Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

Archives of Pharmacal Research

Volumn 25, Issue 2, 2002, Pages 151-153

  Lee, Hyun Tai ^a   Yang, Seung Won ^b   Kyeong, Ho Kim ^c   Seo, Eun Kyoung ^a   Mar, Woongchon ^b  

^a Ewha Womans University   (South Korea)

^b Seoul National University   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

2,3 Dihydroaromaticin; Bigelovin; Ergolide; iNOS inhibitor; Inula britannica var. chinensis

Indexed keywords

ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; SESQUITERPENE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; INULA; MOUSE;

ANIMALS; ENZYME INHIBITORS; INULA; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SESQUITERPENES;

EID: 0036545562     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02976555     Document Type: Article

References (12)

1. Bensky, D., Gamble, A., Kaptchuk, T. J., and Bensky, L. L., Chinese Herbal Medicine: Materia Medica. Eastland Press, Seattle, pp. 193-194, (1993).
2. Bohlmann, F. and Mahanta, P. K., Zwei neue pseudoguajanolide aus Telekia speciosa. Phytochemistry, 18, 887-888 (1979).
3. Brosnan, C. F., Battistini, L., Raine, C. S., Dickson, D. W., Casadevall, A., and Lee, S. C., Reactive nitrogen intermediates in human neuropathology: an overview. Dev. Neurosci., 16, 152-161 (1994).
4. Escott, K. J., Beech, J. S., Haga, K. K., Williams, S. C., Meldrum, B. S., and Bath, P. M., Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab., 18, 281-287 (1998).
5. 15N]-nitrite in biological fluids. Anal. Biochem., 126, 131-138 (1982).
6. Han, J. W., Lee, B. G., Kim, Y. K., Yoon, J. W., Jin, H. K., Hong, S., Lee, H. Y., Lee, K. R., and Lee, H. W., Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kB. Br. J. Pharmacol., 133, 503-512 (2001).
7. Hukkanen, M., Hughes, F. J., Buttery, L. D., Gross, S. S., Evans, T. J., Seddon, S., Riveros-Moreno, V., Macintyre, I., and Polak, J. M., Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role of osteoblast metabolic activity. Endocrinology, 136, 5445-5453 (1995).
8. Licinio, J., Prolo, P., McCann, S. M., and Wong, M. L., Brain iNOS: current understanding and clinical implications. Mol. Med. Today, 5, 225-232 (1999).
9. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 16, 55-63 (1983).
10. Ohshima, H. and Bartsch, H., Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res., 305, 253-264 (1994).
11. Park, E. J. and Kim J., Cytotoxic sesquiterpene lactones from Inula Britannica. Planta Med., 64, 752-754 (1998).
12. Wang, Q., Zhou, B. N., Zhang, R. W., Lin, Y. Y., Lin, L. Z., Gil, R. R., and Cordell, G. A., Cytotoxicity and NMR spectral assignments of ergolide and bigelovin. Planta Med., 62, 166-168 (1996).