Alkaloids from Cassytha filiformis and related aporphines: Antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases

Planta Medica

Volumn 70, Issue 5, 2004, Pages 407-413

  Hoet, Sara ^a   Stévigny, Caroline ^a   Block, Sébastien ^a   Opperdoes, Frederik ^b   Colson, Pierre ^c   Baldeyrou, Brigitte ^d   Lansiaux, Amélie ^d   Bailly, Christian ^d   Quetin Leclercq, Joëlle ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d INSERM   (France)

Author keywords

Antitrypanosomal activity; Aporphine alkaloids; Cassytha filiformis; Cytotoxicity; DNA interaction; Lauraceae; Topoisomerase inhibition

Indexed keywords

ACTINODAPHNINE; ALKALOID; ANTITRYPANOSOMAL AGENT; APORPHINE DERIVATIVE; BOLDINE; BULBOCAPNINE; CASSYTHINE; DICENTRINE; DNA; DNA TOPOISOMERASE; GLAUCINE; INTERCALATING AGENT; ISOCORYDINE; UNCLASSIFIED DRUG;

ANGIOSPERM; ARTICLE; CARCINOMA CELL; CASSYTHA FILIFORMIS; CATALYSIS; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DNA BINDING; FEMALE; HUMAN; HUMAN CELL; IC 50; LINEAR DICHROISM; MEDICINAL PLANT; MOLECULAR INTERACTION; NONHUMAN; TRYPANOSOMA BRUCEI; ULTRAVIOLET SPECTROSCOPY; UTERINE CERVIX CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APORPHINES; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LAURACEAE; PHYTOTHERAPY; PLANT EXTRACTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

CASSYTHA; CASSYTHA FILIFORMIS; LAURACEAE; MAGNOLIOPHYTA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI;

EID: 2642572614     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-818967     Document Type: Article

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