Discovery of 7- N -piperazinylthiazolo[5,4- d ]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity

Journal of Medicinal Chemistry

Volumn 54, Issue 2, 2011, Pages 655-668

  Jang, Mi Yeon ^a   Lin, Yuan ^b   De Jonghe, Steven ^b   Gao, Ling Jie ^b   Vanderhoydonck, Bart ^b   Froeyen, Mathy ^a   Rozenski, Jef ^a   Herman, Jean ^b   Louat, Thierry ^b   Van Belle, Kristien ^b   Waer, Mark ^b   Herdewijn, Piet ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

7 N PIPERAZINYLTHIAZOLO[5,4 D]PYRIMIDINE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; GRAFT REJECTION; IC 50; MIXED LYMPHOCYTE REACTION; ORGAN TRANSPLANTATION;

ANIMALS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRANSPLANTATION, HOMOLOGOUS;

EID: 78751676018     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101254z     Document Type: Article

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