4
  • 25
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird P.W. The power and the promise of DNA methylation markers. Nat. Rev. Cancer 2003, 3:253-266.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 26
    • 23844517119 scopus 로고    scopus 로고
    • Diagnostic and therapeutic applications of epigenetics
    • Miyamoto K., Ushijima T. Diagnostic and therapeutic applications of epigenetics. Jpn. J. Clin. Oncol. 2005, 35:293-301.
    • (2005) Jpn. J. Clin. Oncol. , vol.35 , pp. 293-301
    • Miyamoto, K.1    Ushijima, T.2
  • 27
    • 34047190317 scopus 로고    scopus 로고
    • Epigenetic field for cancerization
    • Ushijima T. Epigenetic field for cancerization. J. Biochem. Mol. Biol. 2007, 40:142-150.
    • (2007) J. Biochem. Mol. Biol. , vol.40 , pp. 142-150
    • Ushijima, T.1
  • 33
    • 0042284883 scopus 로고    scopus 로고
    • SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions
    • Sato N., Fukushima N., Maehara N., Matsubayashi H., Koopmann J., Su G.H., Hruban R.H., Goggins M. SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene 2003, 22:5021-5030.
    • (2003) Oncogene , vol.22 , pp. 5021-5030
    • Sato, N.1    Fukushima, N.2    Maehara, N.3    Matsubayashi, H.4    Koopmann, J.5    Su, G.H.6    Hruban, R.H.7    Goggins, M.8
  • 35
    • 18844448016 scopus 로고    scopus 로고
    • Abrogation of DUSP6 by hypermethylation in human pancreatic cancer
    • Xu S., Furukawa T., Kanai N., Sunamura M., Horii A. Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. J. Hum. Genet. 2005, 50:159-167.
    • (2005) J. Hum. Genet. , vol.50 , pp. 159-167
    • Xu, S.1    Furukawa, T.2    Kanai, N.3    Sunamura, M.4    Horii, A.5
  • 36
    • 32044467674 scopus 로고    scopus 로고
    • Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers
    • Sato N., Fukushima N., Chang R., Matsubayashi H., Goggins M. Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers. Gastroenterology 2006, 130:548-565.
    • (2006) Gastroenterology , vol.130 , pp. 548-565
    • Sato, N.1    Fukushima, N.2    Chang, R.3    Matsubayashi, H.4    Goggins, M.5
  • 38
    • 0037389979 scopus 로고    scopus 로고
    • Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age- related phenomenon in gastrointestinal tissues
    • Matsubayashi H., Sato N., Fukushima N., Yeo C.J., Walter K.M., Brune K., Sahin F., Hruban R.H., Goggins M. Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age- related phenomenon in gastrointestinal tissues. Clin. Cancer Res. 2003, 9:1446-1452.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1446-1452
    • Matsubayashi, H.1    Sato, N.2    Fukushima, N.3    Yeo, C.J.4    Walter, K.M.5    Brune, K.6    Sahin, F.7    Hruban, R.H.8    Goggins, M.9
  • 39
    • 13444291198 scopus 로고    scopus 로고
    • Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma
    • Sato N., Parker A.R., Fukushima N., Miyagi Y., Iacobuzio-Donahue C.A., Eshleman J.R., Goggins M. Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. Oncogene 2005, 24:850-858.
    • (2005) Oncogene , vol.24 , pp. 850-858
    • Sato, N.1    Parker, A.R.2    Fukushima, N.3    Miyagi, Y.4    Iacobuzio-Donahue, C.A.5    Eshleman, J.R.6    Goggins, M.7
  • 42
    • 0042575343 scopus 로고    scopus 로고
    • Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms
    • Fukushima N., Sato N., Sahin F., Su G.H., Hruban R.H., Goggins M. Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Br. J. Cancer 2003, 89:338-343.
    • (2003) Br. J. Cancer , vol.89 , pp. 338-343
    • Fukushima, N.1    Sato, N.2    Sahin, F.3    Su, G.H.4    Hruban, R.H.5    Goggins, M.6
  • 43
    • 0041559969 scopus 로고    scopus 로고
    • Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanINs
    • Jansen M., Fukushima N., Rosty C., Walter K., Altink R., Heek T.V., Hruban R., Offerhaus J.G., Goggins M. Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanINs. Cancer Biol. Ther. 2002, 1:293-296.
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 293-296
    • Jansen, M.1    Fukushima, N.2    Rosty, C.3    Walter, K.4    Altink, R.5    Heek, T.V.6    Hruban, R.7    Offerhaus, J.G.8    Goggins, M.9
  • 44
    • 0035577825 scopus 로고    scopus 로고
    • Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma
    • Ueki T., Toyota M., Skinner H., Walter K.M., Yeo C.J., Issa J.P., Hruban R.H., Goggins M. Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma. Cancer Res. 2001, 61:8540-8546.
    • (2001) Cancer Res. , vol.61 , pp. 8540-8546
    • Ueki, T.1    Toyota, M.2    Skinner, H.3    Walter, K.M.4    Yeo, C.J.5    Issa, J.P.6    Hruban, R.H.7    Goggins, M.8
  • 45
    • 0036097181 scopus 로고    scopus 로고
    • Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
    • Fukushima N., Sato N., Ueki T., Rosty C., Walter K.M., Wilentz R.E., Yeo C.J., Hruban R.H., Goggins M. Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am. J. Pathol. 2002, 160:1573-1581.
    • (2002) Am. J. Pathol. , vol.160 , pp. 1573-1581
    • Fukushima, N.1    Sato, N.2    Ueki, T.3    Rosty, C.4    Walter, K.M.5    Wilentz, R.E.6    Yeo, C.J.7    Hruban, R.H.8    Goggins, M.9
  • 47
    • 33745848467 scopus 로고    scopus 로고
    • Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma
    • Sato N., Fukushima N., Matsubayashi H., Iacobuzio-Donahue C.A., Yeo C.J., Goggins M. Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma. Cancer 2006, 107:251-257.
    • (2006) Cancer , vol.107 , pp. 251-257
    • Sato, N.1    Fukushima, N.2    Matsubayashi, H.3    Iacobuzio-Donahue, C.A.4    Yeo, C.J.5    Goggins, M.6
  • 49
    • 79958733589 scopus 로고    scopus 로고
    • Microarray coupled with methyl-CpG targeted transcriptional activation (MeTA-array) identifies hypermethylated genes containing the stringent criteria of CpG islands at high frequency
    • Sato Y., Horii A., Fukushige S. Microarray coupled with methyl-CpG targeted transcriptional activation (MeTA-array) identifies hypermethylated genes containing the stringent criteria of CpG islands at high frequency. Epigenetics 2011, 6:752-759.
    • (2011) Epigenetics , vol.6 , pp. 752-759
    • Sato, Y.1    Horii, A.2    Fukushige, S.3
  • 50
    • 79960563683 scopus 로고    scopus 로고
    • Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array)
    • Shimizu H., Horii A., Sunamura M., Motoi F., Egawa S., Unno M., Fukushige S. Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array). Biochem. Biophys. Res. Commun. 2011, 411:162-167.
    • (2011) Biochem. Biophys. Res. Commun. , vol.411 , pp. 162-167
    • Shimizu, H.1    Horii, A.2    Sunamura, M.3    Motoi, F.4    Egawa, S.5    Unno, M.6    Fukushige, S.7
  • 51
    • 0036141349 scopus 로고    scopus 로고
    • Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
    • Rosty C., Ueki T., Argani P., Jansen M., Yeo C.J., Cameron J.L., Hruban R.H., Goggins M. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am. J. Pathol. 2002, 160:45-50.
    • (2002) Am. J. Pathol. , vol.160 , pp. 45-50
    • Rosty, C.1    Ueki, T.2    Argani, P.3    Jansen, M.4    Yeo, C.J.5    Cameron, J.L.6    Hruban, R.H.7    Goggins, M.8
  • 53
    • 1542636969 scopus 로고    scopus 로고
    • Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling
    • Sato N., Fukushima N., Matsubayashi H., Goggins M. Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. Oncogene 2004, 23:1531-1538.
    • (2004) Oncogene , vol.23 , pp. 1531-1538
    • Sato, N.1    Fukushima, N.2    Matsubayashi, H.3    Goggins, M.4
  • 55
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression
    • Wilentz R.E., Iacobuzio-Donahue C.A., Argani P., McCarthy D.M., Parsons J.L., Yeo C.J., Kern S.E., Hruban R.H. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 2000, 60:2002-2006.
    • (2000) Cancer Res. , vol.60 , pp. 2002-2006
    • Wilentz, R.E.1    Iacobuzio-Donahue, C.A.2    Argani, P.3    McCarthy, D.M.4    Parsons, J.L.5    Yeo, C.J.6    Kern, S.E.7    Hruban, R.H.8
  • 56
    • 24044529771 scopus 로고    scopus 로고
    • Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas
    • Furukawa T., Fujisaki R., Yoshida Y., Kanai N., Sunamura M., Abe T., Takeda K., Matsuno S., Horii A. Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. Mod. Pathol. 2005, 18:1034-1042.
    • (2005) Mod. Pathol. , vol.18 , pp. 1034-1042
    • Furukawa, T.1    Fujisaki, R.2    Yoshida, Y.3    Kanai, N.4    Sunamura, M.5    Abe, T.6    Takeda, K.7    Matsuno, S.8    Horii, A.9
  • 57
    • 27644466889 scopus 로고    scopus 로고
    • Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling
    • Sato N., Matsubayashi H., Abe T., Fukushima N., Goggins M. Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling. Clin. Cancer Res. 2005, 11:4681-4688.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4681-4688
    • Sato, N.1    Matsubayashi, H.2    Abe, T.3    Fukushima, N.4    Goggins, M.5
  • 59
    • 56649085104 scopus 로고    scopus 로고
    • Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas
    • Hong S.M., Kelly D., Griffith M., Omura N., Li A., Li C.P., Hruban R.H., Goggins M. Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas. Mod. Pathol. 2008, 21:1499-1507.
    • (2008) Mod. Pathol. , vol.21 , pp. 1499-1507
    • Hong, S.M.1    Kelly, D.2    Griffith, M.3    Omura, N.4    Li, A.5    Li, C.P.6    Hruban, R.H.7    Goggins, M.8
  • 60
    • 39749128967 scopus 로고    scopus 로고
    • CpG island methylation profile of pancreatic intraepithelial neoplasia
    • Sato N., Fukushima N., Hruban R.H., Goggins M. CpG island methylation profile of pancreatic intraepithelial neoplasia. Mod. Pathol. 2008, 21:238-244.
    • (2008) Mod. Pathol. , vol.21 , pp. 238-244
    • Sato, N.1    Fukushima, N.2    Hruban, R.H.3    Goggins, M.4
  • 61
    • 0242522859 scopus 로고    scopus 로고
    • Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas
    • Kim S.G., Wu T.T., Lee J.H., Yun Y.K., Issa J.P., Hamilton S.R., Rashid A. Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas. Mod. Pathol. 2003, 16:1086-1094.
    • (2003) Mod. Pathol. , vol.16 , pp. 1086-1094
    • Kim, S.G.1    Wu, T.T.2    Lee, J.H.3    Yun, Y.K.4    Issa, J.P.5    Hamilton, S.R.6    Rashid, A.7
  • 64
    • 79961187284 scopus 로고    scopus 로고
    • Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development
    • Zhang S., Hao J., Xie F., Hu X., Liu C., Tong J., Zhou J., Wu J., Shao C. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis 2011, 32:1183-1189.
    • (2011) Carcinogenesis , vol.32 , pp. 1183-1189
    • Zhang, S.1    Hao, J.2    Xie, F.3    Hu, X.4    Liu, C.5    Tong, J.6    Zhou, J.7    Wu, J.8    Shao, C.9
  • 66
    • 57049090610 scopus 로고    scopus 로고
    • MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival
    • Dillhoff M., Liu J., Frankel W., Croce C., Bloomston M. MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival. J. Gastrointest. Surg. 2008, 12:2171-2176.
    • (2008) J. Gastrointest. Surg. , vol.12 , pp. 2171-2176
    • Dillhoff, M.1    Liu, J.2    Frankel, W.3    Croce, C.4    Bloomston, M.5
  • 68
    • 77949564293 scopus 로고    scopus 로고
    • Aberrant microRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma
    • Ryu J.K., Hong S.M., Karikari C.A., Hruban R.H., Goggins M.G., Maitra A. Aberrant microRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology 2010, 10:66-73.
    • (2010) Pancreatology , vol.10 , pp. 66-73
    • Ryu, J.K.1    Hong, S.M.2    Karikari, C.A.3    Hruban, R.H.4    Goggins, M.G.5    Maitra, A.6
  • 69
    • 77954354936 scopus 로고    scopus 로고
    • Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels
    • Li A., Omura N., Hong S.-M., Vincent A., Walter K., Griffith M., Borges M., Goggins M. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res. 2010, 70:5226-5237.
    • (2010) Cancer Res. , vol.70 , pp. 5226-5237
    • Li, A.1    Omura, N.2    Hong, S.-M.3    Vincent, A.4    Walter, K.5    Griffith, M.6    Borges, M.7    Goggins, M.8
  • 70
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park S.M., Gaur A.B., Lengyel E., Peter M.E. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008, 22:894-907.
    • (2008) Genes Dev. , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 71
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M., Lee E.S., Hu G., Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem. 2008, 283:14910-14914.
    • (2008) J. Biol. Chem. , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 75
    • 0037115392 scopus 로고    scopus 로고
    • Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
    • Fahrner J.A., Eguchi S., Herman J.G., Baylin S.B. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res. 2002, 62:7213-7218.
    • (2002) Cancer Res. , vol.62 , pp. 7213-7218
    • Fahrner, J.A.1    Eguchi, S.2    Herman, J.G.3    Baylin, S.B.4
  • 80
    • 0027139910 scopus 로고
    • Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin
    • Orlando V., Paro R. Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin. Cell 1993, 75:1187-1198.
    • (1993) Cell , vol.75 , pp. 1187-1198
    • Orlando, V.1    Paro, R.2
  • 81
    • 39449088572 scopus 로고    scopus 로고
    • Genome-wide approaches to studying chromatin modifications
    • Schones D.E., Zhao K. Genome-wide approaches to studying chromatin modifications. Nat. Rev. Genet. 2008, 9:179-191.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 179-191
    • Schones, D.E.1    Zhao, K.2
  • 82
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • Seligson D.B., Horvath S., Shi T., Yu H., Tze S., Grunstein M., Kurdistani S.K. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 2005, 435:1262-1266.
    • (2005) Nature , vol.435 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3    Yu, H.4    Tze, S.5    Grunstein, M.6    Kurdistani, S.K.7
  • 83
    • 58149214373 scopus 로고    scopus 로고
    • Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2
    • Ougolkov A.V., Bilim V.N., Billadeau D.D. Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin. Cancer Res. 2008, 14:6790-6796.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6790-6796
    • Ougolkov, A.V.1    Bilim, V.N.2    Billadeau, D.D.3
  • 85
    • 84888200404 scopus 로고    scopus 로고
    • Carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas: loss of microRNA-101 promotes overexpression of histone methyltransferase EZH2, Ann. Surg. Oncol. Epub ahead of print.
    • O. Nakahara, H. Takamori, M. Iwatsuki, Y. Baba, Y. Sakamoto, H. Tanaka, A. Chikamoto, K. Horino, T. Beppu, K. Kanemitsu, Y. Honda, K. Iyama, H. Baba, Carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas: loss of microRNA-101 promotes overexpression of histone methyltransferase EZH2, Ann. Surg. Oncol. Epub ahead of print.
    • Nakahara, O.1    Takamori, H.2    Iwatsuki, M.3    Baba, Y.4    Sakamoto, Y.5    Tanaka, H.6    Chikamoto, A.7    Horino, K.8    Beppu, T.9    Kanemitsu, K.10    Honda, Y.11    Iyama, K.12    Baba, H.13


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.