The effect of primary particle surface energy on agglomeration rate in fluidised bed wet granulation

Powder Technology

Volumn 181, Issue 2, 2008, Pages 160-168

  Thielmann, Frank ^a   Naderi, Majid ^a   Ansari, Mansoor A ^b   Stepanek, Frantisek ^b  

^a Application Science   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Inverse gas chromatography; Monte Carlo simulation; Population balance model; Spreading; Surface energy; Wetting

Indexed keywords

COMPUTER SIMULATION; INTERFACIAL ENERGY; MONTE CARLO METHODS; WETTING;

INVERSE GAS CHROMATOGRAPHY; POPULATION BALANCE MODEL; SPREADING;

FLUIDIZED BEDS;

HYDROXYPROPYLCELLULOSE;

COMPUTER SIMULATION; FLUIDIZED BEDS; INTERFACIAL ENERGY; MONTE CARLO METHODS; WETTING;

AQUEOUS SOLUTION; ARTICLE; CONTACT ANGLE; DRUG GRANULATION; FLUIDIZED BED; INVERSE GAS CHROMATOGRAPHY; MONTE CARLO METHOD; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPE; SURFACE PROPERTY; VISCOSITY; WETTABILITY;

EID: 38149058870     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2006.12.015     Document Type: Article

References (24)

1. Kristensen H.G., and Schaefer T. A review of pharmaceutical wet granulation. Drug Dev. Ind. Pharm. 13 (1987) 803-872
2. Rowe R.C. Surface free energy and polarity effects in the granulation of a model system. Int. J. Pharm. 53 (1989) 75-78
3. Planinšek O., Pišek R., Trojak A., and Srčič S. The utilisation of free-energy parameters for the selection of a suitable binder in fluidized bed granulation. Int. J. Pharm. 207 (2000) 77-88
4. Zhang D., Flory J.H., Panmai S., Batra U., and Kaufman M.J. Wettability of pharmaceutical solids: its measurement and influence on wet granulation. Colloids Surf., A Physicochem. Eng. Asp. 206 (2002) 547-554
5. Simons S.J.R., and Fairbrother R.J. Direct observation of liquid binder-particle interactions: the role of wetting behaviour in agglomerate growth. Powder Technol. 110 (2000) 44-58
6. Simons S.J.R., Rossetti D., Pagliai P., Ward R., and Fitzpatrick S. The relationship between surface properties and binder performance in granulation. Chem. Eng. Sci. 60 (2005) 4055-4060
7. Boerefijn R., and Hounslow M.J. Studies of fluid bed granulation in an industrial R&D context. Chem. Eng. Sci. 60 (2005) 3879-3890
8. Michaels J.N. Towards rational design of powder processes. Powder Technol. 138 (2003) 1-6
9. M.J.V. Goldschmidt, Hydrodynamic modelling of fluidised bed spray granulation, PhD Thesis, Twente University, Enschede, The Netherlands, (2001).
10. Clarke A., Blake T.D., Carruthers K., and Woodward A. Spreading and imbibition of liquid droplets on porous surfaces. Langmuir 18 (2002) 2980-2984
11. Stepanek F., and Rajniak P. Liquid morphologies on particles with macroscopic surface roughness. Langmuir 22 (2006) 917-923
12. Ennis B.J., Tardos G., and Pfeffer R. A microlevel-based characterization of granulation phenomena. Powder Technol. 56 (1991) 257-272
13. Tardos G.I., Khan M.I., and Mort P.R. Critical parameters and limiting conditions in binder granulation of fine powders. Powder Technol. 94 (1997) 245-258
14. Talu I., Tardos G.I., and Khan M.I. Computer simulation of wet granulation. Powder Technol. 110 (2000) 59-75
15. Link K.C., and Schlunder E.-U. Fluidized bed spray granulation: investigation of the coating process on a single sphere. Chem. Eng. Process. 36 (1997) 443-457
16. Hemati M., Cherif R., Saleh K., and Pont V. Fluidized bed coating and granulation: influence of process-related variables and physicochemical properties on the growth kinetics. Powder Technol. 130 (2003) 18-34
17. Walker G.M., Holland C.R., Ahmad M.N., Fox J.N., and Kells A.G. Prediction of fertilizer granulation: effect of binder viscosity on random coalescence model. Ind. Eng. Chem. Res. 40 (2001) 2128-2133
18. Grimsey I., Feeley J., and York P. Analysis of the surface energy of pharmaceutical powders by inverse gas chromatography. J. Pharm. Sci. 91 (2002) 571-583
19. F. Thielmann, D.J. Burnett, K. Lusvardi, T. Duerig, Correlating drug-binder adhesive strengths with tablet performance, Presented at Formula IV: Frontiers in Formulation Science, London, 4-7 July 2005.
20. Mukhopadhyay P., and Schreiber H.P. Aspects of acid-base interactions and use of inverse gas chromatography. Colloids Surf., A Physicochem. Eng. Asp. 100 (1995) 47
21. Lin Y., Lee K., and Matsoukas T. Solution of the population balance equation using constant-number Monte Carlo. Chem. Eng. Sci. 57 (2002) 2241-2252
22. Gidaspow D. Multiphase flow and fluidization: continuum and kinetic theory descriptions (1994), Academic Press, Boston
23. Cryer S.A. Modeling agglomeration processes in fluid-bed granulation. AIChE J. 45 (1999) 2069-2078
24. Stepanek F., and Ansari M.A. Computer simulation of granule microstructure formation. Chem. Eng. Sci. 60 (2005) 4019-4029