Snake venom components enhance pain upon subcutaneous injection: An initial examination of spinal cord mediators

Pain

Volumn 111, Issue 1-2, 2004, Pages 65-76

  Chacur, Marucia ^a,c   Gutiérrez, José Maria ^b   Milligan, Erin D ^c   Wieseler Frank, Julie ^c   Britto, Luiz R G ^d   Maier, Steven F ^c   Watkins, Linda R ^c   Cury, Yara ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Allodynia; Astrocytes; Cyclooxygenase; Glia; Hyperalgesia; Microglia; Nitric oxide; Phospholipase A2; Proinflammatory cytokines

Indexed keywords

7 NITROINDAZOLE; ASPARTIC ACID; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; FLUOROCITRIC ACID; LYSINE; LYSINE DERIVATIVE; N 6 (1 IMINOETHYL)LYSINE; NEURONAL NITRIC OXIDE SYNTHASE; NEUTRALIZING ANTIBODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHOLIPASE A2; PROSTANOID; SNAKE VENOM; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; METABOLIC INHIBITION; NONHUMAN; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; SNAKE; SPINAL CORD;

ANIMALS; ANTIBODIES; BIOLOGICAL MARKERS; CITRATES; CROTALID VENOMS; CYCLOOXYGENASE INHIBITORS; CYTOKINES; HYPERALGESIA; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-1; MALE; NEUROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PAIN THRESHOLD; PHOSPHOLIPASES A; PROSTAGLANDINS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4344630159     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2004.06.001     Document Type: Article

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