-
5
-
-
84857743319
-
-
doi:10.1038/nrd3681
-
Scannell, J. W.; Blanckley, A.; Boldon, H.; Warrington, B. Nat. Rev. Drug Discovery 2012, 11, 191-200. doi:10.1038/nrd3681
-
(2012)
Nat. Rev. Drug Discovery
, vol.11
, pp. 191-200
-
-
Scannell, J.W.1
Blanckley, A.2
Boldon, H.3
Warrington, B.4
-
6
-
-
48149083026
-
-
doi:10.1002/cmdc.200700008
-
Baxendale, I. R.; Hayward, J. J.; Ley, S. V.; Tranmer, G. K. ChemMedChem 2007, 2, 768-788. doi:10.1002/cmdc.200700008
-
(2007)
ChemMedChem
, vol.2
, pp. 768-788
-
-
Baxendale, I.R.1
Hayward, J.J.2
Ley, S.V.3
Tranmer, G.K.4
-
7
-
-
79955053789
-
-
doi:10.3762/bjoc.7.57
-
Baumann, M.; Baxendale, I. R.; Ley, S. V.; Nikbin, N. Beilstein J. Org. Chem. 2011, 7, 442-495. doi:10.3762/bjoc.7.57
-
(2011)
Beilstein J. Org. Chem.
, vol.7
, pp. 442-495
-
-
Baumann, M.1
Baxendale, I.R.2
Ley, S.V.3
Nikbin, N.4
-
8
-
-
84883992039
-
-
S. K., Eds.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany doi:10.1002/9783527634880.ch8
-
Kiuru, P.; Yli-Kauhaluoma, J. Pyridine and Its Derivatives. In Heterocycles in Natural Product Synthesis; Majumdar, K.; Chattopadhyay, S. K., Eds.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2011; pp 267-297. doi:10.1002/9783527634880.ch8
-
(2011)
Heterocycles in Natural Product Synthesis; Majumdar, K.; Chattopadhyay
, pp. 267-297
-
-
Kiuru, P.1
Pyridine, Y.J.2
Derivatives, I.3
-
9
-
-
0029886581
-
Comparison of the effects of pyridine and its metabolites on rat liver and kidney
-
DOI 10.1016/0378-4274(96)03660-0
-
Carlson, G. P. Toxicol. Lett. 1996, 85, 173-178. doi:10.1016/0378- 4274(96)03660-0 (Pubitemid 26164337)
-
(1996)
Toxicology Letters
, vol.85
, Issue.3
, pp. 173-178
-
-
Carlson, G.P.1
-
10
-
-
78650379608
-
-
doi:10.1021/jm100888d
-
Pryde, D. C.; Dalvie, D.; Hu, Q.; Jones, P.; Obach, R. S.; Tran, T.-D. J. Med. Chem. 2010, 53, 8441-8460. doi:10.1021/jm100888d
-
(2010)
J. Med. Chem.
, vol.53
, pp. 8441-8460
-
-
Pryde, D.C.1
Dalvie, D.2
Hu, Q.3
Jones, P.4
Obach, R.S.5
Tran, T.-D.6
-
11
-
-
0028575501
-
-
doi:10.1021/jm00052a005
-
Garvey, D. S.; Wasicak, J. T.; Elliott, R. L.; Lebold, S. A.; Hettinger, A.-N.; Carrera, G. M.; Lin, N.-H.; He, Y.; Holladay, M. W.; Anderson, D. J.; Cadman, E. D.; Raszkiewicz, J. L.; Sullivan, J. P.; Arneric, S. P. J. Med. Chem. 1994, 37, 4455-4463. doi:10.1021/jm00052a005
-
(1994)
J. Med. Chem.
, vol.37
, pp. 4455-4463
-
-
Garvey, D.S.1
Wasicak, J.T.2
Elliott, R.L.3
Lebold, S.A.4
Hettinger, A.-N.5
Carrera, G.M.6
Lin, N.-H.7
He, Y.8
Holladay, M.W.9
Anderson, D.J.10
Cadman, E.D.11
Raszkiewicz, J.L.12
Sullivan, J.P.13
Arneric, S.P.14
-
12
-
-
0034124493
-
Bioisosteric replacement strategy for the synthesis of 1-azacyclic compounds with high affinity for the central nicotinic cholinergic receptors
-
DOI 10.1016/S0968-0896(00)00063-8, PII S0968089600000638
-
Olesen, P. H.; Tønder, J. E.; Hansen, J. B.; Hansen, H. C.; Rimvall, K. Bioorg. Med. Chem. 2000, 8, 1443-1450. doi:10.1016/S0968-0896(00) 00063-8 (Pubitemid 30398464)
-
(2000)
Bioorganic and Medicinal Chemistry
, vol.8
, Issue.6
, pp. 1443-1450
-
-
Olesen, P.H.1
Tonder, J.E.2
Hansen, J.B.3
Hansen, H.C.4
Rimvall, K.5
-
13
-
-
0037186458
-
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165
-
DOI 10.1021/jm010936y
-
Gohlke, H.; Gündisch, D.; Schwarz, S.; Seitz, G.; Tilotta, M. C.; Wegge, T. J. Med. Chem. 2002, 45, 1064-1072. doi:10.1021/jm010936y (Pubitemid 34173916)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.5
, pp. 1064-1072
-
-
Gohlke, H.1
Gundisch, D.2
Schwarz, S.3
Seitz, G.4
Tilotta, M.C.5
Wegge, T.6
-
14
-
-
0029841644
-
2 receptor antagonist and synthetase inhibitor ridogrel
-
DOI 10.1021/jm960341g
-
Heinisch, G.; Holzer, W.; Kunz, F.; Langer, T.; Lukavsky, P.; Pechlaner, C.; Weissenberger, H. J. Med. Chem. 1996, 39, 4058-4064. doi:10.1021/JM960341G (Pubitemid 26327442)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.20
, pp. 4058-4064
-
-
Heinisch, G.1
Holzer, W.2
Kunz, F.3
Langer, T.4
Lukavsky, P.5
Pechlaner, C.6
Weissenberger, H.7
-
15
-
-
0037450398
-
The Bohlmann-Rahtz route to functionalised pyridine scaffolds and their use in library synthesis
-
DOI 10.1016/S0040-4039(03)00034-0, PII S0040403903000340
-
Bashford, K. E.; Burton, M. B.; Cameron, S.; Cooper, A. L.; Hogg, R. D.; Kane, P. D.; MacManus, D. A.; Matrunola, C. A.; Moody, C. J.; Robertson, A. A. B.; Warne, M. R. Tetrahedron Lett. 2003, 44, 1627-1629. doi:10.1016/S0040- 4039(03)00034-0 (Pubitemid 36170099)
-
(2003)
Tetrahedron Letters
, vol.44
, Issue.8
, pp. 1627-1629
-
-
Bashford, K.E.1
Burton, M.B.2
Cameron, S.3
Cooper, A.L.4
Hogg, R.D.5
Kane, P.D.6
MacManus, D.A.7
Matrunola, C.A.8
Moody, C.J.9
Robertson, A.A.B.10
Warne, M.R.11
-
16
-
-
3042558198
-
De novo synthesis of substituted pyridines
-
DOI 10.1016/j.tet.2004.04.043, PII S0040402004005939
-
Henry, G. D. Tetrahedron 2004, 60, 6043-6061. doi:10.1016/j.tet.2004.04. 043 (Pubitemid 38824592)
-
(2004)
Tetrahedron
, vol.60
, Issue.29
, pp. 6043-6061
-
-
Henry, G.D.1
-
18
-
-
84880567562
-
-
doi:10.1021/ol4013525
-
Lehmann, J.; Alzien, T.; Martin, R. E.; Britton, R. Org. Lett. 2013, 15, 3550-3553. doi:10.1021/ol4013525
-
(2013)
Org. Lett.
, vol.15
, pp. 3550-3553
-
-
Lehmann, J.1
Alzien, T.2
Martin, R.E.3
Britton, R.4
-
19
-
-
0032505253
-
-
doi:10.1016/S0040-4039(98)01438-5
-
Pabst, G. R.; Schmid, K.; Sauer, J. Tetrahedron Lett. 1998, 39, 6691-6694. doi:10.1016/S0040-4039(98)01438-5
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 6691-6694
-
-
Pabst, G.R.1
Schmid, K.2
Sauer, J.3
-
20
-
-
0037419452
-
Synthesis of aminonicotinonitriles and diaminopyridines through base-catalyzed ring transformation of 2H-pyran-2-ones
-
DOI 10.1021/jo0204496
-
Agarwal, N.; Goel, A.; Ram, V. J. J. Org. Chem. 2003, 68, 2983-2985. doi:10.1021/jo0204496 (Pubitemid 36512682)
-
(2003)
Journal of Organic Chemistry
, vol.68
, Issue.7
, pp. 2983-2985
-
-
Agarwal, N.1
Goel, A.2
Ram, V.J.3
-
21
-
-
0032485313
-
Microwave assisted combinatorial chemistry. Synthesis of substituted pyridines
-
DOI 10.1016/S0040-4039(97)10796-1, PII S0040403997107961
-
Cotterill, I. C.; Usyatinsky, A. Y.; Arnold, J. M.; Clark, D. S.; Dordick, J. S.; Michels, P. C.; Khmelnitski, Y. L. Tetrahedron Lett. 1998, 39, 1117-1120. doi:10.1016/S0040-4039(97)10796-1 (Pubitemid 28076184)
-
(1998)
Tetrahedron Letters
, vol.39
, Issue.10
, pp. 1117-1120
-
-
Cotterill, I.C.1
Usyatinsky, A.Ya.2
Arnold, J.M.3
Clark, D.S.4
Dordick, J.S.5
Michels, P.C.6
Khmelnitsky, Y.L.7
-
22
-
-
0037328212
-
Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors
-
DOI 10.1016/S0960-894X(02)00943-5, PII S0960894X02009435
-
Enyedy, I. J.; Sakamuri, S.; Zaman, W. A.; Johnson, K. M.; Wang, S. Bioorg. Med. Chem. Lett. 2003, 13, 513-517. doi:10.1016/S0960-894X(02)00943-5 (Pubitemid 36259725)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.3
, pp. 513-517
-
-
Enyedy, I.J.1
Sakamuri, S.2
Zaman, W.A.3
Johnson, K.M.4
Wang, S.5
-
23
-
-
13844255129
-
-
doi:10.1016/j.apcata.2004.08.029
-
Chuck, R. Appl. Catal., A 2005, 280, 75-82. doi:10.1016/j.apcata.2004.08. 029
-
(2005)
Appl. Catal., A
, vol.280
, pp. 75-82
-
-
Chuck, R.1
-
24
-
-
58049206659
-
-
doi:10.1016/j.molcata.2008.10.010
-
Krishna Mohan, K. V. V.; Suresh Kumar Reddy, K.; Narender, N.; Kulkarni, S. J. J. Mol. Catal. A: Chem. 2009, 298, 99-102. doi:10.1016/j.molcata.2008.10. 010
-
(2009)
J. Mol. Catal. A: Chem.
, vol.298
, pp. 99-102
-
-
Krishna Mohan, K.V.V.1
Suresh Kumar Reddy, K.2
Narender, N.3
Kulkarni, S.J.4
-
26
-
-
84888624294
-
-
U.S. Patent 5,066,809, Nov 19
-
Suresh, D. D.; DiCosimo, R.; Loiseau, R.; Friedrich, M. S.; Szabo, H.-C. Preparation of 3-Methylpyridine from 2-Methylglutaronitrile. U.S. Patent 5,066,809, Nov 19, 1991.
-
(1991)
Preparation of 3-Methylpyridine from 2-Methylglutaronitrile
-
-
Suresh, D.D.1
Dicosimo, R.2
Loiseau, R.3
Friedrich, M.S.4
Szabo, H.-C.5
-
27
-
-
0026063683
-
-
doi:10.1021/jm00105a069
-
Piwinski, J. J.; Wong, J. K.; Green, M. J.; Ganguly, A. K.; Billah, M. M.; West, R. E., Jr.; Kreutner, W. J. Med. Chem. 1991, 34, 457-461. doi:10.1021/jm00105a069
-
(1991)
J. Med. Chem.
, vol.34
, pp. 457-461
-
-
Piwinski, J.J.1
Wong, J.K.2
Green, M.J.3
Ganguly, A.K.4
Billah, M.M.5
West Jr., R.E.6
Kreutner, W.7
-
28
-
-
33748638016
-
Review article: The clinical pharmacology of proton pump inhibitors
-
DOI 10.1111/j.1365-2036.2006.02943.x
-
Sachs, G.; Shin, J. M.; Howden, C. W. Aliment. Pharmacol. Ther. 2006, 23 (Suppl. 2), 2-8. doi:10.1111/j.1365-2036.2006.02943.x (Pubitemid 44383831)
-
(2006)
Alimentary Pharmacology and Therapeutics
, vol.23
, Issue.SUPPL. 2
, pp. 2-8
-
-
Sachs, G.1
Shin, J.M.2
Howden, C.W.3
-
30
-
-
0001524038
-
-
doi:10.1016/S0040-4020(01)87693-6
-
Katrizky, A. R.; Ostercamp, D. L.; Yousaf, T. I. Tetrahedron 1987, 43, 5171-5186. doi:10.1016/S0040-4020(01)87693-6
-
(1987)
Tetrahedron
, vol.43
, pp. 5171-5186
-
-
Katrizky, A.R.1
Ostercamp, D.L.2
Yousaf, T.I.3
-
31
-
-
0028335891
-
The synthesis of BRL 49653 - A novel and potent antihyperglycaemic agent
-
DOI 10.1016/S0960-894X(01)80325-5
-
Cantello, B. C. C.; Cawthorne, M. A.; Haigh, D.; Hindley, R. M.; Smith, S. A.; Thurlby, P. L. Bioorg. Med. Chem. Lett. 1994, 4, 1181-1184. doi:10.1016/S0960-894X(01)80325-5 (Pubitemid 24164192)
-
(1994)
Bioorganic and Medicinal Chemistry Letters
, vol.4
, Issue.10
, pp. 1181-1184
-
-
Cantello, B.C.C.1
Cawthorne, M.A.2
Haigh, D.3
Hindley, R.M.4
Smith, S.A.5
Thurlby, P.L.6
-
32
-
-
0027988554
-
[[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents
-
DOI 10.1021/jm00049a017
-
Cantello, B. C. C.; Cawthorne, M. A.; Cottam, G. P.; Duff, P. T.; Haigh, D.; Hindley, R. M.; Lister, C. A.; Smith, S. A.; Thurlby, P. L. J. Med. Chem. 1994, 37, 3977-3985. doi:10.1021/jm00049a017 (Pubitemid 24379687)
-
(1994)
Journal of Medicinal Chemistry
, vol.37
, Issue.23
, pp. 3977-3985
-
-
Cantello, B.C.C.1
Cawthorne, M.A.2
Cottam, G.P.3
Duff, P.T.4
Haigh, D.5
Hindley, R.M.6
Lister, C.A.7
Smith, S.A.8
Thurlby, P.L.9
-
33
-
-
77950341668
-
-
doi:10.1016/j.tet.2010.03.006
-
Gaonkar, S. L.; Shimizu, H. Tetrahedron 2010, 66, 3314-3317. doi:10.1016/j.tet.2010.03.006
-
(2010)
Tetrahedron
, vol.66
, pp. 3314-3317
-
-
Gaonkar, S.L.1
Shimizu, H.2
-
35
-
-
8744290489
-
3-Cyano-4,6-dimethyl-2-pyridone (Guareschi pyridone)
-
DOI 10.1107/S1600536803029295
-
Rybakov, V. B.; Bush, A. A.; Babaev, E. B.; Aslanov, L. A. Acta Crystallogr., Sect. E 2004, 60, o160-o161. doi:10.1107/S1600536803029295 (Pubitemid 40650397)
-
(2004)
Acta Crystallographica Section E: Structure Reports Online
, vol.60
, Issue.2
-
-
Rybakov, V.B.1
Bush, A.A.2
Babaev, E.V.3
Aslanov, L.A.4
-
36
-
-
0002117767
-
-
Zimmerman, H. E.; Grunewald, G. L.; Paufler, R. M. Org. Synth. 1966, 46, 101-104.
-
(1966)
Org. Synth.
, vol.46
, pp. 101-104
-
-
Zimmerman, H.E.1
Grunewald, G.L.2
Paufler, R.M.3
-
37
-
-
33947092368
-
-
doi:10.1021/jo00406a058
-
Parker, R. H.; Jones, W. M. J. Org. Chem. 1978, 43, 2548-2550. doi:10.1021/jo00406a058
-
(1978)
J. Org. Chem.
, vol.43
, pp. 2548-2550
-
-
Parker, R.H.1
Jones, W.M.2
-
40
-
-
0037283277
-
A new route for manufacture of 3-cyano-1-naphthalenecarboxylic acid
-
DOI 10.1021/op025571l
-
Ashworth, I. W.; Bowden, M. C.; Dembofsky, B.; Levin, D.; Moss, W.; Robinson, E.; Szczur, N.; Virica, J. Org. Process Res. Dev. 2003, 7, 74-81. doi:10.1021/op025571l (Pubitemid 36228741)
-
(2003)
Organic Process Research and Development
, vol.7
, Issue.1
, pp. 74-81
-
-
Ashworth, I.W.1
Bowden, M.C.2
Dembofsky, B.3
Levin, D.4
Moss, W.5
Robinson, E.6
Szczur, N.7
Virica, J.8
-
41
-
-
0347537933
-
-
doi:10.1039/b307549d
-
Li, X.; Abell, C.; Warrington, B. H.; Ladlow, M. Org. Biomol. Chem. 2003, 1, 4392-4395. doi:10.1039/b307549d
-
(2003)
Org. Biomol. Chem.
, vol.1
, pp. 4392-4395
-
-
Li, X.1
Abell, C.2
Warrington, B.H.3
Ladlow, M.4
-
42
-
-
33747437978
-
-
doi:10.1002/jhet.5570430413
-
Prashanta Kumar, B. R.; Nanjan, M. J.; Suresh, B.; Karvekar, M. D.; Adhikary, L. J. Heterocycl. Chem. 2006, 43, 897-903. doi:10.1002/jhet.5570430413
-
(2006)
J. Heterocycl. Chem.
, vol.43
, pp. 897-903
-
-
Prashanta Kumar, B.R.1
Nanjan, M.J.2
Suresh, B.3
Karvekar, M.D.4
Adhikary, L.5
-
46
-
-
84888630323
-
-
W.O. Patent WO2004000810, Dec 31
-
Adiyaman, M.; Guner, D.; Ridvanoglu, N.; Yurdakul, A. A. Process for the Production of substituted Phenyl Ethers. W.O. Patent WO2004000810, Dec 31, 2003.
-
(2003)
Process for the Production of Substituted Phenyl Ethers
-
-
Adiyaman, M.1
Guner, D.2
Ridvanoglu, N.3
Yurdakul, A.A.4
-
47
-
-
37549005590
-
-
doi:10.1016/j.bmcl.2007.10.067
-
Nersesian, D. L.; Black, L. A.; Miller, T. R.; Vortherms, T. A.; Esbenshade, T. A.; Hancock, A. A.; Cowart, M. D. Bioorg. Med. Chem. Lett. 2008, 18, 355-359. doi:10.1016/j.bmcl.2007.10.067
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 355-359
-
-
Nersesian, D.L.1
Black, L.A.2
Miller, T.R.3
Vortherms, T.A.4
Esbenshade, T.A.5
Hancock, A.A.6
Cowart, M.D.7
-
48
-
-
84888610566
-
-
W.O. Patent WO02088120, Nov 7
-
Halama, A.; Hejtmankova, L.; Lustig, P.; Richter, J.; Srsnova, L.; Jirman, J. Method for obtaining Pioglitazone as an antidiabetic agent. W.O. Patent WO02088120, Nov 7, 2002.
-
(2002)
Method for Obtaining Pioglitazone As An Antidiabetic Agent
-
-
Halama, A.1
Hejtmankova, L.2
Lustig, P.3
Richter, J.4
Srsnova, L.5
Jirman, J.6
-
51
-
-
17644394937
-
-
Martina, S. D.; Vesta, K. S.; Ripley, T. L. Ann. Pharmacother. 2005, 39, 854-862.
-
(2005)
Ann. Pharmacother.
, vol.39
, pp. 854-862
-
-
Martina, S.D.1
Vesta, K.S.2
Ripley, T.L.3
-
52
-
-
77951809399
-
-
doi:10.1021/ol100453x
-
Rohbogner, C. J.; Wirth, S.; Knochel, P. Org. Lett. 2010, 9, 1984-1987. doi:10.1021/ol100453x
-
(2010)
Org. Lett.
, vol.9
, pp. 1984-1987
-
-
Rohbogner, C.J.1
Wirth, S.2
Knochel, P.3
-
53
-
-
0034670533
-
-
doi:10.1021/jo000870z
-
Davies, I. W.; Marcoux, J.-F.; Corley, E. G.; Journet, M.; Cai, D.-W.; Palucki, M.; Wu, J.; Larsen, R. D.; Rossen, K.; Pye, P. J.; DiMichele, L.; Dormer, P.; Reider, P. J. J. Org. Chem. 2000, 65, 8415-8420. doi:10.1021/jo000870z
-
(2000)
J. Org. Chem.
, vol.65
, pp. 8415-8420
-
-
Davies, I.W.1
Marcoux, J.-F.2
Corley, E.G.3
Journet, M.4
Cai, D.-W.5
Palucki, M.6
Wu, J.7
Larsen, R.D.8
Rossen, K.9
Pye, P.J.10
Dimichele, L.11
Dormer, P.12
Reider, P.J.13
-
54
-
-
0034725734
-
An efficient preparation of vinamidinium hexafluorophosphate salts
-
DOI 10.1021/jo000159u
-
Davies, I. W.; Marcoux, J.-F.; Wu, J.; Palucki, M.; Corley, E. G.; Robbins, M. A.; Tsou, N.; Ball, R. G.; Dormer, P.; Larsen, R. D.; Reider, P. J. J. Org. Chem. 2000, 65, 4571-4574. doi:10.1021/jo000159u (Pubitemid 30620566)
-
(2000)
Journal of Organic Chemistry
, vol.65
, Issue.15
, pp. 4571-4574
-
-
Davies, I.W.1
Marcoux, J.-F.2
Wu, J.3
Palucki, M.4
Corley, E.G.5
Robbins, M.A.6
Tsou, N.7
Ball, R.G.8
Dormer, P.9
Larsen, R.D.10
Reider, P.J.11
-
55
-
-
0032705719
-
Mode of action of fluoroquinolones
-
DOI 10.2165/00003495-199958002-00002
-
Hooper, D. C. Drugs 1999, 58 (Suppl. 2), 6-10. doi:10.2165/00003495- 199958002-00002 (Pubitemid 29500078)
-
(1999)
Drugs
, vol.58
, Issue.SUPPL. 2
, pp. 6-10
-
-
Hooper, D.C.1
-
56
-
-
0036279219
-
-
Andriole, V. T. Formulary 2002, 37 (Suppl. 3), 13-15.
-
(2002)
Formulary
, vol.37 SUPPL. 3
, pp. 13-15
-
-
Andriole V, T.1
-
57
-
-
84888592316
-
-
Eur. Patent EP 1 832 587 A1, Sept 12
-
Cosme, G. A.; Fernandez, L. S. P.; Molina, P. A.; Palomo, N. F.; Villasante, P. J. Method for Preparing Moxifloxacin and Moxifloxacin Hydrochloride. Eur. Patent EP 1 832 587 A1, Sept 12, 2007.
-
(2007)
Method for Preparing Moxifloxacin and Moxifloxacin Hydrochloride
-
-
Cosme, G.A.1
Fernandez, L.S.P.2
Molina, P.A.3
Palomo, N.F.4
Villasante, P.J.5
-
58
-
-
84888584211
-
-
U.S. Patent 4,990,517, Feb 5
-
Petersen, U.; Schenke, T.; Krebs, A.; Grohe, K.; Schriewer, M.; Haller, I.; Metzger, K. G.; Endermann, R.; Zeiler, H.-J. 7-(1-Pyrrolidinyl)-3-quinolone- and naphthyridonecarboxylic acid Derivatives as Antibacterial Agents and Feed Additives. U.S. Patent 4,990,517, Feb 5, 1991.
-
(1991)
7-(1-Pyrrolidinyl)-3-quinolone- And Naphthyridonecarboxylic Acid Derivatives As Antibacterial Agents and Feed Additives
-
-
Petersen, U.1
Schenke, T.2
Krebs, A.3
Grohe, K.4
Schriewer, M.5
Haller, I.6
Metzger, K.G.7
Endermann, R.8
Zeiler, H.-J.9
-
59
-
-
84888606929
-
-
U.S. Patent 5,607,942, March 4
-
Petersen, U.; Schenke, T.; Krebs, A.; Grohe, K.; Schriewer, M.; Haller, I.; Metzger, K. G.; Endermann, R.; Zeiler, H.-J. 7-(1-Pyrrolidinyl)-3-quinolone- and naphthyridonecarbolxylic acid Derivatives as Antibacterial Agents and Feed Additives. U.S. Patent 5,607,942, March 4, 1997.
-
(1997)
7-(1-Pyrrolidinyl)-3-quinolone- And Naphthyridonecarbolxylic Acid Derivatives As Antibacterial Agents and Feed Additives
-
-
Petersen, U.1
Schenke, T.2
Krebs, A.3
Grohe, K.4
Schriewer, M.5
Haller, I.6
Metzger, K.G.7
Endermann, R.8
Zeiler, H.-J.9
-
60
-
-
84888610843
-
-
Ger. Patent DE 4 208 792 A1, March 23
-
Petersen, U.; Schenke, T.; Krebs, A.; Schenke, T.; Philipps, T.; Grohe, K.; Bremm, K.-D.; Endermann, R.; Metzger, K. G. New Quinoline and Naphthyridinonecarboxylic Acid Derivatives. Ger. Patent DE 4 208 792 A1, March 23, 1993.
-
(1993)
New Quinoline and Naphthyridinonecarboxylic Acid Derivatives
-
-
Petersen, U.1
Schenke, T.2
Krebs, A.3
Schenke, T.4
Philipps, T.5
Grohe, K.6
Bremm, K.-D.7
Endermann, R.8
Metzger, K.G.9
-
61
-
-
84888581418
-
-
U.S. Patent 2008/0221329 A1, Sept 11
-
Cheng, Y.; Femg, S.; Wang, Z. Novel and Economical Process for Preparing (S,S)-2,8-Diazabicyclo[4.3.0]nonane and its Enantiomer. U.S. Patent 2008/0221329 A1, Sept 11, 2008.
-
(2008)
Novel and Economical Process for Preparing (S,S)-2,8-Diazabicyclo[4.3.0] nonane and Its Enantiomer
-
-
Cheng, Y.1
Femg, S.2
Wang, Z.3
-
62
-
-
30044438352
-
-
U.S. Patent 4,777,253, Oct 11
-
Chu, D. T.; Mitscher, L. A. Process for Preparation of Racemate and Optically Active Ofloxacin and Related Derivatives. U.S. Patent 4,777,253, Oct 11, 1988.
-
(1988)
Process for Preparation of Racemate and Optically Active Ofloxacin and Related Derivatives
-
-
Chu, D.T.1
Mitscher, L.A.2
-
64
-
-
54049084255
-
-
doi:10.1021/ol801399w
-
Bridgwood, K. L.; Veitch, G. E.; Ley, S. V. Org. Lett. 2008, 16, 3627-3629. doi:10.1021/ol801399w
-
(2008)
Org. Lett.
, vol.16
, pp. 3627-3629
-
-
Bridgwood, K.L.1
Veitch, G.E.2
Ley, S.V.3
-
66
-
-
84888626939
-
-
U.S. Patent 4,572,909, Feb 25
-
Campbell, S. F.; Cross, P. E.; Stubbs, J. K. 2-(Secondary Aminoalkoxymethyl)dihydropyridine Derivatives as Anti-Ischaemic and Anti-Hypertensive Agents. U.S. Patent 4,572,909, Feb 25, 1986.
-
(1986)
2-(Secondary Aminoalkoxymethyl)dihydropyridine Derivatives As Anti-Ischaemic and Anti-Hypertensive Agents
-
-
Campbell, S.F.1
Cross, P.E.2
Stubbs, J.K.3
-
67
-
-
0031450345
-
Pharmacokinetic behaviour of R-(+)- and S-(-)-amlodipine after single enantiomer administration
-
DOI 10.1016/S0378-4347(97)00394-0, PII S0378434797003940
-
Lukŝa, J.; Josic, D.; Kremser, M.; Kopitar, Z.; Milutinovic, S. J. Chromatogr., B 1997, 703, 185-193. doi:10.1016/S0378-4347(97)00394-0 (Pubitemid 28011257)
-
(1997)
Journal of Chromatography B: Biomedical Applications
, vol.703
, Issue.1-2
, pp. 185-193
-
-
Luksa, J.1
Josic, D.2
Kremser, M.3
Kopitar, Z.4
Milutinovic, S.5
-
68
-
-
0037138236
-
-
Kim, S.-C.; Choi, K.-M.; Cheong, C.-S. Bull. Korean Chem. Soc. 2002, 23, 143-144.
-
(2002)
Bull. Korean Chem. Soc.
, vol.23
, pp. 143-144
-
-
Kim, S.-C.1
Choi, K.-M.2
Cheong, C.-S.3
-
69
-
-
0013346127
-
-
doi:10.1016/S0040-4039(00)88453-1
-
Sircar, I.; Anderson, K. R.; Bonadies, L. Tetrahedron Lett. 1988, 29, 6835-6838. doi:10.1016/S0040-4039(00)88453-1
-
(1988)
Tetrahedron Lett.
, vol.29
, pp. 6835-6838
-
-
Sircar, I.1
Anderson, K.R.2
Bonadies, L.3
-
71
-
-
84888600346
-
-
U.S. Patent 5,856,346, Jan 5
-
Andersen, K. H.; Nordlander, M.; Westerlund, R. C. Short-Acting Dihydropyridines. U.S. Patent 5,856,346, Jan 5, 1999.
-
(1999)
Short-Acting Dihydropyridines
-
-
Andersen, K.H.1
Nordlander, M.2
Westerlund, R.C.3
-
74
-
-
0027241691
-
-
doi:10.1021/jm00064a005
-
Andersen, K. E.; Braestrup, C.; Gronwald, F. C.; Joergensen, A. S.; Nielsen, E. B.; Sonnewald, U.; Soerensen, P. O.; Suzdak, P. D.; Knutsen, L. J. S. J. Med. Chem. 1993, 36, 1716-1725. doi:10.1021/jm00064a005
-
(1993)
J. Med. Chem.
, vol.36
, pp. 1716-1725
-
-
Andersen, K.E.1
Braestrup, C.2
Gronwald, F.C.3
Joergensen, A.S.4
Nielsen, E.B.5
Sonnewald, U.6
Soerensen, P.O.7
Suzdak, P.D.8
Knutsen, L.J.S.9
-
75
-
-
33749436403
-
-
doi:10.1002/ejoc.200600558
-
Lei, A.; Chen, M.; He, M.; Zhang, X. Eur. J. Org. Chem. 2006, 4343-4347. doi:10.1002/ejoc.200600558
-
(2006)
Eur. J. Org. Chem.
, pp. 4343-4347
-
-
Lei, A.1
Chen, M.2
He, M.3
Zhang, X.4
-
78
-
-
77955136606
-
-
doi:10.1021/ol101200z
-
Arai, N.; Akashi, M.; Sugizaki, S.; Ooka, H.; Inoue, T.; Ohkuma, T. Org. Lett. 2010, 12, 3380-3383. doi:10.1021/ol101200z
-
(2010)
Org. Lett.
, vol.12
, pp. 3380-3383
-
-
Arai, N.1
Akashi, M.2
Sugizaki, S.3
Ooka, H.4
Inoue, T.5
Ohkuma, T.6
-
79
-
-
77953561028
-
-
doi:10.1021/ol1004356
-
Wang, S.; Onaran, M. B.; Seto, C. T. Org. Lett. 2010, 12, 2690-2693. doi:10.1021/ol1004356
-
(2010)
Org. Lett.
, vol.12
, pp. 2690-2693
-
-
Wang, S.1
Onaran, M.B.2
Seto, C.T.3
-
81
-
-
74049162952
-
-
doi:10.1016/j.bmcl.2009.12.024
-
Mattei, P.; Boehringer, M.; Di Gorgio, P.; Fischer, H.; Hennig, M.; Huwyler, J.; Koçer, B.; Kuhn, B.; Loeffler, B. M.; MacDonald, A.; Narquizian, R.; Rauber, E.; Sebokova, E.; Sprecher, U. Bioorg. Med. Chem. Lett. 2010, 20, 1109-1113. doi:10.1016/j.bmcl.2009.12.024
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 1109-1113
-
-
Mattei, P.1
Boehringer, M.2
Di Gorgio, P.3
Fischer, H.4
Hennig, M.5
Huwyler, J.6
Koçer, B.7
Kuhn, B.8
Loeffler, B.M.9
Macdonald, A.10
Narquizian, R.11
Rauber, E.12
Sebokova, E.13
Sprecher, U.14
-
82
-
-
79957446940
-
-
doi:10.1021/op2000207
-
Albrecht, S.; Adam, J.-M.; Bromberger, U.; Diodone, R.; Fettes, A.; Fischer, R.; Goeckel, V.; Hildbrand, S.; Moine, G.; Weber, M. Org. Process Res. Dev. 2011, 15, 503-514. doi:10.1021/op2000207
-
(2011)
Org. Process Res. Dev.
, vol.15
, pp. 503-514
-
-
Albrecht, S.1
Adam, J.-M.2
Bromberger, U.3
Diodone, R.4
Fettes, A.5
Fischer, R.6
Goeckel, V.7
Hildbrand, S.8
Moine, G.9
Weber, M.10
-
83
-
-
36148971574
-
Therapeutic review: Antiretroviral drugs
-
DOI 10.1177/0091270007308034
-
Warnke, D.; Barreto, J.; Temesgen, Z. J. Clin. Pharmacol. 2007, 47, 1570-1579. doi:10.1177/0091270007308034 (Pubitemid 350115302)
-
(2007)
Journal of Clinical Pharmacology
, vol.47
, Issue.12
, pp. 1570-1579
-
-
Warnke, D.1
Barreto, J.2
Temesgen, Z.3
-
84
-
-
84888589605
-
-
Jap. Patent 58038268 A, March 5
-
Matsutame, C.; Uchiumi, C.; Asada, H.; Umetsu, T. Preparation of Uracil. Jap. Patent 58038268 A, March 5, 1983.
-
(1983)
Preparation of Uracil
-
-
Matsutame, C.1
Uchiumi, C.2
Asada, H.3
Umetsu, T.4
-
86
-
-
84982068675
-
-
doi:10.1002/cber.19811140404
-
Vorbrüggen, H.; Krolikiewicz, K.; Bennua, B. Chem. Ber. 1981, 114, 1234-1255. doi:10.1002/cber.19811140404
-
(1981)
Chem. Ber.
, vol.114
, pp. 1234-1255
-
-
Vorbrüggen, H.1
Krolikiewicz, K.2
Bennua, B.3
-
87
-
-
0029030360
-
-
doi:10.1021/jo00113a050
-
Jin, H.; Siddiqui, M. A.; Evans, C. A.; Tse, H. L. A.; Mansour, T. S.; Goodyear, M. D.; Ravenscroft, P.; Beels, C. D. J. Org. Chem. 1995, 60, 2621-2623. doi:10.1021/jo00113a050
-
(1995)
J. Org. Chem.
, vol.60
, pp. 2621-2623
-
-
Jin, H.1
Siddiqui, M.A.2
Evans, C.A.3
Tse, H.L.A.4
Mansour, T.S.5
Goodyear, M.D.6
Ravenscroft, P.7
Beels, C.D.8
-
88
-
-
66249141273
-
-
doi:10.1021/op800228h
-
Roy, B. N.; Singh, G. P.; Srivastava, D.; Jadhav, H. S.; Saini, M. B.; Aher, U. B. Org. Process Res. Dev. 2009, 13, 450-455. doi:10.1021/op800228h
-
(2009)
Org. Process Res. Dev.
, vol.13
, pp. 450-455
-
-
Roy, B.N.1
Singh, G.P.2
Srivastava, D.3
Jadhav, H.S.4
Saini, M.B.5
Aher, U.B.6
-
89
-
-
52449097240
-
-
doi:10.1021/jm800245z
-
Summa, V.; Petrocchi, A.; Bonelli, F.; Crescenzi, B.; Donghi, M.; Ferrara, M.; Fiore, F.; Gardelli, C.; Paz, O. G.; Hazuda, D. J.; Jones, P.; Kinzel, O.; Laufer, R.; Monteagudo, E.; Muraglia, E.; Nizi, E.; Orvieto, F.; Pace, P.; Pescatore, G.; Scarpelli, R.; Witmer, M. V.; Rowley, M. J. Med. Chem. 2008, 51, 5843-5855. doi:10.1021/jm800245z
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5843-5855
-
-
Summa, V.1
Petrocchi, A.2
Bonelli, F.3
Crescenzi, B.4
Donghi, M.5
Ferrara, M.6
Fiore, F.7
Gardelli, C.8
Paz, O.G.9
Hazuda, D.J.10
Jones, P.11
Kinzel, O.12
Laufer, R.13
Monteagudo, E.14
Muraglia, E.15
Nizi, E.16
Orvieto, F.17
Pace, P.18
Pescatore, G.19
Scarpelli, R.20
Witmer, M.V.21
Rowley, M.22
more..
-
90
-
-
56249135699
-
-
WO Patent 2006/060712 A2, June 8
-
Belyk, K. M.; Morrison, H. G.; Jones, P.; Summa, V. Potassium Salt of an HIV-Integrase Inhibitor. WO Patent 2006/060712 A2, June 8, 2006.
-
(2006)
Potassium Salt of An HIV-Integrase Inhibitor
-
-
Belyk, K.M.1
Morrison, H.G.2
Jones, P.3
Summa, V.4
-
91
-
-
47049102883
-
-
doi:10.1002/anie.200703681
-
Pye, P. J.; Zhong, Y.-L.; Jones, G. O.; Reamer, R. A.; Houk, K. N.; Askin, D. Angew. Chem., Int. Ed. 2008, 47, 4134-4136. doi:10.1002/anie.200703681
-
(2008)
Angew. Chem., Int. Ed.
, vol.47
, pp. 4134-4136
-
-
Pye, P.J.1
Zhong, Y.-L.2
Jones, G.O.3
Reamer, R.A.4
Houk, K.N.5
Askin, D.6
-
92
-
-
33947544770
-
N-substituted ureas and thioureas in Biginelli reaction promoted by chlorotrimethylsilane: Convenient synthesis of N1-alkyl-, N1-aryl-, and N1,N3-dialkyl-3,4-dihydropyrimidin-2(1H)-(thi)ones
-
DOI 10.1055/s-2007-965881
-
Ryabukhin, S. V.; Plaskon, A. S.; Ostapchuk, E. N.; Volochnyuk, D. M.; Tolmachev, A. A. Synthesis 2007, 417-427. doi:10.1055/s-2007-965881 (Pubitemid 46474225)
-
(2007)
Synthesis
, Issue.3
, pp. 0417-0427
-
-
Ryabukhin, S.V.1
Plaskon, A.S.2
Ostapchuk, E.N.3
Volochnyuk, D.M.4
Tolmachev, A.A.5
-
93
-
-
84888585238
-
-
U.S. Patent 7,674,901 B2, March 9
-
Szczepek, W.; Luniewski, W.; Kaczmarek, L.; Zagrodzki, B.; Samson-Lazinska, D.; Szelejewski, W.; Skarzynski, M. Process for Preparation of Imatinib Base. U.S. Patent 7,674,901 B2, March 9, 2010.
-
(2010)
Process for Preparation of Imatinib Base
-
-
Szczepek, W.1
Luniewski, W.2
Kaczmarek, L.3
Zagrodzki, B.4
Samson-Lazinska, D.5
Szelejewski, W.6
Skarzynski, M.7
-
94
-
-
84874492496
-
-
doi:10.1039/C2OB27003J
-
Deadman, B. J.; Hopkin, M. D.; Baxendale, I. R.; Ley, S. V. Org. Biomol. Chem. 2013, 11, 1766-1800. doi:10.1039/C2OB27003J
-
(2013)
Org. Biomol. Chem.
, vol.11
, pp. 1766-1800
-
-
Deadman, B.J.1
Hopkin, M.D.2
Baxendale, I.R.3
Ley, S.V.4
-
95
-
-
77949853471
-
-
doi:10.1039/c001550d
-
Hopkin, M. D.; Baxendale, I. R.; Ley, S. V. Chem. Commun. 2010, 46, 2450-2452. doi:10.1039/c001550d
-
(2010)
Chem. Commun.
, vol.46
, pp. 2450-2452
-
-
Hopkin, M.D.1
Baxendale, I.R.2
Ley, S.V.3
-
96
-
-
84874471133
-
-
doi:10.1039/C2OB27002A
-
Hopkin, M. D.; Baxendale, I. R.; Ley, S. V. Org. Biomol. Chem. 2013, 11, 1822-1839. doi:10.1039/C2OB27002A
-
(2013)
Org. Biomol. Chem.
, vol.11
, pp. 1822-1839
-
-
Hopkin, M.D.1
Baxendale, I.R.2
Ley, S.V.3
-
97
-
-
51049104607
-
-
U.S. Patent 5,747,498, May 5
-
Schnur, R. C.; Arnold, L. D. Alkynyl- and Azido-Substituted 4-Anilinoquinazolines. U.S. Patent 5,747,498, May 5, 1998.
-
(1998)
Alkynyl- And Azido-Substituted 4-Anilinoquinazolines
-
-
Schnur, R.C.1
Arnold, L.D.2
-
98
-
-
33646430087
-
-
Knesl, P.; Roeseling, D.; Jordis, U. Molecules 2006, 11, 286-297.
-
(2006)
Molecules
, vol.11
, pp. 286-297
-
-
Knesl, P.1
Roeseling, D.2
Jordis, U.3
-
99
-
-
35148865335
-
Improved synthesis of gefitinib and erlotinib hydrochloride- anticancer agents
-
DOI 10.1080/00397910701483761, PII 782880108
-
Chandregowda, V.; Rao, G. V.; Reddy, G. C. Synth. Commun. 2007, 37, 3409-3415. doi:10.1080/00397910701483761 (Pubitemid 47537122)
-
(2007)
Synthetic Communications
, vol.37
, Issue.19
, pp. 3409-3415
-
-
Chandregowda, V.1
Rao, G.V.2
Reddy, G.C.3
-
100
-
-
35348832556
-
-
doi:10.1021/op700054p
-
Chandregowda, V.; Rao, G. V.; Reddy, G. C. Org. Process Res. Dev. 2007, 11, 813-816. doi:10.1021/op700054p
-
(2007)
Org. Process Res. Dev.
, vol.11
, pp. 813-816
-
-
Chandregowda, V.1
Rao, G.V.2
Reddy, G.C.3
-
101
-
-
77957906365
-
-
Eur. Patent EP 1 481 971 B1, Nov 16
-
Nishino, S.; Hirotsu, K.; Shima, H.; Harada, T.; Oda, H. Process for Producing 4-Aminoquinazoline Compounds. Eur. Patent EP 1 481 971 B1, Nov 16, 2011.
-
(2011)
Process for Producing 4-Aminoquinazoline Compounds
-
-
Nishino, S.1
Hirotsu, K.2
Shima, H.3
Harada, T.4
Oda, H.5
-
102
-
-
0035843962
-
Structural mechanism for statin inhibition of HMG-CoA reductase
-
DOI 10.1126/science.1059344
-
Istvan, E. S.; Deisenhofer, J. Science 2001, 292, 1160-1164. doi:10.1126/science.1059344 (Pubitemid 32440937)
-
(2001)
Science
, vol.292
, Issue.5519
, pp. 1160-1164
-
-
Istvan, E.S.1
Deisenhofer, J.2
-
103
-
-
84888625605
-
-
U.S. Patent 5,260,440, Nov 9
-
Hirai, K.; Ishiba, T.; Koike, H.; Watanabe, M. Pyrimidine Derivatives. U.S. Patent 5,260,440, Nov 9, 1993.
-
(1993)
Pyrimidine Derivatives
-
-
Hirai, K.1
Ishiba, T.2
Koike, H.3
Watanabe, M.4
-
104
-
-
0031081522
-
Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors
-
DOI 10.1016/S0968-0896(96)00248-9, PII S0968089696002489
-
Watanabe, M.; Koike, H.; Ishiba, T.; Okada, T.; Seo, S.; Hirai, K. Bioorg. Med. Chem. 1997, 5, 437-444. doi:10.1016/S0968-0896(96)00248-9 (Pubitemid 27091350)
-
(1997)
Bioorganic and Medicinal Chemistry
, vol.5
, Issue.2
, pp. 437-444
-
-
Watanabe, M.1
Koike, H.2
Ishiba, T.3
Okada, T.4
Seo, S.5
Hirai, K.6
-
105
-
-
46049089700
-
-
doi:10.1002/ejoc.200700813
-
Andrushko, N.; Andrushko, V.; König, G.; Spannenberg, A.; Börner, A. Eur. J. Org. Chem. 2008, 847-853. doi:10.1002/ejoc.200700813
-
(2008)
Eur. J. Org. Chem.
, pp. 847-853
-
-
Andrushko, N.1
Andrushko, V.2
König, G.3
Spannenberg, A.4
Börner, A.5
-
106
-
-
29344451883
-
A general and efficient method for the formylation of aryl and heteroaryl bromides
-
DOI 10.1002/anie.200502697
-
Klaus, S.; Neumann, H.; Zapf, A.; Strübing, D.; Hübner, S.; Almena, J.; Riermeier, T.; Gross, P.; Sarich, M.; Krahnert, W.-R.; Rossen, K.; Beller, M. Angew. Chem., Int. Ed. 2006, 45, 154-158. doi:10.1002/anie.200502697 (Pubitemid 43004010)
-
(2006)
Angewandte Chemie - International Edition
, vol.45
, Issue.1
, pp. 154-158
-
-
Klaus, S.1
Neumann, H.2
Zapf, A.3
Strubing, D.4
Hubner, S.5
Almena, J.6
Riermeier, T.7
Gross, P.8
Sarich, M.9
Krahnert, W.-R.10
Rossen, K.11
Beller, M.12
-
107
-
-
80053601542
-
-
doi:10.1039/c1md00074h
-
Wermuth, C. G. MedChemComm 2011, 2, 935-941. doi:10.1039/c1md00074h
-
(2011)
MedChemComm
, vol.2
, pp. 935-941
-
-
Wermuth C, G.1
-
108
-
-
73549086640
-
-
Gutknecht condensation. Wiley, doi:10.1002/9780470638859.conrr289
-
Gutknecht condensation. Comprehensive Organic Name Reactions and Reagents; Wiley, 2010; pp 1302-1304. doi:10.1002/9780470638859.conrr289
-
(2010)
Comprehensive Organic Name Reactions and Reagents
, pp. 1302-1304
-
-
-
109
-
-
20844441945
-
Varenicline: An alpha;4β2 nicotinic receptor partial agonist for smoking cessation
-
DOI 10.1021/jm050069n
-
Coe, J. W.; Brooks, P. R.; Vetelino, M. G.; Wirtz, M. C.; Arnold, E. P.; Huang, J.; Sands, S. B.; Davis, T. I.; Lebel, L. A.; Fox, C. B.; Shrikhande, A.; Heym, J. H.; Schaeffer, E.; Rollema, H.; Lu, Y.; Mansbach, R. S.; Chambers, L. K.; Rovetti, C. C.; Schulz, D. W.; Tingley, F. D., III; 'Neill, B. T. J. Med. Chem. 2005, 48, 3474-3477. doi:10.1021/jm050069n (Pubitemid 40664098)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.10
, pp. 3474-3477
-
-
Coe, J.W.1
Brooks, P.R.2
Vetelino, M.G.3
Wirtz, M.C.4
Arnold, E.P.5
Huang, J.6
Sands, S.B.7
Davis, T.I.8
Lebel, L.A.9
Fox, C.B.10
Shrikhande, A.11
Heym, J.H.12
Schaeffer, E.13
Rollema, H.14
Lu, Y.15
Mansbach, R.S.16
Chambers, L.K.17
Rovetti, C.C.18
Schulz, D.W.19
Tingley III, F.D.20
O'Neill, B.T.21
more..
-
110
-
-
79952493373
-
-
WO Patent 2006/0900236, Aug 31
-
Busch, F. R.; Hawkins, J. M.; Mustakis, L. G.; Sinay, T. G., Jr.; Watson, T. J. M. Preparation of High Purity Substituted Quinoxaline. WO Patent 2006/0900236, Aug 31, 2006.
-
(2006)
Preparation of High Purity Substituted Quinoxaline
-
-
Busch, F.R.1
Hawkins, J.M.2
Mustakis, L.G.3
Sinay Jr., T.G.4
Watson, T.J.M.5
-
111
-
-
3242715287
-
Preparation of 1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine via Pd-catalyzed cyclization
-
DOI 10.1021/ol049316s
-
Singer, R. A.; McKinley, J. D.; Barbe, G.; Farlow, R. A. Org. Lett. 2004, 6, 2357-2360. doi:10.1021/ol049316s (Pubitemid 38952539)
-
(2004)
Organic Letters
, vol.6
, Issue.14
, pp. 2357-2360
-
-
Singer, R.A.1
McKinley, J.D.2
Barbe, G.3
Farlow, R.A.4
-
113
-
-
84888593326
-
-
U.S. Patent 2008/0146800 A1, June 19
-
Kavishwar, G. A.; Kavishwar, S. G.; Naik, A. M.; Sawant, S. D. Process for the Preparation of Eszopiclone. U.S. Patent 2008/0146800 A1, June 19, 2008.
-
(2008)
Process for the Preparation of Eszopiclone
-
-
Kavishwar, G.A.1
Kavishwar, S.G.2
Naik, A.M.3
Sawant, S.D.4
-
114
-
-
33644845743
-
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
-
DOI 10.1016/j.str.2005.11.019, PII S0969212606000694
-
Groll, M.; Berkers, C. R.; Ploegh, H. L.; Ovaa, H. Structure 2006, 14, 451-456. doi:10.1016/j.str.2005.11.019 (Pubitemid 43363478)
-
(2006)
Structure
, vol.14
, Issue.3
, pp. 451-456
-
-
Groll, M.1
Berkers, C.R.2
Ploegh, H.L.3
Ovaa, H.4
-
115
-
-
44449138158
-
Asymmetric copper-catalyzed synthesis of α-amino boronate esters from N-tert-butanesulfinyl aldimines
-
DOI 10.1021/ja800829y
-
Beenen, M. A.; An, C.; Ellman, J. A. J. Am. Chem. Soc. 2008, 130, 6910-6911. doi:10.1021/ja800829y (Pubitemid 351770116)
-
(2008)
Journal of the American Chemical Society
, vol.130
, Issue.22
, pp. 6910-6911
-
-
Beenen, M.A.1
An, C.2
Ellman, J.A.3
-
116
-
-
38549126119
-
Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework
-
DOI 10.1016/j.bmc.2007.10.018, PII S096808960700884X
-
Källström, S.; Leino, R. Bioorg. Med. Chem. 2008, 16, 601-635. doi:10.1016/j.bmc.2007.10.018 (Pubitemid 351163050)
-
(2008)
Bioorganic and Medicinal Chemistry
, vol.16
, Issue.2
, pp. 601-635
-
-
Kallstrom, S.1
Leino, R.2
-
117
-
-
33745807624
-
Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists
-
DOI 10.1021/jm060051s
-
Habashita, H.; Kokubo, M.; Hamano, S.; Hamanaka, N.; Toda, M.; Shibayama, S.; Tada, H.; Sagawa, K.; Fukushima, D.; Maeda, K.; Mitsuya, H. J. Med. Chem. 2006, 49, 4140-4152. doi:10.1021/jm060051s (Pubitemid 44036659)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.14
, pp. 4140-4152
-
-
Habashita, H.1
Kokubo, M.2
Hamano, S.-I.3
Hamanaka, N.4
Toda, M.5
Shibayama, S.6
Tada, H.7
Sagawa, K.8
Fukushima, D.9
Maeda, K.10
Mitsuya, H.11
-
118
-
-
77956050442
-
-
doi:10.1055/s-0030-1257906
-
Dömling, A.; Huang, Y. Synthesis 2008, 2859-2883. doi:10.1055/s-0030-1257906
-
(2008)
Synthesis
, pp. 2859-2883
-
-
Dömling, A.1
Huang, Y.2
-
119
-
-
33846354589
-
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite
-
DOI 10.1016/j.bmcl.2006.10.084, PII S0960894X06012637
-
Nishizawa, R.; Nishiyama, T.; Hisaichi, K.; Matsunaga, N.; Minamoto, C.; Habashita, H.; Takaoka, Y.; Toda, M.; Shibayama, S.; Tada, H.; Sagawa, K.; Fukushima, D.; Maeda, K.; Mitsuya, H. Bioorg. Med. Chem. Lett. 2007, 17, 727-731. doi:10.1016/j.bmcl.2006.10.084 (Pubitemid 46127639)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.3
, pp. 727-731
-
-
Nishizawa, R.1
Nishiyama, T.2
Hisaichi, K.3
Matsunaga, N.4
Minamoto, C.5
Habashita, H.6
Takaoka, Y.7
Toda, M.8
Shibayama, S.9
Tada, H.10
Sagawa, K.11
Fukushima, D.12
Maeda, K.13
Mitsuya, H.14
-
120
-
-
0023900102
-
-
doi:10.1002/ardp.19883210406
-
Scheffler, G.; Engel, J.; Kutscher, B.; Sheldrick, W. S.; Bell, P. Arch. Pharm. 1988, 321, 205-208. doi:10.1002/ardp.19883210406
-
(1988)
Arch. Pharm.
, vol.321
, pp. 205-208
-
-
Scheffler, G.1
Engel, J.2
Kutscher, B.3
Sheldrick, W.S.4
Bell, P.5
-
122
-
-
37049070597
-
-
doi:10.1039/P19860001011
-
Attwood, M. R.; Hassall, C. H.; Kröhn, A.; Lawton, G.; Redshaw, S. J. Chem. Soc., Perkin Trans. 1 1986, 1011-1019. doi:10.1039/P19860001011
-
(1986)
J. Chem. Soc., Perkin Trans.
, vol.1
, pp. 1011-1019
-
-
Attwood, M.R.1
Hassall, C.H.2
Kröhn, A.3
Lawton, G.4
Redshaw, S.5
-
123
-
-
84888629043
-
-
U.S. Patent 4,602,017, July 22
-
Baxter, M. G.; Miller, A. A.; Sawyer, D. A. Substituted Aromatic Compounds. U.S. Patent 4,602,017, July 22, 1986.
-
(1986)
Substituted Aromatic Compounds
-
-
Baxter, M.G.1
Miller, A.A.2
Sawyer, D.A.3
-
124
-
-
84888620451
-
-
U.S. Patent 4,560,687, Dec 24
-
Baxter, M. G.; Elphick, A. R.; Miller, A. A.; Sawyer, D. A. Substituted Aromatic Compounds. U.S. Patent 4,560,687, Dec 24, 1985.
-
(1985)
Substituted Aromatic Compounds
-
-
Baxter, M.G.1
Elphick, A.R.2
Miller, A.A.3
Sawyer, D.A.4
-
125
-
-
84888585817
-
-
U.S. Patent 4,689,338, Aug 25
-
Gerster, J. F. 1H-Imidazo[4,5-c]quinolin-4-amines and Antiviral Use. U.S. Patent 4,689,338, Aug 25, 1987.
-
(1987)
1H-Imidazo[4,5-c]quinolin-4-amines and Antiviral Use
-
-
Gerster J, F.1
-
126
-
-
84888612172
-
-
Eur. Patent EP 1529781 A1, May 11
-
Allegrini, P.; Castaldi, G. A.; Colombo, L.; Mariotti, E. Process for the Preparation of Imiquimod and Intermediates thereof. Eur. Patent EP 1529781 A1, May 11, 2005.
-
(2005)
Process for the Preparation of Imiquimod and Intermediates Thereof
-
-
Allegrini, P.1
Castaldi, G.A.2
Colombo, L.3
Mariotti, E.4
-
127
-
-
0345708168
-
Modern synthetic methods for copper-mediated C(aryl)-O, C(aryl)-N, and C(aryl)-S bond formation
-
DOI 10.1002/anie.200300594
-
Ley, S. V.; Thomas, A. W. Angew. Chem., Int. Ed. 2003, 42, 5400-5449. doi:10.1002/anie.200300594 (Pubitemid 37466273)
-
(2003)
Angewandte Chemie - International Edition
, vol.42
, Issue.44
, pp. 5400-5449
-
-
Ley, S.V.1
Thomas, A.W.2
-
129
-
-
79955542814
-
-
doi:10.1128/AAC.00976-10
-
Pirrone, V.; Thakkar, N.; Jacobson, J. M.; Wigdahl, B.; Krebs, F. C. Antimicrob. Agents Chemother. 2011, 55, 1831-1842. doi:10.1128/AAC.00976-10
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 1831-1842
-
-
Pirrone, V.1
Thakkar, N.2
Jacobson, J.M.3
Wigdahl, B.4
Krebs, F.C.5
-
130
-
-
84888595693
-
-
Eur. Patent EP 1857458A1, Nov 21
-
Rossi, A.; Vecchio, E.; Pizzocaro, R.; Bedeschi, A. Process of Preparation of Abacavir. Eur. Patent EP 1857458A1, Nov 21, 2007.
-
(2007)
Process of Preparation of Abacavir
-
-
Rossi, A.1
Vecchio, E.2
Pizzocaro, R.3
Bedeschi, A.4
-
131
-
-
78751676018
-
-
doi:10.1021/jm101254z
-
Jang, M.-Y.; Lin, Y.; De Jonghe, S.; Gao, L.-J.; Vanderhoydonk, B.; Froeyen, M.; Rozenski, J.; Herman, J.; Louat, T.; Van Belle, K.; Waer, M.; Herdewijn, P. J. Med. Chem. 2011, 54, 655-668. doi:10.1021/jm101254z
-
(2011)
J. Med. Chem.
, vol.54
, pp. 655-668
-
-
Jang, M.-Y.1
Lin, Y.2
De Jonghe, S.3
Gao, L.-J.4
Vanderhoydonk, B.5
Froeyen, M.6
Rozenski, J.7
Herman, J.8
Louat, T.9
Van Belle, K.10
Waer, M.11
Herdewijn, P.12
-
132
-
-
84866006402
-
-
doi:10.1021/ol3020418
-
Nair, D. K.; Mobin, S. M.; Namboothiri, I. N. N. Org. Lett. 2012, 14, 4580-4583. doi:10.1021/ol3020418
-
(2012)
Org. Lett.
, vol.14
, pp. 4580-4583
-
-
Nair, D.K.1
Mobin, S.M.2
Namboothiri, I.N.N.3
-
133
-
-
77951776225
-
-
Sumalatha, Y.; Reddy, T. R.; Reddy, P. P.; Satyanarayana, B. ARKIVOC 2009, No. ii, 315-320.
-
(2009)
ARKIVOC
, vol.2
, pp. 315-320
-
-
Sumalatha, Y.1
Reddy, T.R.2
Reddy, P.P.3
Satyanarayana, B.4
-
134
-
-
84872088566
-
-
doi:10.1039/C2SC21850J
-
Guetzoyan, L.; Nikbin, N.; Baxendale, I. R.; Ley, S. V. Chem. Sci. 2013, 4, 764-769. doi:10.1039/C2SC21850J
-
(2013)
Chem. Sci.
, vol.4
, pp. 764-769
-
-
Guetzoyan, L.1
Nikbin, N.2
Baxendale, I.R.3
Ley, S.V.4
-
135
-
-
77953370981
-
-
Naik, A. M.; Sawant, S. D.; Kavishwar, G. A.; Kavishwar, S. G. Int. J. ChemTech Res. 2010, 2, 1-3.
-
(2010)
Int. J. ChemTech Res.
, vol.2
, pp. 1-3
-
-
Naik, A.M.1
Sawant, S.D.2
Kavishwar, G.A.3
Kavishwar, S.G.4
-
136
-
-
44649155158
-
-
doi:10.1016/j.pbb.2008.01.001
-
Licata, S. C.; Rowlett, J. K. Pharmacol., Biochem. Behav. 2008, 90, 74-89. doi:10.1016/j.pbb.2008.01.001
-
(2008)
Pharmacol., Biochem. Behav.
, vol.90
, pp. 74-89
-
-
Licata, S.C.1
Rowlett, J.K.2
-
137
-
-
13344284559
-
Scaffold hopping
-
DOI 10.1016/j.ddtec.2004.10.009, PII S1740674904000460
-
Böhm, H.-J.; Flohr, A.; Stahl, M. Drug Discovery Today: Technol. 2004, 1, 217-224. doi:10.1016/j.ddtec.2004.10.009 (Pubitemid 40197570)
-
(2004)
Drug Discovery Today: Technologies
, vol.1
, Issue.3
, pp. 217-224
-
-
Bohm, H.-J.1
Flohr, A.2
Stahl, M.3
-
138
-
-
84888591889
-
-
U.S. Patent 2008/0045547 A1, Feb 21
-
Lippa, A. S.; Chen, Z.; Skolnick, P. Salts and Co-Crystals of Pyrazolopyrimidine Compounds, Compositions thereof and Methods for their Production and Use. U.S. Patent 2008/0045547 A1, Feb 21, 2008.
-
(2008)
Salts and Co-Crystals of Pyrazolopyrimidine Compounds, Compositions Thereof and Methods for Their Production and Use
-
-
Lippa, A.S.1
Chen, Z.2
Skolnick, P.3
-
139
-
-
34547914483
-
Flow and batch mode focused microwave synthesis of 5-amino-4- cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines
-
DOI 10.1039/b709043a
-
Smith, C. J.; Iglesias-Sigüenza, F. J.; Baxendale, I. R.; Ley, S. V. Org. Biomol. Chem. 2007, 5, 2758-2761. doi:10.1039/b709043a (Pubitemid 47258233)
-
(2007)
Organic and Biomolecular Chemistry
, vol.5
, Issue.17
, pp. 2758-2761
-
-
Smith, C.J.1
Iglesias-Siguenza, F.J.2
Baxendale, I.R.3
Ley, S.V.4
-
140
-
-
33847070745
-
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure-activity relationships
-
DOI 10.1016/j.bmcl.2006.12.116, PII S0960894X0700042X
-
Powell, D.; Gopalsamy, A.; Wang, Y. D.; Zhang, N.; Miranda, M.; McGinnis, J. P.; Rabindran, S. K. Bioorg. Med. Chem. Lett. 2007, 17, 1641-1645. doi:10.1016/j.bmcl.2006.12.116 (Pubitemid 46274362)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.6
, pp. 1641-1645
-
-
Powell, D.1
Gopalsamy, A.2
Wang, Y.D.3
Zhang, N.4
Miranda, M.5
McGinnis, J.P.6
Rabindran, S.K.7
-
142
-
-
13844272010
-
Synthesis of commercial phosphodiesterase(V) inhibitors
-
DOI 10.1021/op040019c
-
Dunn, P. J. Org. Process Res. Dev. 2005, 9, 88-97. doi:10.1021/op040019c (Pubitemid 40249112)
-
(2005)
Organic Process Research and Development
, vol.9
, Issue.1
, pp. 88-97
-
-
Dunn, P.J.1
-
144
-
-
0034605211
-
Polymer-supported reagents for multi-step organic synthesis: Application to the synthesis of sildenafil
-
DOI 10.1016/S0960-894X(00)00383-8, PII S0960894X00003838
-
Baxendale, I. R.; Ley, S. V. Bioorg. Med. Chem. Lett. 2000, 10, 1983-1986. doi:10.1016/S0960-894X(00)00383-8 (Pubitemid 30663355)
-
(2000)
Bioorganic and Medicinal Chemistry Letters
, vol.10
, Issue.17
, pp. 1983-1986
-
-
Baxendale, I.R.1
Ley, S.V.2
-
145
-
-
24144502360
-
A novel method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)- ones
-
DOI 10.1021/jo051014w
-
Heim-Riether, A.; Healy, J. J. Org. Chem. 2005, 70, 7331-7337. doi:10.1021/jo051014w (Pubitemid 41233272)
-
(2005)
Journal of Organic Chemistry
, vol.70
, Issue.18
, pp. 7331-7337
-
-
Heim-Riether, A.1
Healy, J.2
-
147
-
-
0037818564
-
-
Darkes, M. J. M.; Plosker, G. L.; Jarvis, B. Am. J. Cancer (Auckland, N. Z.) 2002, 1, 55-80.
-
(2002)
Am. J. Cancer (Auckland, N. Z.)
, vol.1
, pp. 55-80
-
-
Darkes, M.J.M.1
Plosker, G.L.2
Jarvis, B.3
-
148
-
-
37049074462
-
-
doi:10.1039/P19900001705
-
Alves, M. J.; Booth, B. L.; Fernanda, M.; Proenç, J. R. P. J. Chem. Soc., Perkin Trans. 1 1990, 1705-1712. doi:10.1039/P19900001705
-
(1990)
J. Chem. Soc., Perkin Trans.
, vol.1
, pp. 1705-1712
-
-
Alves, M.J.1
Booth, B.L.2
Fernanda, M.3
Proenç, J.R.P.4
-
149
-
-
37049073318
-
-
doi:10.1039/P29940001949
-
Alves, M. J.; Booth, B. L.; Carvalho, A.; Eastwood, P. R.; Nezhat, L.; Pritchard, R. G.; Fernanda, M.; Proença, J. R. P. J. Chem. Soc., Perkin Trans. 2 1994, 1949-1956. doi:10.1039/P29940001949
-
(1994)
J. Chem. Soc., Perkin Trans.
, vol.2
, pp. 1949-1956
-
-
Alves, M.J.1
Booth, B.L.2
Carvalho, A.3
Eastwood, P.R.4
Nezhat, L.5
Pritchard, R.G.6
Fernanda, M.7
Proença, J.R.P.8
-
150
-
-
0000345568
-
-
doi:10.1021/ja01122a037
-
Elion, G. B.; Burgi, C.; Hitchings, G. H. J. Am. Chem. Soc. 1952, 74, 411-414. doi:10.1021/ja01122a037
-
(1952)
J. Am. Chem. Soc.
, vol.74
, pp. 411-414
-
-
Elion, G.B.1
Burgi, C.2
Hitchings, G.H.3
-
151
-
-
0034770672
-
Synthesis of aryl(orbenzyl)-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidines
-
DOI 10.1081/SCC-100107009
-
Yahya-Zadeh, A.; Booth, B. L. Synth. Commun. 2001, 31, 3617-3622. doi:10.1081/SCC-100107009 (Pubitemid 32983403)
-
(2001)
Synthetic Communications
, vol.31
, Issue.23
, pp. 3617-3622
-
-
Yahya-Zadeh, A.1
Booth, B.L.2
-
153
-
-
78649440712
-
-
U.S. Patent 5,260,291, Nov 9
-
Lunt, E.; Stevens, M. F. G.; Stone, R.; Wooldridge, K. R. H.; Newlands, E. D. Tetrazine Derivatives. U.S. Patent 5,260,291, Nov 9, 1993.
-
(1993)
Tetrazine Derivatives
-
-
Lunt, E.1
Stevens, M.F.G.2
Stone, R.3
Wooldridge, K.R.H.4
Newlands, E.D.5
-
155
-
-
84888597032
-
-
Eur. Patent EP 2151442 A2, Feb 10
-
Turchetta, S.; De Ferra, L.; Zenoni, M.; Anibaldi, M. Process for Preparing Temozolomide. Eur. Patent EP 2151442 A2, Feb 10, 2010.
-
(2010)
Process for Preparing Temozolomide
-
-
Turchetta, S.1
De Ferra, L.2
Zenoni, M.3
Anibaldi, M.4
-
156
-
-
65649142070
-
-
doi:10.1021/jm801513z
-
Pitt, W. R.; Parry, D. M.; Perry, B. G.; Groom, C. R. J. Med. Chem. 2009, 52, 2952-2963. doi:10.1021/jm801513z
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2952-2963
-
-
Pitt, W.R.1
Parry, D.M.2
Perry, B.G.3
Groom, C.R.4
|