Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8- tetrachlorodibenzo-p-dioxin in the antarctic fish trematomus bernacchii: oxidative effects on biotransformation pathway

Environmental Toxicology and Chemistry

Volumn 28, Issue 4, 2009, Pages 818-825

  Benedetti, Maura ^a   Fattorini, Daniele ^a   Martuccio, Giacomo ^a   Nigro, Marco ^b   Regoli, Francesco ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Chemical mixtures; Cytochrome P450; Interactions; Oxidative stress; Trematomus bernacchii

Indexed keywords

BIOLOGICAL EFFECTS; CELLULAR LEVELS; CHEMICAL MIXTURES; CYTOCHROME P450; GLUTATHIONE CONTENTS; HEME GROUPS; HYDROXYL RADICALS; IN FIELDS; INHIBITORY EFFECTS; INTERACTIONS; LIMITING AVAILABILITIES; OXIDATIVE STATUS; PEROXYL RADICALS; PROTEIN EXPRESSION LEVELS; SCAVENGING CAPACITIES; TETRACHLORODIBENZO P DIOXINS; TRACE METALS; TREMATOMUS BERNACCHII;

FREE RADICAL REACTIONS; HYDROGEN; HYDROGEN PEROXIDE; LEAD; LEAD ALLOYS; MERCURY (METAL); MIXTURES; NICKEL; PORPHYRINS; TRACE ANALYSIS; WET ETCHING;

TRACE ELEMENTS;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CATALASE; COPPER ION; CYTOCHROME P450 1A1; ETHOXYRESORUFIN DEETHYLASE; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LEAD; MERCURY; NICKEL; PEROXY RADICAL;

ANTIOXIDANT; BIOMARKER; BIOTRANSFORMATION; CATALYSIS; CONCENTRATION (COMPOSITION); COPPER; GADOID; HYDROGEN PEROXIDE; HYDROXYL RADICAL; INHIBITION; LEAD; MERCURY (ELEMENT); NICKEL; OXIDATION; PEROXY RADICAL; POLLUTION EFFECT; POLLUTION EXPOSURE; SYNERGISM; TCDD; TRACE METAL;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOTRANSFORMATION; CHEMICAL INTERACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVE SITE; FISH; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTARCTIC REGIONS; BIOTRANSFORMATION; CATALASE; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LIVER; METALS; OXIDATION-REDUCTION; PERCIFORMES; PEROXIDES; TETRACHLORODIBENZODIOXIN;

LOTELLA RHACINA; SEBASTES SCHLEGELI; TREMATOMUS BERNACCHII;

EID: 64849103104     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/08-066.1     Document Type: Article

References (40)

1. Stegeman JJ, Lech JJ. 1991. Cytochrome P450 monooxygenase systems in aquatic species: Carcinogen metabolism and bio-markers for carcinogen and pollutant exposure. Environ Health Perspect 90:101-109.
2. Livingstone DR. 1996. Cytochrome P450 in pollution monitoring: Use of cytochrome P4501A (CYP1 A) as a biomarker of organic pollution in aquatic and other organisms. In Richardson M, ed, Environmental Xenobiotics, Taylor & Francis, London, UK, pp 143-160.
3. Goksøyr A, Förlin L. 1992. The cytochrome P450 system in fish, aquatic toxicology and environmental monitoring. Aquat Toxicol 22:287-311.
4. Livingstone DR. 2001. Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. Mar Pollut Bull 42:656-666.
5. Schlezinger JJ, Stegeman JJ. 2001. Induction and suppression of cytochrome P4501A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Steno-tomus chrysops). Aquat Toxicol 52:101-115.
6. Schlezinger JJ, Struntz WDJ, Goldstone JV, Stegeman JJ. 2006. Uncoupling of cytochrome P4501A and stimulation of reactive oxygen species production by coplanar polychlorinated biphenyl congeners. Aquat Toxicol 11:422-432.
7. Koehler A. 2004. The gender-specific risk to liver toxicity and cancer of flounder (Platichthys flesus (L.)) at the German Wadden Sea coast. Aquat Toxicol 70:257-276.
8. Gorbi S, Baldini C, Regoli F. 2005. Seasonal variability of me-tallothioneins, cytochrome P450, Bile metabolites and oxyradical metabolism in the European eel Anguilla anguilla L. (Anguilli-dae) and striped mullet Mugil cephalus L. (Mugilidae). Arch Environ Contam Toxicol 49:62-70.
9. Regoli F, Nigro M, Benedetti M, Gorbi S, Pretti C, Gervasi PG, Fattorini D. 2005. Interactions between metabolism of trace metals and xenobiotics agonists of the Ah receptor in the Antarctic fish Trematomus bernacchii: Environmental perspectives. Environ Toxicol Chem 24:1475-1482.
10. 2+. Free Radical Biol Med 39.1499-1511.
11. Sorrentino C, Roy NK, Courtenay SC, Wirgin I. 2005. Coex-posure to metals modulates CYP 1A mRNA inducibility in Atlantic tomcod Microgadus tomcod from two populations. Aquat Toxicol 75:238-252.
12. Gravato C, Teles M, Oliveira M, Santos MA. 2006. Oxidative stress, liver biotransformation and genotoxic effects induced by copper in Anguilla anguilla L. The influence of pre-exposure to β-naphthoflavone. Chemosphere 65:1821-1830.
13. Benedetti M, Martuccio G, Fattorini D, Canapa A. Barucca M, Nigro M, Regoli F. 2007. Oxidative and modulatory effects of trace metals on metabolism of polycyclic aromatic hydrocarbons in the Antarctic fish Trematomus bernacchii. Aquat Toxicol 85: 167-175.
14. Barouki R, Morel Y. 2001. Repression of cytochrome P450 1A1 gene expression by oxidative stress: Mechanisms and biological implications. Biochem Pharmacol 61:511-516.
15. Tully DB, Collins BJ, Overstreet JD, Smith CS, Gregg ED, Mum-taz MM, Chapin RE. 2000. Effects of arsenic, cadmium, chromium and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 Cells. Toxicol Appl Pharm 168:79-90.
16. Sandvik M, Beyer J, Goksøyr A, Hylland K, Egaas E, Skaare JU. 1997. Interactions of benzo[a ]pyrene, 2,3,3',4,4',5-hexachloro-biphenyl (PCB-156) and cadmium on biomarker responses in flounder (Platichthys flesus L.). Biomarkers 2:153-160.
17. Viarengo A. Bettela E, Fabbri R, Burlando B, Lafaurie M. 1997. Heavy metal inhibition of EROD activity in liver microsomes from the bass Dicentrarchus labrax exposed to organic xenobiotics: Role of GSH in the reduction of heavy metal effects. Mar Environ Res 44:1-11.
18. Regoli F, Winston GW, Gorbi S, Frenzilli G, Nigro M, Corsi I, Focardi S. 2003. Integrating enzymatic responses to organic chemical exposure with total oxyradical absorbing capacity and DNA damage in the European eel Anguilla anguilla. Environ Toxicol Chem 22:2120-2129.
19. Bargagli R. 2005. Antarctic Ecosystems. Environmental Contamination, Climate Change, and Human Impact, Springer-Verlag, Berlin, Germany.
20. Corsolini S, Romeo T, Ademollo N, Greco S, Focardi S. 2002. POPs in key species of marine Antarctic ecosystem. Microchem 7 73:187-193.
21. Regoli F, Winston GW. 1999. Quantification of total oxidant scavenging capacity (TOSC) of antioxidants for peroxynitrite, peroxyl radicals and hydroxyl radicals. Toxicol Appl Pharmacol 156:96-105.
22. Regoli F, Principato G, Bertoli E, Nigro M, Orlando E. 1997. Biochemical characterization of the antioxidant system in the scallop Adamussium colbecki, as a sentinel organism for monitoring the Antarctic environment. Polar Biol 17:251-258.
23. Regoli F, Nigro M, Bompadre S, Winston GW. 2000. Total oxidant scavenging capacity (TOSC) of microsomal and cytosolic fractions from Antarctic, Arctic and Mediterranean scallops: Differentiation between three potent oxidants. Aquat Toxicol 49:13-25.
24. Regoli F, Nigro M, Chiantore M, Winston GW. 2002. Seasonal variations of susceptibility to oxidative stress in Adamussium colbecki, a key bìoindicator species for the Antarctic marine environment. Sci Total Environ 289:205-211.
25. Regoli F, Nigro M, Benedetti M, Fattorini D, Gorbi S. 2005. Antioxidant efficiency in early life stages of the Antarctic sil-verfìsh, Pleuragramma antarcticum: Responsiveness to pro-ox-idant conditions of platelet ice and chemical exposure. Aquat Toxicol 75:43-52.
26. Camus L, Birkely SR, Jones MB, Børseth JF, Grøsvik BE, Gul-liksen B, Lonne OJ, Regoli F, Depledge MH. 2003. Biomarker responses and PAH uptake in Mya truncata following exposure to oil-contaminated sediment in an Arctic Fjord (Svalbard). Sci Total Environ 308:221-234.
27. Camus L, Gulliksen B, Depledge MH, Jones MB. 2005. Polar bivalves are characterized by high antioxidant defences. Polar Res 24:111-118.
28. Canapa A, Barucca M, Gorbi S, Benedetti M, Zucchi S, Biscotti MA, Olmo E, Nigro M, Regoli F. 2007. Vitellogenin gene expression in males of the Antarctic fish Trematomus bernacchii from Terra Nova Bay (Ross Sea): A role for environmental cadmium? Chemosphere 66:1270-1277.
29. Jimenez B, Fossi MC, Nigro M, Focardi S. 1999. Biomarker approach to evaluating the impact of scientific stations on the Antarctic environment using Trematomus bernacchii as a bìoindicator organism. Chemosphere 39:2073-2078.
30. Miller HC, Mills GN, Bembo DG, Macdonald JA, Evans CW. 1999. Induction of cytochrome P4501A (CYP1 A) in Trematomus bernacchii as an indicator of environmental pollution in Antarctica: Assessment by quantitative RT-PCR. Aquat Toxicol 44:183-193.
31. Di Bello D, Vaccaro E, Longo V, Regoli F, Nigro M, Benedetti M, Gervasi PG, Pretti C. 2007. Presence and inducibility by ß-naphthoflavone of CYP1A1, CYP1B1 and phase II enzymes in Trematomus bernacchii, an Antarctic fish. Aquat Toxicol 84:19-26.
32. Chao SH, Suzuki Y, Zysk JR, Cheung WY. 1984. Activation of calmodulin by various metal cation as a function of ionic radium. Mol Pharmacol 26:75-82.
33. Korashy HM, El-Kadi AOS. 2004. Differential effects of mercury, lead, and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa lclc7 cells. Toxicology 201:153-172.
34. Barker CW, Fargan JB, Pasco DS. 1994. Down-regulation of P450 1A1 and P450 1A2 in isolated hepatocytes by oxidative stress. J Biol Chem 269:3985-3990.
35. Morel Y, Barouki R. 1998. Down-regulation of cytochrome P4501A1 gene promoter by oxidative stress-critical contribution of nuclear factor 1. J Biol Chem 273:26969-26976.
36. Bargagli R, Nelli L, Ancora S, Focardi S. 1996. Elevated cadmium accumulation in marine organisms from Terra Nova Bay (Antarctica). Polar Biol 16:513-520.
37. Kim JS, Ahn T, Yim SK, Yun CH. 2002. Differential effect of copper (II) on the cytochrome P450 enzymes and NADPH-cy-tochrome P450 reductase: Inhibition of cytochrome P450-cata-lyzed reactions by copper(Π) ion. Biochemistry 41:9438-9447.
38. Oliveira M, Santos MA, Pacheco M. 2004. Glutathione protects heavy metal-induced inhibition of hepatic microsomal ethoxy-resorufin O-deethylase activity in Dicentrarchus labrax L. Eco-toxicol Environ Saf 58:379-385.
39. Christie NT, Costa M. 1984. In vitro assessment of the toxicity of metal compounds. IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA. Biol Trace Elem Res 6:139-158.
40. Lim HW, Hong S, Jin W, Lim S, Kim SJ, Kang HJ, Park EH, Ahn K, Lim CJ. 2005. Up-regulation of defences enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells. Exp Mol Med 37:497-506.