Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production - A critical review

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 814-832

  Kumar, Ashish ^a   Gernaey, Krist V ^b   Beer, Thomas De ^a   Nopens, Ingmar ^a  

^a GHENT UNIVERSITY   (Belgium)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Calibration; High shear wet granulation; Measurement techniques; Process modelling; Twin screw granulator

Indexed keywords

BATCH PROCESS; COMPARTMENT MODEL; COMPUTER MODEL; CONTINUOUS PROCESS; DRUG BIOAVAILABILITY; DRUG GRANULATION; DRUG INDUSTRY; DRUG MANUFACTURE; EXPERIMENTATION; HIGH SHEAR WET GRANULATION; MOISTURE; PARTICLE SIZE; POROSITY; PROCESS DESIGN; REVIEW; SIMULATION; STEADY STATE; TABLET MANUFACTURE;

CALIBRATION; HIGH SHEAR WET GRANULATION; MEASUREMENT TECHNIQUES; PROCESS MODELLING; TWIN-SCREW GRANULATOR;

COMPUTER SIMULATION; DESICCATION; DRUG COMPOUNDING; EQUIPMENT DESIGN; MODELS, THEORETICAL; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POWDERS; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84889080100     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.09.013     Document Type: Review

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