Drug library screen to identify compounds that decrease secreted Aβ from a human cell line

Current Alzheimer Research

Volumn 2, Issue 2, 2005, Pages 255-259

  Chakrabarti, Enakshi ^b   Smith, Jonathan D ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Amyloid peptide; Amyloid precursor protein; Drug screen

Indexed keywords

AMYLOID BETA PROTEIN; PROTEIN INHIBITOR;

ALZHEIMER DISEASE; CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AMYLOID BETA-PROTEIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; NEUROPROTECTIVE AGENTS;

EID: 20844459490     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/1567205053585738     Document Type: Conference Paper

References (19)

1. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766 (2001).
2. Golde TE, Eckman CB and Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim Biophys Acta 1502: 172-187 (2000).
3. Younkin SG. The role of A beta 42 in Alzheimer's disease. J Physiol Paris 92: 289-292 (1998).
4. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2: 864-870 (1996).
5. Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383: 710-713 (1996).
6. Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4: 97-100 (1998).
7. Haugabook SJ, Yager DM, Eckman EA, Golde TE, Younkin SG and Eckman CB. High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta). J Neurosci Methods 108: 171-179 (2001).
8. Levin-Allerhand JA, Lominska CE, Wang J and Smith JD. 17α-estradiol and 17β-estradiol treatments are effective in lowering cerebral amyloid-β levels in AβPPSWE transgenic mice. J Alzheim Dis 4: 449-457 (2002).
9. Buxbaum JD, Koo EH and Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc Natl Acad Sci USA 90: 9195-9198 (1993).
10. Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414: 212-216 (2001).
11. Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 112: 440-449 (2003).
12. Buxbaum JD, Koo EH and Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc Natl Acad Sci USA 90: 9195-9198 (1993).
13. Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L et al. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 4: 447-451 (1998).
14. Gouras GK, Xu H, Gross RS, Greenfield JP, Hai B, Wang R et al. Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci USA 97: 1202-1205 (2000).
15. Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414: 212-216 (2001).
16. Yager D, Watson M, Healy B, Eckman EA and Eckman CB. Natural product extracts that reduce accumulation of the Alzheimer's amyloid beta peptide: selective reduction in A beta42. J Mol Neurosci 19: 129-133 (2002).
17. Zheng H, Xu H, Uljon SN, Gross R, Hardy K, Gaynor J et al. Modulation of A beta peptides by estrogen in mouse models. Journal of Neurochemistry 80: 191-196 (2002).
18. Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 112: 440-449 (2003).
19. Yager D, Watson M, Healy B, Eckman EA and Eckman CB. Natural product extracts that reduce accumulation of the Alzheimer's amyloid beta peptide: selective reduction in A beta42. J Mol Neurosci 19: 129-133 (2002).