Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Milano, Giuseppina ^a,b   Bianciardi, Paola ^c   Rochemont, Viviane ^a   Vassalli, Giuseppe ^a,d   von Segesser, Ludwig K ^a   Corno, Antonio F ^e   Guazzi, Marco ^b   Samaja, Michele ^c  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b CENTRO CARDIOLOGICO MONZINO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d DIVISION OF CARDIOLOGY   (Switzerland)

^e Prince Salman Heart Center ^*  (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRATE; NITRITE; PHOSPHODIESTERASE V; PLACEBO; PROTEIN KINASE B; SILDENAFIL;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DISEASE RESISTANCE; DNA FRAGMENTATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REOXYGENATION;

ANIMALS; APOPTOSIS; BODY WEIGHT; CARDIOMEGALY; CARDIOTONIC AGENTS; CELL HYPOXIA; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXYGEN; PHOSPHODIESTERASE 5 INHIBITORS; POLYCYTHEMIA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 82155188820     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027910     Document Type: Article

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