Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis: Essential role of nitric oxide signaling

Journal of Biological Chemistry

Volumn 280, Issue 13, 2005, Pages 12944-12955

  Das, Anindita ^a   Xi, Lei ^a   Kukreja, Rakesh C ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CARDIOLOGY; CELLS; DRUG PRODUCTS; ENZYMES; ESTERS; FLUORESCENCE; LIVING SYSTEMS STUDIES; NITRIC ACID; RNA;

MITOCHONDRIAL MEMBRANE; PHOSPHODIESTERASE-5 INHIBITOR; SIMULATED ISCHEMIA (SI); VENTRICULAR MYOCYTES;

ENZYME INHIBITION;

5,5',6,6' TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE; CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; FLUORESCENT DYE; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; SILDENAFIL; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HEART INFARCTION PREVENTION; HEART MUSCLE CELL; HEART MUSCLE REPERFUSION; HEART PROTECTION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MOLECULAR PROBE; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONTENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; BENZIMIDAZOLES; BLOTTING, WESTERN; CARBOCYANINES; CASPASE 3; CASPASES; CELL SURVIVAL; CELLS, CULTURED; DNA PRIMERS; DNA, COMPLEMENTARY; ENZYME ACTIVATION; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; L-LACTATE DEHYDROGENASE; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, KNOCKOUT; MITOCHONDRIA; MUSCLE CELLS; MYOCYTES, CARDIAC; NECROSIS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXYGEN; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRYPAN BLUE;

EID: 16844382827     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404706200     Document Type: Article

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