Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7222-7231

  Suzuki, Takayoshi ^a,b   Ozasa, Hiroki ^c   Itoh, Yukihiro ^a   Zhan, Peng ^a   Sawada, Hideyuki ^a   Mino, Koshiki ^d   Walport, Louise ^e   Ohkubo, Rei ^d   Kawamura, Akane ^e   Yonezawa, Masato ^f   Tsukada, Yuichi ^g   Tumber, Anthony ^h   Nakagawa, Hidehiko ^c   Hasegawa, Makoto ^d   Sasaki, Ryuzo ^d   Mizukami, Tamio ^d   Schofield, Christopher J ^e   Miyata, Naoki ^c  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF TOKYO   (Japan)

^g KYUSHU UNIVERSITY   (Japan)

^h UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (9 CYCLOHEPTYL N HYDROXYNONANAMIDO)PROPANOIC ACID; 3 (9 CYCLOHEXYL N HYDROXYNONANAMIDO)PROPANOIC ACID; 3 (9 CYCLOPENTYL N HYDROXYNONANAMIDO)PROPANOIC ACID; 3 (9 CYCLOPROPYL N HYDROXYNONANAMIDO)PROPANOIC ACID; 3 (N HYDROXY 9 PHENYLNONANAMIDO)PROPANOIC ACID; 3 (N HYDROXYDECANAMIDO)PROPANOIC ACID; 3 [HYDROXYL(10 METHYLUNDECANOYL)AMINO]PROPANOATE; HISTONE DEMETHYLASE; HYDROXAMIC ACID DERIVATIVE; LYSINE DERIVATIVE; METHYL 3 [HYDROXYL(10 METHYLUNDECANOYL)AMINO]PROPANOATE; TERT BUTYL 3 (9 CYCLOPROPYL N HYDROXYNONANAMIDO)PROPANOATE; TERT BUTYLL 3 (N BENZYLOXY 9 CYCLOPROPYLNONANAMIDO)PROPANOATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HISTONE DEMETHYLASES; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR;

EID: 84884997299     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400624b     Document Type: Article

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