Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury. Immunohistochemical study in rat model

Acta Cirurgica Brasileira

Volumn 28, Issue 4, 2013, Pages 282-287

  Armstrong, Dinani Matoso Fialho de Oliveira ^a   Armstrong, Anderson da Costa ^b   Figueiredo, Regina Célia Bressan Queiroz ^c   Florentino, Joao Eduardo ^d   Saad, Paulo Fernandes ^b   Fox Talbot, Karen ^e   Halushka, Marc Kenneth ^e   Berkowitz, Dan E ^e   Taha, Murched Omar ^f   Fagundes, Djalma José ^f  

^a Federal University of São Francisco Valley UNIVASF   (Brazil)

^b UNIVASF   (Brazil)

^c Ctro de Pesq Aggeu Magalhaes   (Brazil)

^d FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Caspase 3; Muscle; Phosphodiesterase 5 inhibitors; Rats; Reperfusion in0jury; Skeletal

Indexed keywords

CASPASE 3; SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIMB ISCHEMIA; MALE; NONHUMAN; RAT; REPERFUSION INJURY; REPRODUCIBILITY; SKELETAL MUSCLE;

EID: 84876940708     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502013000400008     Document Type: Article

References (20)

1. Blaisdell FW. The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. Cardiovasc Surg. 2002;10(6):620-30.
2. Gillani S, Cao J, Suzuki T, Hak DJ. The effect of ischemia reperfusion injury on skeletal muscle. Injury. 2012;43(6):670-5.
3. Wang WZ, Fang XH, Stephenson LL, Khiabani KT, Zamboni WA. Ischemia/reperfusion-induced necrosis and apoptosis in the cells isolated from rat skeletal muscle. J Orthop Res. 2008;26(3):351-6.
4. Lopez-Neblina F, Toledo AH, Toledo-Pereyra LH. Molecular biology of apoptosis in ischemia and reperfusion. J Invest Surg. 2005;18(6):335-50.
5. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nunez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 2009;16(1):3-11.
6. Sotoudeh A, Takhtfooladi MA, Jahanshahi A, Asl AH, Takhtfooladi HA, Khansari M. Effect of N-acetylcysteine on lung injury induced by skeletal muscle ischemia-reperfusion. Histopathlogical study in rat model. Acta Cir Bras. 2012;27(2):168-71.
7. Henderson PW, Jimenez N, Ruffino J, Sohn AM, Weinstein AL, Krijgh DD, Reiffel AJ, Spector JA. Therapeutic delivery of hydrogen sulfide for salvage of ischemic skeletal muscle after the onset of critical ischemia. J Vasc Surg. 2011;53(3):785-91.
8. Wang WZ, Baynosa RC, Zamboni WA. Therapeutic interventions against reperfusion injury in skeletal muscle. J Surg Res. 2011;171(1):175-82.
9. Oruc O, Inci K, Aki FT, Zeybek D, Muftuoglu SF, Kilinc K, Ergen A. Sildenafil attenuates renal ischemia reperfusion injury by decreasing leukocyte infiltration. Acta Histochem. 2010;112(4):337-44.
10. Kukreja RC, Salloum F, Das A, Ockaili R, Yin C, Bremer YA, Fisher PW, Wittkamp M, Hawkins J, Chou E, Kukreja AK, Wang X, Marwaha VR, Xi L. Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications. Vascul Pharmacol. 2005;42(5-6):219-32.
11. Lledo-Garcia E, Subira-Rios D, Rodriguez-Martinez D, Dulin E, Alvarez-Fernandez E, Hernandez-Fernandez C, del Canizo-Lopez JF. Sildenafil as a protecting drug for warm ischemic kidney transplants: experimental results. J Urol. 2009;182(3):1222-5.
12. Hynes BG, Margey RJ, Ruggiero N, 2nd, Kiernan TJ, Rosenfield K, Jaff MR. Endovascular management of acute limb ischemia. Ann Vasc Surg. 2012;26(1):110-24.
13. Adiseshiah M, Round JM, Jones DA. Reperfusion injury in skeletal muscle: a prospective study in patients with acute limb ischaemia and claudicants treated by revascularization. Br J Surg. 1992;79(10):1026-9.
14. Brasileiro JL, Fagundes DJ, Miiji LON, Oshima CTF, Teruya R, Marks G, Inouye CM, Santos MA. Isquemia e reperfusão de músculo sóleo de ratos sob ação da pentoxifilina. J Vasc Bras. 2007;6(1):13.
15. Carmo-Araujo EM, Dal-Pai-Silva M, Dal-Pai V, Cecchini R, Anjos Ferreira AL. Ischaemia and reperfusion effects on skeletal muscle tissue: morphological and histochemical studies. Int J Exp Pathol. 2007;88(3):147-54.
16. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol. 1999;83(5A):35C-44C.
17. Corbin JD, Francis SH. Pharmacology of phosphodiesterase-5 inhibitors. Int J Clin Pract. 2002;56(6):453-9.
18. Hemnes AR, Champion HC. Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension. Expert Rev Cardiovasc Ther. 2006;4(3):293-300.
19. Zhang RL, Zhang Z, Zhang L, Wang Y, Zhang C, Chopp M. Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia. J Neurosci Res. 2006;83(7):1213-9.
20. Medeiros PJ, Villarim Neto A, Lima FP, Azevedo IM, Leao LR, Medeiros AC. Effect of sildenafil in renal ischemia/reperfusion injury in rats. Acta Cir Bras. 2010;25(6):490-5.