Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165

Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2002, Pages 1064-1072

  Gohlke, Holger ^a   Gündisch, Daniela ^b   Schwarz, Simone ^a   Seitz, Gunther ^a   Tilotta, Maria Cristina ^b   Wegge, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

(2 CHLORO 5 PYRIDYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (4 PYRIDAZINYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (PYRAZINYL 5 YL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (PYRIMIDIN 5 YL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 PYRIDIN 3 YL 9 AZABICYCLO[4.2.1]NON 2 ENE; 3 DIETHYLBORANYLPYRIDINE; 9 AZABICYCLO[4.2.1]NONAN 2 ONE; ANATOXIN A; DIAZINE DERIVATIVE; DUB 165; EPIBATIDINE; FERRUGININE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NITROGEN; ORGANOTIN COMPOUND; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RECEPTOR SUBTYPE; TRIFLUOROMETHANESULFONIC ACID VINYL ESTER; UB 165; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CALCULATION; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; DRUG PURITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; QUALITATIVE ANALYSIS; RAT; RECEPTOR AFFINITY; STEREOISOMERISM; STILLE REACTION; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE; SUZUKI REACTION; SWINE;

ADRENAL GLANDS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; BRAIN; BRIDGED COMPOUNDS; LIGANDS; NICOTINIC AGONISTS; PYRAZINES; PYRIDAZINES; PYRIDINES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0037186458     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010936y     Document Type: Article

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