Re-SET-ting heterochromatin by histone methyltransferases

Trends in Cell Biology

Volumn 11, Issue 6, 2001, Pages 266-273

  Jenuwein, Thomas ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; HISTONE; LYSINE; METHYLTRANSFERASE;

ACETYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; DROSOPHILA; GENE EXPRESSION; HETEROCHROMATIN; METHYLATION; MITOSIS; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; TRANSCRIPTION REGULATION;

EID: 0035371872     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02001-3     Document Type: Review

References (89)

1. Paro, R. (2000) Chromatin regulation. Formatting genetic text. Nature 406, 579-580
2. Orlando, V. and Paro, R. (1995) Chromatin multiprotein complexes involved in the maintenance of transcription patterns. Curr. Opin. Genet. Dev. 5, 174-179
3. Karpen, G. and Allshire, R.C. (1997) The case for epigenetic effects on centromere identity and function. Trends Genet. 13, 489-496
4. Jeppesen, P. and Turner, B.M. (1993) The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell 74, 281-289
5. Hendzel, M.J. et al. (1997) Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106, 348-360
6. Kornberg, R.D. (1974) Chromatin structure: a repeating unit of histones and DNA. Science 184, 868-871
7. Luger, K. et al. (1997) Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389, 251-260
8. Strahl, B.D. and Allis, C.D. (2000) The language of covalent histone modifications. Nature 403, 41-45
9. Turner, B.M. (2000) Histone acetylation and an epigenetic code. BioEssays 22, 836-845
10. Brownell, J.E. et al. (1996) Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84, 843-851
11. Taunton, J. et al. (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408-411
12. Hsu, J-Y. et al. (2000) Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell, 102, 279-291
13. Gary, J.D. and Clarke, S. (1998) RNA and protein interactions modulated by protein arginine methylation. Prog. Nucleic Acid Res. Mol. Biol. 61, 65-131
14. Chen, D. et al. (1999) Regulation of transcription by a protein methyltransferase. Science 284, 2174-2177
15. Desrosiers, R. and Tanguay, R.M. (1988) Methylation of Drosophila histones at proline, lysine and arginine residues during heat shock. J. Biol. Chem. 263, 4686-4692
16. Murray, K. (1964) The occurrence of ε-N-methyl lysine in histones. Biochemistry 3, 10-15
17. DeLange, R.J. et al. (1970) Calf thymus histone 3: sequences of the amino- and carboxy-terminal regions and of the regions containing lysyl residues modified by acetylation and methylation. Biochem. Biophys. Res. Commun. 40, 989-993
18. Sarnow, P. et al. (1981) A histone H4-specific methyltransferase. Properties, specificity and effects on nucleosomal histones. Biochim. Biophys. Acta 655, 349-358
19. Byvoet, P. et al. (1986) Effect of exogenous histone H5 on integration of histone H1 in rat liver chromatin. Correlations with aberrant ε-N-methylation of histone H1. Biochim. Biophys. Acta 867, 163-175
20. Franke, K. et al. (1998) Expression of murine H1 histone genes during postnatal development. Biochim. Biophys. Acta 1398, 232-242
21. Cheung, P. et al. (2000). Signalling to chromatin through histone modifications. Cell 103, 263-271
22. Byvoet, P. et al. (1972) The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cells. Arch. Biochem. Biophys. 148, 558-567
23. Hendzel, M.J. and Davie, J.R. (1989) Distribution of methylated histones and histone methyltransferases in chicken erythrocyte chromatin. J. Biol. Chem. 264, 19208-19214
24. Annunziato, A.T. et al. (1995) Relationship between methylation and acetylation of arginine-rich histones in cycling and arrested HeLa cells. Biochemistry 34, 2916-2924
25. Strahl, B.D. et al. (1999) Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Titrahymena. Proc. Natl. Acad. Sci. U. S. A. 96, 14967-14972
26. Roth, S.Y. et al. (2001) Histone acetyltransferases. Ann. Rev. Biochem. 70, 81-120
27. Rea, S. et al. (2000) Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-599
28. Tschiersch, B. et al. (1994) The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 13, 3822-3831
29. Zhang, X. et al. (2000) Crystal structure of the conserved core of protein arginine methyltransferase PRMT3. EMBO J. 19, 3509-3519
30. O'Carroll, D. et al. (2000) Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol. Cell. Biol. 20, 9423-9433
31. Milner, C.M. and Campbell, R.D. (1993) The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats. Biochem. J. 290, 811-818
32. Jenuwein, T. et al. (1998) SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell. Mol. Life Sci. 54, 80-93
33. Jones, R.S. and Gelbart, W.M. (1993) The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13, 6357-6366
34. Stassen, M.J. et al. (1995) The Drosophila trithorax protein contains a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech. Dev. 52, 209-223
35. Waring, P.M. and Cleary, M.L. (1997) Disruption of a homolog of trithorax by 11q23 translocations: leukemogenic and transcriptional implications. Curr. Top. Microbiol. Immunol. 220, 1-23
36. Huang, N. et al. (1998) Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators. EMBO J. 17, 3398-3412
37. Stec, I. et al. (1998) WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma. Hum. Mol. Genet. 7, 1071-1082
38. ε-methyltransferase. Protein Expres. Purif. 14, 104-112
39. Polevoda, B. et al. (2000) Cytochrome c methyltransferase, Ctm 1p, of yeast. J. Biol. Chem. 275, 20508-20513
40. Hendrich, B. and Bird, A. (1998) Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol. 18, 6538-6547
41. Huang, S. et al. (1998) The PR domain of the Rb-binding zinc finger protein RIZ is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. J. Biol. Chem. 273, 15933-15939
42. Cui, X. et al. (1998) Association of SET domain and myotubularin-related proteins modulates growth control. Nature Genet. 18, 331-337
43. Tripoulas, N. et al. (1996) The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes contains a SET domain and a PHD finger. Genetics 143, 913-928
44. Melcher, M. et al. (2000) Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation and mitotic progression. Mol. Cell. Biol. 20, 3728-3741
45. Aagaard, L. et al. (1999) Functional mammalian homologues of the Drosophila PEV modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 18, 1923-1938
46. Aagaard, L. et al. (2000) Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres. J. Cell Sci. 113, 817-829
47. Wallrath, L.L. (1998) Unfolding the mysteries of heterochromatin. Curr. Opin. Genet. Dev. 8, 147-153
48. Jones, D.A. et al. (2000) Mammalian chromodomain proteins: their role in genome organisation and expression. BioEssays 22, 124-127
49. Lachner, M. et al. (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature, 410 116-120
50. + disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J. Cell Sci. 109, 2637-2648
51. Ivanova, A.V. et al. (1998) The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Nature Genet. 19, 192-195
52. Platero, J.S. et al. (1995). Functional analysis of the chromo domain of HP-1. EMBO J. 14, 3977-3986
53. Dhalluin, C. et al. (1999) Structure and ligand of a histone acetyltransferase bromodomain. Nature 399, 491-496
54. II250 double bromodomain module. Science 288, 1422-1425
55. Bannister, A.J. et al. (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124
56. Brasher, S.V. et al. (2000) The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. EMBO J. 19, 1587-1597
57. Cowieson, N.P. et al. (2000) Dimerisation of a chromo shadow domain and distinctions from the chromodomain as revealed by structural analysis. Curr. Biol. 10, 517-525
58. Nakayama, J-I. et al. (2001) In vivo role of histone H3 lysine 9 methylation in a conserved pathway leading to heterochromatin assembly and epigenetic gene silencing. Science 292, 110-113
59. Firestein, R. et al. (2000) SET domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9. Mol. Cell. Biol. 20, 4900-4909
60. Kornberg, R.D. and Lorch, Y. (1999) Chromatin-modifying and -remodelling complexes. Curr Opin. Genet. Dev. 9, 148-151
61. Sassone-Corsi, P. et al. (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285, 886-891
62. Johnson, C.A. and Turner, B.M. (1999) Histone deacetylases: complex transducers of nuclear signals. Semin. Cell Dev. Biol. 10, 179-188
63. Murzina, N. et al. (1999) Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. Mol. Cell 4, 529-540
64. Murphy, T.D. and Karpen, G.H. (1998) Centromeres take flight: alpha satellite and the quest for the human centromere. Cell 93, 317-320
65. Csink, A.K. and Henikoff, S. (1998) Something from nothing: the evolution and utility of satellite repeats. Trends Genet. 14, 200-204
66. Taddei, A. et al. (2001) Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases in mammalian cells. Nat. Cell Biol. 3, 114-120
67. Heitz, E. (1928) Das Heterochromatin der Moose. Jhrb. wiss. Botanik 69, 762-818
68. Reuter, G. and Spierer, P. (1992) Position effect variegation and chromatin proteins. BioEssays 14, 605-612
69. Pidoux, A.L. and Allshire, R.C. (2000) Centromeres: getting a grip on chromosomes. Curr. Opin. Cell Biol. 12, 308-319
70. Cléard, F. et al. (1997) SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J. 16, 5280-5288
71. Ekwall, K. et al. (1997) Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres. Cell 91, 1021-1032
72. Ball, L.J. et al. (1997) Structure of the chromatin binding (chromo) domain from mouse modifier protein 1. EMBO J. 16, 2473-2481
73. Akhtar, A. et al. (2000) Chromodomains are protein-RNA interaction modules. Nature 407, 405-409
74. Bokar, J.A. et al. (1997) Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 3, 1233-1247
75. Brown, S.W. (1966) Heterochromatin. Science 151, 417-425
76. Williams, L. and Grafi, G. (2000) The retinoblastoma protein - a bridge to heterochromatin. Trends Plant Sci. 5, 239-240
77. Nielsen, A.L. et al. (1999) Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 18, 6385-6395
78. Vandel, L. and Trouche, D. (2001) Physical association between the histone acetyl transferase CBP and a histone methyl transferase. EMBO Reports 2, 21-26
79. Bird, A. and Wollfe, A.P. (1999) Methylation-induced repression - belts, braces, and chromatin. Cell 99, 451-454
80. Spencer, V.A. and Davie, J.R. (1999) Role of covalent modifications of histones in regulating gene expression. Gene 240, 1-12
81. Sullivan, K.F. et al. (1994) Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. J. Cell Biol. 127, 581-592
82. Costanzi, C. and Pehrson, J.R. (1998) Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature 393, 599-601
83. Zuckerkandl, E. (1974) A possible role of 'inert' heterochromatin in cell differentiation. Biochimie 56, 937-954
84. Prasad, R. et al. (1997) Structure and expression pattern of human ALR, a novel gene with strong homology to All-1 involved in acute leukemia and to Drosophila trithorax. Oncogene 15, 549-560
85. Nislow, C. et al. (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol. Biol. Cell 8, 2421-2436
86. Laible, G. et al. (1997) Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16, 3219-3232
87. Holdeman, R. et al. (1998) MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein. Development 125, 2457-2467
88. Goodrich, J. et al. (1997) A Polycomb-group gene regulates homeotic gene expression in Arabidopsis. Nature 386, 44-51
89. Yu, J. et al. (2000) Transcriptional repression by Blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol. Cell. Biol. 20, 2592-2603