Stability and repeatability of a continuous twin screw granulation and drying system

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 1031-1038

  Vercruysse, J ^a   Delaet, U ^b   Van Assche, I ^b   Cappuyns, P ^b   Arata, F ^c   Caporicci, G ^c   De Beer, T ^a   Remon, J P ^a   Vervaet, C ^a  

^a GHENT UNIVERSITY   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c Janssen Cilag SpA Italia   (Italy)

Author keywords

Continuous production; Continuous twin screw granulation and drying; Granule and tablet quality; Process transfer; Repeatability; Stability

Indexed keywords

CELLULOSE; MAGNESIUM STEARATE; STARCH; STARCH GLYCOLATE SODIUM; WATER;

ARTICLE; DRUG GRANULATION; DRUG GRANULE; DRUG QUALITY; DRUG SOLUBILITY; DRUG STABILITY; DRY POWDER; FILTER; FLOW; OUTCOME ASSESSMENT; PARTICLE SIZE; PRESSURE; PROCESSING; STEADY STATE; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TABLET MANUFACTURE; TABLET PROPERTY; TABLET THICKNESS; TORQUE; WATER TEMPERATURE;

CONTINUOUS PRODUCTION; CONTINUOUS TWIN SCREW GRANULATION AND DRYING; GRANULE AND TABLET QUALITY; PROCESS TRANSFER; REPEATABILITY; STABILITY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; EXCIPIENTS; PARTICLE SIZE; POWDERS; PRESSURE; REPRODUCIBILITY OF RESULTS; SOLUBILITY; STARCH; TABLETS; TEMPERATURE;

EID: 84889103013     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.05.002     Document Type: Article

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