Bioisosteric replacement strategy for the synthesis of 1-azacyclic compounds with high affinity for the central nicotinic cholinergic receptors

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 6, 2000, Pages 1443-1450

  Olesen, Preben H ^a   Tønder, Janne E ^a   Hansen, John Bondo ^a   Hansen, Holger C ^a   Rimvall, Karin ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLCARBACHOL; NICOTINIC AGENT; NICOTINIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CONFORMATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50; MOLECULAR MODEL; NONHUMAN; RAT; RECEPTOR AFFINITY;

AZA COMPOUNDS; BICYCLO COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RECEPTORS, NICOTINIC;

EID: 0034124493     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00063-8     Document Type: Article

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