Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms

Marine Environmental Research

Volumn 93, Issue , 2014, Pages 106-117

  Regoli, Francesco ^a   Giuliani, Maria Elisa ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Antioxidants; Environmental pollutants; Marine organisms; Nrf2; Oxidative stress; ROS; Transcription factors

Indexed keywords

ENVIRONMENTAL IMPLICATIONS; ENVIRONMENTAL POLLUTANTS; MARINE ORGANISMS; NRF2; OXIDATIVE STRESS BIOMARKERS; POST-TRANSCRIPTIONAL MODIFICATION; REACTIVE OXYGEN SPECIES; ROS;

CHEMICAL COMPOUNDS; CHEMICAL MODIFICATION; CHEMICAL STABILITY; ENZYMES; GENE EXPRESSION REGULATION; MARINE BIOLOGY; METABOLISM; MIXTURES; OXIDATIVE STRESS; POLLUTION; TRANSCRIPTION FACTORS;

ANTIOXIDANTS;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALKYLPHENOL; AROMATIC NITRO COMPOUND; HALOGENATED HYDROCARBON; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LUBRICATING AGENT; MESSENGER RNA; PESTICIDE; PETROLEUM; PLASTICIZER; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRACE METAL; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT; ENVIRONMENTAL FACTOR; ENVIRONMENTAL FATE; MARINE ECOSYSTEM; MARINE POLLUTION; OXIDATION; PROTEIN; RNA;

ARTICLE; CATALYSIS; ECOTOXICITY; GENE EXPRESSION; MARINE SPECIES; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN METABOLISM; RNA STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WASTING SYNDROME; WATER POLLUTANT; XENOBIOTIC METABOLISM;

ANTIOXIDANTS; ENVIRONMENTAL POLLUTANTS; MARINE ORGANISMS; NRF2; OXIDATIVE STRESS; ROS; TRANSCRIPTION FACTORS;

ANIMALS; AQUATIC ORGANISMS; BIOLOGICAL MARKERS; GENE EXPRESSION; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; WATER POLLUTANTS, CHEMICAL;

EID: 84892542109     PISSN: 01411136     EISSN: 18790291     Source Type: Journal    
DOI: 10.1016/j.marenvres.2013.07.006     Document Type: Article

References (117)

1. Bacon B.R., Britton R.S. Hepatic injury in chronic iron overload. Role of lipid peroxidation. Chem. Biol. Interact. 1989, 70:183-226.
2. Baird L., Dinkova-Kostova A.T. The cytoprotective role of the Keap1-Nrf2 pathway. Arch. Toxicol. 2011, 85:241-272.
3. Barker C.W., Fagan J.B., Fasco D.S. Down-regulation of P4501A1 and P450 1A2 in isolated hepatocytes by oxidative stress. J.Biol. Chem. 1994, 269:3985-3990.
4. Barnes P.J., Karin M. Nuclear factor-kappa B: a pivotal transcription factor in chronic inflammatory diseases. N.Engl. J. Med. 1997, 336:1066-1071.
5. Barouki R., Morel Y. Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological implications. Biochem. Pharmacol. 2001, 61:511-516.
6. Bartosz G. Reactive oxygen species: destroyers or messengers. Biochem. Pharmacol. 2009, 77:1303-1315.
7. Benedetti M., Martuccio G., Fattorini D., Canapa A., Barucca M., Nigro M., Regoli F. Oxidative and modulatory effects of trace metals on metabolism of polycyclic aromatic hydrocarbons in the Antarctic fish Trematomus bernacchii. Aquat. Toxicol. 2007, 85:167-175.
8. Benedetti M., Fattorini D., Martuccio G., Nigro M., Regoli F. Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Antarctic fish Trematomus bernacchii: oxidative effects on biotransformation pathway. Environ. Toxicol. Chem. 2009, 28:818-825.
9. Bilbao E., Raingeard D., de Cerio O.D., Ortiz-Zarragoitia M., Ruiz P., Izagirre U., Orbea A., Marigomez I., Cajaraville M.P., Cancio I. Effects of exposure to prestige-like heavy fuel oil and to perfluorooctane sulfonate on conventional biomarkers and target gene transcription in the thicklip grey mullet Chelon labrosus. Aquat. Toxicol. 2010, 98:282-296.
10. Burczynski M.E., Penning T.M. Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldoketo reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor. Cancer Res. 2000, 60:908-915.
11. Cajaraville M.P., Cancio I., Ibabe A., Orbea A. Peroxisome proliferation as a biomarker in environmental pollution assessment. Microsc. Res. Technol. 2003, 61:191-202.
12. Canesi L., Borghi C., Ciacci C., Fabbri R., Vergani L., Gallo G. Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas. Mol. Cell. Endocrinol. 2007, 276:36-44.
13. Canesi L., Borghi C., Ciacci C., Fabbri R., Lorusso L.C., Vergani L., Marcomini A., Poiana G. Short-term effects of environmentally relevant concentrations of EDC mixtures on Mytilus galloprovincialis digestive gland. Aquat. Toxicol. 2008, 87:272-279.
14. Cao C., Leng Y., Kufe D. Catalase activity is regulated by c-Abl and Arg in the oxidative stress response. J.Biol. Chem. 2003, 278:29667-29675.
15. Cao C., Leng Y., Liu X., Yi Y., Li P., Kufe D. Catalase is regulated by ubiquiti-nation and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases. Biochemistry 2003, 42:10348-10353.
16. Cao C., Leng Y., Huang W., Liu X., Kufe D. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J.Biol. Chem. 2003, 278:39609-39614.
17. Carpenter D.O., Arcaro K., Spink D.C. Understanding the human health effects of chemical mixtures. Environ. Health Perspect. 2002, 110:25-42.
18. Chan W.K., Yao G., Gu Y.-Z., Bradfield C.A. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways: demonstration of competition and compensation. J.Biol. Chem. 1999, 274:12115-12123.
19. Christie N.T., Costa M. Invitro assessment of the toxicity of metal compounds. IV. Disposition of metals in cells: interactions with membranes, glutathione, metallothionein, and DNA. Biol. Trace Elem. Res. 1984, 6:139-158.
20. Copple I.M., Goldring C.E., Kitteringham N.R., Park B.K. The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity. Toxicology 2008, 246:24-33.
21. Corsini E., Asti L., Viviani B., Marinovich M., Galli C.L. Sodium arsenate induces overproduction of interleukin-1 alpha in murine keratinocytes: role of mitochondria. J.Invest. Dermatol. 1999, 113:760-765.
22. Craig P.M., Wood C.M., McClelland G.B. Oxidative stress response and gene expression with acute copper exposure in zebrafish (Danio rerio). Am. J. Physiol. Reg. 2007, 293:R1882-R1892.
23. Cullinan S.B., Gordan J.D., Jin J., Harper J.W., Diehl J.A. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-Based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol. Cell. Biol. 2004, 24:8477-8486.
24. Della Torre C., Bocci E., Focardi S., Corsi I. Differential expression and efflux activity of ABCB and ABCC transport proteins in gills and hemocytes of Mytilus galloprovincialis and their involvement in cadmium response. Mar. Environ. Res. 2013, (in press).
25. Della Torre C., Corsi I., Arukwe A., Alcaro L., Amato E., Focardi S. Effects of 2,4,6-trinitrotoluene (TNT) on phase I and phase II biotransformation enzymes in European eel Anguilla anguilla (Linnaeus, 1758). Mar. Environ. Res. 2008, 66:9-11.
26. Di Bello D., Vaccaro E., Longo V., Regoli F., Nigro M., Benedetti M., Gervasi P.G., Pretti C. Presence and inducibility by beta-naphthoflavone of CYP1A1, CYP1B1 and phase II enzymes in Trematomus bernacchii, an Antarctic fish. Aquat. Toxicol. 2007, 84:19-26.
27. Di Giulio R.T., Benson W.H., Sanders B.M., Van Veld P.A. Biochemical mechanisms: metabolism, adaptation, and toxicity. Fundamentals of Aquatic Toxicology. Effects, Environmental Fate and Risk Assessment 1995, 523-561. Taylor & Francis, Washington, DC. G.M. Rand (Ed.).
28. Dinkova-Kostova A.T., Holtzclaw W.D., Kensler T.W. The role of Keap1 in cellular protective responses. Chem. Res. Toxicol. 2005, 18:1779-1791.
29. Fang Y., Yang H., Wang T., Liu B., Zhao H., Chen M. Metallothionein and superoxide dismutase responses to sublethal cadmium exposure in the clam Mactra veneriformis. Comp. Biochem. Phys. C 2010, 151:325-333.
30. Forman H.J., Fukuto J.M., Torres M. Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. Am. J. Physiol. Cell Physiol. 2004, 287:C246-C256.
31. Frenzilli G., Bocchetti R., Pagliarecci M., Nigro M., Annarumma F., Scarcelli V., Fattorini D., Regoli F. Time-course evaluation of ROS-mediated toxicity in mussels, Mytilus galloprovincialis, during a field translocation experiment. Mar. Environ. Res. 2004, 58:609-613.
32. Giuliani M.E., Benedetti M., Arukwe A., Regoli F. Transcriptional and catalytic responses of antioxidant and biotransformation pathways in mussels, Mytilus galloprovincialis, exposed to chemical mixtures. Aquat. Toxicol. 2013, 134-135:120-127.
33. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine 2007, Oxford University Press, New York. fourth ed.
34. Hansen B.H., Rømma S., Garmo Ø.A., Olsvik P.A., Andersen R.A. Antioxidative stress proteins and their gene expression in brown trout (Salmo trutta) from three rivers with different heavy metal levels. Comp. Biochem. Physiol. 2006, 143:263-274.
35. Hansen H.B., Rømma S., Garmo Ø.A., Pedersen S.A., Olsvik P.A., Andersen R.A. Induction and activity of oxidative stress-related proteins during waterborne Cd/Zn-exposure in brown trout (Salmo trutta). Chemosphere 2007, 67:2241-2249.
36. Hayes J.D., McLellan L.I. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic. Res. 1999, 31:273-300.
37. Honkakoski P., Negishi M. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem. J. 2000, 347:321-337.
38. Hu R., Xu C., Shen G., Jain M.R., Khor T.O., Gopalkrishnan A., Lin W., Reddy B., Chan J.Y., Kong A.-N.T. Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Lett. 2006, 243:170-192.
39. Huang H.C., Nguyen T., Pickett C.B. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J.Biol. Chem. 2002, 277:42769-42774.
40. Hughes E.M., Gallagher E.P. Effects of b-naphthoflavone on hepatic biotransformation and glutathione biosynthesis in largemouth bass (Micropterus salmoides). Mar. Environ. Res. 2004, 58:675-679.
41. Inoue S., Kawanishi S. ESR evidence for superoxide, hydroxyl radicals and singlet oxygen produced from hydrogen peroxide and nickel(II) complex of glycylglycyl-L-histidine. Biochem. Biophys. Res. Commun. 1989, 159:445-451.
42. Ishii T., Itoh K., Takahashi S., Sato H., Yanagawa T., Katoh Y., Bannai S., Yamamoto M. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J.Biol. Chem. 2000, 275:16023-16029.
43. Itoh K., Wakabayashi N., Katoh Y., Ishii T., O'Connor T., Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 2003, 8:379-391.
44. Jacobs J.M., Nichols C.E., Andrew A.S., Marek D.E., Wood S.G., Sinclair P.R., Wrighton S.A., Kostrubsky V.E., Sinclair J.F. Effect of arsenite on induction of CYP1A1, CYP2B, and CYP3A in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol. 1999, 157:51-59.
45. Jin Y., Zhang X., Shu L., Chen L., Sun L., Qian H., Liu W., Fu Z. Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere 2010, 78:846-852.
46. Kammann U., Lang T., Berkau A.-J., Klempt M. Biological effect monitoring in dab (Limanda limanda) using gene transcript of CYP1A1 or EROD. A comparison. Environ. Sci. Pollut. Res. 2008, 15:600-605.
47. Klerks P.L., Weis J.S. Genetic adaptation to heavy metals in aquatic organisms: a review. Environ. Pollut. 1987, 45:173-205.
48. Kobayashi M., Yamamoto M. Nrf2-Keap1 regulation of cellular defense mechanism against electrophiles and reactive oxygen species. Advan Enzyme Regul. 2006, 46:113-140.
49. Kobayashi M., Itoh K., Suzuki T., Osanai H., Nishikawa K., Katoh Y., Takagi Y., Yamamoto M. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 2002, 7:807-820.
50. Kolluri S.K., Weiss C., Koff A., Göttlicher M. p27(Kip1) induction and inhibition of proliferation by intracellular Ah receptor in developing thymus and hepatoma cells. Gene Dev. 1999, 13:1742-1753.
51. Krivoruchko A., Storey K.B. Activation of antioxidant defenses in response to freezing in freeze-tolerant painted turtle hatchlings. Biochim. Biophys. Acta 2010, 1800:662-668.
52. Kwak M.K., Itoh K., Yamamoto M., Kensler T.W. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell Biol. 2002, 22:2883-2892.
53. Kwak M.K., Wakabayashi N., Itoh K., Motohashi H., Yamamoto M., Kensler T.W. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival. J.Biol. Chem. 2003, 278:8135-8145.
54. Lee O.H., Jain A.K., Papusha V., Jaiswal A.K. An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance. J.Biol. Chem. 2007, 282:36412-36420.
55. Leier I., Jedlitschky G., Buchholz U., Center M., Cole S.P.C., Deeley R.G., Keppler D. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugated export pump. Biochem. J. 1996, 314:433-437.
56. Leonard S.S., Harris G.K., Shi X. Metal-induced oxidative stress and signal transduction. Free Radic. Biol. Med. 2004, 37:1921-1942.
57. Leonard M.O., Kieran N.E., Howell K., Burne M.J., Varadarajan R., Dhakshinamoorthy S., Porter A.G., O'Farrelly C., Rabb H., Taylor C.T. Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J. 2006, 20:2624-2626.
58. Li N.X., Karin M. Is NF-kappa B the sensor of oxidative stress?. FASEB J. 1999, 13:1137-1143.
59. Li M., Pascual G., Glass C.K. Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 2000, 20:4699-4707.
60. Limón-Pacheco J., Gonsebatt M.E. The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutat. Res. Genet. Toxicol. Environ. Mutagen 2009, 674:137-147.
61. Liu P.C.C., Matsumura F. Differential effects of 2,3,7,8-tetrachlorodibenzo-p dioxin on the adipose-type and brain-type glucose transporters in mice. Mol. Pharmacol. 1995, 47:65-73.
62. Livingstone D.R. Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. Mar. Pollut. Bull. 2001, 42:656-666.
63. Ma Q., Whitlock J.P. The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol. Cell. Biol. 1996, 16:2144-2150.
64. Matikainen T., Perez G.I., Jurisicova A., Pru J.K., Schlezinger J.J., Ryu H.-Y., Laine J., Sakai T., Korsmeyer S.J., Casper R.F., Sherr D.H., Tilly J.L. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat. Genet. 2001, 28:355-360.
65. McMahon M., Itoh K., Yamamoto M., Hayes J.D. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J.Biol. Chem. 2003, 278:21592-21600.
66. Meister A. On the biochemistry of glutathione. Glutathione Centennial. Molecular Perspectives and Clinical Implications 1989, 3-21. Academic Press, San Diego. N. Taniguchi (Ed.).
67. Meyer J.N., Smith J.D., Winston G.W., Di Giulio R.T. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquat. Toxicol. 2003, 65:377-395.
68. Morel Y., Barouki R. Down-regulation of cytochrome P4501A1 gene promoter by oxidative stress-critical contribution of nuclear factor 1. J.Biol. Chem. 1998, 273:26969-26976.
69. Morel Y., Barouki R. Repression of gene expression by oxidative stress. Biochem. J. 1999, 342:481-496.
70. Mortensen A.S., Braathen M., Sandvik M., Arukwe A. Effects of hydroxy-polychlorinated biphenyl (OH-PCB) congeners on the xenobiotic bio-transformation gene expression patterns in primary culture of Atlantic salmon (Salmo salar) hepatocytes. Ecotoxicol. Environ. Saf. 2007, 68:351-360.
71. Muraoka S., Miura T. Inhibition by uric acid of free radicals that damage biological molecules. Pharmacol. Toxicol. 2003, 93:284-289.
72. Nahrgang J., Camus L., Gonzalez P., Goksøyr A., Christiansen J.S., Hop H. PAH biomarker responses in polar cod (Boreogadus saida) exposed to benzo[a]pyrene. Aquat. Toxicol. 2009, 94:309-319.
73. Nahrgang J., Camus L., Gonzalez P., Jönsson M., Christiansen J.S., Hop H. Biomarker responses in polar cod (Boreogadus saida) exposed to dietary crude oil. Aquat. Toxicol. 2010, 96:77-83.
74. Nahrgang J., Jönsson M., Camus L. EROD activity in liver and gills of polar cod (Boreogadus saida) exposed to waterborne and dietary crude oil. Mar. Environ. Res. 2010, 70:120-123.
75. Nguyen T., Sherratt P.J., Huang H.C., Yang C.S., Pickett C.B. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J.Biol. Chem. 2003, 278:4536-4541.
76. Nie M., Blankenship A.L., Giesy J.P. Interaction between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways. Environ. Toxicol. Pharmacol. 2001, 10:17-27.
77. Nikinmaa M., Rytkonen K.T. Functional genomics in aquatic toxicology-do not for-get the function. Aquat. Toxicol. 2011, 105S:16-24.
78. Ning J.L., Mo L.W., Lai X.N. Low- and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2. Ch. Med. J. (Engl) 2010, 123:1063-1069.
79. Nordberg J., Arnér S.J. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med. 2001, 31:1287-1312.
80. Olsvik P.A., Lie K.K., Sturve J., Hasselberg L., Andersen O.K. Transcriptional effects of nonylphenol, bisphenol A and PBDE-47 in liver of juvenile Atlantic cod (Gadus morhua). Chemosphere 2009, 75:360-367.
81. Osburn W.O., Kensler T.W. Nrf2 signaling: an adaptive response pathway for protection against environmental insults. Mutat. Res. 2008, 659:31-39.
82. Puga A., Barnes S.J., Dalton T.P., Chang C.-Y., Knudsen E.S., Maier M.A. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J.Biol. Chem. 2000, 275:2943-2950.
83. Regoli F., Principato G. Glutathione, glutathione-dependent and antioxidant enzymes in mussels, Mytilus galloprovincialis, exposed to metals under field and laboratory conditions: implications for the use of chemical biomarkers. Aquat. Toxicol. 1995, 31:143-164.
84. Regoli F., Winston G.W. Application of a new method for measuring the total oxyradical scavenging capacity in marine invertebrates. Mar. Environ. Res. 1998, 46:439-442.
85. Regoli F., Winston G.W. Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals. Toxicol. Appl. Pharmacol. 1999, 156:96-105.
86. Regoli F., Gorbi S., Frenzilli G., Nigro M., Corsi I., Focardi S., Winston G.W. Oxidative stress in ecotoxicology: from the analysis of individual antioxidants to a more integrated approach. Mar. Environ. Res. 2002, 54:419-423.
87. Regoli F., Winston G.W., Gorbi S., Frenzilli G., Nigro M., Corsi I., Focardi S. Integrating enzymatic responses to organic chemical exposure with total oxyradical absorbing capacity and DNA damage in the European eel Anguilla anguilla. Environ. Toxicol. Chem. 2003, 22:2120-2129.
88. Regoli F., Frenzilli G., Bocchetti R., Annarumma F., Scarcelli V., Fattorini D., Nigro M. Time-course variations of oxyradical metabolism, DNA integrity and lysosomal stability in mussels, Mytilus galloprovincialis, during a field translocation experiment. Aquat. Toxicol. 2004, 68:167-178.
89. Regoli F., Nigro M., Benedetti M., Gorbi S., Pretti C., Gervasi P.G., Fattorini D. Interactions between metabolism of trace metals and xenobiotic agonists of the aryl hydrocarbon receptor in the Antarctic fish Trematomus bernacchii: environmental perspectives. Environ. Toxicol. Chem. 2005, 24:1475-1482.
90. Regoli F., Benedetti M., Giuliani M.E. Antioxidant defenses and acquisition of tolerance to chemical stress. Tolerance to Environmental Contaminants 2011, 153-173. CRC Press, Boca Raton, FL. C. Amiard-Triquet, P.S. Rainbow, M. Roméo (Eds.).
91. Regoli F., Giuliani M.E., Benedetti M., Arukwe A. Molecular and biochemical biomarkers in environmental monitoring: a comparison of biotransformation and antioxidant defense systems in multiple tissues. Aquat. Toxicol. 2011, 105(3-4 Suppl.):56-66.
92. 2: regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid. Redox Signal. 2005, 7:619-626.
93. Roberts A.P., Oris J.T., Stubblefield W.A. Gene expression in caged juvenile Coho salmon (Oncorhynchys kisutch) exposed to the waters of Prince William Sound, Alaska. Mar. Poll. Bull. 2006, 52:1527-1532.
94. Roberts R.A., James N.H., Cosulich S., Hasmall S.C., Orphanides G. Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?. Toxicol. Lett. 2001, 120:301-306.
95. Rowlands J.C., Gustafsson J.A. Aryl hydrocarbon receptor-mediated signal transduction. Crit. Rev. Toxicol. 1997, 27:109-134.
96. Schlezinger J.J., Struntz W.D.J., Goldstone J.V., Stegeman J.J. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat. Toxicol. 2006, 77:422-432.
97. Schrader M., Fahimi H.D. Peroxisomes and oxidative stress. Biochim. Biophys. Acta 2006, 1763:1755-1766.
98. Shi X.L., Dalal N.S. On the mechanism of the chromate reduction by glutathione: ESR evidence for the glutathionyl radical and an isolable Cr(V) intermediate. Biochem. Biophys. Res. Commun. 1988, 156:137-142.
99. Shi X., Mao Y., Knapton A.D., Ding M., Rojanasakul Y., Gannett P.M., Dalal N., Liu K. Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: role of a Cr(IV)-mediated Fenton-like reaction. Carcinogenesis 1994, 15:2475-2478.
100. Shi H., Hudson L.G., Liu K.J. Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radic. Biol. Med. 2004, 37:582-593.
101. Stegeman J.J., Lech J.J. Cytochrome P450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure. Environ. Health Perspect. 1991, 90:101-109.
102. Stewart D., Killeen E., Naquin R., Alam S., Alam J. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J.Biol. Chem. 2003, 278:2396-2402.
103. Sun Z., Zhang S., Chan J.Y., Zhang D.D. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol. Cell. Biol. 2007, 27:6334-6349.
104. Suzuki T., Takagi Y., Osanai H., Li L., Takeuchi M., Katoh Y., Kobayashi M., Yamamoto M. Pi class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish. Biochem. J. 2005, 388:65-73.
105. Thimmulappa R.K., Mai K.H., Srisuma S., Kensler T.W., Yamamoto M., Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 2002, 62:5196-5203.
106. Tian Y., Ke S., Denison M.S., Rabson A.B., Gallo M.A. Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. J.Biol. Chem. 1999, 274:510-515.
107. Toledano M.B., Leonard W.J. Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction invitro. P.Natl. Acad. Sci. USA 1991, 88:4328-4332.
108. Tong K.I., Katoh Y., Kusunoki H., Itoh K., Tanaka T., Yamamoto M. Keapl recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol. Cell. Biol. 2006, 26:2887-2900.
109. Tsukamoto H. Redox regulation of cytokine expression in Kupffer cells. Antioxid. Redox Signal. 2002, 4:405-414.
110. Vakharia D.D., Liu N., Pause R., Fasco M., Bessette E., Zhang Q.-Y., Kaminsky L.S. Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Toxicol. Appl. Pharmacol. 2001, 170:93-103.
111. Viarengo A., Burlando B., Ceratto N., Panfoli I. Antioxidant role of metallothioneins: a comparative overview. Cell. Mol. Biol. 2000, 46:407-417.
112. Viarengo A., Lowe D., Bolognesi C., Fabbri E., Koehler A. The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms. Comp. Biochem. Physiol. C 2007, 146:281-300.
113. Wakabayashi N., Dinkova-Kostova A.T., Holtzclaw W.D., Kang M.I., Kobayashi A., Yamamoto M., Kensler T.W., Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. P.Natl. Acad. Sci. USA 2004, 101:2040-2045.
114. Wei P., Zhang J., Egan-Haftey M., Liang S., Moore D.D. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature (London) 2000, 407:920-923.
115. Whitlock J.P., Okino S.T., Dong L., Ko H.P., Clarke-Katzenberg R., Ma Q., Li H. Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription. FASEB J. 1996, 10:809-818.
116. Winterbourn C.C., Hampton M.B. Thiol chemistry and specificity in redox signaling. Free Radic. Biol. Med. 2008, 45:549-561.
117. Xie W., Barwick J.L., Simon C.M., Pierce A.M., Safe S., Blumberg B., Guzelian P.S., Evans R.M. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Gene Dev. 2000, 14:3014-3023.