메뉴 건너뛰기




Volumn 8, Issue 5, 2013, Pages 1265-1276

Cannabinoids decrease the Th17 inflammatory autoimmune phenotype

Author keywords

Cannabinoid; EAE; Encephalitogenic T cells; IL 10; IL 17; IL 6

Indexed keywords

CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; DRONABINOL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SEROTONIN 1A RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VANILLOID RECEPTOR 1;

EID: 84891372183     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-013-9493-1     Document Type: Article
Times cited : (107)

References (72)
  • 1
    • 70349735887 scopus 로고    scopus 로고
    • Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNγ but have a spectrum of IL-17 profiles
    • 19692128 10.1016/j.jneuroim.2009.07.007 1:CAS:528:DC%2BD1MXht1Gmt7%2FF 2761534
    • Abromson-Leeman S, Bronson RT, Dorf ME (2009) Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNγ but have a spectrum of IL-17 profiles. J Neuroimmunol 215:10-24
    • (2009) J Neuroimmunol , vol.215 , pp. 10-24
    • Abromson-Leeman, S.1    Bronson, R.T.2    Dorf, M.E.3
  • 2
    • 79953697662 scopus 로고    scopus 로고
    • 5-HT and the immune system
    • 21393060 10.1016/j.coph.2011.02.004 1:CAS:528:DC%2BC3MXks1WqsrY%3D 3144148
    • Ahern GP (2011) 5-HT and the immune system. Curr Opin Pharmacol 11:29-33
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 29-33
    • Ahern, G.P.1
  • 4
    • 33847420442 scopus 로고    scopus 로고
    • Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis
    • 17329437 10.1523/JNEUROSCI.4814-06.2007 1:CAS:528:DC%2BD2sXjsVymsLY%3D
    • Benito C, Romero JP, Tolón RM, Clemente D, Docagne F, Hillard CJ, Guaza C, Romero J (2007) Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. J Neurosci 27:2396-2402
    • (2007) J Neurosci , vol.27 , pp. 2396-2402
    • Benito, C.1    Romero, J.P.2    Tolón, R.M.3    Clemente, D.4    Docagne, F.5    Hillard, C.J.6    Guaza, C.7    Romero, J.8
  • 5
    • 0019986548 scopus 로고
    • Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: Process of selection of lines and characterization of the cells
    • 6177753 1:STN:280:DyaL383hsFWisg%3D%3D
    • Ben-Nun A, Cohen IR (1982) Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. J Immunol 129:303-308
    • (1982) J Immunol , vol.129 , pp. 303-308
    • Ben-Nun, A.1    Cohen, I.R.2
  • 6
    • 0023879766 scopus 로고
    • Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma
    • 3126227 1:CAS:528:DyaL1cXhs1Gqtr8%3D
    • Billiau A, Heremans H, Vandekerckhove F, Dijkmans R, Sobis H, Meulepas E, Carton H (1988) Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J Immunol 140:1506-1510
    • (1988) J Immunol , vol.140 , pp. 1506-1510
    • Billiau, A.1    Heremans, H.2    Vandekerckhove, F.3    Dijkmans, R.4    Sobis, H.5    Meulepas, E.6    Carton, H.7
  • 7
    • 80051664599 scopus 로고    scopus 로고
    • Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
    • Booz GW (2011) Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med 1054-1061
    • (2011) Free Radic Biol Med , pp. 1054-1061
    • Booz, G.W.1
  • 8
    • 0034457826 scopus 로고    scopus 로고
    • Cell contact-mediated signaling of monocytes by stimulated T cells: A major pathway for cytokine induction
    • 11022117 1:CAS:528:DC%2BD3cXotFKqsLk%3D
    • Burger D (2000) Cell contact-mediated signaling of monocytes by stimulated T cells: a major pathway for cytokine induction. Eur Cytokine Netw 11:346-353
    • (2000) Eur Cytokine Netw , vol.11 , pp. 346-353
    • Burger, D.1
  • 9
    • 77952493930 scopus 로고    scopus 로고
    • Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors
    • 20098669 10.1371/journal.pone.0008688 2809084
    • Cencioni MT, Chiurchiù V, Catanzaro G, Borsellino G, Bernardi G, Battistini L, Maccarrone M (2010) Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. PLoS One 5:e8688
    • (2010) PLoS One , vol.5 , pp. 8688
    • Cencioni, M.T.1    Chiurchiù, V.2    Catanzaro, G.3    Borsellino, G.4    Bernardi, G.5    Battistini, L.6    MacCarrone, M.7
  • 10
    • 79954937143 scopus 로고    scopus 로고
    • The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: Evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells
    • 21310228 10.1016/j.bbi.2011.01.020 1:CAS:528:DC%2BC3MXltFOrtbs%3D
    • Correa F, Hernangómez-Herrero M, Mestre L, Loría F, Docagne F, Guaza C (2011) The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. Brain Behav Immun 25:736-749
    • (2011) Brain Behav Immun , vol.25 , pp. 736-749
    • Correa, F.1    Hernangómez-Herrero, M.2    Mestre, L.3    Loría, F.4    Docagne, F.5    Guaza, C.6
  • 13
    • 30344486638 scopus 로고    scopus 로고
    • Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    • 16400026 10.2353/ajpath.2006.050500 1:CAS:528:DC%2BD28XhtVKktr4%3D 1592672
    • El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI (2006) Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol 168:235-244
    • (2006) Am J Pathol , vol.168 , pp. 235-244
    • El-Remessy, A.B.1    Al-Shabrawey, M.2    Khalifa, Y.3    Tsai, N.T.4    Caldwell, R.B.5    Liou, G.I.6
  • 14
    • 82655189157 scopus 로고    scopus 로고
    • Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
    • 10.1371/journal.pone.0028668 22163051 10.1371/journal.pone.0028668 1:CAS:528:DC%2BC3MXhs1Kht73J 3230631
    • Esposito G, Scuderi C, Valenza M, Togna GI, Latina V, De Filippis D, Cipriano M, Carratù MR, Iuvone T, Steardo L (2011) Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement. PLoS One 6:e28668. doi: 10.1371/journal.pone.0028668
    • (2011) PLoS One , vol.6 , pp. 28668
    • Esposito, G.1    Scuderi, C.2    Valenza, M.3    Togna, G.I.4    Latina, V.5    De Filippis, D.6    Cipriano, M.7    Carratù, M.R.8    Iuvone, T.9    Steardo, L.10
  • 15
    • 77955489317 scopus 로고    scopus 로고
    • Anti-TNF therapy, from rationale to standard of care: What lessons has it taught us?
    • 20601610 10.4049/jimmunol.1090051 1:CAS:528:DC%2BC3cXotlymu78%3D
    • Feldmann M, Maini RN (2010) Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us? J Immunol 185:791-794
    • (2010) J Immunol , vol.185 , pp. 791-794
    • Feldmann, M.1    Maini, R.N.2
  • 16
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • 8598493 1:CAS:528:DyaK28XlsVGj
    • Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman L, Dalton D, Fathman CG (1996) Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156:5-7
    • (1996) J Immunol , vol.156 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3    Ridgway, W.4    Dinisco, C.5    Steinman, L.6    Dalton, D.7    Fathman, C.G.8
  • 17
    • 55149123753 scopus 로고    scopus 로고
    • Th17 cytokines and their emerging roles in inflammation and autoimmunity
    • 19161418 10.1111/j.1600-065X.2008.00712.x 1:CAS:528:DC%2BD1MXhsFGls77J
    • Fouser LA, Wright JF, Dunussi-Joannopoulos K, Collins M (2008) Th17 cytokines and their emerging roles in inflammation and autoimmunity. Immunol Rev 226:87-102
    • (2008) Immunol Rev , vol.226 , pp. 87-102
    • Fouser, L.A.1    Wright, J.F.2    Dunussi-Joannopoulos, K.3    Collins, M.4
  • 18
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • 16200070 10.1038/ni1254 1:CAS:528:DC%2BD2MXhtFamsb7J
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Weaver CT (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123-1132
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Weaver, C.T.6
  • 19
    • 79953658580 scopus 로고    scopus 로고
    • Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
    • 21483776 10.1371/journal.pone.0018281 1:CAS:528:DC%2BC3MXkvVekur0%3D 3069975
    • Hegde VL, Nagarkatti PS, Nagarkatti M (2011) Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol. PLoS One 6:e18281
    • (2011) PLoS One , vol.6 , pp. 18281
    • Hegde, V.L.1    Nagarkatti, P.S.2    Nagarkatti, M.3
  • 20
    • 0021929098 scopus 로고
    • Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: Fluorescence studies
    • 2983062 1:CAS:528:DyaL2MXktVSntL0%3D
    • Hillard CJ, Harris RA, Bloom AS (1985) Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: fluorescence studies. J Pharmacol Exp Ther 232:579-588
    • (1985) J Pharmacol Exp Ther , vol.232 , pp. 579-588
    • Hillard, C.J.1    Harris, R.A.2    Bloom, A.S.3
  • 21
    • 70349189518 scopus 로고    scopus 로고
    • Non-psychotropic plant cannabinoids: New therapeutic opportunities from an ancient herb
    • 19729208 10.1016/j.tips.2009.07.006 1:CAS:528:DC%2BD1MXhtFyqtbzF
    • Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R (2009) Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 30:515-527
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3    Di Marzo, V.4    Mechoulam, R.5
  • 22
    • 84876556444 scopus 로고    scopus 로고
    • Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells
    • 23637839 10.1371/journal.pone.0061462 1:CAS:528:DC%2BC3sXntVOisb0%3D 3634783
    • Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R, Gao F, Coppola G, Geschwind D, Vogel Z (2013) Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells. PLoS One 8:e61462
    • (2013) PLoS One , vol.8 , pp. 61462
    • Juknat, A.1    Pietr, M.2    Kozela, E.3    Rimmerman, N.4    Levy, R.5    Gao, F.6    Coppola, G.7    Geschwind, D.8    Vogel, Z.9
  • 23
    • 0042934012 scopus 로고    scopus 로고
    • Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes
    • 12805480 10.1124/jpet.103.051961 1:CAS:528:DC%2BD3sXmvVehtL8%3D
    • Kaplan BL, Rockwell CE, Kaminski NE (2003) Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. J Pharmacol Exp Ther 306:1077-1085
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 1077-1085
    • Kaplan, B.L.1    Rockwell, C.E.2    Kaminski, N.E.3
  • 24
  • 26
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • 16785554 1:CAS:528:DC%2BD28XlvV2ntbg%3D
    • Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y (2006) IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177:566-573
    • (2006) J Immunol , vol.177 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5    Kakuta, S.6    Sudo, K.7    Iwakura, Y.8
  • 27
    • 76249095734 scopus 로고    scopus 로고
    • Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NFkappaB and interferon-β/STAT proinflammatory pathways in BV-2 microglial cells
    • 19910459 10.1074/jbc.M109.069294 1:CAS:528:DC%2BC3cXjsVSntw%3D%3D 2804319
    • Kozela E, Pietr M, Juknat A, Rimmerman N, Levy R, Vogel Z (2010) Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NFkappaB and interferon-β/STAT proinflammatory pathways in BV-2 microglial cells. J Biol Chem 285:1616-1626
    • (2010) J Biol Chem , vol.285 , pp. 1616-1626
    • Kozela, E.1    Pietr, M.2    Juknat, A.3    Rimmerman, N.4    Levy, R.5    Vogel, Z.6
  • 28
    • 79960293903 scopus 로고    scopus 로고
    • Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
    • 21449980 10.1111/j.1476-5381.2011.01379.x 1:CAS:528:DC%2BC3MXps1Sis78%3D 3165959
    • Kozela E, Lev N, Kaushansky N, Eilam R, Rimmerman N, Levy R, Ben-Nun A, Juknat A, Vogel Z (2011) Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice. Br J Pharmacol 163:1507-1519
    • (2011) Br J Pharmacol , vol.163 , pp. 1507-1519
    • Kozela, E.1    Lev, N.2    Kaushansky, N.3    Eilam, R.4    Rimmerman, N.5    Levy, R.6    Ben-Nun, A.7    Juknat, A.8    Vogel, Z.9
  • 29
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
    • Lenercept Multiple Sclerosis Study Group, and the University of British Columbia MS/MRI Analysis Group 10.1212/WNL.53.3.457
    • Lenercept Multiple Sclerosis Study Group, and the University of British Columbia MS/MRI Analysis Group (1999) TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 53:457-465
    • (1999) Neurology , vol.53 , pp. 457-465
  • 31
    • 0031933496 scopus 로고    scopus 로고
    • The cytokine storm in multiple sclerosis
    • 9532586 10.1191/135245898678909141 1:CAS:528:DyaK1cXitVGrurs%3D
    • Link H (1998) The cytokine storm in multiple sclerosis. Mult Scler 4:12-15
    • (1998) Mult Scler , vol.4 , pp. 12-15
    • Link, H.1
  • 33
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • 10852536 10.1002/1531-8249(200006)47:6<707: AID-ANA3>3.0.CO;2-Q 1:STN:280:DC%2BD3czgvFektA%3D%3D
    • Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47:707-717
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 34
    • 0024596492 scopus 로고
    • Delta 9-tetrahydrocannabinol: A novel treatment for experimental autoimmune encephalomyelitis
    • 2542370 10.1016/0165-5728(89)90075-1 1:CAS:528:DyaL1MXktlegs7s%3D
    • Lyman WD, Sonett JR, Brosnan CF, Elkin R, Bornstein MB (1989) Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. J Neuroimmunol 23:73-81
    • (1989) J Neuroimmunol , vol.23 , pp. 73-81
    • Lyman, W.D.1    Sonett, J.R.2    Brosnan, C.F.3    Elkin, R.4    Bornstein, M.B.5
  • 35
    • 33645774927 scopus 로고    scopus 로고
    • Distribution of cannabinoid receptors in the central and peripheral nervous system
    • 16596779 10.1007/3-540-26573-2-10 1:CAS:528:DC%2BD2MXkvFeqsL0%3D
    • Mackie K (2005) Distribution of cannabinoid receptors in the central and peripheral nervous system. Handb Exp Pharmacol 168:299-325
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 299-325
    • MacKie, K.1
  • 36
    • 84862695017 scopus 로고    scopus 로고
    • Th17 cells: Biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies
    • 22640807 10.1016/j.ajpath.2012.03.044 1:CAS:528:DC%2BC38XhtFOitbbF
    • Maddur MS, Miossec P, Kaveri SV, Bayry J (2012) Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol 181:8-18
    • (2012) Am J Pathol , vol.181 , pp. 8-18
    • Maddur, M.S.1    Miossec, P.2    Kaveri, S.V.3    Bayry, J.4
  • 37
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • 10920191 10.1073/pnas.160105897 1:CAS:528:DC%2BD3cXmtVensbs%3D 16904
    • Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R, Feldmann M (2000) The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci 97:9561-9566
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3    Malik, A.S.4    Andreakos, E.5    Mechoulam, R.6    Feldmann, M.7
  • 39
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • 10335518 1:CAS:528:DyaK1MXjtFyms70%3D
    • Matusevicius D, Kivisäkk P, He B, Kostulas N, Ozenci V, Fredrikson S, Link H (1999) Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 5:101-104
    • (1999) Mult Scler , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisäkk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6    Link, H.7
  • 40
    • 18244396915 scopus 로고    scopus 로고
    • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    • 15845890 10.1161/01.STR.0000163083.59201.34
    • Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, Fujiwara M (2005) Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 36:1077-1082
    • (2005) Stroke , vol.36 , pp. 1077-1082
    • Mishima, K.1    Hayakawa, K.2    Abe, K.3    Ikeda, T.4    Egashira, N.5    Iwasaki, K.6    Fujiwara, M.7
  • 43
    • 0031822204 scopus 로고    scopus 로고
    • The role of macrophages in THC-induced alteration of the cytokine network
    • 9666273 10.1007/978-1-4615-5347-2-23 1:CAS:528:DyaK1cXmvFGksrw%3D
    • Newton C, Klein T, Friedman H (1998) The role of macrophages in THC-induced alteration of the cytokine network. Adv Exp Med Biol 437:207-214
    • (1998) Adv Exp Med Biol , vol.437 , pp. 207-214
    • Newton, C.1    Klein, T.2    Friedman, H.3
  • 44
    • 84867894231 scopus 로고    scopus 로고
    • Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors
    • 23059426 10.1038/nri3321 1:CAS:528:DC%2BC38XhsV2rs7fL 3584691
    • Oestreich KJ, Weinmann AS (2012) Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol 12:799-804
    • (2012) Nat Rev Immunol , vol.12 , pp. 799-804
    • Oestreich, K.J.1    Weinmann, A.S.2
  • 45
    • 77954175115 scopus 로고    scopus 로고
    • Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for modulation of inflammatory disease
    • 19833407 10.1016/j.imbio.2009.09.007
    • O'Sullivan SE, Kendall DA (2010) Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease. Immunobiology 215:611-616
    • (2010) Immunobiology , vol.215 , pp. 611-616
    • O'Sullivan, S.E.1    Kendall, D.A.2
  • 46
    • 0023221133 scopus 로고
    • Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
    • 3110648 10.1212/WNL.37.7.1097 1:STN:280:DyaL2s3lvVOksQ%3D%3D
    • Panitch HS, Hirsch RL, Schindler J, Johnson KP (1987) Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology 37:1097-1102
    • (1987) Neurology , vol.37 , pp. 1097-1102
    • Panitch, H.S.1    Hirsch, R.L.2    Schindler, J.3    Johnson, K.P.4
  • 48
    • 12744258029 scopus 로고    scopus 로고
    • Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
    • 15670612 10.1016/j.lfs.2004.10.025 1:CAS:528:DC%2BD2MXntVSksQ%3D%3D
    • Pertwee RG (2005) Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci 76:1307-1324
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 49
    • 0034023285 scopus 로고    scopus 로고
    • Interferon gamma production in blood lymphocytes correlates with disability score in multiple sclerosis patients
    • 10694841 1:STN:280:DC%2BD3c7mtFShtg%3D%3D
    • Petereit HF, Richter N, Pukrop R, Bamborschke S (2000) Interferon gamma production in blood lymphocytes correlates with disability score in multiple sclerosis patients. Mult Scler 6:19-23
    • (2000) Mult Scler , vol.6 , pp. 19-23
    • Petereit, H.F.1    Richter, N.2    Pukrop, R.3    Bamborschke, S.4
  • 50
    • 0033986604 scopus 로고    scopus 로고
    • Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells
    • 10594923 10.1002/(SICI)1098-1136(20000101)29:1<58: AID-GLIA6>3.0.CO;2-W 1:STN:280:DC%2BD3c%2Fmt1Orsg%3D%3D
    • Puffenbarger RA, Boothe AC, Cabral GA (2000) Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells. Glia 29:58-69
    • (2000) Glia , vol.29 , pp. 58-69
    • Puffenbarger, R.A.1    Boothe, A.C.2    Cabral, G.A.3
  • 51
    • 77954175124 scopus 로고    scopus 로고
    • Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
    • 19457575 10.1016/j.imbio.2009.04.001 1:CAS:528:DC%2BC3cXpsVCks70%3D 3005548
    • Rieder SA, Chauhan A, Singh U, Nagarkatti M, Nagarkatti P (2010) Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology 215:598-560
    • (2010) Immunobiology , vol.215 , pp. 598-560
    • Rieder, S.A.1    Chauhan, A.2    Singh, U.3    Nagarkatti, M.4    Nagarkatti, P.5
  • 52
    • 85027927333 scopus 로고    scopus 로고
    • The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells
    • 21533611 10.1007/s10571-011-9692-3 1:CAS:528:DC%2BC3MXps1Wit70%3D
    • Rimmerman N, Juknat A, Kozela E, Levy R, Bradshaw HB, Vogel Z (2011) The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells. Cell Mol Neurobiol 31:921-930
    • (2011) Cell Mol Neurobiol , vol.31 , pp. 921-930
    • Rimmerman, N.1    Juknat, A.2    Kozela, E.3    Levy, R.4    Bradshaw, H.B.5    Vogel, Z.6
  • 53
    • 84876549166 scopus 로고    scopus 로고
    • Cannabinoid signaling through non-CB1, -non-CB2 GPCR targets in microglia
    • M.E. Abood R.G. Sorensen N. Stella (eds) Springer New York 10.1007/978-1-4614-4669-9-7
    • Rimmerman N, Kozela E, Levy R, Vogel Z, Juknat A (2013) Cannabinoid signaling through non-CB1, -non-CB2 GPCR targets in microglia. In: Abood ME, Sorensen RG, Stella N (eds) Endocannabinoids: actions at non-CB1/CB2 cannabinoid receptors. Springer, New York, pp 143-171
    • (2013) Endocannabinoids: Actions at non-CB1/CB2 Cannabinoid Receptors , pp. 143-171
    • Rimmerman, N.1    Kozela, E.2    Levy, R.3    Vogel, Z.4    Juknat, A.5
  • 54
    • 0028245010 scopus 로고
    • Interleukin-10 prevents experimental allergic encephalomyelitis in rats
    • 7515815 10.1002/eji.1830240629 1:CAS:528:DyaK2cXkvVSltLs%3D
    • Rott O, Fleischer B, Cash E (1994) Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 24:1434-1440
    • (1994) Eur J Immunol , vol.24 , pp. 1434-1440
    • Rott, O.1    Fleischer, B.2    Cash, E.3
  • 56
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
    • 9862671 1:CAS:528:DyaK1cXotFWqs7c%3D
    • Samoilova EB, Horton JL, Hilliard B, Liu TS, Chen Y (1998) IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 161:6480-6486
    • (1998) J Immunol , vol.161 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Liu, T.S.4    Chen, Y.5
  • 57
    • 79960296602 scopus 로고    scopus 로고
    • Animal models for autoimmune and inflammatory diseases
    • J.E. Coligan A.M. Kruisbeek D.H. Margulies E.M. Shevach W. Strober (eds) John Wiley & Sons New York
    • Shevach EM (2011) Animal models for autoimmune and inflammatory diseases. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds) Current protocols in immunology. John Wiley & Sons, New York, pp 15.0.1-15.0.5
    • (2011) Current Protocols in Immunology , pp. 1501-1505
    • Shevach, E.M.1
  • 58
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • 8819477 1:CAS:528:DyaK28XmtVSjs74%3D
    • Showalter VM, Compton DR, Martin BR, Abood ME (1996) Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278:989-999
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 60
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • 15771584 10.1146/annurev.immunol.23.021704.115707 1:CAS:528: DC%2BD2MXktFOju7w%3D
    • Sospedra M, Martin R (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23:683-747
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 61
    • 33846966636 scopus 로고    scopus 로고
    • A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
    • 17290272 10.1038/nm1551 1:CAS:528:DC%2BD2sXhsVykuro%3D
    • Steinman L (2007) A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 13:139-145
    • (2007) Nat Med , vol.13 , pp. 139-145
    • Steinman, L.1
  • 62
    • 42449086335 scopus 로고    scopus 로고
    • Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice
    • 18362339 10.1073/pnas.0712131105 1:CAS:528:DC%2BD1cXksVCqt7k%3D 2278190
    • Stern JN, Keskin DB, Zhang H, Lv H, Kato Z, Strominger JL (2008) Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc Natl Acad Sci U S A 105:5172-5176
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5172-5176
    • Stern, J.N.1    Keskin, D.B.2    Zhang, H.3    Lv, H.4    Kato, Z.5    Strominger, J.L.6
  • 63
    • 77954177664 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: An overview
    • 20153077 10.1016/j.imbio.2009.12.005 1:CAS:528:DC%2BC3cXpsVCks7w%3D
    • Tanasescu R, Constantinescu CS (2010) Cannabinoids and the immune system: an overview. Immunobiology 215:588-597
    • (2010) Immunobiology , vol.215 , pp. 588-597
    • Tanasescu, R.1    Constantinescu, C.S.2
  • 64
    • 0034332949 scopus 로고    scopus 로고
    • Modulation of the IL-10/IL-12 cytokine circuit by interferon-beta inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis
    • 11063821 10.1016/S0165-5728(00)00384-2 1:CAS:528:DC%2BD3cXovVyltbo%3D
    • Tuohy VK, Yu M, Yin L, Mathisen PM, Johnson JM, Kawczak JA (2000) Modulation of the IL-10/IL-12 cytokine circuit by interferon-beta inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis. J Neuroimmunol 111:55-63
    • (2000) J Neuroimmunol , vol.111 , pp. 55-63
    • Tuohy, V.K.1    Yu, M.2    Yin, L.3    Mathisen, P.M.4    Johnson, J.M.5    Kawczak, J.A.6
  • 65
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • 16473830 10.1016/j.immuni.2006.01.001 1:CAS:528:DC%2BD28XitVOks7s%3D
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 67
    • 33646404921 scopus 로고    scopus 로고
    • Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
    • 16698671 10.1080/08916930500356674 1:CAS:528:DC%2BD28XktVyntrc%3D
    • Weiss L, Zeira M, Reich S, Har-Noy M, Mechoulam R, Slavin S, Gallily R (2006) Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity 39:143-151
    • (2006) Autoimmunity , vol.39 , pp. 143-151
    • Weiss, L.1    Zeira, M.2    Reich, S.3    Har-Noy, M.4    Mechoulam, R.5    Slavin, S.6    Gallily, R.7
  • 68
    • 0032928662 scopus 로고    scopus 로고
    • Remembering MOG: Autoantibody mediated demyelination in multiple sclerosis?
    • 9930860 10.1038/5514 1:STN:280:DyaK1M7ivVSmsg%3D%3D
    • Wekerle H (1999) Remembering MOG: autoantibody mediated demyelination in multiple sclerosis? Nat Med 5:153-154
    • (1999) Nat Med , vol.5 , pp. 153-154
    • Wekerle, H.1
  • 69
    • 0030587910 scopus 로고    scopus 로고
    • IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • 8871615 1:CAS:528:DyaK28Xmtlahtbw%3D
    • Willenborg DO, Fordham S, Bernard CC, Cowden WB, Ramshaw IA (1996) IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 157:3223-3227
    • (1996) J Immunol , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 70
    • 0035421324 scopus 로고    scopus 로고
    • Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE)
    • 11488634 10.1006/jaut.2001.0520 1:STN:280:DC%2BD3MvktlKgtg%3D%3D
    • Yura M, Takahashi I, Serada M, Koshio T, Nakagami K, Yuki Y, Kiyono H (2001) Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). J Autoimmun 17:17-25
    • (2001) J Autoimmun , vol.17 , pp. 17-25
    • Yura, M.1    Takahashi, I.2    Serada, M.3    Koshio, T.4    Nakagami, K.5    Yuki, Y.6    Kiyono, H.7
  • 71
    • 82755165048 scopus 로고    scopus 로고
    • Type i IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation
    • 22163016 10.1371/journal.pone.0028432 1:CAS:528:DC%2BC3MXhs1Khur7F 3232207
    • Zhang L, Yuan S, Cheng G, Guo B (2011) Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS One 6:e28432
    • (2011) PLoS One , vol.6 , pp. 28432
    • Zhang, L.1    Yuan, S.2    Cheng, G.3    Guo, B.4
  • 72
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • 17581537 10.1038/ni1488 1:CAS:528:DC%2BD2sXptlSkurw%3D
    • Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8:967-974
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6    Levy, D.E.7    Leonard, W.J.8    Littman, D.R.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.