Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging

Experimental Neurology

Volumn 201, Issue 1, 2006, Pages 75-83

  Hwang, In Koo ^a   Yoo, Ki Yeon ^a   Jung, Boo Kyoung ^a   Cho, Jun Hwi ^b   Kim, Do Hoon ^a   Kang, Tae Cheon ^a   Kwon, Young Guen ^c   Kim, Yong Sun ^a   Won, Moo Ho ^a  

^a Hallym University   (South Korea)

^b Kangwon National University   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Aging; Brain derived neurotrophic factor; Dentate gyrus; Gerbil; Hippocampus proper; Immunohistochemistry; Memory; Messenger RNA; Western blot

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

AGING; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CELL LOSS; CONTROLLED STUDY; CORRELATION ANALYSIS; DENTATE GYRUS; GERBIL; HIPPOCAMPUS; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MAZE TEST; NERVE CELL; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; TISSUE DISTRIBUTION; WESTERN BLOTTING; WORKING MEMORY;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL COUNT; DENTATE GYRUS; GERBILLINAE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MEMORY; NEURONS;

EID: 33747091242     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.02.129     Document Type: Article

References (32)

1. Chao H.M., Sakai R.R., Ma L.Y., and McEwen B.S. Adrenal steroid regulation of neurotrophic factor expression in the rat hippocampus. Endocrinology 139 (1998) 3112-3118
2. Crutcher K.A., Scott S.A., Liang S., Everson W.V., and Weingartner J. Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J. Neurosci. 13 (1993) 2540-2550
3. Hafidi A., Lanjun G., and Sanes D.H. Age-dependent failure of axon regeneration in organotypic culture of gerbil auditory midbrain. J. Neurobiol. 41 (1999) 267-280
4. Hattiangady B., Rao M.S., Shetty G.A., and Shetty A.K. Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus. Exp. Neurol. 195 (2005) 353-371
5. Hayashi M., Yamashita A., and Shimizu K. Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging. Brain Res. 749 (1997) 283-289
6. Hayashi M., Mistunaga F., Ohira K., and Shimizu K. Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey. Brain Res. 918 (2001) 191-196
7. He D.Z., and Dallos P. Expression of potassium channels in gerbil outer hair cells during development does not require neural induction. Dev. Brain Res. 103 (1997) 95-97
8. Hofer M., Pagliusi S.R., Hohn A., Leibrock J., and Barde Y.A. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 9 (1990) 2459-2464
9. Hwang I.K., Kim D.W., Yoo K.Y., Kim D.S., Kim K.S., Kang J.H., Choi S.Y., Kim Y.S., Kang T.C., and Won M.H. Age-related changes of gamma-aminobutyric acid transaminase immunoreactivity in the hippocampus and dentate gyrus of the Mongolian gerbil. Brain Res. 1017 (2004) 77-84
10. Hwang I.K., Yoo K.Y., Park J.K., Nam Y.S., Lee I.S., Kang J.H., Choi S.Y., Lee J.Y., Kang T.C., and Won M.H. Ischemia-related changes of adrenocorticotropic hormone immunoreactivity and its protective effect in the gerbil hippocampus after transient forebrain ischemia. Neuroscience 126 (2004) 871-877
11. Hwang I.K., Yoon D.K., Yoo K.Y., Eum W.S., Bahn J.H., Kim D.W., Kang J.H., Kwon H.Y., Kang T.C., Choi S.Y., and Won M.H. Ischemia-related change of ceruloplasmin immunoreactivity in neurons and astrocytes in the gerbil hippocampus and dentate gyrus. Neurochem. Int. 44 (2004) 601-607
12. Katoh-Semba R., Asano T., Ueda H., Morishita R., Takeuchi I.K., Inaguma Y., and Kato K. Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J. 16 (2002) 1328-1330
13. Knusel B., Beck K.D., Winslow J.W., Rosenthal A., Burton L.E., Widmer H.R., Nikolics K., and Hefti F. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J. Neurosci. 12 (1992) 4391-4402
14. Korte M., Carroll P., Wolf E., Brem G., Thoenen H., and Bonhoeffer T. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 8856-8860
15. Lapchak P.A., Araujo D.M., Beck K.D., Finch C.E., Johnson S.A., and Hefti F. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiol. Aging 14 (1993) 121-126
16. Lee T.H., Kato H., Chen S.T., Kogure K., and Itoyama Y. Expression disparity of brain-derived neurotrophic factor immunoreactivity and mRNA in ischemic hippocampal neurons. NeuroReport 13 (2002) 2271-2275
17. Linnarsson S., Björklund A., and Ernfors P. Learning deficit in BDNF mutant mice. Eur. J. Neurosci. 9 (1997) 2581-2587
18. Medd A.M., and Bianchi L.M. Analysis of BDNF production in the aging gerbil cochlea. Exp. Neurol. 162 (2000) 390-393
19. Ming Y., Bergman E., Edström E., and Ulfhake B. Reciprocal changes in the expression of neurotrophin mRNAs in target tissues and peripheral nerves of aged rats. Neurosci. Lett. 273 (1999) 187-190
20. Mizuno M., Yamada K., Olariu A., Nawa H., and Nabeshima T. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J. Neurosci. 20 (2000) 7116-7121
21. Narisawa-Saito M., and Nawa H. Differential regulation of hippocampal neurotrophins during aging in rats. J. Neurochem. 67 (1996) 1124-1131
22. Nibuya M., Morinobu S., and Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatment. J. Neurosci. 15 (1995) 7539-7547
23. Phillips H.D., Hains J.M., Armanini M., Laramee G.R., Johnson S.A., and Winslow J.W. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7 (1991) 695-702
24. Rich S.T. The Mongolian gerbil (Meriones unguiculatus) in research. Lab. Anim. Care 18 (1968) 235-243
25. Ridder S., Chourbaji S., Hellweg R., Urani A., Zacher C., Schmid W., Zink M., Hörtnagl H., Flor H., Henn F.A., Schütz G., and Gass P. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci. 29 (2005) 6243-6250
26. Rihn L.L., and Claiborne B.J. Dendritic growth and regression in rat dentate granule cells during late postnatal development. Dev. Brain Res. 54 (1990) 115-124
27. Schaaf M.J., Hoetelmans R.W., de Kloet E.R., and Vreugdenhil E. Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus. J. Neurosci. Res. 48 (1997) 334-341
28. Shuaib A., Murabit M.A., Kanthan R., Howlett W., and Wishart T. The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluations. Neurosci. Lett. 204 (1996) 1-4
29. Smith M.A., Makino S., Kvetnansky R., and Post R.M. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J. Neurosci. 15 (1995) 1768-1777
30. Thoenen H. Neurotrophins and neuronal plasticity. Science 270 (1995) 593-598
31. Tolwani R.J., Buckmaster P.S., Varma S., Cosgaya J.M., Wu Y., Suri C., and Shooter E.M. BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus. Neuroscience 114 (2002) 795-805
32. Yurek D.M., and Fletcher-Turner A. Lesion-induced increase of BDNF is greater in the striatum of young versus old rat brain. Exp. Neurol. 161 (2000) 392-396