Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa

Pharmacology Biochemistry and Behavior

Volumn 81, Issue 3, 2005, Pages 466-477

  Jürgensen, Sofia ^a   DalBó, Sílvia ^a   Angers, Paul ^b   Soares Santos, Adair Roberto ^a   Ribeiro do Valle, Rosa Maria ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

5 HT2 receptors; Antinociception; Mechanism of action; Uncaria tomentosa

Indexed keywords

ACETIC ACID; ALKALOID; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ARGININE; ATROPINE; CAPSAICIN; FORMALDEHYDE; KETANSERIN; MONOAMINE; MUSCARINIC RECEPTOR BLOCKING AGENT; NALTREXONE; NITRIC OXIDE; OPIATE ANTAGONIST; PRAZOSIN; RESERPINE; SEROTONIN 2 ANTAGONIST; SEROTONIN 2 RECEPTOR; UNCARIA TOMENTOSA EXTRACT; YOHIMBINE; ANALGESIC AGENT; PLANT MEDICINAL PRODUCT; SEROTONIN ANTAGONIST;

ABDOMEN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; HOT PLATE TEST; LATENT PERIOD; MALE; MODEL; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PRECURSOR; PRIORITY JOURNAL; STIMULATION; TAIL FLICK TEST; THERMAL STIMULATION; UNCARIA TOMENTOSA; WRITHING TEST; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METHODOLOGY; MOTOR ACTIVITY; PAIN ASSESSMENT; PHYSIOLOGY; PHYTOTHERAPY;

UNCARIA TOMENTOSA;

ACETIC ACID; ANALGESICS; ANIMALS; ARGININE; ATROPINE; BEHAVIOR, ANIMAL; CAPSAICIN; CAT'S CLAW; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; KETANSERIN; MALE; MICE; MOTOR ACTIVITY; NALTREXONE; PAIN; PAIN MEASUREMENT; PHYTOTHERAPY; PLANT PREPARATIONS; PRAZOSIN; RECEPTORS, SEROTONIN, 5-HT2; RESERPINE; SEROTONIN ANTAGONISTS; YOHIMBINE;

EID: 22044437947     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2005.04.004     Document Type: Article

References (65)

1. J.L. Aguilar, P. Rojas, A. Marcelo, A. Plaza, R. Bauer, and E. Reininger Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae) J Ethnopharmacol 81 2002 271 276
2. C. Akesson, H. Lindgren, R.W. Pero, T. Leanderson, and F. Ivars An extract of Uncaria tomentosa inhibiting cell division and NF-κB activity without inducing cell death Int Immunopharmacol 3 2003 1889 1900
3. 2 receptors in nociceptive transmission Brain Res 543 1991 335 340
4. 3 receptor-mediated antinociception: possible release of GABA J Neurosci 11 1991 1881 1888
5. A. Ameri The effects of Aconitum alkaloids on the central nervous system Prog Neurobiol 56 1998 211 235
6. R. Aquino, F. De Simone, and C. Pizza Plant metabolites, structure in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda J Nat Prod 52 1989 679 685
7. R. Aquino, V. De Feo, F. De Simone, C. Pizza, and G. Cirino Plant metabolites, new compounds and anti-inflammatory activity of Uncaria tomentosa J Nat Prod 54 1991 453 459
8. R. Aquino, N. De Tommasi, F. De Simone, and C. Pizza Triterpenes and quinovic acid glycosides from Uncaria tomentosa Phytochemistry 45 5 1997 1035 1040
9. L. Bardin, J. Lavarenne, and A. Eschalier Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats Pain 86 2000 11 18
10. A.I. Basbaum, and H.L. Fields Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry Annu Rev Neurosci 7 1984 309 338
11. M.J. Caterina, M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 1997 816 824
12. C.R. Chapman, K.L. Casey, R. Dubner, K.M. Foley, R.H. Graceley, and A.E. Reading Pain measurement: an overview Pain 22 1985 1 31
13. F.E. D'Amour, and D.L. Smith A method for determining loss of pain sensation J Pharmacol Exp Ther 72 1941 74 79
14. N.B. Eddy, and D. Leimbach Synthetic analgesics: II. Dithienyl-butenyl and dithienylbutylamines J Pharmacol Exp Ther 107 1953 385 393
15. E. Elisabetsky, T.A. Amador, R.R. Albuquerque, D.S. Nunes, and A.C.T. Carvalho Analgesic activity of Psychotria colorata (Willd. ex R. and S.) Muell. Arg. alkaloids J Ethnopharmacol 48 1995 77 83
16. H.L. Fields, M.M. Heinricher, and P. Mason Neurotransmitters in nociceptive modulatory circuits Annu Rev Neurosci 14 1991 219 245
17. A. Ginkel Identification of the alkaloids and flavonoids from Uncaria tomentosa bark by TLC in quality control Phytother Res 10 1996 18 19
18. P. Holzer Capsaicin as a tool for studying sensory neuron functions Adv Exp Med Biol 298 1991 3 16
19. S. Hunskaar, and K. Hole The formalin test in mice: dissociation between inflammatory and non-inflammatory pain Pain 30 1987 103 114
20. S. Hunskaar, O.B. Fasmer, and K. Hole Formalin test in mice, a useful technique for evaluating mild analgesics J Neurosci Methods 14 1985 69 73
21. J.L. Hylden, and G.L. Wilcox Intrathecal serotonin in mice: analgesia and inhibition of a spinal action of substance P Life Sci 33 1983 789 795
22. G. Jancso Pathobiological reactions of C-fibre primary sensory neurones to peripheral nerve injury Exp Physiol 77 1992 405 431
23. T.S. Jensen, and T.L. Yaksh Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat Brain Res 363 1986 99 113
24. D. Julius, and A.I. Basbaum Mechanisms molecular of nociception Nature 413 2001 203 210
25. 2 receptors expressed in Xenopus oocyte Eur J Pharmacol 444 2002 39 45
26. K. Keplinger, G. Laus, M. Wurm, M.P. Dierich, and H. Teppner Uncaria tomentosa (Willd.) DC.-ethnomedicinal use and new pharmacological, toxicological and botanical results J Ethnopharmacol 64 1999 23 34
27. M. Kitajima, M. Yokoya, H. Takayama, and N. Aimi Synthesis and absolute configuration of a new 3,4-dihydro-beta-carboline-type alkaloid, 3,4-dehydro-5(S)-5-carboxystrictosidine, isolated from Peruvian Una de Gato (Uncaria tomentosa) Chem Pharm Bull 50 2002 1376 1378
28. R. Koster, M. Anderson, and E.J. Beer Acetic acid for analgesic screening Fed Proc 18 1959 412
29. T. Kumazawa, K. Mizumura, H. Koda, and H. Fukusako EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in response to bradykinin and heat J Neurophysiol 75 1996 2361 2368
30. E. Küpeli, M. KosCombining ogonekar, E. YesCombining ogonekilada, K.H.C. BasCombining ogoneker, and C. BasCombining ogoneker A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species Life Sci 72 2002 645 657
31. G. Laus, and D. Keplinger Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance liquid chromatography J Chromatogr A 662 1994 243 249
32. G. Laus, D. Brössner, and K. Keplinger Alkaloids of Peruvian Uncaria tomentosa Phytochemistry 45 1997 855 860
33. D. Le Bars, G. Guilbaud, I. Jurna, and J.M. Besson Differential effects of morphine on responses of dorsal horn lamina V type cells elicited by A and C fiber stimulation in the spinal cat Brain Res 115 1976 518 524
34. D. Le Bars, M. Gozariu, and S.W. Cadden Animal models of nociception Pharmacol Rev 53 2001 597 652
35. I. Lemaire, V. Assinewe, P. Cano, D.V.C. Awang, and J.T. Arnason Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Uña de gato) J Ethnopharmacol 64.1999 109 115
36. S.F. Martin, and M. Mortimore New methods for the synthesis of oxindole alkaloids. Total synthesis of isopteropodine and pteropodine Tetrahedron Lett 31 1990 4557 4560
37. J. Martindale, P.A. Bland-Ward, and I.P. Chessell Inhibition of C-fibre mediated sensory transmission in the rat following intraplantar formalin Neurosci Lett 316 2001 33 36
38. K. Matsumoto, M. Mizowaki, T. Suchitra, H. Takayama, S. Sakai, and N. Aimi Antinociceptive action of mitragynine in mice: evidence for the involvement of supraspinal opioid receptors Life Sci 59 1996 1149 1155
39. K. Matsumoto, S. Horie, H. Ishikawa, H. Takayama, N. Aimi, and D. Ponglux Antinociceptive effect of 7-hydroxymitragynine in mice: discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa Life Sci 74 2004 2144 2155
40. M.J. Millan Serotonin (5-HT) and pain: a reappraisal of its role in the light of receptor multiplicity Semin Neurosci 7 1995 409 419
41. M.J. Millan Descending control of pain Prog Neurobiol 66 2002 355 474
42. M.J.S. Miller, F.M. Angeles, B.K. Reuter, P. Bobrowski, and M. Sandoval Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis BMC Complement Altern Med 1 2001 11
43. 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa Phytochemistry 57 2001 781 785
44. P.W. Reeh, and M. Kress Molecular physiology of proton transduction in nociceptors Curr Opin Pharmacol 1 2001 45 51
45. R.A. Ribeiro, M.L. Vale, F.M. Thomazzi, A.B.P. Paschoalato, S. Poole, and S.H. Ferreira Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice Eur J Pharmacol 387 2000 111 118
46. R. Rizzi, F. Re, A. Bianchi, V. De Feo, F. De Simone, and L. Bianchi Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts J Ethnopharmacol 38 1993 63 77
47. J.H. Rosland, S. Hunskaar, and K. Hole Diazepam attenuates morphine antinociception test-dependently in mice Pharmacol Toxicol 66 1990 382 386
48. T. Sakurada, K. Katsumata, K. Tan-no, S. Saturada, and K. Kisara The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord Neuropharmacology 31 1992 1279 1285
49. T. Sakurada, A. Sugiyama, C. Sakurada, K. Tanno, S. Sakurada, and K. Kisara Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse Neurochem Int 29 1996 271 278
50. T. Sakurada, T. Matsumura, T. Moriyama, C. Sakurada, S. Ueno, and S. Sakurada Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice Pharmacol Biochem Behav 75 2003 115 121
51. M. Sandoval, R.M. Charbonnet, N.N. Okuhama, A.M. Trentacosti, and M.J.S. Miller Cat's claw inhibits TNFα production and scavenges free radicals: role in cytoprotection Free Radic Biol Med 29 2000 71 78
52. M. Sandoval-Chacón, J.H. Thompson, X.J. Zhang, X. Liu, E.E. Mannick, and H. Sadowska-Krowicka Anti-inflammatory actions of cat's claw: the role of NF-κB Aliment Pharmacol Ther 12 1998 1279 1289
53. A.R.S Santos, and J.B. Calixto Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice Neurosci Lett 235 1997 73 76
54. 3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test Eur J Pharmacol 424 2001 45 52
55. J. Sawynok, and A. Reid Interactions of descending serotonergic systems with other neurotransmitters in the modulation of nociception Behav Brain Res 73 1996 63 68
56. Y. Sheng, R.W. Pero, and H. Wagner Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa Phytomedicine 7 2000 137 143
57. Y. Sheng, C. Bryngelsson, and R.W. Pero Enhanced DNA repair, immune function and reduced toxicity of C-MED-100™, a novel aqueous extract from Uncaria tomentosa J Ethnopharmacol 69 2000 115 126
58. H. Stuppner, S. Sturm, and G. Konwalinka HPLC analysis of the main oxindole alkaloids from Uncaria tomentosa Chromatographia 34 1992 597 600
59. H. Stuppner, S. Sturm, and G. Konwalinka Capillary electrophoretic analysis of oxindole alkaloids from Uncaria tomentosa J Chromatogr 609 1992 375 380
60. A. Tjølsen, and K. Hole Animal models of analgesia A. Dickenson J. Besson The pharmacology of pain (Handbook of experimental pharmacology) vol. 30/I 1997 Springer Verlag Berlin 1 20
61. A. Tjølsen, O.G. Berge, S. Hunskaar, J.H. Rosland, and K. Hole The formalin test: an evaluation of the method Pain 51 1992 5 17
62. M. Tominaga, M.J. Caterina, A.B. Malmberg, T.A. Rosen, H. Gilbert, and K. Skinner The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 1998 531 543
63. A. Verotta, F. Orsini, M. Sbacchi, M.A. Scheildler, T.A. Amadorc, and E. Elisabetsky Synthesis and antinociceptive activity of chimonanthines and pyrrolidinoindoline-type alkaloids Bioorg Med Chem 10 2002 2133 2142
64. L. Vyklicky Techniques for the study of pain in animals Adv Pain Res Ther 3 1979 727 745
65. P. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110