Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8

Organic Letters

Volumn 15, Issue 2, 2013, Pages 414-417

  Williams, David E ^a   Dalisay, Doralyn S ^a,d   Li, Fengling ^b   Amphlett, James ^a   Maneerat, Wisanu ^a   Chavez, Miguel Angel Garcia ^a   Wang, Yan Alexander ^a   Matainaho, Teatulohi ^c   Yu, Wenyu ^b   Brown, Peter J ^b   Arrowsmith, Cheryl H ^b   Vedadi, Masoud ^b   Andersen, Raymond J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF PAPUA NEW GUINEA   (Papua New Guinea)

^d WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE LYSINE METHYLTRANSFERASE; NAHUOIC ACID A; POLYKETIDE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE; SEDIMENT; STREPTOMYCES;

GEOLOGIC SEDIMENTS; HISTONE-LYSINE N-METHYLTRANSFERASE; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLYKETIDES; STREPTOMYCES;

EID: 84872517716     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol303416k     Document Type: Article

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