Wet granulation in a twin-screw extruder: Implications of screw design

Journal of Pharmaceutical Sciences

Volumn 99, Issue 4, 2010, Pages 2090-2103

  Thompson, M R ^a   Sun, J ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Excipients; Extrusion; Granulation; Particle sizing; Powder technology; Processing; Screw design; Wetting

Indexed keywords

LACTOSE; POVIDONE;

ARTICLE; DRUG GRANULATION; EQUIPMENT; EQUIPMENT DESIGN; MACHINE; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; TWIN SCREW EXTRUDER;

EID: 77949790579     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21973     Document Type: Article

References (28)

1. Vervaet C, Remon JP. 2005. Continuous granulation in the pharmaceutical industry. Chem Eng Sci 60:3949-3957.
2. Lodaya M, Mollan M, Ghebre-Sellassie I. 2003. Twin-screw wet granulation. In: Ghebre-Sellassie I, Martin C, editors. Pharmaceutical extrusion technology. 1st edition. New York: M. Dekker. pp 323-343.
3. Goodhart FW, Draper JR, Ninger FC. 1973. Design and use of a laboratory extruder for pharmaceutical granulations. Pharm Technol 62:133-136.
4. Ghebre-Sellassie I, Martin C. (Eds). 2003. Pharmaceutical Extrusion Technology (Drug and the Pharmaceutical Sciences, Vol 133), NY: Taylor and Francis Group, 400pp.
5. Gamlen MJ, Eardley C. 1986. Continuous extrusion using a Baker Perkins MP50 (multipurpose) extruder. Drug Dev Ind Pharm 12:1701-1713.
6. Lindberg NO, Myrenas M, Tufvesson C, Olbjer L. 1988. Extrusion of an effervescent granulation with a twin screw extruder, Baker Perkins Mpf 50d - Determination of mean residence time. Drug Dev Ind Pharm 14:649-655.
7. Lindberg NO, Tufvesson C, Holm P, Olbjer L. 1988. Extrusion of an effervescent granulation with a twin screw extruder, Baker Perkins Mpf 50-D-Influence on intragranular porosity and liquid saturation. Drug Dev Ind Pharm 14:1791-1798.
8. Lindberg NO, Tufvesson C, Olbjer L. 1987. Extrusion of an effervescent granulation with a twin screw extruder, Baker Perkins Mpf 50-D. Drug Dev Ind Pharm 13:1891-1913.
9. Kleinebudde P, Lindner H. 1993. Experiments with an instrumented twin-screw extruder using a single-step granulation extrusion process. Int J Pharm 94:49-58.
10. Kleinebudde P, Solvberg AJ, Lindner H. 1994. The power-consumption- controlled extruder - A tool for pellet production. J Pharm Pharmacol 46: 542-546.
11. Keleb EI, Vermeire A, Vervaet C, Remon JP. 2001. Cold extrusion as a continuous single-step granulation and tabletting process. Eur J Pharm Biopharm 52:359-368.
12. Keleb EI, Vermeire A, Vervaet C, Remon JP. 2002. Continuous twin screw extrusion for the wet granulation of lactose. Int J Pharm 239:69-80.
13. Keleb EI, Vermeire A, Vervaet C, Remon JP. 2004. Twin screw granulation as a simple and efficient tool for continuous wet granulation. Int J Pharm 273:183-194.
14. Repka MA, Battu SK, Upadhye SB, Thumma S, Crowley MM, Zhang F, Martin C, McGinity JW. 2007. Pharmaceutical applications of hot-melt extrusion: Part II. Drug Dev Ind Pharm 33:1043-1057.
15. Van Melkebeke B, Vermeulen B, Vervaet C, Remon JP. 2006. Melt granulation using a twin-screw extruder: A case study. Int J Pharm 326:89-93.
16. Djuric D, Kleinebudde P. 2008. Impact of screw elements on continuous granulation with a twinscrew extruder. J Pharm Sci 97:4934-4942.
17. Shah U. 2005. Use of a modified twin-screw extruder to develop a high-strength tablet dosage form. Pharm Technol 29:52-66.
18. Van Melkebeke B, Vervaet C, Remon JP. 2008. Validation of a continuous granulation process using a twin-screw extruder. Int J Pharm 356: 224-230.
19. Martelli FG. (Ed.) 1983. Twin screw extruders: A basic understanding. New York: Van Nostrand Reinhold Co. x, 137pp.
20. Booy ML. 1978. Geometry of fully wiped twin-screw equipment. Polym Eng Sci 18:973-984.
21. Roos E, Steffens M, Zimmermann D. 2004. Screw design for co-rotating twin-screw extruders. Plast Addit Compound 6:38-41.
22. Shimizu Y, Cundall PA. 2001. Three-dimensional DEM simulations of bulk handling by screw conveyors. J Eng Mech 127:864-872.
23. Walker GM, Holland CR, Ahmad MMN, Craig DQM. 2005. Influence of process parameters on fluidised hot-melt granulation and tablet pressing of pharmaceutical powders. Chem Eng Sci 60:3867-3877.
24. Tousey MD. 2002. Optimal tablet press operation: Machine versus granulation. Pharm Technol 26: 52-60.
25. Tousey MD. 2004. Preventing and fixing weight and hardness defects: Strategies for production personnel. Tablets Capsules 2:34-38.
26. Reynolds GK, Biggs CA, Salman AD, Hounslow MJ. 2004. Non-uniformity of binder distribution in highshear granulation. Powder Technol 140:203-208.
27. Bravo VL, Hrymak AN, Wright JD. 2004. Study of particle trajectories, residence times and flow behavior in kneading discs of intermeshing co-rotating twin-screw extruders. Polymer Eng Sci 44:779-793.
28. Wauters PAL, van de Water R, Litster JD, Meesters GMH, Scarlett B. 2002. Growth and compaction behaviour of copper concentrate granules in a rotating drum. Powder Technol 124:230-237.