Pathologic lesions in neurodegenerative diseases

Progress in Molecular Biology and Translational Science

Volumn 107, Issue , 2012, Pages 1-40

  Thompson, Paul M ^a   Vinters, Harry V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyloid ligands; Brain amyloid; Dementia; Keywords; MRI; Neuroimaging; Neuropathology; PET; Scanning

Indexed keywords

EID: 84859581618     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385883-2.00009-6     Document Type: Chapter

References (126)

1. G.G. Kovacs, and H. Budka Current concepts of neuropathological diagnostics in practice: neurodegenerative diseases Clin Neuropathol 29 2010 271 288
2. D.L. Wolfe To see for one's self. The art of autopsy has a long history and an uncertain figure Am Sci 98 2010 228 235
3. M. Goedert, and B. Ghetti Alois Alzheimer: his life and times Brain Pathol 17 2007 57 62
4. H.V. Vinters, M.A. Farrell, P.S. Mischel, and K.H. Anders Diagnostic neuropathology 1998 Marcel Dekker New York pp. 453-507
5. 11 C]PIB in a nondemented population. Potential antecedent marker of Alzheimer disease Neurology 67 2006 446 452 (Pubitemid 44214969)
6. G.W. Small, S. Komo, A. LaRue, S. Saxena, M.E. Phelps, J.C. Mazziotta, A.M. Saunders, J.L. Haines, M.A. Pericak-Vance, and A.D. Roses Early detection of Alzheimer's disease by combining apolipoprotein E and neuroimaging Ann N Y Acad Sci 802 1996 70 78 (Pubitemid 27055501)
7. G.W. Small, V. Kepe, L.M. Ercoli, P. Siddarth, S.Y. Bookheimer, K.J. Miller, H. Lavretsky, A.C. Burggren, G.M. Cole, H.V. Vinters, P.M. Thompson, S.-C. Huang, N. Satyamurthy, M.E. Phelps, and J.R. Barrio PET of brain amyloid and tau in mild cognitive impairment N Engl J Med 355 2006 2652 2663 (Pubitemid 44969124)
8. H.V. Vinters Imaging cerebral microvascular amyloid Ann Neurol 62 2007 209 212 (Pubitemid 47525395)
9. H.W. Querfurth, and F.M. LaFerla Alzheimer's disease N Engl J Med 362 2010 329 344
10. G.G. Kovacs, G. Botond, and H. Budka Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics Acta Neuropathol 119 2010 389 408
11. C.L. Joachim, J.H. Morris, and D.J. Selkoe Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases Ann Neurol 24 1988 50 56
12. H. Braak, and E. Braak Neuropathological staging of Alzheimer related changes Acta Neuropathol 82 1991 239 259
13. P.M. Thompson, K.M. Hayashi, G. de Zubicaray, A.L. Janke, S.E. Rose, and J. Semple Dynamics of gray matter loss in Alzheimer's disease J Neurosci 23 3 2003 994 1005 (Pubitemid 36206191)
14. M.N. Braskie, A.D. Klunder, K.M. Hayashi, H. Protas, V. Kepe, K.J. Miller, S.C. Huang, J.R. Barrio, L.M. Ercoli, P. Siddarth, N. Satyamurthy, J. Liu, A.W. Toga, S.Y. Bookheimer, G.W. Small, and P.M. Thompson Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease Neurobiol Aging 31 10 2010 1669 1678 [Epub 2008 Nov 11]
15. B. Reisberg, E.H. Franssen, S.M. Hasan, I. Monteiro, I. Boksay, and L.E. Souren Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer's and other dementing processes Eur Arch Psychiatry Clin Neurosci 249 Suppl. 3 1999 28 36
16. J.L. Conel The postnatal development of the human cerebral cortex: VIII: the cortex of the six-year child vol. VIII 1967 Harvard University Press Cambridge
17. P.I. Yakovlev, and A.R. Lecours Regional development of the brain in early life 1967 Blackwell Scientific Publications Boston
18. M. Mesulam Brain, mind, and the evolution of connectivity Brain Cogn 42 2000 4 6 (Pubitemid 30193452)
19. G. Bartzokis, P.H. Lu, and J. Mintz Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's disease J Alzheimers Dis 6 2004 S53 S59
20. N. Gogtay, J.N. Giedd, L. Lusk, K.M. Hayashi, D. Greenstein, and A.C. Vaituzis Dynamic mapping of human cortical development during childhood through early adulthood Proc Natl Acad Sci USA 101 21 2004 8174 8179 (Pubitemid 38698073)
21. H. Braak, E. Braak, I. Grundke-Iqbal, and K. Iqbal Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques Neurosci Lett 65 1986 351 355 (Pubitemid 16109665)
22. H. Braak, C. Duyckaerts, E. Braak, and F. Piette Neuropathological staging of Alzheimer-related changes with psychometrically assessed intellectual status B. Corain, K. Iqbal, M. Nicolini, B. Winblad, H. Wisniewski, P. Zatta, Alzheimer's disease: advances in clinical and basic research 1993 Wiley Chichester 131 137
23. D.W. Dickson The pathogenesis of senile plaques J Neuropathol Exp Neurol 56 1997 321 339 (Pubitemid 27465015)
24. G. Blessed, B.E. Tomlinson, and M. Roth The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects Br J Psychiatry 117 1968 797 811
25. D.J. Berlau, K. Kahle-Wrobleski, E. Head, M. Goodus, R. Kim, and C. Kawas Dissociation of neuropathologic findings and cognition. Case report of an apolipoprotein E epsi2/epsi2 genotype Arch Neurol 64 2007 1193 1196 (Pubitemid 47258081)
26. D.W. Dickson Neurodegeneration: the molecular pathology of dementia and movement disorders 2003 ISN Press Basel 414p
27. H.V. Vinters, D.L. Secor, S.L. Read, J.G. Frazee, U. Tomiyasu, T.M. Stanley, J.A. Ferreiro, and M.A. Akers Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: an immunohistochemical and ultrastructural study Ultrastruct Pathol 18 1994 333 348 (Pubitemid 24184171)
28. H. Braak, and E. Braak Neuropil threads occur in the dendrites of tangle-bearing nerve cells Neuropathol Appl Neurobiol 14 1988 39 44
29. K. Wisniewski, G.A. Jervis, R.C. Moretz, and H.W. Wisniewski Alzheimer neurofibrillary tangles in disease other than senile and presenile dementia Ann Neurol 5 1979 288 294 (Pubitemid 9135416)
30. P.S. Mischel, L.P. Nguyen, and H.V. Vinters Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system J Neuropathol Exp Neurol 54 1995 137 153
31. T. Duong, M.J. DeRosa, V. Poukens, H.V. Vinters, and R.S. Fisher Neuronal cytoskeletal abnormalities in human cerebral cortical dysplasia Acta Neuropathol 87 1994 493 503 (Pubitemid 24128977)
32. H.V. Vinters Cerebral amyloid angiopathy. A critical review Stroke 18 1987 311 324 (Pubitemid 17059655)
33. G.G. Glenner, and C.W. Wong Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein Biochem Biophys Res Commun 120 1984 885 890 (Pubitemid 14104991)
34. (b) J.D. Sipe, M.D. Benson, J.N. Buxbaum, S. Ikeda, G. Merlini, M.J.M. Saraiva, and P. Westermark Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis Amyloid J Protein Folding Disord 17 2010 101 104
35. H.V. Vinters, and J.J. Gilbert Cerebral amyloid angiopathy: incidence and complications in the aging brain, II: the distribution of amyloid vascular changes Stroke 14 1983 924 928 (Pubitemid 14205243)
36. T. Miyakawa, T. Kimura, S. Hirata, N. Fujise, T. Ono, K. Ishizuka, and J. Nakabayashi Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease Ann NY Acad Sci 903 2000 46 54 (Pubitemid 30251539)
37. V. Soontornniyomkij, C. Choi, J. Pomakian, and H.V. Vinters High-definition characterization of cerebral beta-amyloid angiopathy in Alzheimer's disease Hum Pathol 41 2010 1601 1608
38. R.O. Weller, D. Boche, and J.A.R. Nicoll Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy Acta Neuropathol 118 2009 87 102
39. J.S. Miners, P. Kehoe, and S. Love Neprilysin protects against cerebral amyloid -angiopathy and ABeta-induced degeneration of cerebrovascular smooth muscle cells Brain Pathol 21 2011 594 605 doi: 10.1111/j.1750-3639.2011.00486.x
40. S.X. Zhang-Nunes, M.L.C. Maat-Schieman, S.G. van Duinen, R.A.C. Roos, M.P. Frosch, and S.M. Greenberg The cerebral beta-amyloid angiopathies: hereditary and sporadic Brain Pathol 16 2006 30 39
41. V. Soontornniyomkij, M.D. Lynch, S. Mermash, J. Pomakian, H. Badkoobehi, R. Clare, and H.V. Vinters Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy Brain Pathol 20 2010 459 467
42. R. Clare, V.G. King, M. Wirenfeldt, and H.V. Vinters Synapse loss in dementias J Neurosci Res 88 2010 2083 2090
43. R.D. Terry, E. Masliah, D.P. Salmon, N. Butters, and R. DeTeresa Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment Ann Neurol 30 1991 572 580
44. P. Davidsson, and K. Blennow Neurochemical dissection of synaptic pathology in Alzheimer's disease Int Psychogeriatr 10 1998 11 23 (Pubitemid 28284556)
45. C. Fu, D.J. Chute, E.S. Farag, J. Garakian, J.L. Cummings, and H.V. Vinters Comorbidity in dementia - an autopsy study Arch Pathol Lab Med 128 2004 32 38
46. M. Gearing, S.S. Mirra, J.C. Hedreen, S.M. Sumi, L.A. Hansen, and A. Heyman The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease Neurology 45 1995 461 466
47. H.V. Vinters, W.G. Ellis, C. Zarow, B.W. Zaias, W.J. Jagust, W.J. Mack, and H.C. Chui Neuropathologic substrates of ischemic vascular dementia J Neuropathol Exp Neurol 59 2000 931 945
48. O.A. Selnes, and H.V. Vinters Vascular cognitive impairment Nat Clin Pract Neurol 2 2006 538 547 (Pubitemid 44445810)
49. L.A. Beckett, D.J. Harvey, A. Gamst, M. Donohue, J. Kornak, H. Zhang, and J.H. Kuo The Alzheimer's Disease Neuroimaging Initiative: annual change in biomarkers and clinical outcomes Alzheimers Dement 6 3 2010 257 264
50. R.C. Petersen, J.E. Parisi, D.W. Dickson, K.A. Johnson, D.S. Knopman, and B.F. Boeve Neuropathologic features of amnestic mild cognitive impairment Arch Neurol 63 2006 665 672
51. J.T. Becker, S.W. Davis, K.M. Hayashi, C.C. Meltzer, A.W. Toga, and O.L. Lopez Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment Arch Neurol 63 1 2006 97 101 (Pubitemid 43063867)
52. S. Bell-McGinty, M.A. Butters, C.C. Meltzer, P.J. Greer, C.F. Reynolds 3rd, and J.T. Becker Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration Am J Psychiatry 159 8 2002 1424 1427 (Pubitemid 34832728)
53. P.M. Thompson, K.M. Hayashi, G.I. de Zubicaray, A.L. Janke, S.E. Rose, J. Semple, M.S. Hong, D.H. Herman, D. Gravano, D.M. Doddrell, and A.W. Toga Mapping hippocampal and ventricular change in Alzheimer disease Neuroimage 22 2004 1754 1766 (Pubitemid 38962663)
54. M.F. Folstein, S.E. Folstein, and P.R. McHugh Mini-mental state. A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
55. L.G. Apostolova, P.H. Lu, S. Rogers, R.A. Dutton, K.M. Hayashi, and A.W. Toga 3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease Alzheimer Dis Assoc Disord 20 4 2006 224 231 (Pubitemid 44900935)
56. L.G. Apostolova, G.G. Akopyan, N. Partiali, C.A. Steiner, R.A. Dutton, and K.M. Hayashi Structural correlates of apathy in Alzheimer's disease Dement Geriatr Cogn Disord 24 2 2007 91 97 (Pubitemid 47094067)
57. L.G. Apostolova, P.H. Lu, S. Rogers, R.A. Dutton, K.M. Hayashi, and A.W. Toga 3D mapping of language networks in clinical and pre-clinical Alzheimer's disease Brain Lang 2007 http://dx.doi.org/10.1016/j.bandl.2007.03.008
58. H.M. Duvernoy The human hippocampus: an atlas of applied anatomy 1988 Bergmann Munich
59. G.B. Frisoni, F. Sabattoli, A.D. Lee, R.A. Dutton, A.W. Toga, and P.M. Thompson In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study Neuroimage 32 1 2006 104 110
60. J.G. Csernansky, L. Wang, S. Joshi, J.P. Miller, M. Gado, and D. Kido Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus. Dementia of the Alzheimer type Neurology 55 11 2000 1636 1643
61. L.G. Apostolova, R.A. Dutton, I.D. Dinov, K.M. Hayashi, A.W. Toga, and J.L. Cummings Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps Arch Neurol 63 5 2006 693 699
62. J.C. Augustinack, A.J. van der Kouwe, M.L. Blackwell, D.H. Salat, C.J. Wiggins, and M.P. Frosch Detection of entorhinal layer II using 7Tesla [corrected] magnetic resonance imaging Ann Neurol 57 4 2005 489 494 (Pubitemid 40471157)
63. S.G. Mueller, L. Stables, A.T. Du, N. Schuff, D. Truran, and N. Cashdollar Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T Neurobiol Aging 28 5 2007 719 726 (Pubitemid 46349348)
64. G.B. Frisoni, M. Pievani, C. Testa, F. Sabattoli, L. Bresciani, and M. Bonetti The topography of grey matter involvement in early and late onset Alzheimer's disease Brain 130 Pt. 3 2007 720 730 (Pubitemid 46410740)
65. D.H.S. Silverman, and M.D. Devous Sr. PET and SPECT imaging in evaluating Alzheimer's disease and related dementias P.J. Ell, S.S. Gambhir, Nuclear medicine in clinical diagnosis and treatment 3rd ed. 2004 Churchill-Livingstone London
66. D.H.S. Silverman, and P.M. Thompson Structural and functional neuroimaging: focusing on mild cognitive impairment Appl Neurol 2 2 2006
67. C. DeCarli, J.R. Atack, M.J. Ball, J.A. Kay, C.L. Grady, P. Fewster, K.D. Pettigrew, S.I. Rapoport, and M.B. Schapiro Post-mortem regional neurofibrillary tangle densities are related to regional cerebral metabolic rates for glucose during life in Alzheimer's disease patients Neurodegeneration 1 1992 113 121
68. H.V. Vinters, W.M. Pardridge, and J. Yang Immunohistochemical study of cerebral amyloid angiopathy. Use of an antiserum to a synthetic 28-amino-acid peptide fragment of the Alzheimer's disease amyloid precursor Hum Pathol 19 1988 214 222 (Pubitemid 18091030)
69. H.V. Vinters, G.S. Nishimura, D.L. Secor, and W.M. Pardridge Immunoreactive A4 and gamma-trace peptide co-localization in amyloidotic arteriolar lesions in the brains of patients with Alzheimer's disease Am J Pathol 137 1990 233 240 (Pubitemid 20232983)
70. V. Kepe, S.C. Huang, G.W. Small, N. Satyamurthy, and J.R. Barrio Visualizing pathology deposits in the living brain of patients with Alzheimer's disease Methods Enzymol 412 2006 144 160 (Pubitemid 44548579)
71. G.W. Small, S.Y. Bookheimer, P.M. Thompson, G.M. Cole, S.C. Huang, V. Kepe, and J.R. Barrio Current and future uses of neuroimaging for cognitively impaired patients Lancet Neurol 7 2 2008 161 172
72. C.C. Rowe, S. Ng, U. Ackermann, S.J. Gong, K. Pike, and G. Savage Imaging beta-amyloid burden in aging and dementia Neurology 68 20 2007 1718 1725 (Pubitemid 46763260)
73. C.R. Jack Jr., M.A. Bernstein, B.J. Borowski, J.L. Gunter, N.C. Fox, P.M. Thompson, N. Schuff, G. Krueger, R.J. Killiany, C.S. Decarli, A.M. Dale, O.W. Carmichael, D. Tosun, and M.W. Weiner Alzheimer's disease neuroimaging initiative. Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative Alzheimers Dement 6 3 2010 212 220 Review
74. D. Galasko, L.A. Hansen, R. Katzman, W. Wiederholt, E. Masliah, R. Terry, R. Hill, P. Lessin, and L.J. Thal Clinical-neuropathological correlations in Alzheimer's disease and related dementias Arch Neurol 51 1994 888 895 (Pubitemid 24286043)
75. P.L. Di Patre, S.L. Read, J.L. Cummings, U. Tomiyasu, L.M. Vartavarian, D.L. Secor, and H.V. Vinters Progression of clinical deterioration and pathological changes in patients with Alzheimer disease evaluated at biopsy and autopsy Arch Neurol 56 1999 1254 1261 (Pubitemid 29473218)
76. J.M. Schott, L. Reiniger, M. Thom, J.L. Holton, J. Grieve, S. Brandner, J.D. Warren, and T. Revesz Brain biopsy in dementia: clinical indications and diagnostic approach Acta Neuropathol 120 2010 327 341
77. S.S. Mirra, A. Heyman, D. McKeel, S.M. Sumi, B.J. Crain, L.M. Brownlee, F.S. Vogel, J.P. Hughes, G. Vanbelle, and L. Berg The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease Neurology 41 1991 479 486
78. Z.S. Khachaturian Diagnosis of Alzheimer's disease Arch Neurol 42 1985 1097 1105 (Pubitemid 16236926)
79. R.C. Petersen, J.E. Parisi, D.W. Dickson, K.A. Johnson, D.S. Knopman, B.F. Boeve, G.A. Jicha, R.J. Ivnik, G.E. Smith, E.G. Tangalos, H. Braak, and E. Kokmen Neuropathologic features of amnestic mild cognitive impairment Arch Neurol 63 2006 665 672
80. H.V. Vinters Neuropathology of amnestic mild cognitive impairment Arch Neurol 63 2006 645 646
81. K.L. Newell, B.T. Hyman, J.H. Growdon, and E.T. Hedley-Whyte Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease J Neuropathol Exp Neurol 58 1999 1147 1155 (Pubitemid 29519838)
82. C.H. Kawas The oldest old and the 90 + study Alzheimers Dement 4 2008 S56 S59
83. M.S. Mega, S. Chen, P.M. Thompson, R.P. Woods, T.J. Karaca, A. Tiwari, H. Vinters, G.W. Small, and A.W. Toga Mapping pathology to metabolism: coregistration of stained whole brain sections to PET in Alzheimer's disease Neuroimage 5 1997 147 153 (Pubitemid 27481519)
84. M.S. Mega, T. Chu, J.C. Mazziotta, K.H. Trivedi, P.M. Thompson, A. Shah, G. Cole, S.A. Frautschy, and A.W. Toga Mapping biochemistry to metabolism: FDG-PET and beta-amyloid burden in Alzheimer's disease Neuroreport 10 14 1999 2911 2917 (Pubitemid 29507752)
85. A.W. Toga, K.L. Ambach, B. Quinn, K. Shankar, and S. Schluender Postmortem anatomy A.W. Toga, J.C. Mazziotta, Brain mapping: the methods 1996 Academic Press San Diego 169 190
86. A.W. Toga, J.C. Mazziotta, and R.P. Woods A high-resolution anatomic reference for PET activation studies Neuroimage 2 2 1995
87. A.W. Toga Visualization and Warping of Multimodality Brain Imagery R.W. Thatcher, M. Hallett, T. Zeffiro, E.R. John, M. Huerta, Functional Neuroimaging: Technical Foundations 1994 171 180
88. J. Annese, A. Pitiot, I.D. Dinov, and A.W. Toga A myelo-architectonic method for the structural classification of cortical areas Neuroimage 21 2004 15 26 (Pubitemid 38114992)
89. J. Annese, M.S. Gazzaniga, and A.W. Toga Localization of the human cortical visual area MT based on computer aided histological analysis Cereb Cortex 15 2004 1044 1053 (Pubitemid 40848073)
90. D.W. Dickson, H. Fujishiro, C. Orr, A. DelleDonne, K.A. Josephs, R. Frigerio, M. Burnett, J.E. Parisi, K.J. Klos, and J.E. Ahlskog Neuropathology of non-motor features of Parkinson disease Parkinsonism Relat Disord 15S3 2009 S1 S5
91. L.S. Forno Neuropathology of Parkinson's disease J Neuropathol Exp Neurol 55 1996 259 272 (Pubitemid 26085575)
92. H. Braak, K. Del Tredici, U. Rub, R.A.I. de Vos, E.N.H.J. Steur, and E. Braak Staging of brain pathology related to sporadic Parkinson's disease Neurobiol Aging 24 2003 197 211 (Pubitemid 36007810)
93. M.E. Kalaitzakis, and R.K.B. Pearce The morbid anatomy of dementia in Parkinson's disease Acta Neuropathol 118 2009 587 598
94. I.G. McKeith, D.W. Dickson, J. Lowe, M. Emre, J.T. O'Brien, H. Feldman, J. Cummings, J.E. Duda, C. Lippa, E.K. Perry, D. Aarsland, H. Arai, and C.G. Ballard Diagnosis and management of dementia with Lewy bodies. Third report of the DLB consortium Neurology 65 2005 1863 1872 (Pubitemid 43970103)
95. E. Maries, B. Dass, T.J. Collier, J.H. Kordower, and K. Steece-Collier The role of alpha-synuclein in Parkinsons's disease: insights from animal models Nat Rev Neurosci 4 2003 727 738 (Pubitemid 37280152)
96. D.W. Dickson, H. Braak, J.E. Duda, C. Duyckaerts, T. Gasser, G.M. Halliday, J. Hardy, J.B. Leverenz, K. Del Tredici, Z.K. Wszolek, and I. Litvan Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria Lancet Neurol 12 2009 1150 1157
97. J.Q. Trojanowski, T. Revesz for the Neuropathology Working Group on MSA Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy Neuropathol Appl Neurobiol 33 2007 615 620 (Pubitemid 350076093)
98. L.G. Apostolova, I. Klement, Y. Bronstein, H.V. Vinters, and J.L. Cummings Multiple system atrophy presenting with language impairment Neurology 67 2006 726 727 (Pubitemid 44273638)
99. K. Wakabayashi, F. Mori, K. Tanji, S. Orimo, and H. Takahashi Involvement of the peripheral nervous system in synucleinopathies, tauopathies, and other neurodegenerative proteinopathies of the brain Acta Neuropathol 120 2010 1 12
100. 18 F-dopa PET and inversion recovery MRI in the diagnosis of Parkinson's disease Neurology 56 2001 1195 1200 (Pubitemid 32405714)
101. D.J. Brooks Neuroimaging in Parkinson's disease NeuroRx 1 2 2004 243 254 (Pubitemid 46613776)
102. M. Hutchinson, and U. Raff Structural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging AJNR Am J Neuroradiol 21 2000 697 701 (Pubitemid 30210433)
103. J.S. Snowden, D. Neary, D.M.A. Mann, P.J. Goulding, and H.J. Testa Progressive language disorder due to lobar atrophy Ann Neurol 31 1992 174 183
104. D. Neary, J.S. Snowden, B. Northen, and P. Goulding Dementia of frontal lobe type J Neurol Neurosurg Psychiatry 51 1988 353 361 (Pubitemid 18097567)
105. A. Brun, B. Englund, L. Gustafson, U. Passant, D.M.A. Mann, D. Neary, and J.S. Snowden Clinical and neuropathological criteria for frontotemporal dementia J Neurol Neurosurg Psychiatry 57 1994 416 418 (Pubitemid 24118135)
106. S. Kumar-Singh, and C. Van Broeckhoven Frontotemporal lobar degeneration: current concepts in the light of recent advances Brain Pathol 17 2007 104 113
107. D.W. Dickson, R. Rademakers, and M.L. Hutton Progressive supranuclear palsy: pathology and genetics Brain Pathol 17 2007 74 82
108. D.S. Knopman, A.R. Mastri, W.H. Frey, J.H. Sung, and T. Rustan Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia Neurology 40 1990 251 256 (Pubitemid 20099433)
109. F. Hernandez, and J. Avila Tauopathies Cell Mol Life Sci 64 2007 2219 2233 (Pubitemid 47347961)
110. J. van Swieten, and M.G. Spillantini Hereditary frontotemporal dementia caused by Tau gene mutations Brain Pathol 17 2007 63 73
111. I.R.A. Mackenzie, M. Baker, S. Pickering-Brown, G.Y.R. Hsiung, C. Lindholm, E. Dwosh, J. Gass, A. Cannon, R. Rademakers, M. Hutton, and H.H. Feldman The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene Brain 129 2006 3081 3090 (Pubitemid 44684527)
112. J. Gass, A. Cannon, I.R. Mackenzie, B. Boeve, M. Baker, and J. Adamson Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration Hum Mol Genet 15 20 2006 2988 3001 (Pubitemid 44530703)
113. E.H. Bigio Update on recent molecular and genetic advances in frontotemporal lobar degeneration J Neuropathol Exp Neurol 67 2008 635 648
114. I.R.A. Mackenzie, M. Neumann, E.H. Bigio, N.J. Cairns, and I. Alafuzoff Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations Acta Neuropathol 117 2009 15 18
115. R.A. Armstrong, W. Ellis, R.L. Hamilton, I.R.A. Mackenzie, J. Hedreen, M. Gearing, T. Montine, J.-P. Vonsattel, E. Head, A.P. Lieberman, and N.J. Cairns Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis J Neural Transm 117 2010 227 239
116. A.C. Wilson, B.N. Dugger, D.W. Dickson, and D.-S. Wang TDP-43 in aging and Alzheimer's disease - a review Int J Clin Exp Pathol 4 2011 147 155
117. P. Heutink Untangling tau-related dementia Hum Mol Genet 9 6 2000 979 986 (Pubitemid 30216109)
118. R.A. Short, D.F. Broderick, A. Patton, Z. Arvanitakis, and N.R. Graff-Radford Different patterns of magnetic resonance imaging atrophy for frontotemporal lobar degeneration syndromes Arch Neurol 62 7 2005 1106 1110 (Pubitemid 41043731)
119. N.R. Graff-Radford, J.W. Russell, and K. Rezai Frontal degenerative dementia and neuroimaging Adv Neurol 66 1995 37 47 discussion 47-50
120. E.J. Kim, G.D. Rabinovici, W.W. Seeley, C. Halabi, H. Shu, M.W. Weiner, S.J. DeArmond, J.Q. Trojanowski, M.L. Gorno-Tempini, B.L. Miller, and H.J. Rosen Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration J Neurol Neurosurg Psychiatry 78 12 2007 1375 1378 [Epub 2007 Jul 5] (Pubitemid 350221422)
121. M. Neumann, D.M. Sampathu, L.K. Kwong, A.C. Truax, M.C. Micsenyi, T.T. Chou, J. Bruce, T. Schuck, M. Grossman, C.M. Clark, L.F. McCluskey, B.L. Miller, E. Masliah, I.R. Mackenzie, H. Feldman, W. Feiden, H.A. Kretzschmar, J.Q. Trojanowski, and V.M. Lee Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 314 5796 2006 130 133 (Pubitemid 44547757)
122. G.D. Rabinovici, and B.L. Miller Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management CNS Drugs 24 5 2010 375 398
123. M.S. Forman, J. Farmer, J.K. Johnson, C.M. Clark, S.E. Arnold, H.B. Coslett, A. Chatterjee, H.I. Hurtig, J.H. Karlawish, H.J. Rosen, V. Van Deerlin, V.M. Lee, B.L. Miller, J.Q. Trojanowski, and M. Grossman Frontotemporal dementia: clinicopathological correlations Ann Neurol 59 6 2006 952 962 (Pubitemid 43830927)
124. D.W. Dickson, P. Davies, C. Bevona, K.H. van Hoeven, S.M. Factor, E. Grober, M.K. Aronson, and H.A. Crystal Hippocampal sclerosis: a common pathological feature of dementia in very old (greater than or equal to 80 years of age) humans Acta Neuropathol 88 1994 212 221 (Pubitemid 24265424)
125. J. Woulfe, D.A. Gray, and I.R.A. Mackenzie FUS-immunoreactive intranuclear inclusions in neurodegenerative disease Brain Pathol 20 2010 589 597
126. B. Dubois, H.H. Feldman, C. Jacava, S.T. DeKosky, P. Barberger-Gateau, J. Cummings, A. Delacourte, D. Galasko, S. Gauthier, G. Jicha, K. Meguro, J. O'Brien, F. Pasquier, P. Robert, M. Rossor, S. Salloway, Y. Stern, P.J. Visser, and P. Scheltens Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria Lancet Neurol 6 2007 734 746 (Pubitemid 47058377)