Scale-up of high shear mixer-granulator based on discrete element analysis

Powder Technology

Volumn 236, Issue , 2013, Pages 149-156

  Nakamura, Hideya ^a   Fujii, Hiroyuki ^a   Watano, Satoru ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Discrete element simulation; Granulation; High shear mixer granulator; Scale up

Indexed keywords

DISCRETE ELEMENT ANALYSIS; DISCRETE ELEMENT SIMULATION; DYNAMIC SIMILARITIES; GRANULATION TIME; HIGH SHEAR; IMPELLER TIP SPEED; MOTION OF PARTICLES; PARTICLE BEHAVIOR; PARTICLE COLLISION; PARTICLE FLOW; PER UNIT; SCALE-UP; SCALING-UP; THREE-DIMENSIONAL DISCRETE ELEMENT METHODS; VESSEL SIZE;

FINITE DIFFERENCE METHOD; GRANULATION; GRANULATORS; KINEMATICS; MIXERS (MACHINERY); MIXING; SHEAR FLOW;

PARTICLES (PARTICULATE MATTER);

EXCIPIENT;

ARTICLE; DISCRETE ELEMENT ANALYSIS; DRUG GRANULATION; ENERGY; GEOMETRY; HIGH SHEAR MIXER GRANULATOR; KINEMATICS; MATHEMATICAL ANALYSIS; PARTICLE SIZE; SCALE UP; SHEAR FLOW; SIMULATION; VALIDITY;

EID: 84873735271     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2012.03.009     Document Type: Article

References (37)

1. Reynolds G.K., Le P.K., Nilpawar A.M. High shear granulation. Granulation 2007, 3-19. Elsevier, Oxford. A.D. Salman, M.J. Hounslow, J.P.K. Sevile (Eds.).
2. Landin M., York P., Cliff M.J., Rowe R.C., Wigmore A.J. Scale-up of pharmaceutical granulation in fixed bowl mixer-granulators. International Journal of Pharmaceutics 1996, 133:127-131.
3. Faure A., Grimsey I.M., Rowe R.C., York P., Cliff M.J. A methodology for the optimization of wet granulation in a model planetary mixer. Pharmaceutical Development and Technology 1998, 3:413-422.
4. Faure A., Grimsey I.M., Rowe R.C., York P., Cliff M.J. Applicability of scale-up methodology for wet granulation processes in Collette Gral high shear mixer-granulators. European Journal of Pharmaceutical Sciences 1999, 8:85-93.
5. Faure A., York P., Rowe R.C. Process control and scale-up of pharmaceutical wet granulation processes: a review. European Journal of Pharmaceutics and Biopharmaceutics 2001, 52:269-277.
6. Schaefer T., Taagegaard B., Thomsen L.J., Kristensen H.G. Melt pelletization in a high shear mixer V. Effects of apparatus variables. European Journal of Pharmaceutical Sciences 1993, 1:133-141.
7. Ramaker J.S., Jelgersma M.A., Vonk P., Kossen N.W.F. Scale-down of a high shear pelletisation process: flow profile and growth kinetics. International Journal of Pharmaceutics 1998, 166:89-97.
8. Sirois P.J., Craig G.D. Scale-up of a high-shear granulation process using a normalized impeller work parameter. Pharmaceutical Development and Technology 2000, 5:365-374.
9. Bardin M., Knight P.C., Seville J.P.K. On control of particle size distribution in granulation using high-shear mixers. Powder Technology 2004, 140:169-175.
10. Sato Y., Okamoto T., Watano S. Scale-up of high shear granulation based on agitation power. Chemical and Pharmaceutical Bulletin 2005, 53:1547-1550.
11. Campbell G.A., Clancy D.J., Zhang J.X., Gupta M.K., Oh C.K. Closing the gap in series scale up of high shear wet granulation process using impeller power and blade design. Powder Technology 2011, 205:184-192.
12. Litster J.D., Hapgood K.P., Michaels J.N., Sims A., Roberts M., Kameneni S.K., Hsu T. Liquid distribution in wet granulation: dimensionless spray flux. Powder Technology 2001, 114:32-39.
13. Litster J.D., Hapgood K.P., Michaels J.N., Sims A., Roberts M., Kameneni S.K. Scale-up of mixer granulators for effective liquid distribution. Powder Technology 2002, 124:272-280.
14. Bock T.K., Kraas U. Experience with the Diosna mini-granulator and assessment of process scalability. European Journal of Pharmaceutics and Biopharmaceutics 2001, 52:297-303.
15. Ameye D., Keleb E., Vervaet C., Remon J.P., Adams E., Massart D.L. Scaling-up of a lactose wet granulation process in Mi-Pro high shear mixers. European Journal of Pharmaceutical Sciences 2002, 17:247-251.
16. Watano S., Okamoto T., Sato Y., Osako Y. Scale-up of high shear granulation based on the internal stress measurement. Chemical and Pharmaceutical Bulletin 2005, 53:351-354.
17. Rahmanian N., Ghadiri M., Ding Y. Effect of scale of operation on granule strength in high shear granulators. Chemical Engineering Science 2008, 63:915-923.
18. Horsthuis G.J.B., van Laarhoven J.A.H., van Rooij R.C.B.M., Vromans H. Studies on upscaling parameters of the Gral high shear granulation process. International Journal of Pharmaceutics 1993, 92:143-150.
19. Leuenberger H. Scale-up of granulation processes with reference to process monitoring. Acta Pharmaceutical Technology 1983, 29:274-280.
20. Tardos G.I., Hapgood K.P., Ipadeola O.O., Michaels J.N. Stress measurements in high-shear granulators using calibrated "test" particles: application to scale-up. Powder Technology 2004, 140:217-227.
21. Ng B.H., Kwan C.C., Ding Y.L., Ghadiri M., Fan X.F., Parker D.J. Granular flow fields in vertical high shear mixer granulators. AICHE Journal 2008, 54:415-426.
22. Hassanpour A., Kwan C.C., Ng B.H., Rahmanian N., Ding Y.L., Antony S.J., Jia X.D., Ghadiri M. Effect of granulation scale-up on the strength of granules. Powder Technology 2009, 189:304-312.
23. Parker D.J., Dijkstra A.E., Martin T.W., Seville J.P.K. Positron emission particle tracking studies of spherical particle motion in rotating drum. Chemical Engineering Science 1997, 52:2011-2022.
24. Cundall P.A., Strack O.D.L. A discrete numerical model for granular assemblies. Geotechnique 1979, 29:47-65.
25. Stewart R.L., Bridgwater J., Zhou Y.C., Yu A.B. Simulated and measured flow of granules in a bladed mixer-a detailed comparison. Chemical Engineering Science 2001, 56:5457-5471.
26. Kuo H.P., Knight P.C., Parker D.J., Adams M.J., Seville J.P.K. Discrete element simulations of a high-shear mixer. Advanced Powder Technology 2004, 15:297-309.
27. Zhou Y.C., Yu A.B., Stewart R.L., Bridgwater J. Microdynamic analysis of the particle flow in a cylindrical bladed mixer. Chemical Engineering Science 2004, 59:1343-1364.
28. Terashita K., Nishimura T., Natsuyama S. Optimization of operating conditions in a high-shear mixer using DEM model: determination of optimal fill level. Chemical and Pharmaceutical Bulletin 2002, 50:1550-1557.
29. Zhou Y.C., Yu A.B., Bridgwater J. Segregation of binary mixture of particles in a bladed mixer. Journal of Chemical Technology and Biotechnology 2003, 78:187-193.
30. Sato Y., Nakamura H., Watano S. Numerical analysis of agitation torque and particle motion in a high shear mixer. Powder Technology 2008, 186:130-136.
31. Zhou Y.C., Wright B.D., Yang R.Y., Xu B.H., Yu A.B. Rolling friction in the dynamic simulation of sandpipe formation. Physica A 1999, 269:536-553.
32. Hassanpour A., Tan H., Bayly A., Gopalkrishnan P., Ng B., Ghadiri M. Analysis of particle motion in a paddle mixer using Discrete Element Method (DEM). Powder Technology 2011, 206:189-194.
33. Sunada H., Hasegawa M., Makino T., Fujita K., Sakamoto H., Tanino T., Kawaguchi T. Study of standard tablet formulation based on granulation. Journal of the Society of Powder Technology, Japan 1997, 34:785-795.
34. Iveson S.M., Litster J.D. Growth regime map for liquid-bound granules. AICHE Journal 1998, 44:1510-1518.
35. Tardos G.I., Khan M.I., Mort P.R. Critical parameters and limiting conditions in binder granulation of fine powders. Powder Technology 1997, 94:245-258.
36. Franks G.V., Lange F.F. Plastic flow of saturated alumina powder compacts: pair potential and strain rate. AICHE Journal 1999, 45:1830-1835.
37. Iveson S.M., Beathe J.A., Page N.W. The dynamic strength of partially saturated powder compacts: the effect of liquid properties. Powder Technology 2002, 127:149-161.