Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 2, 1997, Pages 437-444

  Watanabe, Masamichi ^a   Koike, Haruo ^a   Ishiba, Teruyuki ^a   Okada, Tetsuo ^a   Seo, Shujiro ^a   Hirai, Kentaro ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PRAVASTATIN; ROSUVASTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; LIVER CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; CELLS, CULTURED; ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; RATS; SULFONAMIDES;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0031081522     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00248-9     Document Type: Article

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