-
1
-
-
84861590339
-
-
Available from: www.alz.co.uk/adi/pdf/prevalence.pdf
-
-
-
-
3
-
-
79952666442
-
Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease
-
Ballard C, Corbett A, Sharp S. Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease. Expert Rev Neurother 2011;11:327-9
-
(2011)
Expert Rev Neurother
, vol.11
, pp. 327-329
-
-
Ballard, C.1
Corbett, A.2
Sharp, S.3
-
4
-
-
0017360731
-
Necropsy evidence of central cholinergic deficits in senile dementia
-
Perry EK, Perry RH, Blessed G, Tomlinson G. Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1977;1:189 (Pubitemid 8020501)
-
(1977)
Lancet
, vol.1
, Issue.8004
, pp. 189
-
-
Perry, E.K.1
Perry, R.H.2
Blessed, G.3
Tomlinson, B.E.4
-
5
-
-
0026576890
-
Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease?
-
Lawlor BA, Davis KL. Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease? Biol Psychiatry 1992;31:337-50
-
(1992)
Biol Psychiatry
, vol.31
, pp. 337-350
-
-
Lawlor, B.A.1
Davis, K.L.2
-
6
-
-
33645510613
-
Galantamine for Alzheimer's disease and mild cognitive impairment
-
Loy C, Schneider L. Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 2006(1):CD001747
-
(2006)
Cochrane Database Syst Rev
, Issue.1
-
-
Loy, C.1
Schneider, L.2
-
9
-
-
33846140141
-
Meta-analysis of six-month memantine trials in Alzheimer's disease
-
DOI 10.1016/j.jalz.2006.10.004, PII S1552526006048631
-
Doody RS, Tariot PN, Pfeiffer E, et al. Meta-analysis of six-month memantine trials in Alzheimer's disease. Alzheimers Demen 2007;3:7-17 (Pubitemid 46076022)
-
(2007)
Alzheimer's and Dementia
, vol.3
, Issue.1
, pp. 7-17
-
-
Doody, R.S.1
Tariot, P.N.2
Pfeiffer, E.3
Olin, J.T.4
Graham, S.M.5
-
10
-
-
84861601128
-
-
Available from: www.nice.org.uk/TA111
-
-
-
-
11
-
-
70350517148
-
Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine
-
Rodda J, Morgan S, Walker Z. Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr 2009;21:813-24
-
(2009)
Int Psychogeriatr
, vol.21
, pp. 813-824
-
-
Rodda, J.1
Morgan, S.2
Walker, Z.3
-
12
-
-
0036942425
-
Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease
-
DOI 10.1017/S104161020200858X
-
Gauthier S, Feldman H, Hecker J, et al. Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease. Donepezil MSAD Study Investigators Group. Int Psychogeriatr 2002;14:389-404 (Pubitemid 36331605)
-
(2002)
International Psychogeriatrics
, vol.14
, Issue.4
, pp. 389-404
-
-
Gauthier, S.1
Feldman, H.2
Hecker, J.3
Vellas, B.4
Ames, D.5
Subbiah, P.6
Whalen, E.7
Emir, B.8
Albarede, P.-J.9
Ancill, R.J.10
Atallah, S.11
Bailey, P.12
Black, S.E.13
Borrie, M.J.14
Boundy, K.15
Clarnette, R.16
Cohen, S.17
Darby, D.G.18
Ewer, M.19
Farcnik, K.20
Helme, R.D.21
Hogan, D.22
Kertesz, A.23
Masters, C.24
Maupetit, J.25
McCracken, P.26
Mohr, E.27
Molloy, D.W.28
Mordasini, M.29
Moscovitch, A.30
Patterson, C.31
Pillay, N.32
Rabheru, K.33
Rajput, A.34
Rousseau, F.35
Tessier, D.36
Veloso, F.37
Willmer, J.38
more..
-
13
-
-
34548563836
-
Pharmacological therapy for people with Alzheimer's disease: The balance of clinical effectiveness, ethical issues and social and healthcare costs
-
The Multifaceted Aspects of Alzheimer's Disease: From Social to Molecular Problems
-
Ballard C, Sorensen S, Sharp S. Pharmacological therapy for people with Alzheimer's disease: the balance of clinical effectiveness, ethical issues and social and healthcare costs. J Alzheimers Dis 2007;12:53-9 (Pubitemid 47396304)
-
(2007)
Journal of Alzheimer's Disease
, vol.12
, Issue.1
, pp. 53-59
-
-
Ballard, C.1
Sorensen, S.2
Sharp, S.3
-
14
-
-
33645906519
-
Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: A randomized controlled trial. Video-Imaging Synthesis of Treating Alzheimer's Disease (VISTA) Investigators
-
Rockwood K, Fay S, Song X, et al. Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial. Video-Imaging Synthesis of Treating Alzheimer's Disease (VISTA) Investigators. CMAJ 2006;174:1099-105
-
(2006)
CMAJ
, vol.174
, pp. 1099-1105
-
-
Rockwood, K.1
Fay, S.2
Song, X.3
-
15
-
-
35448953471
-
The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial
-
Rockwood K, Fay S, Gorman M, et al. The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial. BMC Neurol 2007;7:26
-
(2007)
BMC Neurol
, vol.7
, pp. 26
-
-
Rockwood, K.1
Fay, S.2
Gorman, M.3
-
16
-
-
34248572114
-
Cholinesterase inhibitors reduce cortical Aβ in dementia with Lewy bodies
-
DOI 10.1212/01.wnl.0000261920.03297.64, PII 0000611420070515000013
-
Ballard CG, Chalmers KA, Todd C, et al. Cholinesterase inhibitors reduce cortical abeta in dementia with lewy bodies. Neurology 2007;68:1726-9 (Pubitemid 46763261)
-
(2007)
Neurology
, vol.68
, Issue.20
, pp. 1726-1729
-
-
Ballard, C.G.1
Chalmers, K.A.2
Todd, C.3
McKeith, I.G.4
O'Brien, J.T.5
Wilcock, G.6
Love, S.7
Perry, E.K.8
-
17
-
-
67349119257
-
Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer's disease
-
Chalmers KA, Wilcock GK, Vinters HV, et al. Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer's disease. J Neurol 2009;256:717-20
-
(2009)
J Neurol
, vol.256
, pp. 717-720
-
-
Chalmers, K.A.1
Wilcock, G.K.2
Vinters, H.V.3
-
18
-
-
0345872128
-
Memantine treatment in patients with moderate to severe alzheimer disease already receiving donepezil: A randomized controlled trial
-
DOI 10.1001/jama.291.3.317
-
Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 2004;291:317-24 (Pubitemid 38101604)
-
(2004)
Journal of the American Medical Association
, vol.291
, Issue.3
, pp. 317-324
-
-
Tariot, P.N.1
Farlow, M.R.2
Grossberg, G.T.3
Graham, S.M.4
McDonald, S.5
Gergel, I.6
-
20
-
-
42249111378
-
Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: A pooled analysis of 3 studies
-
Wilcock GK, Ballard CG, Cooper JA, Loft H. Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies. J Clin Psychol 2008;69:341-8 (Pubitemid 351549385)
-
(2008)
Journal of Clinical Psychiatry
, vol.69
, Issue.3
, pp. 341-348
-
-
Wilcock, G.K.1
Ballard, C.G.2
Cooper, J.A.3
Loft, H.4
-
21
-
-
12444313989
-
42 in patients with Alzheimer's disease
-
Hock C, Maddalena A, Raschig A, et al. Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease. Amyloid 2003;10(1):1-6 (Pubitemid 36520922)
-
(2003)
Amyloid
, vol.10
, Issue.1
, pp. 1-6
-
-
Hock, C.1
Maddalena, A.2
Raschig, A.3
Muller-Spahn, F.4
Eschweiler, G.5
Hager, K.6
Heuser, I.7
Hampel, H.8
Muller-Thomsen, T.9
Oertel, W.10
Wienrich, M.11
Signorell, A.12
Gonzalez-Agosti, C.13
Nitsch, R.M.14
-
22
-
-
0030902127
-
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease
-
Bodick NC, Offen WW, Levey AI, et al. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Arch Neurol 1997;54:465-73 (Pubitemid 27172867)
-
(1997)
Archives of Neurology
, vol.54
, Issue.4
, pp. 465-473
-
-
Bodick, N.C.1
Offen, W.W.2
Levey, A.I.3
Cutler, N.R.4
Gauthier, S.G.5
Satlin, A.6
Shannon, H.E.7
Tollefson, G.D.8
Rasmussen, K.9
Bymaster, F.P.10
Hurley, D.J.11
Potter, W.Z.12
Paul, S.M.13
-
23
-
-
38949205552
-
Delineating the mechanism of Alzheimer's disease Aβ peptide neurotoxicity
-
DOI 10.1007/s11064-007-9469-8
-
Cappai R, Barnham KJ. Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity. Neurochem Res 2008;33:526-32 (Pubitemid 351230455)
-
(2008)
Neurochemical Research
, vol.33
, Issue.3
, pp. 526-532
-
-
Cappai, R.1
Barnham, K.J.2
-
24
-
-
60349125886
-
Reassessing the amyloid cascade hypothesis of Alzheimer's disease
-
Pimplikar SW. Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int J Biochem Cell Biol 2009;41:1261-8
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 1261-1268
-
-
Pimplikar, S.W.1
-
25
-
-
34447322271
-
Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria
-
DOI 10.1016/S1474-4422(07)70178-3, PII S1474442207701783
-
Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007;6:734-46 (Pubitemid 47058377)
-
(2007)
Lancet Neurology
, vol.6
, Issue.8
, pp. 734-746
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
DeKosky, S.T.4
Barberger-Gateau, P.5
Cummings, J.6
Delacourte, A.7
Galasko, D.8
Gauthier, S.9
Jicha, G.10
Meguro, K.11
O'Brien, J.12
Pasquier, F.13
Robert, P.14
Rossor, M.15
Salloway, S.16
Stern, Y.17
Visser, P.J.18
Scheltens, P.19
-
26
-
-
66349133387
-
Secretase inhibitors and modulators for Alzheimer's disease treatment
-
Tomita T. Secretase inhibitors and modulators for Alzheimer's disease treatment. Expert Rev Neurother 2009;9:661-79
-
(2009)
Expert Rev Neurother
, vol.9
, pp. 661-679
-
-
Tomita, T.1
-
27
-
-
46749115113
-
PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease
-
DOI 10.1016/j.nurt.2008.05.003, PII S1933721308000925
-
Landreth G, Jiang Q, Mandrekar S, Heneka M. PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics 2008;5:481-9 (Pubitemid 351952487)
-
(2008)
Neurotherapeutics
, vol.5
, Issue.3
, pp. 481-489
-
-
Landreth, G.1
Jiang, Q.2
Mandrekar, S.3
Heneka, M.4
-
28
-
-
77049120845
-
Effects of rosiglitazone as monotherapy in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease
-
M Gold M, Alderton C, Zvartau-Hind ME, et al. Effects of rosiglitazone as monotherapy in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease. Alzheimers Dement 2009;5:86
-
(2009)
Alzheimers Dement
, vol.5
, pp. 86
-
-
Gold M, M.1
Alderton, C.2
Zvartau-Hind, M.E.3
-
29
-
-
67650407720
-
Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease
-
Henley DB, May PC, Dean RA, Siemers ER. Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. Expert Opin Pharmacother 2009;10:1657-64
-
(2009)
Expert Opin Pharmacother
, vol.10
, pp. 1657-1664
-
-
Henley, D.B.1
May, P.C.2
Dean, R.A.3
Siemers, E.R.4
-
30
-
-
72549105935
-
Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: A randomized controlled trial
-
Green RC, Schneider LS, Amato A, et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 2009;302:2557-64
-
(2009)
JAMA
, vol.302
, pp. 2557-2564
-
-
Green, R.C.1
Schneider, L.S.2
Amato, A.3
-
32
-
-
45249124737
-
A receptor pharmacology to amyloid precursor protein processing
-
DOI 10.1111/j.1471-4159.2008.05396.x
-
Marcade M, Bourdin J, Loiseau N, et al. Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem 2008;106:392-404 (Pubitemid 351840218)
-
(2008)
Journal of Neurochemistry
, vol.106
, Issue.1
, pp. 392-404
-
-
Marcade, M.1
Bourdin, J.2
Loiseau, N.3
Peillon, H.4
Rayer, A.5
Drouin, D.6
Schweighoffer, F.7
Desire, L.8
-
33
-
-
77953497252
-
Clinical trials of EHT 0202, a neuroprotective and procognitive alpha-secretase stimulator for Alzheimer's disease
-
Desire L, Marcade M, Peillon H, et al. Clinical trials of EHT 0202, a neuroprotective and procognitive alpha-secretase stimulator for Alzheimer's disease. Alzheimers Dement 2009;54:255
-
(2009)
Alzheimers Dement
, vol.54
, pp. 255
-
-
Desire, L.1
Marcade, M.2
Peillon, H.3
-
34
-
-
20944448555
-
Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
-
DOI 10.1212/01.WNL.0000159740.16984.3C
-
Gilman S, Koller M, Black RS, et al. Clinical effects of abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005;64:1553-62 (Pubitemid 40617691)
-
(2005)
Neurology
, vol.64
, Issue.9
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
Jenkins, L.4
Griffith, S.G.5
Fox, N.C.6
Eisner, L.7
Kirby, L.8
Boada Rovira, M.9
Forette, F.10
Orgogozo, J.-M.11
-
35
-
-
47149112621
-
42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
DOI 10.1016/S0140-6736(08)61075-2, PII S0140673608610752
-
Holmes C, Boche D, Wilkinson D, et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008;372:216-23 (Pubitemid 351978111)
-
(2008)
The Lancet
, vol.372
, Issue.9634
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
36
-
-
63249137056
-
Development of affitope vaccines for Alzheimer's disease (AD)-from concept to clinical testing
-
Schneeberger A, Mandler M, Otawa O, et al. Development of affitope vaccines for Alzheimer's disease (AD)-from concept to clinical testing. J Nutr Health Aging 2009;13:264-7
-
(2009)
J Nutr Health Aging
, vol.13
, pp. 264-267
-
-
Schneeberger, A.1
Mandler, M.2
Otawa, O.3
-
37
-
-
76849109048
-
Results of the first-in-man study with the active Abeta immunotherapy CAD106 in Alzheimer patients
-
Winblad B, Minthon L, Floesser A, et al. Results of the first-in-man study with the active Abeta immunotherapy CAD106 in Alzheimer patients. Alzheimers Dement 2009;54:113
-
(2009)
Alzheimers Dement
, vol.54
, pp. 113
-
-
Winblad, B.1
Minthon, L.2
Floesser, A.3
-
38
-
-
58149375748
-
Anti-amyloid-beta immunotherapy in Alzheimer's disease: Relevance of transgenic mouse studies to clinical trials
-
Wilcock DM, Colton CA. Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. J Alzheimers Dis 2008;15:555-69
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 555-569
-
-
Wilcock, D.M.1
Colton, C.A.2
-
39
-
-
70049083865
-
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Relkin NR, Szabo P, Adamiak B, et al. 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging 2009;30:1728-36
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1728-1736
-
-
Relkin, N.R.1
Szabo, P.2
Adamiak, B.3
-
40
-
-
65249091605
-
Safety, tolerability and biomarker effects of an abeta monoclonal antibody administered to patients with Alzheimer's disease
-
Siemers ER, Friedrich S, Dean RA, et al. Safety, tolerability and biomarker effects of an abeta monoclonal antibody administered to patients with Alzheimer's disease. Alzheimers Dement 2008;44:774
-
(2008)
Alzheimers Dement
, vol.44
, pp. 774
-
-
Siemers, E.R.1
Friedrich, S.2
Dean, R.A.3
-
41
-
-
73349091534
-
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
-
Salloway S, Sperling R, Gilman S, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009;73:2061-70
-
(2009)
Neurology
, vol.73
, pp. 2061-2070
-
-
Salloway, S.1
Sperling, R.2
Gilman, S.3
-
42
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
DOI 10.1038/nrm2101, PII NRM2101
-
Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007;8:101-12 (Pubitemid 46432529)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
43
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008;14:837-42
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
-
44
-
-
33845388059
-
A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease
-
DOI 10.1212/01.wnl.0000244346.08950.64, PII 0000611420061128000011
-
Aisen PS, Saumier D, Briand R, et al. A phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006;67:1757-63 (Pubitemid 44900749)
-
(2006)
Neurology
, vol.67
, Issue.10
, pp. 1757-1763
-
-
Aisen, P.S.1
Saumier, D.2
Briand, R.3
Laurin, J.4
Gervais, F.5
Tremblay, P.6
Garceau, D.7
-
45
-
-
80855131315
-
A phase III, placebo-controlled, double-blind, randomized trial of tramiprosate in the clinical management of patients with mild-to-moderate Alzheimer's disease (the Alphase study)
-
April 25-May 02 2009; Seattle, WA, USA. S32.003
-
Aisen P, Gauthier S, Ferris S, et al. A phase III, placebo-controlled, double-blind, randomized trial of tramiprosate in the clinical management of patients with mild-to-moderate Alzheimer's disease (the Alphase study). 61st American Academy of Neurology annual meeting; April 25-May 02 2009; Seattle, WA, USA. S32.003
-
61st American Academy of Neurology Annual Meeting
-
-
Aisen, P.1
Gauthier, S.2
Ferris, S.3
-
46
-
-
33745922350
-
Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model
-
DOI 10.1038/nm1423, PII NM1423
-
McLaurin J, Kierstead ME, Brown ME, et al. Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat Med 2006;12:801-8 (Pubitemid 44050070)
-
(2006)
Nature Medicine
, vol.12
, Issue.7
, pp. 801-808
-
-
McLaurin, J.1
Kierstead, M.E.2
Brown, M.E.3
Hawkes, C.A.4
Lambermon, M.H.L.5
Phinney, A.L.6
Darabie, A.A.7
Cousins, J.E.8
French, J.E.9
Lan, M.F.10
Chen, F.11
Wong, S.S.N.12
Mount, H.T.J.13
Fraser, P.E.14
Westaway, D.15
George-Hyslop, P.St.16
-
47
-
-
77953515555
-
Oral amyloid anti-aggregating agent ELND005 is measurable in CSF and brain of healthy adult men
-
Garzone P, Koller M, Pastrak A, et al. Oral amyloid anti-aggregating agent ELND005 is measurable in CSF and brain of healthy adult men. Alzheimers Dement 2009;5(4):P323
-
(2009)
Alzheimers Dement
, vol.5
, Issue.4
-
-
Garzone, P.1
Koller, M.2
Pastrak, A.3
-
48
-
-
2442606713
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie CW, Bush AI, Mackinnon A, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2004;61:776
-
(2004)
Arch Neurol
, vol.61
, pp. 776
-
-
Ritchie, C.W.1
Bush, A.I.2
MacKinnon, A.3
-
49
-
-
48949098573
-
Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial
-
Lannfelt L, Blennow K, Zetterberg H, et al. Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol 2008;7:779-86
-
(2008)
Lancet Neurol
, vol.7
, pp. 779-786
-
-
Lannfelt, L.1
Blennow, K.2
Zetterberg, H.3
-
50
-
-
79961230030
-
Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease
-
Tariot PN, Schneider LS, Cummings J, et al. Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease. Arch Gen Psychiatry 2011;68:853-61
-
(2011)
Arch Gen Psychiatry
, vol.68
, pp. 853-861
-
-
Tariot, P.N.1
Schneider, L.S.2
Cummings, J.3
-
51
-
-
3142592230
-
GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
-
DOI 10.1038/sj.mp.4001483
-
Mudher A, Shepherd D, Newman TA, et al. GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Mol Psychiatry 2004;9:522-30 (Pubitemid 38903508)
-
(2004)
Molecular Psychiatry
, vol.9
, Issue.5
, pp. 522-530
-
-
Mudher, A.1
Shepherd, D.2
Newman, T.A.3
Mildren, P.4
Jukes, J.P.5
Squire, A.6
Mears, A.7
Berg, S.8
MacKay, D.9
Asuni, A.A.10
Bhat, R.11
Lovestone, S.12
-
52
-
-
77049116286
-
Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology
-
Leroy K, Ando K, Heraud C, et al. Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. J Alzheimers Dis 2010;19:705-19
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 705-719
-
-
Leroy, K.1
Ando, K.2
Heraud, C.3
-
53
-
-
48249096759
-
Feasibility and tolerability study of lithium in Alzheimer's disease
-
Macdonald A, Briggs K, Poppe M, et al. Feasibility and tolerability study of lithium in Alzheimer's disease. Int J Geriatr Psychiatry 2008;23:704-11
-
(2008)
Int J Geriatr Psychiatry
, vol.23
, pp. 704-711
-
-
MacDonald, A.1
Briggs, K.2
Poppe, M.3
-
54
-
-
51349134160
-
Hope in Alzheimer's fight emerges from unexpected places
-
Gura T. Hope in Alzheimer's fight emerges from unexpected places. Nat Med 2008;14:894
-
(2008)
Nat Med
, vol.14
, pp. 894
-
-
Gura, T.1
-
55
-
-
77956666900
-
Dimebon disappointment
-
Jones RW. Dimebon disappointment. Alzheimers Res Ther 2010;2:25
-
(2010)
Alzheimers Res Ther
, vol.2
, pp. 25
-
-
Jones, R.W.1
-
56
-
-
80053531168
-
A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor
-
Weinreb O, Amit T, Bar-Am O, Youdim MB. A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor. Int Rev Neurobiol 2011;100:191-215
-
(2011)
Int Rev Neurobiol
, vol.100
, pp. 191-215
-
-
Weinreb, O.1
Amit, T.2
Bar-Am, O.3
Youdim, M.B.4
-
57
-
-
84861649024
-
-
Available from: http://www.news-medical.net/news/20090923/CERE-110-trial- to-stop-the-progression-of-Alzheimers-disease.aspx
-
-
-
-
58
-
-
70350464733
-
Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles
-
Kurakhmaeva KB, Djindjikhashvili IA, Petrov VE, et al. Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles. J Drug Target 2009;17:564-74
-
(2009)
J Drug Target
, vol.17
, pp. 564-574
-
-
Kurakhmaeva, K.B.1
Djindjikhashvili, I.A.2
Petrov, V.E.3
-
59
-
-
69449091994
-
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
-
Blurton-Jones M, Kitazawa M, Martinez-Coria H, et al. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci USA 2009;106:13594-9
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13594-13599
-
-
Blurton-Jones, M.1
Kitazawa, M.2
Martinez-Coria, H.3
-
60
-
-
77957240989
-
Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease
-
Maher-Edwards G, Zvartau-Hind M, Hunter AJ, et al. Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease. Curr Alzheimer Res 2010;7:374-85
-
(2010)
Curr Alzheimer Res
, vol.7
, pp. 374-385
-
-
Maher-Edwards, G.1
Zvartau-Hind, M.2
Hunter, A.J.3
-
61
-
-
67349093525
-
Clearance mechanisms of Alzheimer's amyloid-beta peptide: Implications for therapeutic design and diagnostic tests
-
Bates KA, Verdile G, Li QX, et al. Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Mol Psychiatry 2009;14:469-86
-
(2009)
Mol Psychiatry
, vol.14
, pp. 469-486
-
-
Bates, K.A.1
Verdile, G.2
Li, Q.X.3
-
62
-
-
33947245344
-
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease
-
DOI 10.1016/j.nbd.2007.01.004, PII S096999610700023X
-
Hemming ML, Selkoe DJ, Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiol Dis 2007;26:273-81 (Pubitemid 46436503)
-
(2007)
Neurobiology of Disease
, vol.26
, Issue.1
, pp. 273-281
-
-
Hemming, M.L.1
Selkoe, D.J.2
Farris, W.3
-
63
-
-
33646433026
-
Antihypertensive medication use and incident Alzheimer disease: The Cache County Study
-
Khachaturian AS, Zandi PP, Lyketsos CG, et al. Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol 2006;63:686-92
-
(2006)
Arch Neurol
, vol.63
, pp. 686-692
-
-
Khachaturian, A.S.1
Zandi, P.P.2
Lyketsos, C.G.3
-
64
-
-
74949131237
-
Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
-
Li NC, Lee A, Whitmer RA, et al. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 2010;340:5465
-
(2010)
BMJ
, vol.340
, pp. 5465
-
-
Li, N.C.1
Lee, A.2
Whitmer, R.A.3
-
65
-
-
7644242460
-
Neuroprotection by tetracyclines
-
DOI 10.1016/j.tips.2004.10.001, PII S0165614704002792
-
Domercq M, Matute C. Neuroprotection by tetracyclines. Trends Pharmacol Sci 2004;25:609-12 (Pubitemid 39458165)
-
(2004)
Trends in Pharmacological Sciences
, vol.25
, Issue.12
, pp. 609-612
-
-
Domercq, M.1
Matute, C.2
-
66
-
-
12144290676
-
A randomized, controlled trial of doxycycline and rifampin for patients with alzheimer's disease
-
DOI 10.1111/j.1532-5415.2004.52109.x
-
Loeb MB, Molloy DW, Smieja M, et al. A Randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease. J Am Geriatr Soc 2004;52:381-7 (Pubitemid 38339518)
-
(2004)
Journal of the American Geriatrics Society
, vol.52
, Issue.3
, pp. 381-387
-
-
Loeb, M.B.1
Molloy, D.W.2
Smieja, M.3
Standish, T.4
Goldsmith, C.H.5
Mahony, J.6
Smith, S.7
Borrie, M.8
Decoteau, E.9
Davidson, W.10
McDougall, A.11
Gnarpe, J.12
O'Donnell, M.13
Chernesky, M.14
-
67
-
-
79955749452
-
The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
-
McClean PL, Parthsarathy V, Faivre E, Holscher C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011;31:6587-94
-
(2011)
J Neurosci
, vol.31
, pp. 6587-6594
-
-
McClean, P.L.1
Parthsarathy, V.2
Faivre, E.3
Holscher, C.4
-
68
-
-
77950352189
-
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
-
Li Y, Duffy KB, Ottinger MA, et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis 2010;19:1205-19
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 1205-1219
-
-
Li, Y.1
Duffy, K.B.2
Ottinger, M.A.3
-
69
-
-
77958057074
-
Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: A single-blind randomized controlled trial of clinical efficacy
-
Clare L, Linden DE, Woods RT, et al. Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. Am J Geriatr Psychiatry 2010;18:928-39
-
(2010)
Am J Geriatr Psychiatry
, vol.18
, pp. 928-939
-
-
Clare, L.1
Linden, D.E.2
Woods, R.T.3
-
70
-
-
65349183538
-
Cognitive training for early-stage Alzheimer's disease and dementia
-
Yu F, Rose KM, Burgener SC, et al. Cognitive training for early-stage Alzheimer's disease and dementia. J Gerontol Nurs 2009;35:23-9
-
(2009)
J Gerontol Nurs
, vol.35
, pp. 23-29
-
-
Yu, F.1
Rose, K.M.2
Burgener, S.C.3
-
71
-
-
0041828589
-
Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: Randomised controlled trial
-
DOI 10.1192/bjp.183.3.248
-
Spector A, Thorgrimsen L, Woods B, et al. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. Br J Psychiatry 2003;183:248-54 (Pubitemid 37070181)
-
(2003)
British Journal of Psychiatry
, vol.183
, Issue.SEPT.
, pp. 248-254
-
-
Spector, A.1
Thorgrimsen, L.2
Woods, B.3
Royan, L.4
Davies, S.5
Butterworth, M.6
Orrell, M.7
-
72
-
-
77953412425
-
Putting brain training to the test
-
Owen AM, Hampshire A, Grahn JA, et al. Putting brain training to the test. Nature 2010;465:775-8
-
(2010)
Nature
, vol.465
, pp. 775-778
-
-
Owen, A.M.1
Hampshire, A.2
Grahn, J.A.3
-
73
-
-
79952611543
-
Exercise training increases size of hippocampus and improves memory
-
Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 2011;108:3017-22
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 3017-3022
-
-
Erickson, K.I.1
Voss, M.W.2
Prakash, R.S.3
-
74
-
-
74949118967
-
Effects of aerobic exercise on mild cognitive impairment: A controlled trial
-
Baker LD, Frank LL, Foster-Schubert K, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol 2010;67:71-9
-
(2010)
Arch Neurol
, vol.67
, pp. 71-79
-
-
Baker, L.D.1
Frank, L.L.2
Foster-Schubert, K.3
-
75
-
-
50949110086
-
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial
-
Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008;300:1027-37
-
(2008)
JAMA
, vol.300
, pp. 1027-1037
-
-
Lautenschlager, N.T.1
Cox, K.L.2
Flicker, L.3
-
76
-
-
34447322271
-
Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria
-
DOI 10.1016/S1474-4422(07)70178-3, PII S1474442207701783
-
Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007;6:734-46 (Pubitemid 47058377)
-
(2007)
Lancet Neurology
, vol.6
, Issue.8
, pp. 734-746
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
DeKosky, S.T.4
Barberger-Gateau, P.5
Cummings, J.6
Delacourte, A.7
Galasko, D.8
Gauthier, S.9
Jicha, G.10
Meguro, K.11
O'Brien, J.12
Pasquier, F.13
Robert, P.14
Rossor, M.15
Salloway, S.16
Stern, Y.17
Visser, P.J.18
Scheltens, P.19
|