The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response

FEBS Letters

Volumn 585, Issue 22, 2011, Pages 3549-3554

  Bernhard, Wendy ^a   Barreto, Kris ^a   Saunders, Amy ^a   Dahabieh, Matthew S ^a   Johnson, Pauline ^a   Sadowski, Ivan ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Molecular Epigenetics Group   (Canada)

Author keywords

Chaetocin; HDAC inhibitor; HIV 1; Latency; SUV39H1

Indexed keywords

CHETOCIN; HISTONE H3; METHYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ACETYLATION; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL CULTURE; CELL LINE; CELL VIABILITY; CELLULAR IMMUNITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LATENT PERIOD; LONG TERMINAL REPEAT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN METHYLATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS REACTIVATION;

ACETYLATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; DRUG SYNERGISM; HISTONE DEACETYLASE INHIBITORS; HISTONES; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; JURKAT CELLS; METHYLATION; METHYLTRANSFERASES; PIPERAZINES; REPRESSOR PROTEINS; T-LYMPHOCYTES; VIRUS ACTIVATION; VIRUS LATENCY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80855148233     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.10.018     Document Type: Article

References (25)

1. D. Bisgrove, M. Lewinski, F. Bushman, and E. Verdin Molecular mechanisms of HIV-1 proviral latency Expert Rev Anti Infect Ther 3 2005 805 814 (Pubitemid 41535402)
2. A.R. Sedaghat, R.F. Siliciano, and C.O. Wilke Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART BMC Infect Dis 8 2008 2
3. D.M. Margolis Eradication therapies for HIV Infection: time to begin again AIDS Res Hum Retroviruses 27 2011 347 353
4. G. Lehrman Depletion of latent HIV-1 infection in vivo: a proof-of-concept study Lancet 366 2005 549 555 (Pubitemid 41140329)
5. N.M. Archin, A. Espeseth, D. Parker, M. Cheema, D. Hazuda, and D.M. Margolis Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid AIDS Res Hum Retroviruses 25 2009 207 212
6. A.F. Victoriano Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression FEBS Lett 585 2011 1103 1111
7. S. Lin, Y. Zhang, H. Ying, and H. Zhu HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells Curr HIV Res 9 2011 202 208
8. I. Sadowski, P. Lourenco, and T. Malcolm Factors controlling chromatin organization and nucleosome positioning for establishment and maintenance of HIV latency Curr HIV Res 6 2008 286 295
9. D.M. Margolis Histone deacetylase inhibitors and HIV latency Curr Opin HIV AIDS 6 2011 25 29
10. J.C. Black, and J.R. Whetstine Chromatin landscape: methylation beyond transcription Epigenetics 6 2011 9 15
11. D. Greiner, T. Bonaldi, R. Eskeland, E. Roemer, and A. Imhof Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 Nat Chem Biol 1 2005 143 145
12. A. Lakshmikuttyamma, S.A. Scott, J.F. DeCoteau, and C.R. Geyer Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition Oncogene 29 2010 576 588
13. J. Chen, T. Malcolm, M.C. Estable, R.G. Roeder, and I. Sadowski TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF J Virol 79 2005 4396 4406 (Pubitemid 40388376)
14. T. Malcolm, J. Kam, P.S. Pour, and I. Sadowski Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus FEBS Lett 582 2008 3903 3908
15. T. Malcolm, J. Chen, C. Chang, and I. Sadowski Induction of chromosomally integrated HIV-1 LTR requires RBF-2 (USF/TFII-I) and Ras/MAPK signaling Virus Genes 35 2007 215 223 (Pubitemid 47087561)
16. B. Berkhout, and K.T. Jeang Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat J Virol 66 1992 139 149
17. J.M. Prins Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy AIDS 13 1999 2405 2410
18. Haas, A., Zimmermann, K. and Oxenius, A. (2011). Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection. J Virol. doi:10.1128/JVI.05607-11.
19. J.S. Mymryk, D. Berard, G.L. Hager, and T.K. Archer Mouse mammary tumor virus chromatin in human breast cancer cells is constitutively hypersensitive and exhibits steroid hormone-independent loading of transcription factors in vivo Mol Cell Biol 15 1995 26 34 (Pubitemid 24379897)
20. J. Friedman, W.K. Cho, C.K. Chu, K.S. Keedy, N.M. Archin, D.M. Margolis, and J. Karn Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2 J Virol 85 2011 9078 9089
21. J.K. Chan, and W.C. Greene NF-kappaB/Rel: agonist and antagonist roles in HIV-1 latency Curr Opin HIV AIDS 6 2011 12 18
22. C.R. Isham, J.D. Tibodeau, W. Jin, R. Xu, M.M. Timm, and K.C. Bible Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress Blood 109 2007 2579 2588 (Pubitemid 46425905)
23. R. Schreck, P. Rieber, and P.A. Baeuerle Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1 EMBO J 10 1991 2247 2258 (Pubitemid 21905698)
24. L.A. Pereira, K. Bentley, A. Peeters, M.J. Churchill, and N.J. Deacon A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter Nucleic Acids Res 28 2000 663 668 (Pubitemid 30068248)
25. K. Imai, H. Togami, and T. Okamoto Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294 J Biol Chem 285 2010 16538 16545