A combined experimental and computational study of wet granulation in a Wurster fluid bed granulator

Powder Technology

Volumn 189, Issue 2, 2009, Pages 190-201

  Rajniak, P ^a   Stepanek, F ^b   Dhanasekharan, K ^c   Fan, R ^c   Mancinelli, C ^a   Chern, R T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c ANSYS INC   (United States)

Author keywords

Agglomeration kernel; CFD; Granulation; Method of moments; Modeling; Population balance

Indexed keywords

AGGLOMERATION KERNEL; AGGLOMERATION RATE; CFD; CFD MODELING; CONTACT MECHANICS (B); DICALCIUM PHOSPHATE (DCPA); MESO SCALE SIMULATIONS; MIXTURE FLOW; MODELING; PB EQUATIONS; PB MODELS; PHARMACEUTICAL EXCIPIENTS; POPULATION BALANCE; QUADRATURE METHODS; SIMULATION RESULTS; SOLID PARTICLES; STOKES NUMBERS; SUCCESS FACTORS; WET GRANULATION;

AGGLOMERATION; BINDERS; CELLULOSE DERIVATIVES; FLUID DYNAMICS; FLUIDIZATION; FLUIDIZED BEDS; GRANULATION; GRANULATORS; GROWTH (MATERIALS); LEAD ALLOYS; PILOT PLANTS; POISSON EQUATION; POPULATION STATISTICS; PROGRAMMING THEORY; RATE CONSTANTS; SURFACE ROUGHNESS; THREE DIMENSIONAL;

METHOD OF MOMENTS;

CALCIUM PHOSPHATE DIBASIC; EXCIPIENT; MANNITOL; MICROCRYSTALLINE CELLULOSE;

ARTICLE; COMPUTATIONAL FLUID DYNAMICS; DRUG GRANULATION; EXPERIMENTAL STUDY; FLUIDIZED BED; GAS; HYDRODYNAMICS; KINETICS; MODEL; PARTICLE SIZE; SIMULATION; SOLID;

AGGLOMERATION; BINDERS; CELLULOSE DERIVATIVES; COMPUTATION; FLUID DYNAMICS; FLUIDIZATION; FLUIDIZED BEDS; GRANULATION; HYDRODYNAMICS; KINETICS; PILOT PLANTS; ROUGHNESS; STATISTICS; SURFACE STRUCTURE; WET PROCESS;

EID: 58749104602     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.04.027     Document Type: Article

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