-
1
-
-
0025954066
-
Ageing and Parkinson's Disease: Substantia Nigra Regional Selectivity
-
Fearnley J. M., Lees A. J.. Ageing and Parkinson's Disease: Substantia Nigra Regional Selectivity. Brain. 1991 ; 114: 2283-2301
-
(1991)
Brain
, vol.114
, pp. 2283-2301
-
-
Fearnley, J.M.1
Lees, A.J.2
-
2
-
-
79955727727
-
The Cholinergic System in Aging and Neuronal Degeneration
-
Schliebs R., Arendt T.. The Cholinergic System in Aging and Neuronal Degeneration. Behav. Brain Res. 2011 ; 221: 555-563
-
(2011)
Behav. Brain Res
, vol.221
, pp. 555-563
-
-
Schliebs, R.1
Arendt, T.2
-
3
-
-
0027480960
-
A Novel Gene Containing a Trinucleotide Repeat That Is Expanded and Unstable on Huntington's Disease Chromosomes
-
A Novel Gene Containing a Trinucleotide Repeat That Is Expanded and Unstable on Huntington's Disease Chromosomes. Cell. 1993 ; 72: 971-983
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
4
-
-
84858693790
-
Role of Mendelian Genes in "sporadic" Parkinson's Disease
-
Lesage S., Brice A.. Role of Mendelian Genes in "Sporadic" Parkinson's Disease. Parkinsonism Relat. Disord. 2012 ; 18: S66 - S70
-
(2012)
Parkinsonism Relat. Disord
, vol.18
-
-
Lesage, S.1
Brice, A.2
-
5
-
-
84865468329
-
The Genetics and Neuropathology of Alzheimer's Disease
-
Schellenberg G. D., Montine T. J.. The Genetics and Neuropathology of Alzheimer's Disease. Acta Neuropathol. 2012 ; 124: 305-323
-
(2012)
Acta Neuropathol
, vol.124
, pp. 305-323
-
-
Schellenberg, G.D.1
Montine, T.J.2
-
6
-
-
84860606785
-
Effective Pharmacological Management of Alzheimer's Disease
-
Atri A.. Effective Pharmacological Management of Alzheimer's Disease. Am. J. Manag. Care. 2011 ; 17: S346 - S355
-
(2011)
Am. J. Manag. Care
, vol.17
-
-
Atri, A.1
-
7
-
-
52949152728
-
Levodopa-Induced Dyskinesias and Their Management
-
Del S. F., Albanese A.. Levodopa-Induced Dyskinesias and Their Management. J. Neurol. 2008 ; 255: 32-41
-
(2008)
J. Neurol
, vol.255
, pp. 32-41
-
-
Del, S.F.1
Albanese, A.2
-
8
-
-
84861607313
-
New and Emerging Treatments for Alzheimer's Disease
-
Corbett A., Ballard C.. New and Emerging Treatments for Alzheimer's Disease. Expert. Opin. Emerg. Drugs. 2012 ; 17: 147-156
-
(2012)
Expert. Opin. Emerg. Drugs
, vol.17
, pp. 147-156
-
-
Corbett, A.1
Ballard, C.2
-
10
-
-
0034678055
-
Harnessing the Power of the Genome in the Search for New Antibiotics
-
Rosamond J., Allsop A.. Harnessing the Power of the Genome in the Search for New Antibiotics. Science. 2000 ; 287: 1973-1976
-
(2000)
Science
, vol.287
, pp. 1973-1976
-
-
Rosamond, J.1
Allsop, A.2
-
12
-
-
35948937147
-
Forty Years of Antipsychotic Drug Research - From Haloperidol to Paliperidone - With Dr. Paul Janssen
-
Awouters F. H., Lewi P. J.. Forty Years of Antipsychotic Drug Research - From Haloperidol to Paliperidone - with Dr. Paul Janssen. Arzneimittelforschung. 2007 ; 57: 625-632
-
(2007)
Arzneimittelforschung
, vol.57
, pp. 625-632
-
-
Awouters, F.H.1
Lewi, P.J.2
-
13
-
-
85044700023
-
Genomics and Drugs: An Interview Conducted by Holger Breithaupt and Caroline Hadley
-
Goodfellow P. N.. Genomics and Drugs: An Interview Conducted by Holger Breithaupt and Caroline Hadley. EMBO Rep. 2004 ; 5: 843-846
-
(2004)
EMBO Rep
, vol.5
, pp. 843-846
-
-
Goodfellow, P.N.1
-
14
-
-
0031152073
-
New Technologies for High-Throughput Screening
-
Burbaum J. J., Sigal N. H.. New Technologies for High-Throughput Screening. Curr. Opin. Chem. Biol. 1997 ; 1: 72-78
-
(1997)
Curr. Opin. Chem. Biol
, vol.1
, pp. 72-78
-
-
Burbaum, J.J.1
Sigal, N.H.2
-
15
-
-
77949300796
-
11C-PiB PET Assessment of Change in Fibrillar Amyloid-Beta Load in Patients with Alzheimer's Disease Treated with Bapineuzumab: A Phase 2, Double-Blind, Placebo-Controlled, Ascending-Dose Study
-
Rinne J. O., Brooks D. J., Rossor M. N., et al. 11C-PiB PET Assessment of Change in Fibrillar Amyloid-Beta Load in Patients with Alzheimer's Disease Treated with Bapineuzumab: A Phase 2, Double-Blind, Placebo-Controlled, Ascending-Dose Study. Lancet Neurol. 2010 ; 9: 363-372
-
(2010)
Lancet Neurol
, vol.9
, pp. 363-372
-
-
Rinne, J.O.1
Brooks, D.J.2
Rossor, M.N.3
-
18
-
-
78649849971
-
Antiepileptic Drug Therapy: The Story so Far
-
Brodie M. J.. Antiepileptic Drug Therapy: The Story So Far. Seizure. 2010 ; 19: 650-655
-
(2010)
Seizure
, vol.19
, pp. 650-655
-
-
Brodie, M.J.1
-
19
-
-
78649255346
-
Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms
-
Pruss R. M.. Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms. CNS Neurol. Disord. Drug Targets. 2010 ; 9: 693-700
-
(2010)
CNS Neurol. Disord. Drug Targets
, vol.9
, pp. 693-700
-
-
Pruss, R.M.1
-
20
-
-
84859107964
-
Cellular Models to Investigate Biochemical Pathways in Parkinson's Disease
-
Alberio T., Lopiano L., Fasano M.. Cellular Models to Investigate Biochemical Pathways in Parkinson's Disease. FEBS J. 2012 ; 279: 1146-1155
-
(2012)
FEBS J
, vol.279
, pp. 1146-1155
-
-
Alberio, T.1
Lopiano, L.2
Fasano, M.3
-
21
-
-
85056067711
-
High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model
-
Titus S. A., Southall N., Marugan J., et al. High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. Curr. Chem. Genom. 2012 ; 6: 79-86
-
(2012)
Curr. Chem. Genom
, vol.6
, pp. 79-86
-
-
Titus, S.A.1
Southall, N.2
Marugan, J.3
-
22
-
-
20844459490
-
Drug Library Screen to Identify Compounds That Decrease Secreted Abeta from a Human Cell Line
-
Chakrabarti E., Smith J. D.. Drug Library Screen to Identify Compounds That Decrease Secreted Abeta from a Human Cell Line. Curr. Alzheimer Res. 2005 ; 2: 255-259
-
(2005)
Curr. Alzheimer Res
, vol.2
, pp. 255-259
-
-
Chakrabarti, E.1
Smith, J.D.2
-
23
-
-
79951531007
-
The Diarylheptanoid (+)-aR,11S-myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule-Associated Protein tau
-
Jones J. R., Lebar M. D., Jinwal U. K., et al. The Diarylheptanoid (+)-aR,11S-myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule-Associated Protein tau. J. Nat. Prod. 2011 ; 74: 38-44
-
(2011)
J. Nat. Prod
, vol.74
, pp. 38-44
-
-
Jones, J.R.1
Lebar, M.D.2
Jinwal, U.K.3
-
25
-
-
63049135666
-
An in Vitro Screening Cascade to Identify Neuroprotective Antioxidants in ALS
-
Barber S. C., Higginbottom A., Mead R. J., et al. An In Vitro Screening Cascade to Identify Neuroprotective Antioxidants in ALS. Free Radic. Biol. Med. 2009 ; 46: 1127-1138
-
(2009)
Free Radic. Biol. Med
, vol.46
, pp. 1127-1138
-
-
Barber, S.C.1
Higginbottom, A.2
Mead, R.J.3
-
26
-
-
77949627096
-
Anti-inflammatory Effects of Synthetic Compound KT-14480 in Lipopolysaccharide-Stimulated Microglia Cells
-
Ock J., Suk K.. Anti-inflammatory Effects of Synthetic Compound KT-14480 in Lipopolysaccharide-Stimulated Microglia Cells. J. Pharm. Pharmacol. 2010 ; 62: 279-285
-
(2010)
J. Pharm. Pharmacol
, vol.62
, pp. 279-285
-
-
Ock, J.1
Suk, K.2
-
27
-
-
84865770337
-
An in Vitro Perspective on the Molecular Mechanisms Underlying Mutant huntingtin Protein Toxicity
-
Cisbani G., Cicchetti F.. An In Vitro Perspective on the Molecular Mechanisms Underlying Mutant huntingtin Protein Toxicity. Cell Death. Dis. 2012 ; 3: e382
-
(2012)
Cell Death. Dis
, vol.3
, pp. 382
-
-
Cisbani, G.1
Cicchetti, F.2
-
28
-
-
0030752709
-
Aggregation of huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
-
DiFiglia M., Sapp E., Chase K. O., et al. Aggregation of huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain. Science. 1997 ; 277: 1990-1993
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
Difiglia, M.1
Sapp, E.2
Chase, K.O.3
-
29
-
-
3142514201
-
Protein Aggregation and Neurodegenerative Disease
-
Ross C. A., Poirier M. A.. Protein Aggregation and Neurodegenerative Disease. Nat. Med. 2004 ; 10: S10 - S17
-
(2004)
Nat. Med
, vol.10
-
-
Ross, C.A.1
Poirier, M.A.2
-
30
-
-
0031255112
-
Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease
-
Hyman B. T., Trojanowski J. Q.. Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease. J. Neuropathol. Exp. Neurol. 1997 ; 56: 1095-1097
-
(1997)
J. Neuropathol. Exp. Neurol
, vol.56
, pp. 1095-1097
-
-
Hyman, B.T.1
Trojanowski, J.Q.2
-
31
-
-
0037174618
-
Alzheimer's Disease Is a Synaptic Failure
-
Selkoe D. J.. Alzheimer's Disease Is a Synaptic Failure. Science. 2002 ; 298: 789-791
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
32
-
-
0033394155
-
Memory and Mental Status Correlates of Modified Braak Staging
-
Grober E., Dickson D., Sliwinski M. J., et al. Memory and Mental Status Correlates of Modified Braak Staging. Neurobiol. Aging. 1999 ; 20: 573-579
-
(1999)
Neurobiol. Aging
, vol.20
, pp. 573-579
-
-
Grober, E.1
Dickson, D.2
Sliwinski, M.J.3
-
33
-
-
0037333666
-
Staging of Brain Pathology Related to Sporadic Parkinson's Disease
-
Braak H., Del T. K., Rub U., et al. Staging of Brain Pathology Related to Sporadic Parkinson's Disease. Neurobiol. Aging. 2003 ; 24: 197-211
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del, T.K.2
Rub, U.3
-
34
-
-
84867787595
-
Systematic Mutagenesis of Alpha-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
-
Burre J., Sharma M., Sudhof T. C.. Systematic Mutagenesis of Alpha-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities. J. Neurosci. 2012 ; 32: 15227-15242
-
(2012)
J. Neurosci
, vol.32
, pp. 15227-15242
-
-
Burre, J.1
Sharma, M.2
Sudhof, T.C.3
-
35
-
-
80053613574
-
Exogenous Alpha-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
-
Volpicelli-Daley L. A., Luk K. C., Patel T. P., et al. Exogenous Alpha-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death. Neuron. 2011 ; 72: 57-71
-
(2011)
Neuron
, vol.72
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Patel, T.P.3
-
36
-
-
81855204959
-
Age-Associated Neurodegeneration and Oxidative Damage to Lipids, Proteins and DNA
-
Radak Z., Zhao Z., Goto S., et al. Age-Associated Neurodegeneration and Oxidative Damage to Lipids, Proteins and DNA. Mol. Aspects Med. 2011 ; 32: 305-315
-
(2011)
Mol. Aspects Med
, vol.32
, pp. 305-315
-
-
Radak, Z.1
Zhao, Z.2
Goto, S.3
-
37
-
-
0034923434
-
Oxidative Damage Is the Earliest Event in Alzheimer Disease
-
Nunomura A., Perry G., Aliev G., et al. Oxidative Damage Is the Earliest Event in Alzheimer Disease. J. Neuropathol. Exp. Neurol. 2001 ; 60: 759-767
-
(2001)
J. Neuropathol. Exp. Neurol
, vol.60
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
-
38
-
-
62549133546
-
Neuroinflammation in Parkinson's Disease: A Target for Neuroprotection?
-
Hirsch E. C., Hunot S.. Neuroinflammation in Parkinson's Disease: A Target for Neuroprotection?. Lancet Neurol. 2009 ; 8: 382-397
-
(2009)
Lancet Neurol
, vol.8
, pp. 382-397
-
-
Hirsch, E.C.1
Hunot, S.2
-
39
-
-
53649103225
-
Identification of Small Molecule Inhibitors of Beta-Amyloid Cytotoxicity through a Cell-Based High-Throughput Screening Platform
-
Seyb K. I., Schuman E. R., Ni J., et al. Identification of Small Molecule Inhibitors of Beta-Amyloid Cytotoxicity through a Cell-Based High-Throughput Screening Platform. J. Biomol. Screen. 2008 ; 13: 870-878
-
(2008)
J. Biomol. Screen
, vol.13
, pp. 870-878
-
-
Seyb, K.I.1
Schuman, E.R.2
Ni, J.3
-
40
-
-
34247603516
-
A Cell-Based Model of Alpha-Synucleinopathy for Screening Compounds with Therapeutic Potential of Parkinson's Disease
-
Zhao D. L., Zou L. B., Zhou L. F., et al. A Cell-Based Model of Alpha-Synucleinopathy for Screening Compounds with Therapeutic Potential of Parkinson's Disease. Acta Pharmacol. Sin. 2007 ; 28: 616-626
-
(2007)
Acta Pharmacol. Sin
, vol.28
, pp. 616-626
-
-
Zhao, D.L.1
Zou, L.B.2
Zhou, L.F.3
-
41
-
-
77957240556
-
Development of a High-Throughput Screening Assay for Cytoprotective Agents in Rotenone-Induced Cell Death
-
Yoon I. S., Au Q., Barber J. R., et al. Development of a High-Throughput Screening Assay for Cytoprotective Agents in Rotenone-Induced Cell Death. Anal. Biochem. 2010 ; 407: 205-210
-
(2010)
Anal. Biochem
, vol.407
, pp. 205-210
-
-
Yoon, I.S.1
Au, Q.2
Barber, J.R.3
-
42
-
-
31644443193
-
A Yeast-Based Model of Alpha-Synucleinopathy Identifies Compounds with Therapeutic Potential
-
Griffioen G., Duhamel H., Van D. N., et al. A Yeast-Based Model of Alpha-Synucleinopathy Identifies Compounds with Therapeutic Potential. Biochim. Biophys. Acta. 2006 ; 1762: 312-318
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 312-318
-
-
Griffioen, G.1
Duhamel, H.2
Van, D.N.3
-
43
-
-
77949438990
-
Compounds from an Unbiased Chemical Screen Reverse Both ER-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models
-
Su L. J., Auluck P. K., Outeiro T. F., et al. Compounds from an Unbiased Chemical Screen Reverse Both ER-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models. Dis. Model. Mech. 2010 ; 3: 194-208
-
(2010)
Dis. Model. Mech
, vol.3
, pp. 194-208
-
-
Su, L.J.1
Auluck, P.K.2
Outeiro, T.F.3
-
44
-
-
67650559419
-
Chemicals Possessing a Neurotrophin-like Activity on Dopaminergic Neurons in Primary Culture
-
Schmidt F., Champy P., Seon-Meniel B., et al. Chemicals Possessing a Neurotrophin-like Activity on Dopaminergic Neurons in Primary Culture. PLoS One. 2009 ; 4: e6215
-
(2009)
PLoS One
, vol.4
, pp. 6215
-
-
Schmidt, F.1
Champy, P.2
Seon-Meniel, B.3
-
45
-
-
9244251118
-
Caenorhabditis elegans MPP+ Model of Parkinson's Disease for High-Throughput Drug Screenings
-
Braungart E., Gerlach M., Riederer P., et al. Caenorhabditis elegans MPP+ Model of Parkinson's Disease for High-Throughput Drug Screenings. Neurodegener. Dis. 2004 ; 1: 175-183
-
(2004)
Neurodegener. Dis
, vol.1
, pp. 175-183
-
-
Braungart, E.1
Gerlach, M.2
Riederer, P.3
-
46
-
-
77950637088
-
A Chemical Screen Identifies Novel Compounds That Overcome Glial-Mediated Inhibition of Neuronal Regeneration
-
Usher L. C., Johnstone A., Erturk A., et al. A Chemical Screen Identifies Novel Compounds That Overcome Glial-Mediated Inhibition of Neuronal Regeneration. J. Neurosci. 2010 ; 30: 4693-4706
-
(2010)
J. Neurosci
, vol.30
, pp. 4693-4706
-
-
Usher, L.C.1
Johnstone, A.2
Erturk, A.3
-
47
-
-
84872171503
-
Prevention of Beta-Amyloid Induced Toxicity in Human iPS Cell-Derived Neurons by Inhibition of Cyclin-Dependent Kinases and Associated Cell Cycle Events
-
Xu X., Lei Y., Luo J., et al. Prevention of Beta-Amyloid Induced Toxicity in Human iPS Cell-Derived Neurons by Inhibition of Cyclin-Dependent Kinases and Associated Cell Cycle Events. Stem Cell Res. 2013 ; 10: 213-227
-
(2013)
Stem Cell Res
, vol.10
, pp. 213-227
-
-
Xu, X.1
Lei, Y.2
Luo, J.3
-
48
-
-
84868506826
-
Discovery of Inhibitors of Microglial Neurotoxicity Acting through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay
-
Hoing S., Rudhard Y., Reinhardt P., et al. Discovery of Inhibitors of Microglial Neurotoxicity Acting through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay. Cell Stem Cell. 2012 ; 11: 620-632
-
(2012)
Cell Stem Cell
, vol.11
, pp. 620-632
-
-
Hoing, S.1
Rudhard, Y.2
Reinhardt, P.3
-
49
-
-
27744553546
-
Neuroprotection of MPTP-Induced Toxicity in Zebrafish Dopaminergic Neurons
-
McKinley E. T., Baranowski T. C., Blavo D. O., et al. Neuroprotection of MPTP-Induced Toxicity in Zebrafish Dopaminergic Neurons. Brain Res. Mol. Brain Res. 2005 ; 141: 128-137
-
(2005)
Brain Res. Mol. Brain Res
, vol.141
, pp. 128-137
-
-
McKinley, E.T.1
Baranowski, T.C.2
Blavo, D.O.3
-
50
-
-
84855904096
-
Brain-Derived Neurotrophic Factor and Alzheimer's Disease: Physiopathology and beyond
-
Diniz B. S., Teixeira A. L.. Brain-Derived Neurotrophic Factor and Alzheimer's Disease: Physiopathology and Beyond. Neuromolecular. Med. 2011 ; 13: 217-222
-
(2011)
Neuromolecular. Med
, vol.13
, pp. 217-222
-
-
Diniz, B.S.1
Teixeira, A.L.2
-
51
-
-
42149165684
-
Neurotrophic Factors as a Therapeutic Target for Parkinson's Disease
-
Evans J. R., Barker R. A.. Neurotrophic Factors as a Therapeutic Target for Parkinson's Disease. Expert. Opin. Ther. Targets. 2008 ; 12: 437-447
-
(2008)
Expert. Opin. Ther. Targets
, vol.12
, pp. 437-447
-
-
Evans, J.R.1
Barker, R.A.2
-
52
-
-
79958046634
-
Central Nervous System Remyelination in Culture - A Tool for Multiple Sclerosis Research
-
Zhang H., Jarjour A. A., Boyd A., et al. Central Nervous System Remyelination in Culture - A Tool for Multiple Sclerosis Research. Exp. Neurol. 2011 ; 230: 138-148
-
(2011)
Exp. Neurol
, vol.230
, pp. 138-148
-
-
Zhang, H.1
Jarjour, A.A.2
Boyd, A.3
-
53
-
-
3142521479
-
Stem Cell Therapy for Human Neurodegenerative Disorders: How to Make It Work
-
Lindvall O., Kokaia Z., Martinez-Serrano A.. Stem Cell Therapy for Human Neurodegenerative Disorders: How to Make It Work. Nat. Med. 2004 ; 10: S42 - S50
-
(2004)
Nat. Med
, vol.10
-
-
Lindvall, O.1
Kokaia, Z.2
Martinez-Serrano, A.3
-
54
-
-
79956217683
-
Translating Stem Cell Studies to the Clinic for CNS Repair: Current State of the Art and the Need for a Rosetta Stone
-
Aboody K., Capela A., Niazi N., et al. Translating Stem Cell Studies to the Clinic for CNS Repair: Current State of the Art and the Need for a Rosetta Stone. Neuron. 2011 ; 70: 597-613
-
(2011)
Neuron
, vol.70
, pp. 597-613
-
-
Aboody, K.1
Capela, A.2
Niazi, N.3
-
55
-
-
23244458855
-
Adult Neurogenesis in the Mammalian Central Nervous System
-
Ming G. L., Song H.. Adult Neurogenesis in the Mammalian Central Nervous System. Annu. Rev. Neurosci. 2005 ; 28: 223-250
-
(2005)
Annu. Rev. Neurosci
, vol.28
, pp. 223-250
-
-
Ming, G.L.1
Song, H.2
-
56
-
-
34548618221
-
A Phenotypic Small-Molecule Screen Identifies an Orphan Ligand-Receptor Pair That Regulates Neural Stem Cell Differentiation
-
Saxe J. P., Wu H., Kelly T. K., et al. A Phenotypic Small-Molecule Screen Identifies an Orphan Ligand-Receptor Pair That Regulates Neural Stem Cell Differentiation. Chem. Biol. 2007 ; 14: 1019-1030
-
(2007)
Chem. Biol
, vol.14
, pp. 1019-1030
-
-
Saxe, J.P.1
Wu, H.2
Kelly, T.K.3
-
57
-
-
84863069956
-
A Chemical Genomics Screen to Discover Genes That Modulate Neural Stem Cell Differentiation
-
Kim K. J., Wang J., Xu X., et al. A Chemical Genomics Screen to Discover Genes That Modulate Neural Stem Cell Differentiation. J. Biomol. Screen. 2012 ; 17: 129-139
-
(2012)
J. Biomol. Screen
, vol.17
, pp. 129-139
-
-
Kim, K.J.1
Wang, J.2
Xu, X.3
-
58
-
-
31044449947
-
A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells
-
Warashina M., Min K. H., Kuwabara T., et al. A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells. Angew. Chem. Int. Ed Engl. 2006 ; 45: 591-593
-
(2006)
Angew. Chem. Int. Ed Engl
, vol.45
, pp. 591-593
-
-
Warashina, M.1
Min, K.H.2
Kuwabara, T.3
-
59
-
-
78049296965
-
A Small Molecule Accelerates Neuronal Differentiation in the Adult Rat
-
Wurdak H., Zhu S., Min K. H., et al. A Small Molecule Accelerates Neuronal Differentiation in the Adult Rat. Proc. Natl. Acad. Sci. U. S. A. 2010 ; 107: 16542-16547
-
(2010)
Proc. Natl. Acad. Sci. U. S. A
, vol.107
, pp. 16542-16547
-
-
Wurdak, H.1
Zhu, S.2
Min, K.H.3
-
60
-
-
84866398196
-
A High-Throughput Screen for Wnt/beta-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors
-
Zhao W. N., Cheng C., Theriault K. M., et al. A High-Throughput Screen for Wnt/beta-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors. J. Biomol. Screen. 2012 ; 17: 1252-1263
-
(2012)
J. Biomol. Screen
, vol.17
, pp. 1252-1263
-
-
Zhao, W.N.1
Cheng, C.2
Theriault, K.M.3
-
61
-
-
77954266958
-
Discovery of a Proneurogenic, Neuroprotective Chemical
-
Pieper A. A., Xie S., Capota E., et al. Discovery of a Proneurogenic, Neuroprotective Chemical. Cell. 2010 ; 142: 39-51
-
(2010)
Cell
, vol.142
, pp. 39-51
-
-
Pieper, A.A.1
Xie, S.2
Capota, E.3
-
62
-
-
84857844315
-
Identification of Modulators of Hair Cell Regeneration in the Zebrafish Lateral Line
-
Namdaran P., Reinhart K. E., Owens K. N., et al. Identification of Modulators of Hair Cell Regeneration in the Zebrafish Lateral Line. J. Neurosci. 2012 ; 32: 3516-3528
-
(2012)
J. Neurosci
, vol.32
, pp. 3516-3528
-
-
Namdaran, P.1
Reinhart, K.E.2
Owens, K.N.3
-
63
-
-
77954142973
-
Drug Reprofiling Using Zebrafish Identifies Novel Compounds with Potential Pro-myelination Effects
-
Buckley C. E., Marguerie A., Roach A. G., et al. Drug Reprofiling Using Zebrafish Identifies Novel Compounds with Potential Pro-myelination Effects. Neuropharmacology. 2010 ; 59: 149-159
-
(2010)
Neuropharmacology
, vol.59
, pp. 149-159
-
-
Buckley, C.E.1
Marguerie, A.2
Roach, A.G.3
-
64
-
-
84870895081
-
Large-Scale Screening Using Familial Dysautonomia Induced Pluripotent Stem Cells Identifies Compounds That Rescue IKBKAP Expression
-
Lee G., Ramirez C. N., Kim H., et al. Large-Scale Screening Using Familial Dysautonomia Induced Pluripotent Stem Cells Identifies Compounds That Rescue IKBKAP Expression. Nat. Biotechnol. 2012 ; 30: 1244-1248
-
(2012)
Nat. Biotechnol
, vol.30
, pp. 1244-1248
-
-
Lee, G.1
Ramirez, C.N.2
Kim, H.3
-
65
-
-
0035289779
-
Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
-
Lipinski C. A., Lombardo F., Dominy B. W., et al. Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings. Adv. Drug Deliv. Rev. 2001 ; 46: 3-26
-
(2001)
Adv. Drug Deliv. Rev
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
-
66
-
-
84856405594
-
Going further Than Lipinski's Rule in Drug Design
-
Walters W. P.. Going further Than Lipinski's Rule in Drug Design. Expert. Opin. Drug Discov. 2012 ; 7: 99-107
-
(2012)
Expert. Opin. Drug Discov
, vol.7
, pp. 99-107
-
-
Walters, W.P.1
-
67
-
-
80053471789
-
The Influence of the "organizational Factor" on Compound Quality in Drug Discovery
-
Leeson P. D., St-Gallay S. A.. The Influence of the "Organizational Factor" on Compound Quality in Drug Discovery. Nat. Rev. Drug Discov. 2011 ; 10: 749-765
-
(2011)
Nat. Rev. Drug Discov
, vol.10
, pp. 749-765
-
-
Leeson, P.D.1
St-Gallay, S.A.2
-
68
-
-
61649109015
-
The Influence of Lead Discovery Strategies on the Properties of Drug Candidates
-
Keseru G. M., Makara G. M.. The Influence of Lead Discovery Strategies on the Properties of Drug Candidates. Nat. Rev. Drug Discov. 2009 ; 8: 203-212
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, pp. 203-212
-
-
Keseru, G.M.1
Makara, G.M.2
-
69
-
-
13844312649
-
ZINC - A Free Database of Commercially Available Compounds for Virtual Screening
-
Irwin J. J., Shoichet B. K.. ZINC - A Free Database of Commercially Available Compounds for Virtual Screening. J. Chem. Inf. Model. 2005 ; 45: 177-182
-
(2005)
J. Chem. Inf. Model
, vol.45
, pp. 177-182
-
-
Irwin, J.J.1
Shoichet, B.K.2
-
70
-
-
79955428497
-
The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics
-
Huang R., Southall N., Wang Y., et al. The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics. Sci. Transl. Med. 2011 ; 3 :
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Huang, R.1
Southall, N.2
Wang, Y.3
-
71
-
-
33947326869
-
What's Wrong with Drug Screening Today
-
Nolan G. P.. What's Wrong with Drug Screening Today. Nat. Chem. Biol. 2007 ; 3: 187-191
-
(2007)
Nat. Chem. Biol
, vol.3
, pp. 187-191
-
-
Nolan, G.P.1
-
73
-
-
0029981526
-
Neuropathology of Parkinson's Disease
-
Forno L. S.. Neuropathology of Parkinson's Disease. J. Neuropathol. Exp. Neurol. 1996 ; 55: 259-272
-
(1996)
J. Neuropathol. Exp. Neurol
, vol.55
, pp. 259-272
-
-
Forno, L.S.1
-
74
-
-
58249110796
-
Induced Pluripotent Stem Cells from a Spinal Muscular Atrophy Patient
-
Ebert A. D., Yu J., Rose F. F., et al. Induced Pluripotent Stem Cells from a Spinal Muscular Atrophy Patient. Nature. 2009 ; 457: 277-280
-
(2009)
Nature
, vol.457
, pp. 277-280
-
-
Ebert, A.D.1
Yu, J.2
Rose, F.F.3
-
75
-
-
84856956771
-
Probing Sporadic and Familial Alzheimer's Disease Using Induced Pluripotent Stem Cells
-
Israel M. A., Yuan S. H., Bardy C., et al. Probing Sporadic and Familial Alzheimer's Disease Using Induced Pluripotent Stem Cells. Nature. 2012 ; 482: 216-220
-
(2012)
Nature
, vol.482
, pp. 216-220
-
-
Israel, M.A.1
Yuan, S.H.2
Bardy, C.3
-
76
-
-
79952172335
-
LRRK2 Mutant iPSC-derived da Neurons Demonstrate Increased Susceptibility to Oxidative Stress
-
Nguyen H. N., Byers B., Cord B., et al. LRRK2 Mutant iPSC-derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress. Cell Stem Cell. 2011 ; 8: 267-280
-
(2011)
Cell Stem Cell
, vol.8
, pp. 267-280
-
-
Nguyen, H.N.1
Byers, B.2
Cord, B.3
-
77
-
-
84881415310
-
Disease Modeling and Drug Screening for Neurological Diseases Using Human Induced Pluripotent Stem Cells
-
Xu X. H., Zhong Z.. Disease Modeling and Drug Screening for Neurological Diseases Using Human Induced Pluripotent Stem Cells. Acta Pharmacol. Sin. 2013 ; 34: 755-764
-
(2013)
Acta Pharmacol. Sin
, vol.34
, pp. 755-764
-
-
Xu, X.H.1
Zhong, Z.2
-
78
-
-
79956153476
-
Cytometric Assessment of Mitochondria Using Fluorescent Probes
-
Cottet-Rousselle C., Ronot X., Leverve X., et al. Cytometric Assessment of Mitochondria Using Fluorescent Probes. Cytometry A. 2011 ; 79: 405-425
-
(2011)
Cytometry A
, vol.79
, pp. 405-425
-
-
Cottet-Rousselle, C.1
Ronot, X.2
Leverve, X.3
-
79
-
-
80054879885
-
Fluorescent and Luminescent Probes for Detection of Reactive Oxygen and Nitrogen Species
-
Chen X., Tian X., Shin I., et al. Fluorescent and Luminescent Probes for Detection of Reactive Oxygen and Nitrogen Species. Chem. Soc. Rev. 2011 ; 40: 4783-4804
-
(2011)
Chem. Soc. Rev
, vol.40
, pp. 4783-4804
-
-
Chen, X.1
Tian, X.2
Shin, I.3
-
80
-
-
33646229338
-
Multiparameter Measurement of Caspase 3 Activation and Apoptotic Cell Death in NT2 Neuronal Precursor Cells Using High-Content Analysis
-
Fennell M., Chan H., Wood A.. Multiparameter Measurement of Caspase 3 Activation and Apoptotic Cell Death in NT2 Neuronal Precursor Cells Using High-Content Analysis. J. Biomol. Screen. 2006 ; 11: 296-302
-
(2006)
J. Biomol. Screen
, vol.11
, pp. 296-302
-
-
Fennell, M.1
Chan, H.2
Wood, A.3
-
81
-
-
38349082689
-
Creation of Engineered Human Embryonic Stem Cell Lines Using phiC31 Integrase
-
Thyagarajan B., Liu Y., Shin S., et al. Creation of Engineered Human Embryonic Stem Cell Lines Using phiC31 Integrase. Stem Cells. 2008 ; 26: 119-126
-
(2008)
Stem Cells
, vol.26
, pp. 119-126
-
-
Thyagarajan, B.1
Liu, Y.2
Shin, S.3
-
82
-
-
78650586157
-
Generation of Induced Pluripotent Stem Cells Using Site-Specific Integration with Phage Integrase
-
Ye L., Chang J. C., Lin C., et al. Generation of Induced Pluripotent Stem Cells Using Site-Specific Integration with Phage Integrase. Proc. Natl. Acad. Sci. U. S. A. 2010 ; 107: 19467-19472
-
(2010)
Proc. Natl. Acad. Sci. U. S. A
, vol.107
, pp. 19467-19472
-
-
Ye, L.1
Chang, J.C.2
Lin, C.3
-
83
-
-
77956044325
-
Composite Primary Neuronal High-Content Screening Assay for Huntington's Disease Incorporating Non-cell-autonomous Interactions
-
Kaltenbach L. S., Bolton M. M., Shah B., et al. Composite Primary Neuronal High-Content Screening Assay for Huntington's Disease Incorporating Non-cell-autonomous Interactions. J. Biomol. Screen. 2010 ; 15: 806-819
-
(2010)
J. Biomol. Screen
, vol.15
, pp. 806-819
-
-
Kaltenbach, L.S.1
Bolton, M.M.2
Shah, B.3
-
84
-
-
84862217753
-
Quantifying Amyloid Beta (Abeta)-Mediated Changes in Neuronal Morphology in Primary Cultures: Implications for Phenotypic Screening
-
Nguyen L., Wright S., Lee M., et al. Quantifying Amyloid Beta (Abeta)-Mediated Changes in Neuronal Morphology in Primary Cultures: Implications for Phenotypic Screening. J. Biomol. Screen. 2012 ; 17: 835-842
-
(2012)
J. Biomol. Screen
, vol.17
, pp. 835-842
-
-
Nguyen, L.1
Wright, S.2
Lee, M.3
-
85
-
-
67649111551
-
An Overview of Cell Phenotypes in HCS: Limitations and Advantages
-
Gasparri F.. An Overview of Cell Phenotypes in HCS: Limitations and Advantages. Expert. Opin. Drug Discov. 2009 ; 4: 643-657
-
(2009)
Expert. Opin. Drug Discov
, vol.4
, pp. 643-657
-
-
Gasparri, F.1
-
86
-
-
79961166537
-
Finding Promiscuous Old Drugs for New Uses
-
Ekins S., Williams A. J.. Finding Promiscuous Old Drugs for New Uses. Pharm. Res. 2011 ; 28: 1785-1791
-
(2011)
Pharm. Res
, vol.28
, pp. 1785-1791
-
-
Ekins, S.1
Williams, A.J.2
-
87
-
-
84862001481
-
Adenosine Signaling Promotes Regeneration of Pancreatic Beta Cells in Vivo
-
Andersson O., Adams B. A., Yoo D., et al. Adenosine Signaling Promotes Regeneration of Pancreatic Beta Cells In Vivo. Cell Metab. 2012 ; 15: 885-894
-
(2012)
Cell Metab
, vol.15
, pp. 885-894
-
-
Andersson, O.1
Adams, B.A.2
Yoo, D.3
-
89
-
-
84857911138
-
Chemoproteomic Approaches to Drug Target Identification and Drug Profiling
-
Bantscheff M., Drewes G.. Chemoproteomic Approaches to Drug Target Identification and Drug Profiling. Bioorg. Med. Chem. 2012 ; 20: 1973-1978
-
(2012)
Bioorg. Med. Chem
, vol.20
, pp. 1973-1978
-
-
Bantscheff, M.1
Drewes, G.2
-
90
-
-
84855874154
-
Chemical Genetics-Based Target Identification in Drug Discovery
-
Cong F., Cheung A. K., Huang S. M.. Chemical Genetics-Based Target Identification in Drug Discovery. Annu. Rev. Pharmacol. Toxicol. 2012 ; 52: 57-78
-
(2012)
Annu. Rev. Pharmacol. Toxicol
, vol.52
, pp. 57-78
-
-
Cong, F.1
Cheung, A.K.2
Huang, S.M.3
-
91
-
-
0037596751
-
Synthetic Small Molecules That Control Stem Cell Fate
-
Ding S., Wu T. Y., Brinker A., et al. Synthetic Small Molecules That Control Stem Cell Fate. Proc. Natl. Acad. Sci. U. S. A. 2003 ; 100: 7632-7637
-
(2003)
Proc. Natl. Acad. Sci. U. S. A
, vol.100
, pp. 7632-7637
-
-
Ding, S.1
Wu, T.Y.2
Brinker, A.3
-
92
-
-
26444523139
-
Diverse Small-Molecule Modulators of SMN Expression Found by High-Throughput Compound Screening: Early Leads towards a Therapeutic for Spinal Muscular Atrophy
-
Jarecki J., Chen X., Bernardino A., et al. Diverse Small-Molecule Modulators of SMN Expression Found by High-Throughput Compound Screening: Early Leads towards a Therapeutic for Spinal Muscular Atrophy. Hum. Mol. Genet. 2005 ; 14: 2003-2018
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 2003-2018
-
-
Jarecki, J.1
Chen, X.2
Bernardino, A.3
-
93
-
-
58149146970
-
DcpS as a Therapeutic Target for Spinal Muscular Atrophy
-
Singh J., Salcius M., Liu S. W., et al. DcpS as a Therapeutic Target for Spinal Muscular Atrophy. ACS Chem. Biol. 2008 ; 3: 711-722
-
(2008)
ACS Chem. Biol
, vol.3
, pp. 711-722
-
-
Singh, J.1
Salcius, M.2
Liu, S.W.3
-
94
-
-
84890809759
-
-
Repligen Announces Licensing Agreement with Pfizer for Spinal Muscular Atrophy Program [press release]. January 3
-
Repligen Announces Licensing Agreement with Pfizer for Spinal Muscular Atrophy Program [press release].January3, 2013. http://www.repligen.com/sites/ default/files/news/pfizersmapartnershipfinal3jan12.pdf.
-
(2013)
-
-
-
95
-
-
63849172494
-
Identifying the Proteins to Which Small-Molecule Probes and Drugs Bind in Cells
-
Ong S. E., Schenone M., Margolin A. A., et al. Identifying the Proteins to Which Small-Molecule Probes and Drugs Bind in Cells. Proc. Natl. Acad. Sci. U. S. A. 2009 ; 106: 4617-4622
-
(2009)
Proc. Natl. Acad. Sci. U. S. A
, vol.106
, pp. 4617-4622
-
-
Ong, S.E.1
Schenone, M.2
Margolin, A.A.3
-
96
-
-
82355165009
-
Identifying Cellular Targets of Small-Molecule Probes and Drugs with Biochemical Enrichment and SILAC
-
Ong S. E., Li X., Schenone M., et al. Identifying Cellular Targets of Small-Molecule Probes and Drugs with Biochemical Enrichment and SILAC. Methods Mol. Biol. 2012 ; 803: 129-140
-
(2012)
Methods Mol. Biol
, vol.803
, pp. 129-140
-
-
Ong, S.E.1
Li, X.2
Schenone, M.3
-
97
-
-
19944432197
-
Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-Reactive Isobaric Tagging Reagents
-
Ross P. L., Huang Y. N., Marchese J. N., et al. Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-Reactive Isobaric Tagging Reagents. Mol. Cell Proteomics. 2004 ; 3: 1154-1169
-
(2004)
Mol. Cell Proteomics
, vol.3
, pp. 1154-1169
-
-
Ross, P.L.1
Huang, Y.N.2
Marchese, J.N.3
-
98
-
-
34948875686
-
Quantitative Chemical Proteomics Reveals Mechanisms of Action of Clinical ABL Kinase Inhibitors
-
Bantscheff M., Eberhard D., Abraham Y., et al. Quantitative Chemical Proteomics Reveals Mechanisms of Action of Clinical ABL Kinase Inhibitors. Nat. Biotechnol. 2007 ; 25: 1035-1044
-
(2007)
Nat. Biotechnol
, vol.25
, pp. 1035-1044
-
-
Bantscheff, M.1
Eberhard, D.2
Abraham, Y.3
-
99
-
-
33749335282
-
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
-
Lamb J., Crawford E. D., Peck D., et al. The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease. Science. 2006 ; 313: 1929-1935
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
-
100
-
-
84870326718
-
Applications of Connectivity Map in Drug Discovery and Development
-
Qu X. A., Rajpal D. K.. Applications of Connectivity Map in Drug Discovery and Development. Drug Discov. Today. 2012 ; 17: 1289-1298
-
(2012)
Drug Discov. Today
, vol.17
, pp. 1289-1298
-
-
Qu, X.A.1
Rajpal, D.K.2
-
101
-
-
84861388460
-
A Chemical Genetic Approach Identifies Piperazine Antipsychotics as Promoters of CNS Neurite Growth on Inhibitory Substrates
-
Johnstone A. L., Reierson G. W., Smith R. P., et al. A Chemical Genetic Approach Identifies Piperazine Antipsychotics as Promoters of CNS Neurite Growth on Inhibitory Substrates. Mol. Cell Neurosci. 2012 ; 50: 125-135
-
(2012)
Mol. Cell Neurosci
, vol.50
, pp. 125-135
-
-
Johnstone, A.L.1
Reierson, G.W.2
Smith, R.P.3
-
102
-
-
33847258674
-
Discovery and Development of SAHA as an Anticancer Agent
-
Marks P. A.. Discovery and Development of SAHA as an Anticancer Agent. Oncogene. 2007 ; 26: 1351-1356
-
(2007)
Oncogene
, vol.26
, pp. 1351-1356
-
-
Marks, P.A.1
-
103
-
-
0032539890
-
A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases
-
Richon V. M., Emiliani S., Verdin E., et al. A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases. Proc. Natl. Acad. Sci. U. S. A. 1998 ; 95: 3003-3007
-
(1998)
Proc. Natl. Acad. Sci. U. S. A
, vol.95
, pp. 3003-3007
-
-
Richon, V.M.1
Emiliani, S.2
Verdin, E.3
-
104
-
-
30344477367
-
Histone Deacetylase Inhibitors and the Promise of Epigenetic (and More) Treatments for Cancer
-
Minucci S., Pelicci P. G.. Histone Deacetylase Inhibitors and the Promise of Epigenetic (and More) Treatments for Cancer. Nat. Rev. Cancer. 2006 ; 6: 38-51
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
|