Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): Anti-proteolytic and anti-hemorrhagic properties

Chemico-Biological Interactions

Volumn 150, Issue 3, 2004, Pages 243-251

  Januário, Ana H ^a   Santos, Simone L ^a   Marcussi, Silvana ^a   Mazzi, Maurício V ^b   Pietro, Rosemeire C L R ^a,c   Sato, Daisy N ^d   Ellena, Javier ^b   Sampaio, Suely V ^b   França, Suzelei C ^a   Soares, Andreimar M ^a  

^a UNIVERSITY OF RIBEIRÃO PRETO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d INSTITUTO ADOLFO LUTZ   (Brazil)

Author keywords

Anti hemorrhagic activity; Anti metalloproteases; Anti ophidian activity; Anti proteolytic activity; Baccharis trimera; Clerodane diterpenoid; Snake venoms

Indexed keywords

CLERODANE DERIVATIVE; COAGULATING AGENT; DITERPENOID; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; PHOSPHOLIPASE A2; PROTEINASE INHIBITOR; SNAKE VENOM; SNAKE VENOM ANTISERUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTERACEAE; BLEEDING; BOTHROPS JARARACUSSU; BOTHROPS NEUWIDII; BUCCHARIS TRIMERA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG UTILIZATION; EDEMA; ENVENOMATION; ENZYME ISOLATION; FIBRINOGENOLYSIS; INHIBITION KINETICS; LYSIS; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; SNAKE; SNAKEBITE; STRUCTURE ANALYSIS;

ANIMALS; BACCHARIS; BLOOD COAGULATION; BOTHROPS; BRAZIL; CASEINS; CROTALID VENOMS; DITERPENES; EDEMA; HEMORRHAGE; MALE; MEDICINE, TRADITIONAL; METALLOPROTEASES; MICE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUSCLE, SKELETAL; PLANT EXTRACTS;

ASTERACEAE; BACCHARIS; BACCHARIS TRIMERA; BOTHROPS JARARACUSSU; BOTHROPS NEUWIEDI; SERPENTES;

EID: 9244258557     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2004.09.016     Document Type: Article

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