Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract

Biochemical and Biophysical Research Communications

Volumn 327, Issue 3, 2005, Pages 742-749

  Cavin, C ^a   Delannoy, M ^a   Malnoe, A ^a   Debefve, E ^a   Touche A ^a   Courtois, D ^a   Schilter, B ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Chicory; Colorectal cancer; Cyclooxygenases; Functional food; Inflammation; Prostaglandin; Sesquiterpene lactones

Indexed keywords

ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; CICHORIUM INTYBUS EXTRACT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GUAIANOLIDE 8 DEOXYLACTUCIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; LACTUCIN; LACTUCOPICRIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIFLUMIC ACID; PLANT EXTRACT; PROSTAGLANDIN E2; SESQUITERPENE LACTONE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARCINOMA CELL; CHICORY; COLON CARCINOMA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION;

ANTI-INFLAMMATORY AGENTS; CHICORY; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HT29 CELLS; HUMANS; INTESTINAL MUCOSA; LACTONES; MEMBRANE PROTEINS; NF-KAPPA B; PLANT EXTRACTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SESQUITERPENES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

CICHORIUM INTYBUS;

EID: 11844257048     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.12.061     Document Type: Article

References (33)

1. R. Hughes, and I. Rowland Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon Carcinogenesis 22 2001 43 47
2. N. Kaur, and A.K. Gupta Applications of inulin and oligofructose in health and nutrition J. Biosci. 27 2002 703 714
3. M.B. Roberfroid, and N.M. Delzene Dietary fructans Annu. Rev. Nutr. 18 1998 117 143
4. F. Bolognani, C.J. Rumney, B. Pool-Zobel, and I. Rowland Effect of lactobacilli, bifidobacteria and inulin on the formation of aberrant crypt foci in rats Eur. J. Nutr. 40 2001 293 300
5. B. Pool-Zobel, J. Van Loo, I. Rowland, and M.B. Roberfroid Experimental evidence on the potential prebiotic fructans to reduce the risk of colon cancer Br. J. Nutr. 87 2002 S273 S281
6. R. Zafar, and S.M. Ali Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J. Ethnopharmacol. 63 1998 227 231
7. F. Poli, G. Sacchetti, B. Tosi, M. Fogagnolo, G. Chillemi, R. Lazzarin, and A. Bruni Variation in the content of the main guaianolides and sugars in Cichorium intybus var "Rosso di Chioggia" selections during cultivation Food Chem. 76 2002 139 147
8. T.A. Van Beek, P. Maas, B.M. King, E. Leclercq, A.G.J. Voragen, and A. De Groot Bitter sesquiterpene lactones from chicory root J. Agric. Food Chem. 38 1990 1035 1038
9. A.J. Garcia-Pineres, V. Castro, G. Mora, T.J. Schmidt, E. Strunck, H.I. Pahl, and I. Merfort Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones J. Biol. Chem. 276 2001 39713 39720
10. S.P. Hehner, T.G. Hofmann, W. Dröge, and M.L. Schmitz The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex J. Immunol. 163 1999 5617 5623
11. O. Rüngeler, V. Castro, G. Mora, N. Gören, W. Vichnewski, H.L. Pahl, I. Merfort, and T.J. Schmidt Inhibition of transcription factor NF-kB by sesquiterpene lactones: a proposed molecular mechanism of action Bioorg. Med. Chem. 7 1999 2343 2352
12. L.J. Marnett, and R.N. Dubois COX-2: a target for colon cancer prevention Annu. Rev. Pharmacol. Toxicol. 42 2002 55 80
13. N. Vaisman, and N. Arber The role of nutrition and chemoprevention in colorectal cancer: from observations to expectations Best Pract. Res. Clin. Gastroenterol. 16 2002 201 217
14. F.A. Fitzpatrick Cyclooxygenase enzymes. Regulation and function Curr. Pharm. Des. 10 2004 577 588
15. F.A. Sinicrope, and S. Gill Role of cyclooxygenase-2 in colorectal cancer Cancer Metastasis Rev. 23 2004 63 67
16. W.L. Smith, D.L. DeWitt, and R.M. Garavito Cyclooxygenases: structural, cellular, and molecular biology Annu. Rev. Biochem. 69 2000 145 182
17. W.L. Smith, R.M. Garavito, and D.L. DeWitt Minireview: prostaglandine endoperoxide H synthases (cyclooxygenases)-1 and -2 J. Biol. Chem. 271 1996 33157 33160
18. J.S. Goodwin, and J. Ceuppens Regulation of immune response by prostaglandins J. Clinl. Immunol. 3 1983 295 314
19. A. Murakami, and I. Kudo Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway Prog. Lipid Res. 43 2004 3 35
20. V. Qiao, G.J. Kosoni, M.I. Tsioulias, R. Koustos, R. Hanif, S.J. Shiff, and B. Rigas Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo Biochim. Biophys. Acta 1258 1995 215 223
21. M. Tsujii, and R.N. Dubois Alterations in cellular adhesion and apoptosis in epithelial cells overexpression prostaglandin endoperoxide synthase 2 Cell 83 1995 493 501
22. P. Patrignani Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer Toxicol. Lett. 112-113 2000 493 498
23. O.C. Trifan, and T. Hla Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis J. Cell. Mol. Med. 7 2003 207 222
24. E. Leclercq, A.G.J. Voragen, L.M. Brugging, and W. Pilnick Effects of light, solvents, and commercial enzymes on the solubility and stability of sesquiterpene lactones from chicory roots Z. Lebenm. Unters Forsh. 187 1988 440 443
25. G.Y. Liu, N. Frank, H. Bartsch, and J.K. Lin Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NF-κB, c-fos/c-jun, and p53 proteins Mol. Carcinogen. 22 1998 235 246
26. K. Zen, A. Karsan, A. Stempien-Otero, E. Yee, J. Tupper, X. Li, T. Erunson, M.A. Kay, C.B. Wilson, R.K. Winn, and J.M. Harlan NF-κB activations is required for human endothelial survival during exposure to tumor necrosis factor-α but not to interleukin-1β or lipopolysaccharide J. Biol. Chem. 274 1999 28808 28815
27. K.M. Leahy, R.L. Ornberg, Y. Wang, B.S. Zweifel, A.T. Koki, and J.L. Masferrer Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo Cancer Res. 62 2002 625 631
28. J. Malarz, A. Stojakowska, and K. Wanda Sesquiterpenes lactones in a hairy root culture of Cichorium intybus Z. Naturforshung. C 57 2002 994 997
29. S.M. Kupchan, M.A. Eakin, and A.M. Thomas Tumor inhibitors. 69. Structure-cytotoxicity relationships am the sesquiterpene lactones J. Med. Chem. 14 1971 1147 1152
30. K.H. Lee, I.H. Hall, E.C. Mar, C.O. Starnes, S.A. ElGebaly, T.G. Waddell, R.I. Hadgraft, C.G. Ruffner, and I. Weidner Science 196 1977 533 536
31. G.H. Snyder, M.J. Cenerazzo, A.J. Karalis, and D. Field Electrostatic influence of local cysteine environments on disulfide exchange kinetics Biochemistry 20 1981 6509 6519
32. Y.S. Surh, K.S. Chun, H.H. Cha, S.S. Han, Y.S. Keum, K.K. Park, and S.S. Lee Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation Mut. Res. 480-481 2001 243 268
33. J.W. Han, B.G. Lee, Y.K. Kim, J.W. Yoon, H.K. Jin, S. Hong, H.Y. Lee, K.R. Lee, and H.W. Lee Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB Br. J. Pharmacol. 133 2001 503 512