Steady states in granulation of pharmaceutical powders with application to scale-up

Powder Technology

Volumn 189, Issue 2, 2009, Pages 295-303

  Michaels, James N ^a   Farber, Leon ^a   Wong, Gordon S ^a   Hapgood, Karen ^b   Heidel, Stephen J ^a   Farabaugh, Julianne ^a   Chou, Jun Hong ^a   Tardos, Gabriel I ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MONASH UNIVERSITY   (Australia)

^c CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Binder addition; Granulation; Scale up; Wet massing

Indexed keywords

CONSTANT SHEARS; CONTROLLED CONDITIONS; CRITICAL PARAMETERS; EXPERIMENTAL EVIDENCES; FINE POWDERS; IDENTICAL PARTICLES; LIMITING CONDITIONS; MOLECULAR DYNAMIC SIMULATIONS; PARTICLE SIZE DISTRIBUTIONS; PHARMACEUTICAL POWDERS; POWDER TECHNOLOGIES; SCALE-UP; SHEAR FORCES; SHEAR GRANULATIONS; SHEAR MIXERS; STEADY STATES; THEORETICAL MODELS; TOTAL AMOUNTS; WET AND DRIES; WET GRANULATIONS; WET MASSES; WET MASSING;

AGGLOMERATION; BINDERS; DRUG PRODUCTS; EXPERIMENTS; GROWTH (MATERIALS); MIXERS (MACHINERY); MOLECULAR DYNAMICS; POWDERS; SHEARING MACHINES; SIZE DISTRIBUTION;

GRANULATION;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG GRANULATION; MASS; MIXER; PARTICLE SIZE; POWDER; SCALE UP; SHEAR STRESS; STEADY STATE; WETTABILITY;

EID: 58349087211     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.04.028     Document Type: Article

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