Design of small molecule epigenetic modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 21-32

  Pachaiyappan, Boobalan ^a   Woster, Patrick M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Acetyllysine; Epigenetic; Histone; Methylarginine; Methyllysine

Indexed keywords

DNA METHYLTRANSFERASE INHIBITOR; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR;

ACUTE LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; DRUG DEVELOPMENT; DRUG STRUCTURE; ENZYME MECHANISM; EPIGENETICS; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HISTONE ACETYLATION; HISTONE METHYLATION; HOMEOSTASIS; IN VITRO STUDY; LARGE CELL LYMPHOMA; MOLECULE; PANCREAS ADENOCARCINOMA; STRUCTURAL HOMOLOGY;

ACETYLLYSINE; EPIGENETIC; HISTONE; METHYLARGININE; METHYLLYSINE;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; EPIGENESIS, GENETIC; EPIGENOMICS; HISTONE DEMETHYLASES; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES;

EID: 84891486208     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.11.001     Document Type: Review

References (145)

1. T. Jenuwein, and C.D. Allis Science 293 2001 1074
2. R.W. Johnstone Nat. Rev. Drug Discovery 1 2002 287
3. X.J. He, T. Chen, and J.K. Zhu Cell Res. 21 2011 442
4. P.A. Marks, T. Miller, and V.M. Richon Curr. Opin. Pharmacol. 3 2003 344
5. K. Luger, A.W. Mader, R.K. Richmond, D.F. Sargent, and T.J. Richmond Nature 389 1997 251
6. P.A. Marks, V.M. Richon, T. Miller, and W.K. Kelly Adv. Cancer Res. 91 2004 137
7. V. Carafa, M. Miceli, L. Altucci, and A. Nebbioso Expert Opin. Ther. Pat. 23 2013 1
8. J. Li, G. Li, and W. Xu Curr Med Chem 20 2012 1858
9. L. Chen Curr. Med. Chem. 18 2011 1936
10. W. Stunkel, and R.M. Campbell J. Biomol. Screen 16 2011 1153
11. P.A. Jones, and S.B. Baylin Cell 128 2007 683
12. H.C. Tsai, and S.B. Baylin Cell Res. 21 2011 502
13. J. Fahy, A. Jeltsch, and P.B. Arimondo Expert Opin. Ther. Pat. 22 2012 1427
14. C. Gros, J. Fahy, L. Halby, I. Dufau, A. Erdmann, J.M. Gregoire, F. Ausseil, S. Vispe, and P.B. Arimondo Biochimie 94 2012 2280
15. A.J. Ruthenburg, C.D. Allis, and J. Wysocka Mol. Cell 25 2007 15
16. C.A. Musselman, M.E. Lalonde, J. Cote, and T.G. Kutateladze Nat. Struct. Mol. Biol. 19 2012 1218
17. A. Portela, and M. Esteller Nat. Biotechnol. 28 2010 1057
18. D. Rossetto, N. Avvakumov, and J. Cote Epigenetics 7 2012 1098
19. C.H. Arrowsmith, C. Bountra, P.V. Fish, K. Lee, and M. Schapira Nat. Rev. 11 2012 384
20. M. Quattrocelli, L. Thorrez, and M. Sampaolesi Recent Pat. Drug Delivery Formulation 7 2013 18
21. I. Robles-Fernandez, F. Rodriguez-Serrano, P.J. Alvarez, R. Ortiz, A.R. Rama, J. Prados, C. Melguizo, E. Alvarez-Manzaneda, and A. Aranega Recent Pat. Anti-Cancer Drug Discovery 8 2013 203
22. J. Chen, F.M. Ghazawi, and Q. Li Epigenetics 5 2010 509
23. D.P. Stiehl, D.M. Fath, D. Liang, Y. Jiang, and N. Sang Cancer Res. 67 2007 2256
24. C.D. Allis, S.L. Berger, J. Cote, S. Dent, T. Jenuwien, T. Kouzarides, L. Pillus, D. Reinberg, Y. Shi, R. Shiekhattar, A. Shilatifard, J. Workman, and Y. Zhang Cell 131 2007 633
25. S.D. Furdas, S. Kannan, W. Sippl, and M. Jung Arch. Pharm. (Weinheim) 345 2012 7
26. S.Y. Roth, J.M. Denu, and C.D. Allis Annu. Rev. Biochem. 70 2001 81
27. T. Kouzarides Cell 128 2007 693
28. S.C. Hodawadekar, and R. Marmorstein Oncogene 26 2007 5528
29. R.C. Trievel, J.R. Rojas, D.E. Sterner, R.N. Venkataramani, L. Wang, J. Zhou, C.D. Allis, S.L. Berger, and R. Marmorstein Proc. Natl. Acad. Sci. U.S.A. 96 1999 8931
30. F.J. Dekker, and H.J. Haisma Drug Discovery Today 14 2009 942
31. S. Isharwal, M.C. Miller, C. Marlow, D.V. Makarov, A.W. Partin, and R.W. Veltri Prostate 68 2008 1097
32. Y. Liu, M.W. Mayo, A.S. Nagji, E.H. Hall, L.S. Shock, A. Xiao, E.B. Stelow, and D.R. Jones Cancer Res. 73 2012 1308
33. F. Manzo, F.P. Tambaro, A. Mai, and L. Altucci Expert Opin. Ther. Pat. 19 2009 761
34. O.D. Lau, T.K. Kundu, R.E. Soccio, S. Ait-Si-Ali, E.M. Khalil, A. Vassilev, A.P. Wolffe, Y. Nakatani, R.G. Roeder, and P.A. Cole Mol. Cell 5 2000 589
35. Y. Zheng, P.R. Thompson, M. Cebrat, L. Wang, M.K. Devlin, R.M. Alani, and P.A. Cole Methods Enzymol. 376 2004 188
36. Olhava, E.J. Chesworth, R. Kuntz, K.W. Richon, V.M. Pollock, R.M. Daigle, S.R. WO 2011/US6331.
37. E.D. Eliseeva, V. Valkov, M. Jung, and M.O. Jung Mol. Cancer Ther. 6 2007 2391
38. L. Stimson, M.G. Rowlands, Y.M. Newbatt, N.F. Smith, F.I. Raynaud, P. Rogers, V. Bavetsias, S. Gorsuch, M. Jarman, A. Bannister, T. Kouzarides, E. McDonald, P. Workman, and G.W. Aherne Mol. Cancer Ther. 4 2005 1521
39. M. Biel, A. Kretsovali, E. Karatzali, J. Papamatheakis, and A. Giannis Angew. Chem., Int. Ed. 43 2004 3974
40. B.C. Smith, and J.M. Denu Biochim. Biophys. Acta. (BBA) - Gene Regul. Mech. 1789 2009 45
41. Q. Feng, H. Wang, H.H. Ng, H. Erdjument-Bromage, P. Tempst, K. Struhl, and Y. Zhang Curr. Biol. 12 2002 1052
42. Y. Zhang, and D. Reinberg Genes Dev. 15 2001 2343
43. C.D. Krause, Z.-H. Yang, Y.-S. Kim, J.-H. Lee, J.R. Cook, and S. Pestka Pharmacol. Ther. 113 2007 50
44. T. Kouzarides Curr. Opin. Genet. Dev. 12 2002 198
45. C. Martin, and Y. Zhang Nat. Rev. Mol. Cell Biol. 6 2005 838
46. K.K. Li, C. Luo, D. Wang, H. Jiang, and Y.G. Zheng Med. Res. Rev. 32 2012 815
47. T. Jenuwein Trends Cell Biol. 11 2001 266
48. R. Schneider, A.J. Bannister, and T. Kouzarides Trends Biochem. Sci. 27 2002 396
49. A. Spannhoff, A.T. Hauser, R. Heinke, W. Sippl, and M. Jung ChemMedChem 4 2009 1568
50. X. Chen, F. Niroomand, Z. Liu, A. Zankl, H.A. Katus, L. Jahn, and C.P. Tiefenbacher Basic Res. Cardiol. 101 2006 346
51. Chesworth, B. Kuntz, K.W. Olhava, E.J. Patane, M.A. WO2011-US63309 2012.
52. S.R. Daigle, E.J. Olhava, C.A. Therkelsen, C.R. Majer, C.J. Sneeringer, J. Song, L.D. Johnston, M.P. Scott, J.J. Smith, Y. Xiao, L. Jin, K.W. Kuntz, R. Chesworth, M.P. Moyer, K.M. Bernt, J.C. Tseng, A.L. Kung, S.A. Armstrong, R.A. Copeland, V.M. Richon, and R.M. Pollock Cancer Cell 20 2011 53
53. S.R. Daigle, E.J. Olhava, C.A. Therkelsen, A. Basavapathruni, L. Jin, P.A. Boriack-Sjodin, C.J. Allain, C.R. Klaus, A. Raimondi, M.P. Scott, N.J. Waters, R. Chesworth, M.P. Moyer, R.A. Copeland, V.M. Richon, and R.M. Pollock Blood 122 2013 1017
54. W. Yu, E.J. Chory, A.K. Wernimont, W. Tempel, A. Scopton, A. Federation, J.J. Marineau, J. Qi, D. Barsyte-Lovejoy, J. Yi, R. Marcellus, R.E. Iacob, J.R. Engen, C. Griffin, A. Aman, E. Wienholds, F. Li, J. Pineda, G. Estiu, T. Shatseva, T. Hajian, R. Al-Awar, J.E. Dick, M. Vedadi, P.J. Brown, C.H. Arrowsmith, J.E. Bradner, and M. Schapira Nat. Commun. 3 2012 1288
55. Y. Yao, P. Chen, J. Diao, G. Cheng, L. Deng, J.L. Anglin, B.V. Prasad, and Y. Song J. Am. Chem. Soc. 133 2011 16746
56. A.D. Ferguson, N.A. Larsen, T. Howard, H. Pollard, I. Green, C. Grande, T. Cheung, R. Garcia-Arenas, S. Cowen, J. Wu, R. Godin, H. Chen, and N. Keen Structure 19 2011 1262
57. D. Greiner, T. Bonaldi, R. Eskeland, E. Roemer, and A. Imhof Nat. Chem. Biol. 1 2005 143
58. W. Bernhard, K. Barreto, A. Saunders, M.S. Dahabieh, P. Johnson, and I. Sadowski FEBS Lett. 585 2011 3549
59. S. Kubicek, R.J. O'Sullivan, E.M. August, E.R. Hickey, Q. Zhang, M.L. Teodoro, S. Rea, K. Mechtler, J.A. Kowalski, C.A. Homon, T.A. Kelly, and T. Jenuwein Mol. Cell 25 2007 473
60. N.A. Malmquist, T.A. Moss, S. Mecheri, A. Scherf, and M.J. Fuchter Proc. Natl. Acad. Sci. U.S.A. 109 2012 16708
61. W. Fiskus, Y. Wang, A. Sreekumar, K.M. Buckley, H. Shi, A. Jillella, C. Ustun, R. Rao, P. Fernandez, J. Chen, R. Balusu, S. Koul, P. Atadja, V.E. Marquez, and K.N. Bhalla Blood 114 2009 2733
62. J. Kikuchi, T. Takashina, I. Kinoshita, E. Kikuchi, Y. Shimizu, J. Sakakibara-Konishi, S. Oizumi, V.E. Marquez, M. Nishimura, and H. Dosaka-Akita Lung Cancer 78 2012 138
63. W. Qi, H. Chan, L. Teng, L. Li, S. Chuai, R. Zhang, J. Zeng, M. Li, H. Fan, Y. Lin, J. Gu, O. Ardayfio, J.H. Zhang, X. Yan, J. Fang, Y. Mi, M. Zhang, T. Zhou, G. Feng, Z. Chen, G. Li, T. Yang, K. Zhao, X. Liu, Z. Yu, C.X. Lu, P. Atadja, and E. Li Proc. Natl. Acad. Sci. U.S.A. 109 2012 21360
64. M.T. McCabe, H.M. Ott, G. Ganji, S. Korenchuk, C. Thompson, G.S. Van Aller, Y. Liu, A.P. Graves, A. Della Pietra 3rd, E. Diaz, L.V. LaFrance, M. Mellinger, C. Duquenne, X. Tian, R.G. Kruger, C.F. McHugh, M. Brandt, W.H. Miller, D. Dhanak, S.K. Verma, P.J. Tummino, and C.L. Creasy Nature 492 2012 108
65. S.K. Verma, X. Tian, L. LaFrance, C. Duquenne, D.P. Suarez, K.A. Newlander, S.P. Romeril, J.L. Burgess, S.W. Grant, J.A. Brackley, A.P. Graves, D.A. Scherzer, A. Shu, C. Thompson, H.M. Van Ott, G.S. Aller, C.A. Machutta, E. Diaz, Y. Jiang, N.W. Johnson, S.D. Knight, R.G. Kruger, M.T. McCabe, D. Dhanak, P.J. Tummino, C.L. Creasy, and W.H. Miller ACS Med. Chem. Lett. 3 2012 1091
66. S.K. Knutson, N.M. Warholic, T.J. Wigle, C.R. Klaus, C.J. Allain, A. Raimondi, M. Porter Scott, R. Chesworth, M.P. Moyer, R.A. Copeland, V.M. Richon, R.M. Pollock, K.W. Kuntz, and H. Keilhack Proc. Natl. Acad. Sci. U.S.A. 110 2013 7922
67. Albrecht, B.K. Audia, J.E. Gagnon, A. Harmange, J.C. Nasveschuk, C. WO/2012/068589.
68. Knight, S.D. Miller, W.H. Newlander, K.A. Verma, S.K. WO/2012/075080.
69. K.D. Konze, A. Ma, F. Li, D. Barsyte-Lovejoy, T. Parton, C.J. Macnevin, F. Liu, C. Gao, X.P. Huang, E. Kuznetsova, M. Rougie, A. Jiang, S.G. Pattenden, J.L. Norris, L.I. James, B.L. Roth, P.J. Brown, S.V. Frye, C.H. Arrowsmith, K.M. Hahn, G.G. Wang, M. Vedadi, and J. Jin ACS Chem. Biol. 8 2013 1324
70. Y.A. Yang, and J. Yu Protein Cell 4 2013 331
71. Y. Yuan, Q. Wang, J. Paulk, S. Kubicek, M.M. Kemp, D.J. Adams, A.F. Shamji, B.K. Wagner, and S.L. Schreiber ACS Chem. Biol. 7 2012 1152
72. M. Vedadi, D. Barsyte-Lovejoy, F. Liu, S. Rival-Gervier, A. Allali-Hassani, V. Labrie, T.J. Wigle, P.A. Dimaggio, G.A. Wasney, A. Siarheyeva, A. Dong, W. Tempel, S.C. Wang, X. Chen, I. Chau, T.J. Mangano, X.P. Huang, C.D. Simpson, S.G. Pattenden, J.L. Norris, D.B. Kireev, A. Tripathy, A. Edwards, B.L. Roth, W.P. Janzen, B.A. Garcia, A. Petronis, J. Ellis, P.J. Brown, S.V. Frye, C.H. Arrowsmith, and J. Jin Nat. Chem. Biol. 7 2011 566
73. D.E. Williams, D.S. Dalisay, F. Li, J. Amphlett, W. Maneerat, M.A. Chavez, Y.A. Wang, T. Matainaho, W. Yu, P.J. Brown, C.H. Arrowsmith, M. Vedadi, and R.J. Andersen Org. Lett. 15 2013 414
74. J.S. Sack, S. Thieffine, T. Bandiera, M. Fasolini, G.J. Duke, L. Jayaraman, K.F. Kish, H.E. Klei, A.V. Purandare, P. Rosettani, S. Troiani, D. Xie, and J.A. Bertrand Biochem. J. 436 2011 331
75. D. Cheng, N. Yadav, R.W. King, M.S. Swanson, E.J. Weinstein, and M.T. Bedford J. Biol. Chem. 279 2004 23892
76. K. Bonham, S. Hemmers, Y.H. Lim, D.M. Hill, M.G. Finn, and K.A. Mowen FEBS J. 277 2010 2096
77. A. Mai, D. Cheng, M.T. Bedford, S. Valente, A. Nebbioso, A. Perrone, G. Brosch, G. Sbardella, F. De Bellis, M. Miceli, and L. Altucci J. Med. Chem. 51 2008 2279
78. N. Fontan, P. Garcia-Dominguez, R. de Alvarez, and A.R. Lera Bioorg. Med. Chem. 21 2013 2056
79. J. Wang, L. Chen, S.H. Sinha, Z. Liang, H. Chai, S. Muniyan, Y.W. Chou, C. Yang, L. Yan, Y. Feng, K.K. Li, M.F. Lin, H. Jiang, Y.G. Zheng, and C. Luo J. Med. Chem. 55 2012 7978
80. M.B. Dillon, D.A. Bachovchin, S.J. Brown, M.G. Finn, H. Rosen, B.F. Cravatt, and K.A. Mowen ACS Chem. Biol. 7 2012 1198
81. A. Spannhoff, R. Machmur, R. Heinke, P. Trojer, I. Bauer, G. Brosch, R. Schule, W. Hanefeld, W. Sippl, and M. Jung Bioorg. Med. Chem. Lett. 17 2007 4150
82. E.M. Bissinger, R. Heinke, A. Spannhoff, A. Eberlin, E. Metzger, V. Cura, P. Hassenboehler, J. Cavarelli, R. Schule, M.T. Bedford, W. Sippl, and M. Jung Bioorg. Med. Chem. 19 2011 3717
83. M. Cho, E. Choi, J.S. Yang, C. Lee, J.J. Seo, B.S. Kim, S.J. Oh, H.M. Kim, K. Lee, S.K. Park, H.J. Kwon, and G. Han ChemMedChem 8 2013 272
84. L. Marek, A. Hamacher, F.K. Hansen, K. Kuna, H. Gohlke, M.U. Kassack, and T. Kurz J. Med. Chem. 56 2013 427
85. M. Malvaez, S.C. McQuown, G.A. Rogge, M. Astarabadi, V. Jacques, S. Carreiro, J.R. Rusche, and M.A. Wood Proc. Natl. Acad. Sci. U.S.A. 110 2013 2647
86. K. Van Beneden, I. Mannaerts, M. Pauwels, C. Van den Branden, and L.A. van Grunsven Fibrogenesis Tissue Repair 6 2013 1
87. Z. Ge, Y. Da, Z. Xue, K. Zhang, H. Zhuang, M. Peng, Y. Li, W. Li, A. Simard, J. Hao, Z. Yao, and R. Zhang Exp. Neurol. 241C 2012 56
88. Y.T. Chen, X.F. Zang, J. Pan, X.L. Zhu, F. Chen, Z.B. Chen, and Y. Xu Clin. Exp. Pharmacol. Physiol. 39 2012 751
89. H. Jia, J. Pallos, V. Jacques, A. Lau, B. Tang, A. Cooper, A. Syed, J. Purcell, Y. Chen, S. Sharma, G.R. Sangrey, S.B. Darnell, H. Plasterer, G. Sadri-Vakili, J.M. Gottesfeld, L.M. Thompson, J.R. Rusche, J.L. Marsh, and E.A. Thomas Neurobiol. Dis. 46 2012 351
90. X. Zhao, D. Allison, B. Condon, F. Zhang, T. Gheyi, A. Zhang, S. Ashok, M. Russell, I. Macewan, Y. Qian, J.A. Jamison, and J.G. Luz J. Med. Chem. 56 2013 963
91. Y. Shi, F. Lan, C. Matson, P. Mulligan, J.R. Whetstine, P.A. Cole, R.A. Casero, and Y. Shi Cell 119 2004 941
92. G. Liang, J.C. Lin, V. Wei, C. Yoo, J.C. Cheng, C.T. Nguyen, D.J. Weisenberger, G. Egger, D. Takai, F.A. Gonzales, and P.A. Jones Proc. Natl. Acad. Sci. U.S.A. 101 2004 7357
93. R. Schneider, A.J. Bannister, F.A. Myers, A.W. Thorne, C. Crane-Robinson, and T. Kouzarides Nat. Cell Biol. 6 2004 73
94. Y. Huang, E. Greene, T. Murray Stewart, A.C. Goodwin, S.B. Baylin, P.M. Woster, and R.A. Casero Jr. Proc. Natl. Acad. Sci. U.S.A. 104 2007 8023
95. P. Stavropoulos, and A. Hoelz Expert Opin. Ther. Targets 11 2007 809
96. E. Metzger, M. Wissmann, N. Yin, J.M. Muller, R. Schneider, A.H. Peters, T. Gunther, R. Buettner, and R. Schule Nature 437 2005 436
97. H. Hou, and H. Yu Curr. Opin. Struct. Biol. 20 2010 739
98. A. Karytinos, F. Forneris, A. Profumo, G. Ciossani, E. Battaglioli, C. Binda, and A. Mattevi J. Biol. Chem. 284 2009 17775
99. D. Rotili, and A. Mai Genes Cancer 2 2011 663
100. C. Loenarz, and C.J. Schofield Nat. Chem. Biol. 4 2008 152
101. T. Takeuchi, Y. Yamazaki, Y. Katoh-Fukui, R. Tsuchiya, S. Kondo, J. Motoyama, and T. Higashinakagawa Genes Dev. 9 1995 1211
102. J.C. Zhou, N.P. Blackledge, A.M. Farcas, and R.J. Klose Mol. Cell Biol. 32 2012 479
103. A.M. Farcas, N.P. Blackledge, I. Sudbery, H.K. Long, J.F. McGouran, N.R. Rose, S. Lee, D. Sims, A. Cerase, T.W. Sheahan, H. Koseki, N. Brockdorff, C.P. Ponting, B.M. Kessler, and R.J. Klose eLife 1 2012 e00205
104. D. Yamada, S. Kobayashi, H. Yamamoto, Y. Tomimaru, T. Noda, M. Uemura, H. Wada, S. Marubashi, H. Eguchi, M. Tanemura, Y. Doki, M. Mori, and H. Nagano Ann. Surg. Oncol. 19 2012 S355
105. J.Y. Kim, K.B. Kim, G.H. Eom, N. Choe, H.J. Kee, H.J. Son, S.T. Oh, D.W. Kim, J.H. Pak, H.J. Baek, H. Kook, Y. Hahn, H. Kook, D. Chakravarti, and S.B. Seo Mol. Cell Biol. 32 2012 2917
106. G. Jin, J. Sun, S.T. Kim, J. Feng, Z. Wang, S. Tao, Z. Chen, L. Purcell, S. Smith, W.B. Isaacs, R.S. Rittmaster, S.L. Zheng, L.D. Condreay, and J. Xu Hum. Mol. Genet. 21 2012 5222
107. W.L. Berry, S. Shin, S.A. Lightfoot, and R. Janknecht Int. J. Oncol. 41 2012 1701
108. J. Antony, F. Oback, L.W. Chamley, B. Oback, and G. Laible Mol. Cell Biol. 33 2012 974
109. B. Berdel, K. Nieminen, Y. Soini, M. Tengstrom, M. Malinen, V.M. Kosma, J.J. Palvimo, and A. Mannermaa BMC Cancer 12 2012 516
110. B.C. Dancy, S.A. Ming, R. Papazyan, C.A. Jelinek, A. Majumdar, Y. Sun, B.M. Dancy, W.J. Drury 3rd, R.J. Cotter, S.D. Taverna, and P.A. Cole J. Am. Chem. Soc. 134 2012 5138
111. T. Suzuki, and N. Miyata J. Med. Chem. 54 2011 8236
112. Johnson, N.W. Kasparec, J. Miller, W.H. Rouse, M.B. Suarez, D.P. Tian, X. WO/2012/135113A2 2012.
113. X. Bi, C. Lopez, C.J. Bacchi, D. Rattendi, and P.M. Woster Bioorg. Med. Chem. Lett. 16 2006 3229
114. S.K. Sharma, S. Hazeldine, M.L. Crowley, A. Hanson, R. Beattie, S. Varghese, T.M. Senanayake, A. Hirata, F. Hirata, Y. Huang, Y. Wu, N. Steinbergs, T. Murray-Stewart, I. Bytheway, R.A. Casero Jr., and P.M. Woster MedChemComm 3 2012 14
115. Y. Huang, T. Murray-Stewart, Y. Wu, S.B. Baylin, L.J. Marton, P.M. Woster, and R.A. Casero Jr. Cancer Chem. Pharmacol. 15 2009 7217
116. Y. Huang, E. Greene, T.M. Stewart, A.C. Goodwin, S.B. Baylin, P.M. Woster, and R.A. Casero Proc. Natl. Acad. Sci. U.S.A. 104 2007 8023
117. Y. Huang, T.M. Stewart, Y. Wu, S.B. Baylin, L.J. Marton, B. Perkins, R.J. Jones, P.M. Woster, and R.A. Casero Jr. Clin. Cancer Res. 15 2009 7217
118. S. Sharma, Y. Wu, N. Steinbergs, M. Crowley, A. Hanson, R.A.J. Casero, and P. Woster J. Med. Chem. 53 2010 5197
119. S. Hazeldine, B. Pachaiyappan, N. Steinbergs, S. Nowotarski, A.S. Hanson, R.A. Casero Jr., and P.M. Woster J. Med. Chem. 55 2012 7378
120. A. Abdulla, X. Zhao, and F. Yang J. Biochem. Pharm. Res. 1 2013 56
121. F. Forneris, C. Binda, A. Adamo, E. Battaglioli, and A. Mattevi J. Biol. Chem. 282 2007 20070
122. B. Dulla, K.T. Kirla, V. Rathore, G.S. Deora, S. Kavela, S. Maddika, K. Chatti, O. Reiser, J. Iqbal, and M. Pal Org. Biomol. Chem. 11 2013 3103
123. D. Willmann, S. Lim, S. Wetzel, E. Metzger, A. Jandausch, W. Wilk, M. Jung, I. Forne, A. Imhof, A. Janzer, J. Kirfel, H. Waldmann, R. Schule, and R. Buettner Int. J. Cancer 131 2012 2704
124. M.L. Schmitt, A.T. Hauser, L. Carlino, M. Pippel, J. Schulz-Fincke, E. Metzger, D. Willmann, T. Yiu, M. Barton, R. Schule, W. Sippl, and M. Jung J. Med. Chem. 56 2013 7334
125. N.R. Rose, S.S. Ng, J. Mecinovic, B.M. Lienard, S.H. Bello, Z. Sun, M.A. McDonough, U. Oppermann, and C.J. Schofield J. Med. Chem. 51 2008 7053
126. A. Thalhammer, J. Mecinovic, C. Loenarz, A. Tumber, N.R. Rose, T.D. Heightman, and C.J. Schofield Org. Biomol. Chem. 9 2011 127
127. L. Kruidenier, C.W. Chung, Z. Cheng, J. Liddle, K. Che, G. Joberty, M. Bantscheff, C. Bountra, A. Bridges, H. Diallo, D. Eberhard, S. Hutchinson, E. Jones, R. Katso, M. Leveridge, P.K. Mander, J. Mosley, C. Ramirez-Molina, P. Rowland, C.J. Schofield, R.J. Sheppard, J.E. Smith, C. Swales, R. Tanner, P. Thomas, A. Tumber, G. Drewes, U. Oppermann, D.J. Patel, K. Lee, and D.M. Wilson Nature 488 2012 404
128. Atkinson, S.J. Barker, M.D. Campbell, M. Humphreys, P. Liddle, J. Sheppard, R.J. Wilson, D.M. WO/2012/052390.
129. T. Suzuki, H. Ozasa, Y. Itoh, P. Zhan, H. Sawada, K. Mino, L. Walport, R. Ohkubo, A. Kawamura, M. Yonezawa, Y. Tsukada, A. Tumber, H. Nakagawa, M. Hasegawa, R. Sasaki, T. Mizukami, C.J. Schofield, and N. Miyata J. Med. Chem. 56 2013 7222
130. M. Sakurai, N.R. Rose, L. Schultz, A.M. Quinn, A. Jadhav, S.S. Ng, U. Oppermann, C.J. Schofield, and A. Simeonov Mol. Biosys. 6 2010 357
131. R. Sanchez, and M.M. Zhou Curr. Opin. Drug Discovery Dev. 12 2009 659
132. X.J. Yang BioEssays 26 2004 1076
133. S. Mujtaba, Y. He, L. Zeng, A. Farooq, J.E. Carlson, M. Ott, E. Verdin, and M.M. Zhou Mol. Cell 9 2002 575
134. P. Filippakopoulos, J. Qi, S. Picaud, Y. Shen, W.B. Smith, O. Fedorov, E.M. Morse, T. Keates, T.T. Hickman, I. Felletar, M. Philpott, S. Munro, M.R. McKeown, Y. Wang, A.L. Christie, N. West, M.J. Cameron, B. Schwartz, T.D. La Heightman, N. Thangue, C.A. French, O. Wiest, A.L. Kung, S. Knapp, and J.E. Bradner Nature 468 2010 1067
135. E. Nicodeme, K.L. Jeffrey, U. Schaefer, S. Beinke, S. Dewell, C.W. Chung, R. Chandwani, I. Marazzi, P. Wilson, H. Coste, J. White, J. Kirilovsky, C.M. Rice, J.M. Lora, R.K. Prinjha, K. Lee, and A. Tarakhovsky Nature 468 2010 1119
136. S.J. Nicholls, A. Gordon, J. Johannson, C.M. Ballantyne, P.J. Barter, H.B. Brewer, J.J. Kastelein, N.C. Wong, M.R. Borgman, and S.E. Nissen Cardiovasc. Drug Ther./Sponsored by the Int. Soc. Cardiovasc. Pharmacother. 26 2012 181
137. Bonetti, P. Boi, M. Ponzoni, M. Tibiletti, M. Stahis, A. Inghirami, G. Noel, K. Zucca, E. Bertoni, F. In 54th ASH Annual Meeting and Exposition, Atlanta, GA (December 8-11, 2012), 2012.
138. D.S. Hewings, M. Wang, M. Philpott, O. Fedorov, S. Uttarkar, P. Filippakopoulos, S. Picaud, C. Vuppusetty, B. Marsden, S. Knapp, S.J. Conway, and T.D. Heightman J. Med. Chem. 54 2011 6761
139. P. Bamborough, H. Diallo, J.D. Goodacre, L. Gordon, A. Lewis, J.T. Seal, D.M. Wilson, M.D. Woodrow, and C.W. Chung J. Med. Chem. 55 2012 587
140. M.A. Dawson, R.K. Prinjha, A. Dittmann, G. Giotopoulos, M. Bantscheff, W.I. Chan, S.C. Robson, C.W. Chung, C. Hopf, M.M. Savitski, C. Huthmacher, E. Gudgin, D. Lugo, S. Beinke, T.D. Chapman, E.J. Roberts, P.E. Soden, K.R. Auger, O. Mirguet, K. Doehner, R. Delwel, A.K. Burnett, P. Jeffrey, G. Drewes, K. Lee, B.J. Huntly, and T. Kouzarides Nature 478 2011 529
141. T. Ito, T. Umehara, K. Sasaki, Y. Nakamura, N. Nishino, T. Terada, M. Shirouzu, B. Padmanabhan, S. Yokoyama, A. Ito, and M. Yoshida Chem. Biol. 18 2011 495
142. P.V. Fish, P. Filippakopoulos, G. Bish, P.E. Brennan, M.E. Bunnage, A.S. Cook, O. Federov, B.S. Gerstenberger, H. Jones, S. Knapp, B. Marsden, K. Nocka, D.R. Owen, M. Philpott, S. Picaud, M.J. Primiano, M.J. Ralph, N. Sciammetta, and J.D. Trzupek J. Med. Chem. 55 2012 9831
143. J.M. Herold, T.J. Wigle, J.L. Norris, R. Lam, V.K. Korboukh, C. Gao, L.A. Ingerman, D.B. Kireev, G. Senisterra, M. Vedadi, A. Tripathy, P.J. Brown, C.H. Arrowsmith, J. Jin, W.P. Janzen, and S.V. Frye J. Med. Chem. 54 2011 2504 2511
144. L.I. James, D. Barsyte-Lovejoy, N. Zhong, L. Krichevsky, V.K. Korboukh, J.M. Herold, C.J. MacNevin, J.L. Norris, C.A. Sagum, W. Tempel, E. Marcon, H. Guo, C. Gao, X.P. Huang, S. Duan, A. Emili, J.F. Greenblatt, D.B. Kireev, J. Jin, W.P. Janzen, P.J. Brown, M.T. Bedford, C.H. Arrowsmith, and S.V. Frye Nat. Chem. Biol. 9 2013 184
145. L.I. James, V.K. Korboukh, L. Krichevsky, B.M. Baughman, J.M. Herold, J.L. Norris, J. Jin, D.B. Kireev, W.P. Janzen, C.H. Arrowsmith, and S.V. Frye J. Med. Chem. 56 2013 7358