Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 9, 2012, Pages 751-758

  Chen, Yan Ting ^a,b   Zang, Xue Feng ^a,b   Pan, Jie ^a,b   Zhu, Xiao Lei ^b,c   Chen, Fei ^b,d   Chen, Zhi Bin ^a,b   Xu, Yun ^a,b,c,d  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b NANJING UNIVERSITY   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Histone deacetylase; Neuroprotection; Stroke

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 6; SHORT HAIRPIN RNA; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; BRAIN ARTERY; BRAIN ISCHEMIA; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROKE; WESTERN BLOTTING;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; INFARCTION, MIDDLE CEREBRAL ARTERY; ISOENZYMES; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR TARGETED THERAPY; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; RNA INTERFERENCE; RNA, MESSENGER; STROKE;

EID: 84865590510     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2012.05729.x     Document Type: Article

References (52)

1. Thiagalingam S, Cheng KH, Lee HJ, Mineva N, Thiagalingam A, Ponte JF. Histone deacetylases: Unique players in shaping the epigenetic histone code. Ann. N.Y. Acad. Sci. 2003; 983: 84-100.
2. Gao L, Cueto MA, Asselbergs F, Atadja P. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 2002; 277: 25 748-55.
3. Zupkovitz G, Grausenburger R, Brunmeir R et al. The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol. Cell Biol. 2010; 30: 1171-81.
4. Yamaguchi T, Cubizolles F, Zhang Y et al. Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev. 2010; 24: 455-69.
5. Majdzadeh N, Wang L, Morrison BE, Bassel-Duby R, Olson EN, D'Mello SR. HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Dev. Neurobiol. 2008; 68: 1076-92.
6. Glenisson W, Castronovo V, Waltregny D. Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. Biochim. Biophys. Acta 2007; 1773: 1572-82.
7. Bolger TA, Yao TP. Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J. Neurosci. 2005; 25: 9544-53.
8. Chen B, Cepko CL. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 2009; 323: 256-9.
9. Chu F, Chou P, Mirkin BL, Mousa SA, Rebbaa A. Cellular conditioning with trichostatin a enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway. Aging Cell 2008; 7: 516-25.
10. Kwon S, Zhang Y, Matthias P. The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 2007; 21: 3381-94.
11. Matthias P, Yoshida M, Khochbin S. HDAC6 a new cellular stress surveillance factor. Cell Cycle 2008; 7: 7-10.
12. Zheng Q, Wang X. Autophagy and the ubiquitin-proteasome system in cardiac dysfunction. Panminerva Med. 2010; 52: 9-25.
13. Matsuoka H, Fujimura T, Hayashi M et al. Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression. Biochem. Pharmacol. 2007; 74: 465-76.
14. Georgopoulos K. From immunity to tolerance through HDAC. Nat. Immunol. 2009; 10: 13-14.
15. Grausenburger R, Bilic I, Boucheron N et al. Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J. Immunol. 2010; 185: 3489-97.
16. Ito K, Hanazawa T, Tomita K, Barnes PJ, Adcock IM. Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: Role of tyrosine nitration. Biochem. Biophys. Res. Commun. 2004; 315: 240-5.
17. Marumo T, Hishikawa K, Yoshikawa M, Hirahashi J, Kawachi S, Fujita T. Histone deacetylase modulates the proinflammatory and fibrotic changes in tubulointerstitial injury. Am. J. Physiol. Renal Physiol. 2010; 298: F133-41.
18. Lundh M, Christensen DP, Rasmussen DN et al. Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. Diabetologia 2010; 53: 2569-78.
19. Chuang DM, Leng Y, Marinova Z, Kim HJ, Chiu CT. Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci. 2009; 32: 591-601.
20. Kazantsev AG, Thompson LM. Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat. Rev. Drug Discov. 2008; 7: 854-68.
21. Frew AJ, Johnstone RW, Bolden JE. Enhancing the apoptotic and therapeutic effects of HDAC inhibitors. Cancer Lett. 2009; 280: 125-33.
22. van der Worp HB, van Gijn J. Clinical practice. Acute ischemic stroke. N. Engl. J. Med. 2007; 357: 572-9.
23. Zhang XH, Lei H, Liu AJ, Zou YX, Shen FM, Su DF. Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive rats. CNS Neurosci. Ther. 2011; 17: 590-8.
24. Xia W, Han J, Huang G, Ying W. Inflammation in ischaemic brain injury: Current advances and future perspectives. Clin. Exp. Pharmacol. Physiol. 2010; 37: 253-8.
25. Taylor JM, Crack PJ. Impact of oxidative stress on neuronal survival. Clin. Exp. Pharmacol. Physiol. 2004; 31: 397-406.
26. Langley B, Brochier C, Rivieccio MA. Targeting histone deacetylases as a multifaceted approach to treat the diverse outcomes of stroke. Stroke 2009; 40: 2899-905.
27. Langley B, D'Annibale MA, Suh K et al. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21 (waf1/cip1) in cell cycle-independent neuroprotection. J. Neurosci. 2008; 28: 163-76.
28. Faraco G, Pancani T, Formentini L et al. Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain. Mol. Pharmacol. 2006; 70: 1876-84.
29. Ryu H, Lee J, Olofsson BA et al. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc. Natl Acad. Sci. USA 2003; 100: 4281-6.
30. Ren M, Leng Y, Jeong M, Leeds PR, Chuang DM. Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: Potential roles of histone deacetylase inhibition and heat shock protein induction. J. Neurochem. 2004; 89: 1358-67.
31. Gibson CL, Murphy SP. Benefits of histone deacetylase inhibitors for acute brain injury: A systematic review of animal studies. J. Neurochem. 2010; 115: 806-13.
32. Bardai FH, D'Mello SR. Selective toxicity by HDAC3 in neurons. Regulation by Akt and GSK3beta. J. Neurosci. 2011; 31: 1746-51.
33. Xu Y, Zhang W, Klaus J et al. Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Proc. Natl Acad. Sci. USA 2006; 103: 14489-94.
34. Qian X, Li J, Ding J, Wang Z, Zhang W, Hu G. Erlotinib activates mitochondrial death pathways related to the production of reactive oxygen species in the human non-small cell lung cancer cell line A549. Clin. Exp. Pharmacol. Physiol. 2009; 36: 487-94.
35. Jia J, Guan D, Zhu W et al. Estrogen inhibits fas-mediated apoptosis in experimental stroke. Exp. Neurol. 2009; 215: 48-52.
36. Rivieccio MA, Brochier C, Willis DE et al. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc. Natl Acad. Sci. USA 2009; 106: 19.
37. Baltan S, Murphy SP, Danilov CA, Bachleda A, Morrison RS. Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. J. Neurosci. 2011; 31: 3990-9.
38. Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003; 115: 727-38.
39. Villagra A, Cheng F, Wang HW et al. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat. Immunol. 2009; 10: 92-100.
40. Bhaskara S, Knutson SK, Jiang G et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 2010; 18: 436-47.
41. Xia Y, Wang J, Liu TJ, Yung WK, Hunter T, Lu Z. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol. Cell 2007; 25: 219-32.
42. Hook SS, Orian A, Cowley SM, Eisenman RN. Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc. Natl Acad. Sci. USA 2002; 99: 13.
43. Hubbert C, Guardiola A, Shao R et al. HDAC6 is a microtubule-associated deacetylase. Nature 2002; 417: 455-8.
44. Matsuyama A, Shimazu T, Sumida Y et al. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 2002; 21: 6820-31.
45. 10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. J. Cell Sci. 2008; 121: 4079-88.
46. Su M, Shi JJ, Yang YP et al. HDAC6 regulates aggresome-autophagy degradation pathway of alpha-synuclein in response to MPP+-induced stress. J. Neurochem. 2011; 117: 112-20.
47. Boyault C, Zhang Y, Fritah S et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007; 21: 2172-81.
48. Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy 2007; 3: 643-5.
49. Pandey UB, Nie Z, Batlevi Y et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007; 447: 859-63.
50. Parmigiani RB, Xu WS, Venta-Perez G et al. HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc. Natl Acad. Sci. USA 2008; 105: 9633-8.
51. Liu H, Hu Q, D'Ercole AJ, Ye P. Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells. Glia 2009; 57: 1-12.
52. Buglio D, Khaskhely NM, Voo KS, Martinez-Valdez H, Liu YJ, Younes A. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood 2011; 117: 2910-17.