메뉴 건너뛰기




Volumn 17, Issue 2, 2012, Pages 147-156

New and emerging treatments for Alzheimer's disease

Author keywords

Alzheimer's disease; Clinical trials; Drugs; Treatments

Indexed keywords

ACI 24; AD 01; AD 02; AF 267B; ALZHEIMER DISEASE VACCINE; AZD 103; BAPINEUZUMAB; BRYOSTATIN 1; CAD 106; CEVIMELINE; CRENEZUMAB; DONEPEZIL; EHT 0202; ELND 005; ETAZOLATE; EVP 6124; GALANTAMINE; GSK 933776; HOMOTAURINE; INOSITOL; LADOSTIGIL; MEMANTINE; MUSCARINIC AGENT; NGX 267; NICOTINIC AGENT; PF 04447943; PF 4494700; PIOGLITAZONE; PLACEBO; PONEZUMAB; PSYCHOTROPIC AGENT; RIVASTIGMINE; RO 4909832; ROSIGLITAZONE; SEMAGACESTAT; SOLANEZUMAB; TALSACLIDINE; TARENFLURBIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; V 950; VANUTIDE CRIDIFICAR; XANOMELINE;

EID: 84861607313     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2012.675327     Document Type: Review
Times cited : (27)

References (76)
  • 1
    • 84861590339 scopus 로고    scopus 로고
    • Available from: www.alz.co.uk/adi/pdf/prevalence.pdf
  • 3
    • 79952666442 scopus 로고    scopus 로고
    • Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease
    • Ballard C, Corbett A, Sharp S. Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease. Expert Rev Neurother 2011;11:327-9
    • (2011) Expert Rev Neurother , vol.11 , pp. 327-329
    • Ballard, C.1    Corbett, A.2    Sharp, S.3
  • 4
    • 0017360731 scopus 로고
    • Necropsy evidence of central cholinergic deficits in senile dementia
    • Perry EK, Perry RH, Blessed G, Tomlinson G. Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1977;1:189 (Pubitemid 8020501)
    • (1977) Lancet , vol.1 , Issue.8004 , pp. 189
    • Perry, E.K.1    Perry, R.H.2    Blessed, G.3    Tomlinson, B.E.4
  • 5
    • 0026576890 scopus 로고
    • Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease?
    • Lawlor BA, Davis KL. Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease? Biol Psychiatry 1992;31:337-50
    • (1992) Biol Psychiatry , vol.31 , pp. 337-350
    • Lawlor, B.A.1    Davis, K.L.2
  • 6
    • 33645510613 scopus 로고    scopus 로고
    • Galantamine for Alzheimer's disease and mild cognitive impairment
    • Loy C, Schneider L. Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 2006(1):CD001747
    • (2006) Cochrane Database Syst Rev , Issue.1
    • Loy, C.1    Schneider, L.2
  • 9
    • 33846140141 scopus 로고    scopus 로고
    • Meta-analysis of six-month memantine trials in Alzheimer's disease
    • DOI 10.1016/j.jalz.2006.10.004, PII S1552526006048631
    • Doody RS, Tariot PN, Pfeiffer E, et al. Meta-analysis of six-month memantine trials in Alzheimer's disease. Alzheimers Demen 2007;3:7-17 (Pubitemid 46076022)
    • (2007) Alzheimer's and Dementia , vol.3 , Issue.1 , pp. 7-17
    • Doody, R.S.1    Tariot, P.N.2    Pfeiffer, E.3    Olin, J.T.4    Graham, S.M.5
  • 10
    • 84861601128 scopus 로고    scopus 로고
    • Available from: www.nice.org.uk/TA111
  • 11
    • 70350517148 scopus 로고    scopus 로고
    • Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine
    • Rodda J, Morgan S, Walker Z. Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr 2009;21:813-24
    • (2009) Int Psychogeriatr , vol.21 , pp. 813-824
    • Rodda, J.1    Morgan, S.2    Walker, Z.3
  • 13
    • 34548563836 scopus 로고    scopus 로고
    • Pharmacological therapy for people with Alzheimer's disease: The balance of clinical effectiveness, ethical issues and social and healthcare costs
    • The Multifaceted Aspects of Alzheimer's Disease: From Social to Molecular Problems
    • Ballard C, Sorensen S, Sharp S. Pharmacological therapy for people with Alzheimer's disease: the balance of clinical effectiveness, ethical issues and social and healthcare costs. J Alzheimers Dis 2007;12:53-9 (Pubitemid 47396304)
    • (2007) Journal of Alzheimer's Disease , vol.12 , Issue.1 , pp. 53-59
    • Ballard, C.1    Sorensen, S.2    Sharp, S.3
  • 14
    • 33645906519 scopus 로고    scopus 로고
    • Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: A randomized controlled trial. Video-Imaging Synthesis of Treating Alzheimer's Disease (VISTA) Investigators
    • Rockwood K, Fay S, Song X, et al. Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial. Video-Imaging Synthesis of Treating Alzheimer's Disease (VISTA) Investigators. CMAJ 2006;174:1099-105
    • (2006) CMAJ , vol.174 , pp. 1099-1105
    • Rockwood, K.1    Fay, S.2    Song, X.3
  • 15
    • 35448953471 scopus 로고    scopus 로고
    • The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial
    • Rockwood K, Fay S, Gorman M, et al. The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial. BMC Neurol 2007;7:26
    • (2007) BMC Neurol , vol.7 , pp. 26
    • Rockwood, K.1    Fay, S.2    Gorman, M.3
  • 17
    • 67349119257 scopus 로고    scopus 로고
    • Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer's disease
    • Chalmers KA, Wilcock GK, Vinters HV, et al. Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer's disease. J Neurol 2009;256:717-20
    • (2009) J Neurol , vol.256 , pp. 717-720
    • Chalmers, K.A.1    Wilcock, G.K.2    Vinters, H.V.3
  • 20
    • 42249111378 scopus 로고    scopus 로고
    • Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: A pooled analysis of 3 studies
    • Wilcock GK, Ballard CG, Cooper JA, Loft H. Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies. J Clin Psychol 2008;69:341-8 (Pubitemid 351549385)
    • (2008) Journal of Clinical Psychiatry , vol.69 , Issue.3 , pp. 341-348
    • Wilcock, G.K.1    Ballard, C.G.2    Cooper, J.A.3    Loft, H.4
  • 23
    • 38949205552 scopus 로고    scopus 로고
    • Delineating the mechanism of Alzheimer's disease Aβ peptide neurotoxicity
    • DOI 10.1007/s11064-007-9469-8
    • Cappai R, Barnham KJ. Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity. Neurochem Res 2008;33:526-32 (Pubitemid 351230455)
    • (2008) Neurochemical Research , vol.33 , Issue.3 , pp. 526-532
    • Cappai, R.1    Barnham, K.J.2
  • 24
    • 60349125886 scopus 로고    scopus 로고
    • Reassessing the amyloid cascade hypothesis of Alzheimer's disease
    • Pimplikar SW. Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int J Biochem Cell Biol 2009;41:1261-8
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1261-1268
    • Pimplikar, S.W.1
  • 26
    • 66349133387 scopus 로고    scopus 로고
    • Secretase inhibitors and modulators for Alzheimer's disease treatment
    • Tomita T. Secretase inhibitors and modulators for Alzheimer's disease treatment. Expert Rev Neurother 2009;9:661-79
    • (2009) Expert Rev Neurother , vol.9 , pp. 661-679
    • Tomita, T.1
  • 27
    • 46749115113 scopus 로고    scopus 로고
    • PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease
    • DOI 10.1016/j.nurt.2008.05.003, PII S1933721308000925
    • Landreth G, Jiang Q, Mandrekar S, Heneka M. PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics 2008;5:481-9 (Pubitemid 351952487)
    • (2008) Neurotherapeutics , vol.5 , Issue.3 , pp. 481-489
    • Landreth, G.1    Jiang, Q.2    Mandrekar, S.3    Heneka, M.4
  • 28
    • 77049120845 scopus 로고    scopus 로고
    • Effects of rosiglitazone as monotherapy in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease
    • M Gold M, Alderton C, Zvartau-Hind ME, et al. Effects of rosiglitazone as monotherapy in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease. Alzheimers Dement 2009;5:86
    • (2009) Alzheimers Dement , vol.5 , pp. 86
    • Gold M, M.1    Alderton, C.2    Zvartau-Hind, M.E.3
  • 29
    • 67650407720 scopus 로고    scopus 로고
    • Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease
    • Henley DB, May PC, Dean RA, Siemers ER. Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. Expert Opin Pharmacother 2009;10:1657-64
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 1657-1664
    • Henley, D.B.1    May, P.C.2    Dean, R.A.3    Siemers, E.R.4
  • 30
    • 72549105935 scopus 로고    scopus 로고
    • Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: A randomized controlled trial
    • Green RC, Schneider LS, Amato A, et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 2009;302:2557-64
    • (2009) JAMA , vol.302 , pp. 2557-2564
    • Green, R.C.1    Schneider, L.S.2    Amato, A.3
  • 33
    • 77953497252 scopus 로고    scopus 로고
    • Clinical trials of EHT 0202, a neuroprotective and procognitive alpha-secretase stimulator for Alzheimer's disease
    • Desire L, Marcade M, Peillon H, et al. Clinical trials of EHT 0202, a neuroprotective and procognitive alpha-secretase stimulator for Alzheimer's disease. Alzheimers Dement 2009;54:255
    • (2009) Alzheimers Dement , vol.54 , pp. 255
    • Desire, L.1    Marcade, M.2    Peillon, H.3
  • 36
    • 63249137056 scopus 로고    scopus 로고
    • Development of affitope vaccines for Alzheimer's disease (AD)-from concept to clinical testing
    • Schneeberger A, Mandler M, Otawa O, et al. Development of affitope vaccines for Alzheimer's disease (AD)-from concept to clinical testing. J Nutr Health Aging 2009;13:264-7
    • (2009) J Nutr Health Aging , vol.13 , pp. 264-267
    • Schneeberger, A.1    Mandler, M.2    Otawa, O.3
  • 37
    • 76849109048 scopus 로고    scopus 로고
    • Results of the first-in-man study with the active Abeta immunotherapy CAD106 in Alzheimer patients
    • Winblad B, Minthon L, Floesser A, et al. Results of the first-in-man study with the active Abeta immunotherapy CAD106 in Alzheimer patients. Alzheimers Dement 2009;54:113
    • (2009) Alzheimers Dement , vol.54 , pp. 113
    • Winblad, B.1    Minthon, L.2    Floesser, A.3
  • 38
    • 58149375748 scopus 로고    scopus 로고
    • Anti-amyloid-beta immunotherapy in Alzheimer's disease: Relevance of transgenic mouse studies to clinical trials
    • Wilcock DM, Colton CA. Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. J Alzheimers Dis 2008;15:555-69
    • (2008) J Alzheimers Dis , vol.15 , pp. 555-569
    • Wilcock, D.M.1    Colton, C.A.2
  • 39
    • 70049083865 scopus 로고    scopus 로고
    • 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
    • Relkin NR, Szabo P, Adamiak B, et al. 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging 2009;30:1728-36
    • (2009) Neurobiol Aging , vol.30 , pp. 1728-1736
    • Relkin, N.R.1    Szabo, P.2    Adamiak, B.3
  • 40
    • 65249091605 scopus 로고    scopus 로고
    • Safety, tolerability and biomarker effects of an abeta monoclonal antibody administered to patients with Alzheimer's disease
    • Siemers ER, Friedrich S, Dean RA, et al. Safety, tolerability and biomarker effects of an abeta monoclonal antibody administered to patients with Alzheimer's disease. Alzheimers Dement 2008;44:774
    • (2008) Alzheimers Dement , vol.44 , pp. 774
    • Siemers, E.R.1    Friedrich, S.2    Dean, R.A.3
  • 41
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • Salloway S, Sperling R, Gilman S, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009;73:2061-70
    • (2009) Neurology , vol.73 , pp. 2061-2070
    • Salloway, S.1    Sperling, R.2    Gilman, S.3
  • 42
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
    • DOI 10.1038/nrm2101, PII NRM2101
    • Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007;8:101-12 (Pubitemid 46432529)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.2 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 43
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008;14:837-42
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3
  • 44
    • 33845388059 scopus 로고    scopus 로고
    • A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease
    • DOI 10.1212/01.wnl.0000244346.08950.64, PII 0000611420061128000011
    • Aisen PS, Saumier D, Briand R, et al. A phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006;67:1757-63 (Pubitemid 44900749)
    • (2006) Neurology , vol.67 , Issue.10 , pp. 1757-1763
    • Aisen, P.S.1    Saumier, D.2    Briand, R.3    Laurin, J.4    Gervais, F.5    Tremblay, P.6    Garceau, D.7
  • 45
    • 80855131315 scopus 로고    scopus 로고
    • A phase III, placebo-controlled, double-blind, randomized trial of tramiprosate in the clinical management of patients with mild-to-moderate Alzheimer's disease (the Alphase study)
    • April 25-May 02 2009; Seattle, WA, USA. S32.003
    • Aisen P, Gauthier S, Ferris S, et al. A phase III, placebo-controlled, double-blind, randomized trial of tramiprosate in the clinical management of patients with mild-to-moderate Alzheimer's disease (the Alphase study). 61st American Academy of Neurology annual meeting; April 25-May 02 2009; Seattle, WA, USA. S32.003
    • 61st American Academy of Neurology Annual Meeting
    • Aisen, P.1    Gauthier, S.2    Ferris, S.3
  • 47
    • 77953515555 scopus 로고    scopus 로고
    • Oral amyloid anti-aggregating agent ELND005 is measurable in CSF and brain of healthy adult men
    • Garzone P, Koller M, Pastrak A, et al. Oral amyloid anti-aggregating agent ELND005 is measurable in CSF and brain of healthy adult men. Alzheimers Dement 2009;5(4):P323
    • (2009) Alzheimers Dement , vol.5 , Issue.4
    • Garzone, P.1    Koller, M.2    Pastrak, A.3
  • 48
    • 2442606713 scopus 로고    scopus 로고
    • Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
    • Ritchie CW, Bush AI, Mackinnon A, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2004;61:776
    • (2004) Arch Neurol , vol.61 , pp. 776
    • Ritchie, C.W.1    Bush, A.I.2    MacKinnon, A.3
  • 49
    • 48949098573 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial
    • Lannfelt L, Blennow K, Zetterberg H, et al. Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol 2008;7:779-86
    • (2008) Lancet Neurol , vol.7 , pp. 779-786
    • Lannfelt, L.1    Blennow, K.2    Zetterberg, H.3
  • 50
    • 79961230030 scopus 로고    scopus 로고
    • Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease
    • Tariot PN, Schneider LS, Cummings J, et al. Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease. Arch Gen Psychiatry 2011;68:853-61
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 853-861
    • Tariot, P.N.1    Schneider, L.S.2    Cummings, J.3
  • 52
    • 77049116286 scopus 로고    scopus 로고
    • Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology
    • Leroy K, Ando K, Heraud C, et al. Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. J Alzheimers Dis 2010;19:705-19
    • (2010) J Alzheimers Dis , vol.19 , pp. 705-719
    • Leroy, K.1    Ando, K.2    Heraud, C.3
  • 53
    • 48249096759 scopus 로고    scopus 로고
    • Feasibility and tolerability study of lithium in Alzheimer's disease
    • Macdonald A, Briggs K, Poppe M, et al. Feasibility and tolerability study of lithium in Alzheimer's disease. Int J Geriatr Psychiatry 2008;23:704-11
    • (2008) Int J Geriatr Psychiatry , vol.23 , pp. 704-711
    • MacDonald, A.1    Briggs, K.2    Poppe, M.3
  • 54
    • 51349134160 scopus 로고    scopus 로고
    • Hope in Alzheimer's fight emerges from unexpected places
    • Gura T. Hope in Alzheimer's fight emerges from unexpected places. Nat Med 2008;14:894
    • (2008) Nat Med , vol.14 , pp. 894
    • Gura, T.1
  • 55
  • 56
    • 80053531168 scopus 로고    scopus 로고
    • A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor
    • Weinreb O, Amit T, Bar-Am O, Youdim MB. A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor. Int Rev Neurobiol 2011;100:191-215
    • (2011) Int Rev Neurobiol , vol.100 , pp. 191-215
    • Weinreb, O.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4
  • 57
    • 84861649024 scopus 로고    scopus 로고
    • Available from: http://www.news-medical.net/news/20090923/CERE-110-trial- to-stop-the-progression-of-Alzheimers-disease.aspx
  • 58
    • 70350464733 scopus 로고    scopus 로고
    • Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles
    • Kurakhmaeva KB, Djindjikhashvili IA, Petrov VE, et al. Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles. J Drug Target 2009;17:564-74
    • (2009) J Drug Target , vol.17 , pp. 564-574
    • Kurakhmaeva, K.B.1    Djindjikhashvili, I.A.2    Petrov, V.E.3
  • 59
    • 69449091994 scopus 로고    scopus 로고
    • Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    • Blurton-Jones M, Kitazawa M, Martinez-Coria H, et al. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci USA 2009;106:13594-9
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13594-13599
    • Blurton-Jones, M.1    Kitazawa, M.2    Martinez-Coria, H.3
  • 60
    • 77957240989 scopus 로고    scopus 로고
    • Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease
    • Maher-Edwards G, Zvartau-Hind M, Hunter AJ, et al. Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease. Curr Alzheimer Res 2010;7:374-85
    • (2010) Curr Alzheimer Res , vol.7 , pp. 374-385
    • Maher-Edwards, G.1    Zvartau-Hind, M.2    Hunter, A.J.3
  • 61
    • 67349093525 scopus 로고    scopus 로고
    • Clearance mechanisms of Alzheimer's amyloid-beta peptide: Implications for therapeutic design and diagnostic tests
    • Bates KA, Verdile G, Li QX, et al. Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Mol Psychiatry 2009;14:469-86
    • (2009) Mol Psychiatry , vol.14 , pp. 469-486
    • Bates, K.A.1    Verdile, G.2    Li, Q.X.3
  • 62
    • 33947245344 scopus 로고    scopus 로고
    • Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease
    • DOI 10.1016/j.nbd.2007.01.004, PII S096999610700023X
    • Hemming ML, Selkoe DJ, Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiol Dis 2007;26:273-81 (Pubitemid 46436503)
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 273-281
    • Hemming, M.L.1    Selkoe, D.J.2    Farris, W.3
  • 63
    • 33646433026 scopus 로고    scopus 로고
    • Antihypertensive medication use and incident Alzheimer disease: The Cache County Study
    • Khachaturian AS, Zandi PP, Lyketsos CG, et al. Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol 2006;63:686-92
    • (2006) Arch Neurol , vol.63 , pp. 686-692
    • Khachaturian, A.S.1    Zandi, P.P.2    Lyketsos, C.G.3
  • 64
    • 74949131237 scopus 로고    scopus 로고
    • Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
    • Li NC, Lee A, Whitmer RA, et al. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 2010;340:5465
    • (2010) BMJ , vol.340 , pp. 5465
    • Li, N.C.1    Lee, A.2    Whitmer, R.A.3
  • 65
    • 7644242460 scopus 로고    scopus 로고
    • Neuroprotection by tetracyclines
    • DOI 10.1016/j.tips.2004.10.001, PII S0165614704002792
    • Domercq M, Matute C. Neuroprotection by tetracyclines. Trends Pharmacol Sci 2004;25:609-12 (Pubitemid 39458165)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.12 , pp. 609-612
    • Domercq, M.1    Matute, C.2
  • 67
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean PL, Parthsarathy V, Faivre E, Holscher C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011;31:6587-94
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 68
    • 77950352189 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
    • Li Y, Duffy KB, Ottinger MA, et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis 2010;19:1205-19
    • (2010) J Alzheimers Dis , vol.19 , pp. 1205-1219
    • Li, Y.1    Duffy, K.B.2    Ottinger, M.A.3
  • 69
    • 77958057074 scopus 로고    scopus 로고
    • Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: A single-blind randomized controlled trial of clinical efficacy
    • Clare L, Linden DE, Woods RT, et al. Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. Am J Geriatr Psychiatry 2010;18:928-39
    • (2010) Am J Geriatr Psychiatry , vol.18 , pp. 928-939
    • Clare, L.1    Linden, D.E.2    Woods, R.T.3
  • 70
    • 65349183538 scopus 로고    scopus 로고
    • Cognitive training for early-stage Alzheimer's disease and dementia
    • Yu F, Rose KM, Burgener SC, et al. Cognitive training for early-stage Alzheimer's disease and dementia. J Gerontol Nurs 2009;35:23-9
    • (2009) J Gerontol Nurs , vol.35 , pp. 23-29
    • Yu, F.1    Rose, K.M.2    Burgener, S.C.3
  • 71
    • 0041828589 scopus 로고    scopus 로고
    • Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: Randomised controlled trial
    • DOI 10.1192/bjp.183.3.248
    • Spector A, Thorgrimsen L, Woods B, et al. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. Br J Psychiatry 2003;183:248-54 (Pubitemid 37070181)
    • (2003) British Journal of Psychiatry , vol.183 , Issue.SEPT. , pp. 248-254
    • Spector, A.1    Thorgrimsen, L.2    Woods, B.3    Royan, L.4    Davies, S.5    Butterworth, M.6    Orrell, M.7
  • 72
    • 77953412425 scopus 로고    scopus 로고
    • Putting brain training to the test
    • Owen AM, Hampshire A, Grahn JA, et al. Putting brain training to the test. Nature 2010;465:775-8
    • (2010) Nature , vol.465 , pp. 775-778
    • Owen, A.M.1    Hampshire, A.2    Grahn, J.A.3
  • 73
    • 79952611543 scopus 로고    scopus 로고
    • Exercise training increases size of hippocampus and improves memory
    • Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 2011;108:3017-22
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3017-3022
    • Erickson, K.I.1    Voss, M.W.2    Prakash, R.S.3
  • 74
    • 74949118967 scopus 로고    scopus 로고
    • Effects of aerobic exercise on mild cognitive impairment: A controlled trial
    • Baker LD, Frank LL, Foster-Schubert K, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol 2010;67:71-9
    • (2010) Arch Neurol , vol.67 , pp. 71-79
    • Baker, L.D.1    Frank, L.L.2    Foster-Schubert, K.3
  • 75
    • 50949110086 scopus 로고    scopus 로고
    • Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial
    • Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008;300:1027-37
    • (2008) JAMA , vol.300 , pp. 1027-1037
    • Lautenschlager, N.T.1    Cox, K.L.2    Flicker, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.