SCOPUS 정보 검색 플랫폼

Volumn 99, Issue 4, 2000, Pages 255-260

Science, art and drug discovery: A personal perspective

Author keywords

cGMP; Clinical trials; Combinatorial chemistry; Drug discovery; Erectile dysfunction; Food and Drugs Administration approval; Genomics; High throughput screening; Nitric oxide; Pharmacogenetics; Phosphodiesterases 5; Sildenafil (Viagra ); Target validation

Indexed keywords

CYCLIC GMP; ISOENZYME; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; PYRAZOLOPYRIMIDINE DERIVATIVE; SILDENAFIL; ZAPRINAST;

BLOOD FLOW; CARDIOVASCULAR EFFECT; COMPUTER MODEL; CONFERENCE PAPER; DRUG APPROVAL; DRUG DESIGN; DRUG POTENCY; DRUG RESEARCH; ERECTILE DYSFUNCTION; FOOD AND DRUG ADMINISTRATION; HUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TECHNOLOGY;

EID: 0033787344 PISSN: 01435221 EISSN: None Source Type: Journal
DOI: 10.1042/cs0990255 Document Type: Conference Paper

Times cited : (76)

References (15)

1
- 0344671145
- Chem. Britain, January
- (1999) Making the love drug , pp. 24-26
- Palmer, E.¹

2
- 85037926666
- Pfizer Research Proposal
- (1995)
- Campbell, S.F.¹ Roberts, D.A.²

3
- 0028802726
- Cyclic nucleotide phosphodiesterases; functional implications of multiple isoforms
- (1995) Physiol. Rev. , vol.75 , pp. 725-748
- Beavo, J.A.¹

4
- 0033522211
- Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro
- (1999) Am. J. Cardiol. , vol.83
- Wallis, R.M.¹ Corbin, J.D.² Francis, S.H.³ Ellis, P.⁴

5
- 0032502708
- Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells
- (1998) Life Sci. , vol.62 , pp. 309-318
- Moreland, R.B.¹ Goldstein, I.² Traish, A.³

6
- 0026630039
- Nitric oxide mediates relaxation in rabbit and human corpus cavernosum smooth muscle
- (1992) Urol. Res. , vol.20 , pp. 253-257
- Knispel, H.H.¹ Goessl, C.² Beckmann, R.³

7
- 0026353632
- Nitric oxide as a mediator of relaxation of the corpus cavernosum response to nonadrenergic, noncholinergic neurotransmission
- (1992) N. Engl. J. Med. , vol.326 , pp. 90-94
- Rajfer, J.¹ Aronson, W.J.² Bush, P.A.³ Dorey, F.J.⁴ Ignarro, L.J.⁵

8
- 0032445219
- Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
- (1998) J. Urol. , vol.159 , pp. 2164-2171
- Ballard, S.A.¹ Gingell, C.J.² Tang, K.³ Turner, L.A.⁴ Price, M.E.⁵ Naylor, A.M.⁶

9
- 0028036149
- Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Ageing Study
- (1994) J. Urol. , vol.151 , pp. 54-61
- Feldman, H.A.¹ Goldstein, I.² Hatzichristou, D.G.³ Krane, R.J.⁴ McKinley, J.B.⁵

10
- 0030926566
- The international index of erectile dysfunction (IIEF): A multidimensional scale for assessment of erectile dysfunction
- (1997) Urology , vol.49 , pp. 822-830
- Rosen, R.C.¹ Riley, A.² Wagner, G.³ Osterloh, I.A.⁴ Kirkpatrick, J.⁵ Mishra, A.⁶

11
- 0032516296
- Oral sildenafil in the treatment of erectile dysfunction
- (1998) N. Engl. J. Med. , vol.338 , pp. 1397-1404
- Goldstein, I.¹ Lue, T.F.² Padma-Nathan, H.³ Rosen, R.C.⁴ Steers, W.D.⁵ Wicker, P.A.⁶

12
- 0033522214
- Overall cardiovascular profile of sildenafil citrate
- (1999) Am. J. Cardiol. , vol.83
- Zusman, R.M.¹ Morales, A.² Glasser, D.B.³ Osterloh, I.H.⁴

13
- 0033522215
- Cardiovascular data on sildenafil citrate
- (1999) Am. J. Cardiol. , vol.83
- Zusman, R.M.¹

14
- 0034677966
- Drug discovery: A historical perspective
- (2000) Science , vol.287 , pp. 1960-1964
- Drews, J.¹

15
- 0032872173
- How many leads from HTS?
- (1999) Drug Discovery Today , vol.4 , pp. 447-448
- Lahana, R.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.