Ethnopharmacology of medicinal plants: Asia and the pacific

Ethnopharmacology of Medicinal Plants: Asia and the Pacific

Volumn , Issue , 2007, Pages 1-228

  Wiart, Christophe ^a  

^a NONE

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[No Author keywords available]

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EID: 84892360530     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-59745-160-4     Document Type: Book

References (330)

1. Bernard P, Scior T, Didier B, Hibert M, Berthon JY. Ethnopharmacology and bioinformatic combination for leads discovery: Application to phospholipase A(2) inhibitors. Phytochemistry 2001;58:865-874.
2. Vishwanath BS, Fawzy AA, Franson R, et al. Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid. Inflammation 1988;12:549-561.
3. Wu TS, Leu YL, Chan YY. Aristofolin-A, a denitro-Aristolochic acid glycoside and other constituents from aristolochia kaempferi. Phytochemistry 1998;49:2509-2510.
4. Wu TS, Leu YL, Chan YY. Constituents from the stem and root of Aristolochia kaempferi. Biol Pharm Bull 2000;23:1216-1219.
5. Pezzuto JM, Swanson SM, Mar W, Che CT, Cordell GA, Fong HH Evaluation of the mutagenic and cytostatic potential of aristolochic acid (3, 4-methylenedioxy-8- methoxy-10-nitrophenanthrene-1-carboxylic acid) and several of its derivatives. Mutat Res 1988;206:447-454.
6. Levi M, Guchelaar HJ, Woerdenbag HJ, Zhu YP. Acute hepatitis in a patient using a Chinese herbal tea-A case report. Pharm World Sci 1998;20:43-44.
7. Hong CH, Sun KH, Jin O, Sun SK, Kyung AN, Sang KL. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002;83:153-159.
8. Mikaye A, Yamamoto H, Takebayashi Y, Imai H, Honda K. The novel natural product YM-26567-1: A competitive inhibitor of group II phospholipase A2. J Pharmacol Exp Ther 1992;263:1302-1307.
9. Chang HW, Baek SH, Chung KW, Son KH, Kim HP, Kang SS. Inactivation of phospholipase A2 by naturally occurring biflavonoid, ochnaflavone. Biochem Biophys Res Commun 1994;205:843-849.
10. Akihisa T, Ken Y, Hirotoshi O, Yoshimasa K. Triterpene alcohols from the flowers of Compositae and their anti-inflammatory effects. Phytochemistry 1996;43:1255-1260.
11. Januário AH, Simone LS, Silvana M, et al. Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): Anti-proteolytic and anti-hemorrhagic properties. Chem Biol Interact 2002;150:243-251.
12. Sala AM, Carmen R, Giner M, Máñez SR. Anti-phospholipase A2 and anti-inflammatory activity of Santolina chamaecyparissus. Life Sci 2000;66:35-40.
13. Sasaki S, Aoyagi S, Hsu HY. The isolation of taraxerol, taraxeryl acetate, and taraxerone from Crossostephium chinense Makino (Compositae). Chem Pharm Bull (Tokyo) 1965;J13:87-88.
14. Li RW, David Lin G, Myers SP, Leach DN. Anti-inflammatory activity of Chinese medicinal vine plants. J Ethnopharmacol 2003;85:61-67.
15. Inagaki I, Sakushima A, Sueo N, Sansei H. Flavones and flavone glucosides from the leaves of Trachelospermum asiaticum. Phytochemistry 1973;12:1498.
16. Nakatani K, Norimichi N, Tsutomu A, Hideyuki Y, Yasushi O. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by -mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem Pharmacol 2002;63:73-79.
17. Cavin C, Delannoy M, Malnoe A, et al. Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract. Biochem Biophys Res Commun 2005;327:742-749.
18. Hu L, Zhongliang CH. Sesquiterpenoid alcohols from Chrysanthemum morifolium. Phytochemistry 1997;44:1287-1290.
19. Sumner H, Umit S, Knight DW, Hoult JRS. Chrysanthemum parthenium (L.); Bernh. Inhibition of 5-lipoxygenase and cyclooxygenase in leukocytes by feverfew: Involvement of sesquiterpene lactones and other components. Biochem Pharmacol 1992;43:2313-2320.
20. Chacur M, Gutierrez JM, Milligan ED, et al. Snake venom components enhance pain upon subcutaneous injection: An initial examination of spinal cord mediators. Pain 2004:111:65-76.
21. Jäger AK, Hutchings A, van Staden J. Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors. J Ethnopharmacol 1996;52:95-100.
22. Kimura Y, Hiromichi O, Shigeru A. Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim Biophysica Acta 1985;834:275-278.
23. Pang L, de las Heras B, Hoult JR. A novel diterpenoid labdane from Sideritis javalambrensis inhibits eicosanoid generation from stimulated macrophages but enhances arachidonate release. Biochem Pharmacol 1996;51:863-868.
24. Singh S, Majumdar DK, Rehan HMS. Evaluation of anti-inflammatory potential of fixed oil of Ocimum sanctum (Holy basil) and its possible mechanism of action. J Ethnopharmacol 1996;54:19-26.
25. Pongprayoon U, Baeckstrom P, Jacobsson U, Lindstrom M, Bohlin L. Compounds inhibiting prostaglandin synthesis isolated from Ipomoea pescaprae. Planta Med 1991;57:515-518.
26. Dewhirst FE. Structure/activity relationship for inhibition of prostaglandin cyclooxygenase by phenolic compounds. Prostaglandins 1980;20:209-222.
27. Kuhn H, Wiesner R, Alder L, Schewe T. Occurrence of free and esterified lipoxygenase products in leaves of Glechoma hederacea L. and other Labiatae. Eur J Biochem 1989; 186:155-162.
28. Henry DY, Gueritte-Voegelein F, Insel PA, Ferry N, Bouguet J, Potier P, Hanoune J. Isolation and characterization of 9-hydroxy-10-trans, 12-cis-octadecadienoic acid, a novel regulator of platelet adenylate cyclase from Glechoma hederacea L. Labiatae. Eur J Biochem 1987;170:389-394.
29. Yashodharan K, Cox PJ, Jaspars M, Lutfun N, Satyajit DS. Isolation, structure elucidation and biological activity of hederacine A and B, two unique alkaloids from Glechoma hederaceae. Tetrahedron 2003;59:6403-6407.
30. Yang LK, Khoo-Beattie C, Goh KL, et al. Ardisiaquinones from Ardisia teysmanniana. Phytochemistry 2001;58:1235-1238.
31. Fukuishi N, Takada T, Fukuyama Y, Akagi M. Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. Phytomedicine 2001;8:460-464.
32. Dana A, Ilse Z, Dingermann T, Müller WE, Steinhilber D, Werz O. Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol 2002;64: 1767-1775.
33. An TY, Ming DS, Hu LH, Liu SJ, Chen ZL. Polyprenylated phloroglucinol derivatives from Hypericum erectum. Phytochemistry 2002;59:395-398.
34. Tornhamre S, Schmidt TJ, Näsman-Glaser B, Ericsson I, Ake L. Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C4 synthase in human blood cells. Biochem Pharmacol 2001;62:903-911.
35. Stavri M, Ford CH, Bucar F, et al. Bioactive constituents of Artemisia monosperma. Phytochemistry 2005;66:233-239.
36. Prieto JM, Giner RM, Recio MC, Manez S, Rios JL. Dual inhibition of cyclooxygenase- 1 and 5-lipoxygenase by aerial part of Bupleurum fruticescens methanol extract. Fitoterapia 2004;75:179-186.
37. Konarev AV, Anisimova IN, Gavrilova VA, et al. Serine proteinase inhibitors in the Compositae: Distribution, polymorphism and properties. Phytochemistry 2002;59: 279-291.
38. Barua RN, Ram PS, Gopalakrishna T, Werner H, Serengolam VG. New melampolides and darutigenol from Sigesbeckia orientalis. Phytochemistry 1980;19:323-325.
39. Zdero CF, Bohlmann RMK, Robinson H. Sesquiterpene lactones and other constituents from Siegesbeckia orientalis and Guizotia scabra. Phytochemistry 1991;30: 1579-1584.
40. Kang BK, Lee EH, Kim HM. Inhibitory effects of Korean folk medicine "Hi-Chum" on histamine release from mast cells in vivo and in vitro. J Ethnopharmacol 1997;57:73-79.
41. Kim HM, Lee JH, Won JH, Park et al. Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens. Phytother Res 2001;15:572-576.
42. He SH, Xie H, Zhang XJ, Wang XJ. Inhibition of histamine release from human mast cells by natural chymase inhibitors. Acta Pharmacol Sin. 2004;25:822-826.
43. Dong XY, Chen M, Jin W, Huang DX, Shen SM, Li HT. Studies on antifertility constituents of Siegesbeckia glabrescens Mak. Yao Xue Xue Bao 1989;24:833-836.
44. Ahmed M, Rahman MT. Alimuzzaman M, Shilpi JA. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia 2001;72:919-921.
45. Herz W, Subramaniam PS, Santhanam PS, Aota K, Hall AL. Structure elucidation of sesquiterpene dilactones from Mikania scandens (L.) Willd. J Org Chem 1970;35: 1453-1464.
46. Gutiérrez AB, Oberti JC, Sosa VE, Herz W. Melampolides from Mikania cordifolia. Phytochemistry 1987;26:2315-2320.
47. Krenn L, Beyer G, Pertz HH, et al. In vitro antispasmodic and anti-inflammatory effects of Drosera rotundifolia. Arzneimittelforschung 2004;54:402-405.
48. Melzig MF, Pertz HH, Krenn L. Anti-inflammatory and spasmolytic activity of extracts from Droserae herba. Phytomedicine 2001;8:225-229.
49. Lastra AL, Ramírez TO, Salazar L, Martínez M, Trujillo-Ferrara J. The ambrosanolide cumanin inhibits macrophage nitric oxide synthesis: Some structural considerations. J Ethnopharmacol 2004;95:221-227.
50. Aldieri E, Atragene D, Bergandi L, et al. Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-B activation. FEBS Lett 2003;552(2-3):141-144.
51. Ryu SY, Oak MH, Yoon SK, et al. Anti-Allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris Planta Med 2000;66:358-360.
52. Hernandez V, del Carmen Recio M, Manez S, Prieto JM, Giner RM, Rios JL. A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa. Planta Med 2001:67;726-731 .
53. Je KH, Han AR, Lee HT, Mar W, Seo EK. The inhibitory principle of lipopolysaccharide- induced nitric oxide production from Inula britannica var. chinensis. Arch Pharm Res 2005;27:83-85.
54. Han M, Wen JK, Zheng B, Zhang DQ. Acetylbritannilatone suppresses NO and PGE2 synthesis in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 gene expression. Life Sci 2004;75:675-684.
55. Lee HT, Yang SW, Kim KH, Seo EK, Mar W. Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase. Arch Pharm Res 2002;25:151-153.
56. Kim EJ, Hye KJ, Yong KK, et al. Suppression by a sesquiterpene lactone from Carpesium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-B activation. Biochem Pharmacol 2001;61:903-910.
57. Kim DK, Baek NI, Choi SU, Lee CO, Lee KR, Zee OP. Four new cytotoxic germacranolides from Carpesium divaricatum. J Nat Prod. 1997;60:1199-1202.
58. Matsuda H, Tadashi K, Iwao T, Hiroki U, Toshio M, Masayuki Y. Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-Activated macrophages: Structure requirement and role of heat shock protein induction. Life Sci 2000;66:2151-2157.
59. Joshi BS, Kamat VN, Govindachari TR. Sesquiterpenes of Neolitsea zeylanica merr. I: Isolation of some constituents. Tetrahedron 1967;23:261-265.
60. Joshi BS, Kamat VN, Govindachari TR. Sesquiterpenes of Neolitsea zeylanica merr. II: Structure of neolinderane. Tetrahedron 1967;23:267-271 .
61. Joshi BS, Kamat VN, Govindachari TR. Sesquiterpenes of Neolitsea zeylanica Merr. III: Structure of zeylanine, zeylanicine and zeylanidine. Tetrahedron 1967;23:273-277.
62. Chen KS, Hsieh PW, Hwang TL, Chang FR, Wu YC. Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma. Nat Prod Res 2005;19:283-286.
63. Choi EM, Hwang JK. Effects of methanolic extract and fractions from Litsea cubeba bark on the production of inflammatory mediators in RAW264.7 cells. Fitoterapia 2004;75:141-148.
64. Chen WY, Ko FN, Wu YC, Lu ST, Teng CM. Vasorelaxing effect in rat thoracic aorta caused by laurotetanine isolated from Litsea cubeba Persoon. J Pharm Pharmacol 1994;46:380-382.
65. Soares MB, Bellintani MC, Ribeiro IM, Tomassini TC, Ribeiro dos Santos R. Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. Eur J Pharmacol 2003;459:107-112.
66. Ficarra R, Ficarra P, Tommasini S, et al. Leaf extracts of some Cordia species: Analgesic and anti-inflammatory activities as well as their chromatographic analysis. Farmaco 1995;50:245-256.
67. Selvanayagam ZE, Gnanavendhan SG, Balakrishna K, et al. Ehretianone, a novel quinonoid xanthene from Ehretia buxifolia with anti-snake venom activity. J Nat Prod 1996;59:664-667.
68. Gokhale AB, Damre AS, Saraf MN. Investigations into the immunomodulatory activity of Argyreia speciosa. J Ethnopharmacol 2003;84:109-114.
69. Dharmasiri MG, Jayakody JR, Galhena G, Liyanage SS, Ratnasooriya W. Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo. J Ethnopharmacol 2003;87:199-206.
70. Alam MI, Gomes A. Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts. J Ethnopharmacol 2003;86: 75-80.
71. Ozaki Y, Sekita S, Soedigdo S, Harada M. Antiinflammatory effect of Graptophyllum pictum (L.) Griff. Chem Pharm Bull (Tokyo) 1989;37:2799-2802.
72. Laupattarakasem P, Houghton PJ, Hoult JR, Itharat. An evaluation of the activity related to inflammation of four plants used in Thailand to treat arthritis. J Ethnopharmacol 2003;85:207-215.
73. De S, Ravishankar B, Bhavsar GC. Investigation of the anti-inflammatory effects of Paederia foetida. J Ethnopharmacol 1994;43:31-38.
74. Olajide OA, Okpako DT, Makinde JM. Anti-inflammatory properties of Bridelia ferruginea stem bark. Inhibition of lipopolysaccaride-induced septic shock and vascular permeability. J Ethnopharmacol 1999;88:221-224.
75. Geetha T, Varalakshmi P. Anticomplement activity of triterpenes from Crataeva nurvala stem bark in adjuvant arthritis in rats. Gen Pharmacol 1999;32:495-497.
76. Matsuda H, Dai Y, Ido Y, et al. Studies on Kochiae fructus. V. Antipruritic effects of oleanolic acid glycosides and the structure-requirement. Biol Pharm Bull 1998;21:1231-1233.
77. Zschocke S, van Staden J. Cryptocarya-species substitute plants for Ocotea bullata? A pharmacological investigation in terms of cyclooxygenase-1 and -2 inhibition. J Ethnopharmacol 2000;71:473-478.
78. Galien C. De alimentorum facultatibus, Lib. I, cap. 34, De simplicium medicamentorum temperamentis ac facultatibus, Lib VII, cap. 10 edit. Kuhn, Lipsiae, 1826.
79. O'Shaughnessy, W. B. On the preparations of the Indian Hemp, or Gunjah (cannabis indica); their effects on the animal system in health, and their utility in the treatment of tetanus and other convulsive diseases. Provincial Medical Journal and Retrospect on the Medical Sciences, London, 1843;5:343-398.
80. Hasrat JA, De Bruyne T, De Backer JP, Vauquelin G, Vlietinck AJ. Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products. J Pharm Pharmacol 1997;49:1145-1149.
81. Ko FN, Yu SM, Su MJ, Wu YC, Teng CM. Pharmacological activity of (-)-discretamine, a novel vascular alpha-Adrenoceptor and 5-hydroxytryptamine receptor antagonist, isolated from Fissistigma glaucescens. Br J Pharmacol. 1993;110:882-888.
82. Khamis S, Bibby MC, Brown JE, Cooper PA, Scowen I, Wright CW. Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a Malaysian plant used traditionally for the treatment of breast cancer. Phytother Res 2004;18:507-510.
83. Lin CH, Chang GJ, Su MJ, Wu YC, Teng CM, Ko FN. Pharmacological characteristics of liriodenine, isolated from Fissistigma glaucescens, a novel muscarinic receptor antagonist in guinea-pigs. Br J Pharmacol 1994;113:275-281.
84. Schultes R.E. Botan. Museum Leaflets, Harvard Univ 1954;16:241.
85. Pinto MMM, Kijjoa A, Tantisewie B, Yoshida M, Gottlieb OR, Arylalkanones from Horsfieldia glabra. Phytochemistry 1988;27:3988-3989.
86. Jossang AP, Jossang HA, Hadi H, Bodo B. Horsfiline, an oxindole alkaloid from Horsfieldia superba. J. Org. Chem 1991;56:6527.
87. Jenett-Siems K, Weigl R, Kaloga M, Schulz J, Eich E. Ipobscurines C and D: macrolactam- type indole alkaloids from the seeds of Ipomoea obscura. Phytochemistry 2003;62:1257-1263.
88. Tyler, V.E. The physiological properties and chemical constituents of some habitforming plants. Lloydia 1966;29:275.
89. French ED, Dillon K, Ali SF. Effects of Ibogaine, and cocaine and morphine after Ibogaine, on ventral tegmental dopamine neurons. Life Sci 1996;59: 199-205.
90. Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer JJ. Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir. J Ethnopharmacol 1998;62:229-234.
91. Abe F, Tatsuo Y, Guevara, BQ. Indole alkaloids from Tabernaemontana pandacaqui in the Philippines. Biochem Syst Ecol 1993;21:847-848.
92. Okuyama E, Gao LH, Yamazaki M. Analgesic components from Bornean medicinal plants, Tabernaemontana pauciflora Blume and Tabernaemontana pandacaqui Poir. Chem Pharm Bull (Tokyo) 1992;40:3358.
93. Van Beek TA, Verpoorte R, Baerheim Svendsen A, Leeuwenberg AJM, Bisset NG. Tabernaemontana L. (Apocynaceae): A review of its taxonomy, phytochemistry, ethnobotany and pharmacology. J Ethnopharmacol 1984;10:156.
94. Toh-Seok K, Kooi-Mow S. Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa. Phytochemistry 1992;63:625-629.
95. Gauthaman K, Adaikan PG, Prasad RNV. Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002;71:1385-1396.
96. Tian-Shung W, Li-Shian S, Shang-Chu K. Alkaloids and other constituents from Tribulus terrestris. Phytochemistry 1999;50:1411-1415.
97. Bremner J, Waya S, Southwell I, et al. A revised structure for the alkaloid, tribulusterine, from Tribulus terrestris L. Aust J Chem 2004;57:273-276.
98. Rosner MH. Severe hyponatremia associated with the combined use of thiazide diuretics and selective serotonin reuptake inhibitors. Am J Med Sci 2004;327: 109-111.
99. In-Won C, Moore NA, Won-Keun O, et al. Behavioral pharmacology of polygalasaponins indicates potential antipsychotic efficacy. Pharmacol Biochem Behav 2002;71:191-195.
100. Jin B, Park J. Studies on the alkaloidal components of Polygala tenuifolia willd. Zhongguo Zhong Yao Za Zhi 1993;18:675-677.
101. Zhang D, Miyase T, Kuroyanagi M, Umehara K, Ueno A. Studies on the constituents of Polygala japonica Houtt. I. Structures of polygalasaponins I-X. Chem Pharm Bull (Tokyo) 1995;43:115-120.
102. Zhang D, Miyase T, Kuroyanagi M, Umehara K, Ueno A. Five new triterpene saponins, polygalasaponins XXVIII-XXXII from the root of Polygala japonica Houtt. Chem Pharm Bull (Tokyo) 1996;44:810-815.
103. Zhang D, Miyase T, Masanori K, Umehara K, Noguchi H. Polygalasaponins XLII-XLVI from roots of Polygala glomerata. Phytochemistry 1998;47:459-466.
104. Zhang D, Miyase T, Kuroyanagi M, Umehara K, Noguchi H. Oligosaccharide polyesters from roots of Polygala glomerata. Phytochemistry 1998;47:45-52.
105. Both FL, Meneghini L, Kerber VA, Henriques AT, Elisabetsky E. Psychopharmacological profile of the alkaloid psychollatine as a 5HT2A/C serotonin modulator. J Nat Prod 2005;68:374-80.
106. Beng W, Hesse A, Herramann M, Kraft R. Structure elucidation of a new anthraquinone derivatives from Rubia tinctorium. Pharmazie 1975;30:330-334.
107. Kasture VS, Deshmukh VK, Chopde CT. Anticonvulsant and behavioral actions of triterpene isolated from Rubia cordifolia Linn. Indian J Exp Biol 2000;38:675-680.
108. Hou WC, Lin RD, Chen CT, Lee MH. Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. J Ethnopharmacol 2005;100:216-220.
109. Masumiya H, Saitoh T, Tanaka Y, et al. Effects of hirsutine and dihydrocorynantheine on the action potentials of sino-Atrial node, atrium and ventricle. Life Sci 1999;65: 2333-2341.
110. Jürgensen S, Dalbó S, Angers P, Santos AR, Ribeiro-do-Valle RM. Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa. Pharmacol Biochem Behav 2005;81:466-477.
111. Klohs MW, Keller F, Williams RE, Toekes MI, Cronheim GE. A chemical and pharmacological investigation of Piper methysticum Forst. J Med Pharm Chem 1959;1:95-103.
112. Jussofie A, Schmiz A, Hiemke C. Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain. Psychopharmacology (Berl) 1994;116:469-474.
113. Cavadas C, Araujo I, Cotrim MD, et al. In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. Arzneimittelforschung 1995;45:753-755.
114. Yuan CS, Mehendale S, Xiao Y, Aung HH, Xie JT, Ang-Lee MK. The gammaaminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg 2004;98:353-358.
115. Wasowski C, Marder M, Viola H, Medina JH, Paladini AC. Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABAA receptors, from Valeriana wallichii. Planta Med 2002;68:934-936.
116. Ping L, Kimihiro M, Tohru Y, Yasushi O. Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells. Dev Brain Res 2003;145:177-183.
117. Prabhu V, Karanth KS, Rao A. Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain. Planta Med 1994;60:114.
118. Sofiyan S, Muzamil A, Khan Shoeb Z, Abdullah S and Fakhrul I. Protective effect of Nardostachys jatamansi in rat cerebral ischemia. Pharmacol Biochem Behav 2003;74:481-486.
119. Shakir A, Khursheed A, Ansari MA, Kabeer JH, Diwakar G. Nardostachys jatamansi protects against liver damage induced by thioacetamide in rats J Ethnopharmacol 2000;71:359-363.
120. Luo HC, Cui YH, Shen YC, Lou ZQ. Clinical observation and pharmacological investigation of the sedative and hypnotic effects of the Chinese drug rhizome and root of Patrinia scabiosaefolia Fisch. J Tradit Chin Med 1986;6:89-94.
121. Won SW, Choi JS, Seligmann O, Wagner H. Sterol and triterpenoid glycosides from the roots of Patrinia scabiosaefolia. Phytochemistry 1983;22:1045-1047.
122. Yang B, Tong L, Jin M, Zhao W, Chen Y. Isolation and identification of triterpenoide compound from Patrinia scabiosaefolia. Zhong Yao Cai 1998;21:513-514.
123. Huen MSY, Kwok-Min H, Leung JWC, Sigel E, Baur R, Wong JTF. Naturally occurring 2-hydroxyl-substituted flavonoids as high-Affinity benzodiazepine site ligands. Biochem Pharmacol 2003;66:2397-2407.
124. Kavvadias D, Monschein VS, Riederer P, Schreier P. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med 2003;69:113-117.
125. Kwok MH, Huen MSY, Wang HY, et al. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem Pharmacol 2002;64:1415-1424.
126. Huen MS, Leung JW, Ng W, et al. Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol 2003;66:125-127.
127. Huen MSY, Hui KM, Leung JWC, et al. Naturally occurring 2-hydroxyl-substituted flavonoids as high-Affinity benzodiazepine site ligands. Biochem Pharmacol 2003;66:2397-2407.
128. Awad R, Arnason JT, Trudeau V, et al. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): A medicinal plant with anxiolytic properties. Phytomedicine 2003;10:640-649.
129. Bienvenu E, Amabeoku GJ, Eagles PK, Scott G, Springfield EP. Anticonvulsant activity of aqueous extract of Leonotis leonurus. Phytomedicine 2002; 9:217-223.
130. Calixto JB, Yunes RA, Rae GA. Effect of crude extracts from Leonotis nepetaefolia (Labiatae) on rat and guinea-pig smooth muscle and rat cardiac muscle. J Pharm Pharmacol 1991;43:529-534.
131. Purushothaman KK, Vasanth S, Connolly JD, Labbe C. 4, 6, 7-Trimethoxy-5- methylchromen-2-one, a new coumarin from Leonotis nepetaefolia. J Chem Soc 1976;23:2594-2595.
132. Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-216.
133. Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000;59:1387-1394.
134. Salah SM, Jager AK. Screening of traditionally used Lebanese herbs for neurological activities. J Ethnopharmacol 2005;97:145-159.
135. Salah SM, Jager AK. Two flavonoids from Artemisia herba-Alba with in vitro GABAAbenzodiazepine receptor activity. J Ethnopharmacol 2005;99:145-146.
136. Jeoung-Hee H, Dong-Ung L, Jae-Tae L, et al. Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol 2000;73:329-333.
137. Ha JH, Shin SM, Lee SK, et al. In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure -Activity correlation. Planta Med 2001;67:877-880.
138. Leong YW, Powell AD. Phenanthrene and other aromatic constituents of Bulbophyllum vaginatum. Phytochemistry 1999;50:1237-1241.
139. Salmi P, Isacson R, Kull B. Dihydrexidine-the first full dopamine D1 receptor agonist. CNS Drug Rev 2004;10:230-242.
140. Yoshikawa M, Murakami T, Kishi A, et al. Novel indole S, O-bisdesmoside, calanthoside, the precursor glycoside of tryptanthrin, indirubin, and isatin, with increasing skin blood flow promoting effects, from two Calanthe species (Orchidaceae). Chem Pharm Bull (Tokyo) 1998;46:886-888.
141. Kudo Y, Tanaka A, Yamada K. Dendrobine, an antagonist of beta-Alanine, taurine and of presynaptic inhibition in the frog spinal cord. Br J Pharmacol 1983;78:709-715.
142. Gruol DL and Smith TG. Opiate antagonism of glycine-evoked membrane polarizations in cultured mouse spinal cord neurons. Brain Res 1981;223:355-365.
143. Schmieden V, Jezequel S, Betz H. Novel antagonists of the inhibitory glycine receptor derived from quinolinic acid compounds. Mol Pharmacol 1996;50:1200-1206.
144. Philippe G. Angenot L Tits M. Frédérich M. About the toxicity of some Strychnos species and their alkaloids Toxicon 2004 44 405-416.
145. Bisset NG, Walker MD. Alkaloids from the stem bark of Strychnos ignatii. Phytochemistry 1974:13:525-526.
146. Pathama L, Michihisa T, Kinzo M, et al. Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes. Euro J Pharmacol 1997;332:321-326.
147. Fujikawa T, Miguchi S, Kanada N, et al. Acanthopanax senticosus Harms as a prophylactic for MPTP-induced Parkinson's disease in rats. J Ethnopharmacol 2005;97: 375-381.
148. Masazumi M, Yoshiteru I, Susumu I, Junzo S. 3-Hydroxy-oleanane-type triterpene glycosyl esters from leaves of Acanthopanax spinosus. Phytochemistry 1993;34: 1599-1602.
149. Masazumi M, Yoshiteru I, Susumu I, Junzo S. Epi-Oleanene type triterpene glycosyl esters from leaves of Acanthopanax spinosus. Phytochemistry 1993;33:891-895.
150. Masazumi M, Susumu I, Hirotoshi S, Yasuaki H, Junzo S, Yoshiteru I. 3-hydroxyoleanene type triterpene glycosyl esters from leaves of Acanthopanax spinosus. Phytochemistry 1997;46:1255-1259.
151. Radad K, Gille G, Moldzio R, Saito H, Ishige K, Rausch WD. Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP-Affected mesencephalic dopaminergic cells. J Neural Transm 2004;111:37-45.
152. Oh KW, Kim HS, Wagner GC. Ginseng total saponin inhibits the dopaminergic depletions induced by methamphetamine. Planta Med 1997;63:80-81.
153. Ty Ph. D, M. Lischewski, H. V. Phiet, A. Preiss, Ph. V. Nguyen, Adam G. 3, 11 - Dihydroxy-23-oxo-lup-20(29)-en-28-oic acid from Acanthopanax trifoliatus. Phytochemistry 1985;24:867-869 .
154. Kiem PV, Cai XF, Minh CV, Lee JJ, Kim YH. Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus. Planta Med 2004;70:282-284.
155. Lee EB, Li DW, Hyun JE, Kim IH, Whang WK. Anti-inflammatory activity of methanol extract of Kalopanax pictus bark and its fractions. J Ethnopharmacol 2001;77:197-201.
156. Li da W, Lee EB, Kang SS, Hyun JE, Whang WK. Activity-guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity. Chem Pharm Bull (Tokyo) 2002;50:900-903.
157. Jongwon C, Keun H, Suk-Hwan K, Kyung-Tae L, Hyeong-Kyu L. Hee-Juhn P. Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent. J Ethnopharmacol 2002;79:113-118.
158. Kim IT, Park YM, Shin KM, et al. Anti-inflammatory and anti-nociceptive effects of the extract from Kalopanax pictus, Pueraria thunbergiana and Rhus verniciflua. J Ethnopharmacol 2004;94:165-173.
159. Lee MW, Kim SU, Hahn DR. Antifungal activity of modified hederagenin glycosides from the leaves of Kalopanax pictum var. chinense. Biol Pharm Bull 2001;24:718-719.
160. Schellenberg R. Treatment for the premenstrual syndrome with Agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ 2001;322:134-137.
161. Dharmasiri MG, Jayakody JR, Galhena G, Liyanage SS, Ratnasooriya WD. Antiinflammatory and analgesic activities of mature fresh leaves of Vitex negundo. J Ethnopharmacol 2003;87:199-206.
162. Alam MI, Gomes A. Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts. J Ethnopharmacol 2003;86:75-80.
163. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D. Chaste tree (Vitex agnus-castus)-pharmacology and clinical indications Phytomedicine 2003;10: 348-357.
164. Li WX, Cui CB, Cai B, Yao XS. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L. J Asian Nat Prod Res 2005;7:95-105.
165. Wang HY, Cai B, Cui CB, Zhang DY, Yang BF. Vitexicarpin, a flavonoid from Vitex trifolia L, induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway. Yao Xue Xue Bao 2005;40:27-31.
166. Naidu PS, Singh A, Kulkarni SK. D2-dopamine receptor and alpha2-Adrenoreceptormediated analgesic response of quercetin. Indian J Exp Biol 2003;41:1400-1404.
167. Ando N, Gorai I, Hirabuki T, Onose R, Hirahara F, Minaguchi H. Prolactin disorders in patients with habitual abortion. Nippon Sanka Fujinka Gakkai Zasshi 1992;44: 650-656.
168. Cauli O, Morelli M. Caffeine and the dopaminergic system. Behav Pharmacol 2005;16:63-77.
169. Arulmozhi DK, Veeranjaneyulu A, Bodhankar SL, Arora SK. Pharmacological studies of the aqueous extract of Sapindus trifoliatus on central nervous system: possible ant migraine mechanisms. J Ethnopharmacol 2005;97:491-496.
170. Arulmozhi DK, Veeranjaneyulu A, Bodhankar SL, Arora SK. Effect of Sapindus trifoliatus on hyperalgesic in vivo migraine models. Braz J Med Biol Res 2005;38:469-475.
171. Kuo YH, Huang HC, Yang Kuo LM, et al. New dammarane-type saponins from the galls of Sapindus mukorossi. J Agric Food Chem 2005;53:4722-4727.
172. Munavvar AS, Gan EK, Loke SE, Mah KF, Wong WH. Effect of an extract of Erioglossum edule on the central nervous system. J Ethnopharmacol 1989;25:217-220.
173. Takagi K, Park EH, Kato H. Anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi Gaertn. Chem Pharm Bull (Tokyo) 1980;28:1183-1188.
174. Birioukova LM, Midzyanovskaya IS, Lensu S, Tuomisto L, van Luijtelaar G. Distribution of D1-like and D2-like dopamine receptors in the brain of genetic epileptic WAG/Rij rats. Epilepsy Res 2005;63:89-96.
175. Amabeoku GJ, Eagles P, Scott G, Mayeng I, Springfield E. Analgesic and antipyretic effects of Dodonaea angustifolia and Salvia africana-lutea. J Ethnopharmacol 2001;75:117-124.
176. Heerden FR. van, Viljoen AM, van Wyk BE. The major flavonoid of Dodonaea angustifolia. Fitoterapia 2000;71:602-604.
177. Pataki I, Adamik A, Jaszberenyi M, Macsai M, Telegdy G. Involvement of transmitters in pituitary adenylate cyclase-Activating polypeptide-induced hyperthermia. Regul Pept 2003;115:187-193.
178. Patel NB. Mechanism of action of cathinone: The active ingredient of khat (Catha edulis). East Afr Med J 2000;77:329-332.
179. Connor J. D, Ruston A, Eyasu M. Comparison of effects of khat extract and amphetamine on motor behaviors in mice. J Ethnopharmacol 2002;81:65-71.
180. Zheng J. Screening of active anti-inflammatory, immunosuppressive and anti-fertility components of Tripterygium wildfordii: III. A comparison of the anti-inflammatory and immunosuppressive activities of 7 diterpene lactones epoxides compounds in vivo. Zhongguo Yixue Kexueyuan Xuebao 1991;13:391-397.
181. Zhao G, Vaszar LT, Qiu D, Shi I, Kao PN. Anti-inflammatory effects of triptolide in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000; 279:L958-L966.
182. Hirsch EC. Glial cells and Parkinson's disease. J Neurol
183. Feng-Qiao L, Xiu-Zhi L., Xi-Bin L, et al. Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation. J Neuroimmunol 2004;148:24-31.
184. Asencio M, Delaquerrière B, Cassels BK, Speisky H, Comoy E, Protais P. Biochemical and behavioral effects of boldine and glaucine on dopamine systems. Pharmacol Biochem Behav 1999;62:7-13.
185. Asencio M, Hurtado-Guzmán C, López JJ, Cassels BK, Protais P, Chagraoui A. Structure- Affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: halogenation and D1 receptor selectivity. Bioorg Med Chem 2005;13:3699-3704.
186. Banning, JW, Uretsky NJ, Patil PN, Beal JL. Reticuline: A dopamine receptor blocker. Life Sci 1980;26:2083-2091.
187. Hoet S, Stevigny C, Block S, et al. Alkaloids from Cassytha filiformis and related aporphines: Anti-trypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. Planta Med 2004;70:407-413.
188. Hegde VR, Dai P, Ladislaw C, Patel MG, Puar MS, Pachter JA. D4 dopamine receptor- selective compounds from the Chinese plant Phoebe chekiangensis. Bioorg Med Chem Lett 1997;7:1207-1212.
189. Drewes SE, Horn MM, Scott RS. -Pyrones and their derivatives from two Cryptocarya species. Phytochemistry 1995;40:321-323.
190. Lia DJ, Mariko K, Hiromitsu T, Sjamsul AA, Norio A. A 6-substituted-5, 6-dihydro- 2-pyrone from Cryptocarya strictifolia. Phytochemistry 2000;54:989-993.
191. Baum SS, Hill R, Rommelspacher H. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry 1998;22:1105-1120.
192. Matsumoto M, Togashi H, Kaku A, Kanno M, Tahara K, Yoshioka M. Cortical GABAergic regulation of dopaminergic responses to psychological stress in the rat dorsolateral striatum. Synaps 2005;56:117-121.
193. Zhao XY, Wang Y, Li Y, et al. Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABAA receptor antagonist in rat brain. Neurosci Lett 2003;337:33-36.
194. Ameri A. Effects of the Aconitum alkaloid songorine on synaptic transmission and paired-pulse facilitation of CA1 pyramidal cells in rat hippocampal slices. Br J Pharmacol 1998;125:461-468.
195. Kim SH, Shin DS, Oh MN, Chung SC, Lee JS, Oh KB. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 2004;68:421-424.
196. Lin CC, Ng LT, Hsu FF, Shieh DE, Chiang LC. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol 2004;31:65-69.
197. Schinella GR, Tournier HA, Prieto JM, Mordujovich de Buschiazzo P, Rios JL. Antioxidant activity of anti-inflammatory plant extracts. Life Sci 2002;70:1023-1033.
198. Lee MK, Kim HS. Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells. Planta Med 1996;62: 31-34.
199. Hsieh MT, Peng WH, Wu CR, Wang WH. The ameliorating effects of the cognitiveenhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytother Res 2000;14:375-377.
200. Laszy J, Laszlovszky I, Gyertyan I. Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats. Psychopharmacology (Berl) 2005; 179:567-575.
201. Cong-Jun Li, Ying-He Li, Pei-Gen X, Tom JM, Watson WH, Krawiec M. An unusual cycloartane triterpenoid from Cimicifuga foetida. Phytochemistry 1996;42:489-494.
202. Pan RL, Chen DH, Si JY, Zhao XH, Shen LG. Studies on the new triterpenoid saponin of the aerial part of Cimicifuga foetida. Zhongguo Zhong Yao Za Zhi 2003;8:230-232.
203. Mahady GB. Black cohosh (Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. Treat Endocrinol 2005;4:177-184.
204. Jarry H, Thelen P, Christoffel V, Spengler B, Wuttke W. Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP. Phytomedicine 2005;12:178-182.
205. Vauquelin G, De Keyser J, Banyingela K, Vanhaelen M. (-) Tetrahydroanisocycline and (-)tetrahydropalmatine binding to D1 and D2 dopaminergic receptors in human putamen. Neurochem Int 1989;15:321-324.
206. Wang Y, Kuroda M, Gao XS, et al. Cepharanthine enhances in vitro and in vivo thermosensitivity of a mouse fibrosarcoma, FSa-II, based on increased apoptosis. Int J Mol Med 2004;13:405-411.
207. Okada K, Sakusabe N, Kobayashi A, Hoshi N, Sato K. Prevention of lung metastasis by intra-tumoural injection of Cepharanthin and staphylococcal enterotoxin B in transplantable rat osteosarcoma. Jpn J Cancer Res 1999;90:928-933.
208. Okamoto M, Ono M, Baba M. Potent inhibition of HIV type 1 replication by an anti-inflammatory alkaloid, cepharanthine, in chronically infected monocytic cells. Res Hum Retroviruses 1998;14:1239-1245.
209. Hu JY, Jin GZ. Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine. Zhongguo Yao Li Xue Bao 1999;20:715-719.
210. Chang CK, Lin MT. DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats. Neurosci Lett 2001;307:163-166.
211. Sousa FCF, Melo CTV, Monteiro AP, et al. Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice. Pharmacol Biochem Behav 2004;78:27-33.
212. Górniak SL, Palermo-Neto J, de Souza-Spinosa H. Effects of a Palicourea marcgravii leaf extract on some dopamine-related behaviors of rats. J Ethnopharmacol 1990;28:329-335.
213. Gupta M, Mazumder UK, Pal DK, Bhattacharya S Anti-steroidogenic activity of methanolic extract of Cuscuta reflexa roxb. stem and Corchorus olitorius Linn. seed in mouse ovary. Indian J Exp Biol 2003;41:641-644.
214. Risa J, Risa A, Adsersen A, et al. Screening of plants used in southern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay. J Ethnopharmacol 2004;93:177-182.
215. Yemitan OK, Salahdeen HM. Neurosedative and muscle relaxant activities of aqueous extract of Bryophyllum pinnatum. Fitoterapia 2005;76:187-193.
216. Jyh-Fei L, Sung YH, Yiing-Ming J, Li-Li Y, Chieh FC. Central inhibitory effects of water extract of Acori graminei rhizoma in mice. J Ethnopharmacol 1998;61:185-193.
217. Sung HW, Reynolds MC, Nan JS, Cassady JM, Snapka RM. Inhibition of topoisomerase II by liriodenine. Biochem Pharmacol 1997;54:467-473.
218. Sagen AL, Sahpaz S, Mavi S, Hostettmann K. Isoquinoline alkaloids from Artabotrys brachypetalus. Biochem Syst Ecol 2003;31:1447-1449.
219. Wu YC, Chen CH, Yang TH, et al. Cytotoxic aporphines from Artabotrys uncinatus and the structure and stereochemistry of artacinatine. Phytochemistry 1989;28: 2191-2195.
220. Wijeratne EMK, Gunatilaka AAL, Kingston DGI, Haltiwanger RC, Eggleston DS. Artabotrine: A novel bioactive alkaloid from Artabotrys zeylanicus. Tetrahedron 1995;51:7877-7882.
221. Achenbach H, Hemrich H. Alkaloids, flavonoids and phenylpropanoids of the West African plant Oxymitra velutina. Phytochemistry 1991;30:1265-1267.
222. Woo SH, Sun NJ, Cassady JM, Snapka RM. Topoisomerase II inhibition by aporphine alkaloids. Biochem Pharmacol 1999; 57:1141-1145.
223. Makhey D, Gatto B, Chiang Y, Liu A, Liu LF, LaVoie EJ. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem 1996;4:781-791.
224. Li G, Lee CS, Woo MH, Lee SH, Chang HW, Son JK. Lignans from the bark of Machilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity. Biol Pharm Bull 2004;27:1147-1150.
225. Huang RL, Chen CC, Huang YL, et al. Anti-tumor effects of D-dicentrine from the root of Lindera megaphylla. Planta Med 1998;64:212-215.
226. Zhou BN, Johnson RK, Mattern MR, et al. Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon. J Nat Prod 2000;63:217-221.
227. Hoet S, Stevigny C, Block S, et al. Alkaloids from Cassytha filiformis and related aporphines: Antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. Planta Med 2004;70:407-413.
228. Chen IS, Chen JJ, Duh CY, Tsai IL. Cytotoxic lignans from formosan Hernandia nymphaeifolia. Phytochemistry 1997;45:991-996.
229. Chen KS, Wu YC, Teng CM, Ko FN, Wu TS. Bioactive alkaloids from Illigera luzonensis. J Nat Prod 1997;60:645-647.
230. Guh JH, Ko FN, Yu SM, Wu YC, Teng CM. Pharmacological evaluation of Nmethyl- Actinodaphnine, a new vascular -Adrenoceptor antagonist, isolated from Illigera luzonensis. Eur J Pharmacol 1995;279: 33-41.
231. Ting CY, Hsu CT, Hsu HT, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol 2003;66:1981-1991.
232. Hande KR. Clinical applications of anticancer drugs targeted to topoisomerase II. Biochim Biophys Acta1998;1400(1-3):173-184.
233. Lee HH. Colouring matters from Prismatomeris malayana. Phytochemistry 1969;8: 501-503.
234. Kanokmedhakul K, Kanokmedhakul S, Phatchana R. Biological activity of anthraquinones and triterpenoids from Prismatomeris fragrans. J Ethnopharmacol 2005;100:284-288.
235. Zhou Z, Jiang SH, Zhu DY, Lin LZ, Cordell GA. Anthraquinones from Knoxia valerianoides. Phytochemistry 1994;36:765-768.
236. Yang YJ, Shu HY, Min ZD. Anthraquinones isolated from Morinda officinalis and Damnacanthus indicus. Yao Xue Xue Bao 1992;27:358-364.
237. Li S, Ouyang Q, Tan X, Shi S, Yao Z. Chemical constituents of Morinda officinalis How. Zhongguo Zhong Yao Za Zhi 1991;11:675-676.
238. Faltynek CR, Schroeder J, Mauvais P, et al. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Biochemistry 1995;34: 12, 404-12, 410.
239. Tosa H, Iinuma M, Asai F, et al. Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II. Biol Pharm Bull 1998;21:641-642.
240. Hiwasa T, Arase Y, Chen Z, et al. Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS Lett 1999;444: 173-176.
241. Zhang ZQ, Li Y, Ming Y, Luo ZP, Zhao YM. The effect of Morinda officinalis How, a Chinese traditional medicinal plant, on the DRL 72-s schedule in rats and the forced swimming test in mice. Pharmacol Biochem Behav 2002;72:39-43.
242. Li YF, Zheng HG, Ming Y, Yi MZ, Zhi PL. Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells. Life Sci 2003;72:933-942.
243. Li YF, Liu YQ, Ming Y, et al. The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone. Life Sci 2004;75: 1531-1538.
244. Wang LK, Johnson RK, Hecht SM. Inhibition of topoisomerase I function by nitidine and fagaronine. Chem Res Toxicol 1993;6:813-818.
245. Larsen AK, Grondard L, Couprie J, et al. The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II. Biochem Pharmacol 1993;46:1403-1412.
246. Ko FN, Chen IS, Wu SJ, Lee LG, Haung TF, Teng CM. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. Biochim Biophys Acta 1990;1052:360-365.
247. Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW, Weichselbaum RR. In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chlorise induces tumor cell toxicity and growth delay in vivo. Clin Cancer Res 2000;6:737-742.
248. Kemény-Beke A, Aradi J, Damjanovich J, et al. Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Lett 2005, in press.
249. Paik SY, Koh KH, Beak SM, Paek SH, Kim JA. The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. Biol Pharm Bull 2005;28: 802-807.
250. Wada S, Reiko T, Akira I, Shunyo M. In vitro inhibitory effects of DNA topoisomerase II by fernane-type triterpenoids isolated from a Euphorbia genus. Bioorg Med Chem Lett 1998;8:2829-2832.
251. Setzer WN, Xiaoming S, Bates RB, et al. A Phytochemical investigation of Alchornea latifolia. Fitoterapia 2000;71:195-198.
252. Vongvanich N, Kittakoop P, Kramyu J, Tanticharoen M, Thebtaranonth Y. Phyllanthusols A and B, cytotoxic norbisabolane glycosides from Phyllanthus acidus Skeels. J Org Chem 2000;65:5420-5423.
253. Sengupta P, Mukhopadhyay J. Terpenoids and related compounds-VII: Triterpenoids of Phyllanthus acidus Skeels. Phytochemistry 1966;5:531-534.
254. Wada S, Iida A, Tanaka R. Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. J Nat Prod 2001;64:1545-1547.
255. Martelli AM, Bortul R, Bareggi R, et al. The pro-Apoptotic drug camptothecin stimulates phospholipase D activity and diacylglycerol production in the nucleus of HL-60 human promyelocytic leukemia cells. Cancer Res 1999;59:3961-3967.
256. Jang DS, Cuendet M, Pawlus AD, et al. Potential cancer chemopreventive constituents of the leaves of Macaranga triloba. Phytochemistry 2004;65: 345-350.
257. Dannenberg AJ, Altorki NK, Boyle JO, et al. Cyclo-oxygenase 2: A pharmacological target for the prevention of cancer. Lancet Oncol 2001;2:544-551.
258. Kniss DA, Garver CL, Perkins DJ, Zimmerman PD, Fertel RH. Taxol enhances macrophage tumoricidal activity via suppression of PGE2 biosynthesis. J Soc Gynecol Invest 1996;3:377A.
259. Sakai K, Fukuda Y, Matsunaga S, Tanaka R, Yamori T. New cytotoxic oleanane-type triterpenoids from the cones of Liquidamber styraciflua. J Nat Prod 2004;67: 1088-1093.
260. Mukherjee KS, Ghosh PK, Mukherjee RK. Diterpenoid quinones of Salvia lanata. Phytochemistry 1983;22:1296-1297.
261. Simões F, Michavila A, Rodríguez B, Maria C, Alvarez G, Hasan M. A quinone methide diterpenoid from the root of Salvia moorciuftiana. Phytochemistry 1986;25: 755-756.
262. Hernández M, Esquive Bl, Cárdenas J, Rodríguez-Hahn L, Ramamoorthy TP. Diterpenoid abietane quinones isolated from Salvia regla. Phytochemistry 1987;26: 3297-3299.
263. González AG, Aguiar ZE, Luis JG, Ravelo AG, Domínguez X. Quinone methide diterpenoids from the roots of Salvia texana. Phytochemistry 1988;27: 1777-1781.
264. Slamenova D, Masterova I, Labaj J, et al. Cytotoxic and DNA-damaging effects of diterpenoid quinones from the roots of Salvia officinalis L. on colonic and hepatic human cells cultured in vitro. Basic Clin Pharmacol Toxicol 2004;94:282-290.
265. Meng LH, Zhang JS, Ding J. Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes. Biochem Pharmacol 2001;62:733-741.
266. Gu L, Xinchu W. Antioxidant activity and components of Salvia plebeia R. Br-A Chinese herb. Food Chem 2001;73:299-305.
267. Liu J, Shen HM, Ong CN. Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG2 cells. Cancer Lett 2000;153:85-93.
268. Chor SY, Hui AY, To KF, et al. Anti-proliferative and pro-Apoptotic effects of herbal medicine on hepatic stellate cell. J Ethnopharmacol 2005;100:180-186.
269. Yang LJ, Jeng CJ, Kung HN, et al. Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells. J Biomed Sci 2005;12: 347-361.
270. Mosaddik MA. In vitro cytotoxicity of tanshinones isolated from Salvia miltiorrhiza Bunge against P388 lymphocytic leukemia cells. Phytomedicine 2003;10:682-685.
271. Lee D-S, Lee SH. Biological activity of dihydrotanshinone I: effect on apoptosis. J Biosci Bioeng 2000;89:292-293.
272. Leone M, Zhai D, Sareth S, Kitada S, Reed JC, Pellecchia M. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res 2003;63:8118-8121.
273. Parker BW, Kaur G, Nieves-Neira W, et al. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 1998;91:458-465.
274. Hayakawa S, Saeki K, Sazuka M, et al. Apoptosis induction by epigallocatechin gallate involves its binding to Fas. Biochem Biophys Res Commun 2001;285: 1102-1106.
275. Adlakha RC, Ashorn CL, Chan D, Zwelling LA. Modulation of 4-(9-Acridinylamino) methanesulfon-m-Anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol. Cancer Res 1989;49:2052-2058.
276. Nikolovska-Coleska Z, Xu L, Hu Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 2004;47:2430-2440.
277. Motoyuki T, Kaoru K, Hironori N, Akira T, Hajime I, Hideto M. Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I. Biochim Biophys Acta 2000;1460:302-310.
278. Inayat-Hussain SH, Osman AB, Din LB, Ali AM, Snowden RT, MacFarlane M, Cain K. Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells. FEBS Lett 1999;456: 379-383.
279. Alkofahi A, Rupprecht J, Smith DL, Chang CJ, McLaughlin JL. Goniothalamin and annonacin: bioactive acetogenins from Goniothamalus giganteus (Annonaceae). Experientia 1988;44:83-85.
280. Alkofahi A, Rupprecht J, Liu YM, Chang CJ, Smith DL, McLaughlin JL. Gigantecin: A novel antimitotic and cytotoxic acetogenin, with non adjacent tetrahydrofurane rings, from Goniothalamus giganteus (Annonaceae). Experientia 1990;46:539-541.
281. Fang XP, Anderson JE, Smith DL, Wood KV, McLaughlin JL. Gigantetronenin and gigantrionenin: novel cytotoxic acetogenins from Goniothalamus giganteus. J Nat Prod 1992;55:1655-1663.
282. Gu ZM, Fang XP, Zeng L, et al. Gonionenin: A new cytotoxic annonaceous acetogenin from Goniothalamus giganteus and the conversion of mono-THF acetogenins to bis-THF cetogenins. J Org Chem 1994;59:3472-3479.
283. Lu Z, Yan Z, Qing Y, Gouen S, Kan H, McLaughlin JL. cis-Gigantrionenin and 4- Acetyl gigantetrocin A, two new bioactive annonaceous acetogenins from Goniothalamus giganteus, and the stereochemistries of acetogenin 1, 2, 5-triols. Bioorg Med Chem 1996;4:1271-1279.
284. Lu Z, Yan Z, McLaughlin JL. Gigantransenins A, B, and C, novel mono-THF acetogenins bearing trans-double bonds, from Goniothalamus giganteus (Annonaceae). Tetrahedron Lett 1996;37:5449-5452.
285. Feras QA, Lingling R, Yan Z, McLaughlin JL. Unusual bioactive annonaceous acetogenins from Goniothalamus giganteus. Tetrahedron 1998;54:5833-5844.
286. Feras QA, Yan Z, Lingling R, McLaughlin JL. Mono-tetrahydrofuran acetogenins from Goniothalamus giganteus. Phytochemistry 1998;49:761-768.
287. Xin PF, Rong S, Zhe-ming G, et al. A new type of cytotoxic annonaceous acetogenin: Giganin from Goniothalamus giganteus. Bioorg Med Chem Lett 1993;3:1153-1156.
288. Jiang Z, Chen Y, Ruo-Yun CH, De-Quan Y. Mono-tetrahydrofuran ring acetogenins from Goniothalamus donnaiensis. Phytochemistry 1997;46:327-331.
289. Ying C, Zhong J, Ruo RC, et al. Two linear acetogenins from Goniothalamus gardneri. Phytochemistry 1998;49:1317-1321.
290. Seidel V, Bailleul F, Waterman PG. Goniothalamusin, a linear acetogenin from Goniothalamus gardneri. Phytochemistry 1999;52:1101-1103.
291. Jewers K, Davis JB, Dougan J, et al. Goniothalamin and its distribution in four Goniothalamus species. Phytochemistry 1972;11:2025-2030.
292. El-Sharkawi S, Yusuf Z, Pihie AHL, Ali AM. Metabolism of goniothalamin in animal and microbial systems. Bull Chim Farmaceutica 1996;135:35-40.
293. Ali AM, Umar-Tsafe N, Mohamed SM, et al. Apopotosis induction in CEM-SS Tlymphoblastic leukemic cell line by goniothalamin. J Biochem Mol Biol Biophys 2001;5:253-261.
294. Pihie AHL, Stanslas J, Din LB. Non-steroid receptor-mediated anti-proliferative activity of styrylpyrone derivative in human breast cancer cell lines. Anticancer Res 1998;18:1739-1743.
295. Ali AM, Mackeen MM, Hamidi M, et al. Cytotoxicity and electron death cell induced by goniothalamin. Planta Med 1997;63:81-83.
296. Lee ATC, Azimahtol HLP, Tan AN. Styrylpyrone derivatives (SPD) induces apopotosis in caspases-7-dependent manner in the human breast cancer cell line MCF-7. Cancer Cell Int 2003;3:1-8.
297. Inayat-Hussain SH, Osman AB, Din LB, et al. Caspase-3 and -7 are activated in goniothalamin-induced apopotosis in human Jurkat T-cells. FEBS Lett 1999;456: 379-383.
298. Inayat-Hussain SH, Annuar BO, Din LB, Ali AM, Ross D. Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells. Toxicol In Vitro 2003; 17: 433-439.
299. Lee ATC, Azimahtol HLP. Styrylpyrone derivative (SPD) induces apoptosis through the up-regulation of bax in the human breast cancer cell line MCF-7. J Biochem Mol Biol 2003;36:269-274.
300. Almudena B, Amparo BM, Rao SK, Cortes D. Styryl-pyrones from Goniothalamus arvensis. Phytochemistry 1998;47:1375-1380.
301. Hisham A, Toubi M, Shuaily W, Ajitha MDB, Fujimoto Y. Cardiobutanolide, a styryllactone from Goniothalamus cardiopetalus. Phytochemistry 2003;62:597-600.
302. Hisham A, Harassi A, Shuaily W, Shizue E, Fujimoto Y. Cardiopetalolactone: A novel styryllactone from Goniothalamus cardiopetalus Tetrahedron 2000; 56:9985-9989.
303. Mu Q, Tang WD, Liu RY, et al. Constituents from the stems of Goniothalamus griffithii. Planta Med 2003;69:826-830.
304. Steven MC, Laily BD, Abdul L, et al. (-)Isoaltholactone: A furanopyrone isolated from Goniothalamus species. Phytochemistry 1990;29:1701-1704.
305. Wang S, Zhang YJ, Chen RY, Yu DQ. Goniolactones A-F, six new styrylpyrone derivatives from the roots of Goniothalamus cheliensis. J Nat Prod 2002;65:835-841.
306. Lan YH, Chang FR, Liaw CC, Wu CC, Chiang MY, Wu YC. Digoniodiol, deoxygoniopypyrone A, and goniofupyrone A: Three new styryl-lactones from Goniothalamus amuyon. Planta Med 2005;71:153-159.
307. Wu YC, Fang-Rong C, Chang-Yih D, Shang-Kwei W, Tian-Shung W. Cytotoxic styrylpyrones of Goniothalamus amuyon. Phytochemistry 1992;31:2851-2853.
308. Hasan CM, Mia MY, Rashid MA, Connolly JD. 5-Acetoxyisogoniothalamin oxide, an epoxystyryl lactone from Goniothalamus sesquipedalis. Phytochemistry 1994;37: 1763-1744.
309. Fasihuddin BA, Wan AT, Siraj O, Atan MS. 5-Acetyl goniothalamin, a styryl dihydropyrone from Goniothalamus uvaroides. Phytochemistry 1991;30:2430-2431.
310. Inayat-Hussain SH, Annuar BO, Laily BD, Naoyuki T. Altholactone, a novel styryllactone induces apoptosis via oxidative stress in human HL-60 leukemia cells. Toxicol Lett 2002;131:153-159.
311. Peris E, Estornell E, Cabedo N, Cortes D, Bermejo A. 3-Acetylaltholactone and related styryl-lactones, mitochondrial respiratory chain inhibitors. Phytochemistry 2000;54:311-315 .
312. Jerzak M, Kasprzycka M, Wierbicki P, Kotarski J, Gorski A. Apoptosis of T cells in the first trimester human deciduas. Am J Reprod Immunol 1998;40: 130-135.
313. Vadillo OF, Avila VMA, Guerrero HC, Arechavaleta VF, Montoya BJ. Apoptosis in trophoblast of patients with recurrent spontaneous abortion of unidentified cause. Ginecol Obstet Mex 2000;68: 122-131.
314. Nkunya MH, Weenen H, Bray DH, Mgani QA, Mwasumbi LB. Antimalarial activity of Tanzanian plants and their active constituents: The genus UvariaPlanta Med 1991;57:341-343.
315. Hufford CD, Babajide O. Oguntimein Dihydrochalcones from Uvaria angolensis. Phytochemistry 1980;19:2036-2038.
316. Mayunga HH, Weenen H, Renner C, Waibel R, Achenbach H. Benzylated dihydrochalcones from Uvaria leptocladon. Phytochemistry 1993;32: 1297-1300.
317. Fall D, Duval RA, Gleye C, Laurens A, Hocquemiller R. Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae. J Nat Prod 2004;67:1041-1043.
318. Nakatani N, Ichimaru M, Moriyasu M, Kato A. Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin. Biol Pharm Bull 2005;28:83-86.
319. Rivero A, Quintana J, Eiroa JL, et al. Potent induction of apoptosis by germacranolide sesquiterpene lactones on human myeloid leukemia cells. Eur J Pharmacol 2003;482:77-84.
320. Lee KH, Ibuka T, Huang HC. Letter: Antitumor agents XIV: molephantinin, a new potent antitumor sesquiterpene lactone from Elephantopus mollis. J Pharm Sci 1975;64:1077-1078.
321. Lee KH, Ibuka T, Furukawa H, Kozuka M, Wu RY, Hall IH, Huang HC. Antitumor agents XXXVIII: Isolation and structural elucidation of novel germacranolides and triterpenes from Elephantopus mollis. J Pharm Sci 1980;69:1050-1056.
322. Hall IH, Liou YF, Lee KH. Antitumor agents LII: The effects of molephantinin on nucleic acid and protein synthesis of Ehrlich ascites cells. J Pharm Sci 1982;71: 687-690.
323. Xie PD, Sang T, Gong XZ. Determination of protocatechuic acid in Blumea riparia (Bl.) DC. by RP-HPLC. Zhongguo Zhong Yao Za Zhi 2000;25: 227-229.
324. Kampa M, Alexaki VI, Notas G, et al. Apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res 2004;6:R63-R74.
325. Stagos D, Kazantzoglou G, Magiatis P, Mitaku S, Anagnostopoulos K, Kouretas D. Effects of plant phenolics and grape extracts from Greek varieties of Vitis vinifera on mitomycin C and topoisomerase I-induced nicking of DNA. Int J Mol Med 2005;15: 1013-1022.
326. Pandey UC, Ram PS, Palaniappan K, Herz W. Isoalantolactone derivatives and germacranolides from Blumea densiflora. Phytochemistry 1985;24: 1509-1514.
327. Wang SY, Chang HN, Lin KT, Lo CP, Yang NS, Shyur LF. Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica. J Agric Food Chem 2003;51:1506-1512.
328. Horinaka M, Yoshida T, Shiraishi T, et al. Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells. Oncogene 2005;24:7180-7189.
329. Dassonneville L, Lansiaux A, Wattez N, et al. Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis. J Nat Prod 2001;64:134-135.
330. Shi Q, Chen K, Li L, et al. Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra. J Nat Prod 1995;58:475-482.